A multinational team comprising of Todor Dudev, Karine Mazmanian, Felix Weng, Cedric Grauffel led by Carmay Lim, Distinguished Research Fellow at the Institute of Biomedical Sciences, has explored this question in a recent publication in Accounts of Chemical Research. They have provided a unifying physicochemical basis that underlies lithium’s multifaceted effects based on its competition as a free monocation with native cations in proteins and as a phosphate-bound polyanionic complex modulating the host protein function.

Article Link: https://www.ncbi.nlm.nih.gov/pubmed/31556294

（細胞與個體生物學研究所）