Ovarian cancer is a highly heterogeneous and malignant female cancer with an overall low survival rate. In particular, advanced ovarian clear cell carcinoma with wildtype p53 has a poor prognosis, drug resistance, metastasis and recurrence. The research team of Dr. Wendy W. Hwang-Verslues at Genomics Research Center found that MEX3A facilitates p53 degradation to drive ovarian cancer growth by circumventing p53-mediated ferroptosis. These findings suggest that targeting MEX3A can be a potential strategy for treating of ovarian cancer expressing wildtype p53 and were published in Cancer Research.

For further information
https://www.genomics.sinica.edu.tw/index.php/tw/news/lastest-news/701-mex3a-p53

Article link:
https://aacrjournals.org/cancerres/article/doi/10.1158/0008-5472.CAN-22-1159/710535/MEX3A-mediates-p53-degradation-to-suppress