A research team led by Dr. Che Ma and Dr. Wen-Hwa Lee in the Genomics Research Center reported they solved complex structure of IL-17RB with a monoclonal antibody against this receptor, and this structure provides important paratope information to guide the design of humanization and affinity maturation of this antibody. Eventually, an affinity matured humanized antibody was demonstrated to have significant inhibition of pancreatic tumorigenesis in an orthotopic mouse model. This research has been published in the journal “Cell Reports“.

For further information:
https://www.genomics.sinica.edu.tw/index.php/en/news/latest-news/697-crystal-structure-of-17b-receptor-complexed-with-antibody-d9-provides-solution-for-guiding-antibody-humanization-and-affinity-maturation

Article link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01411-5