Recent studies indicate that high levels of neutrophil extracellular traps (NETs) were detected in COVID-19 patients’ serum and organs. NETs contribute to immunothrombosis, thereby leading to extensive intravascular coagulopathy and multiple organ dysfunctions. A team led by Dr. Shie-Liang Hsieh at the Genomics Research Center, Academia Sinica reported that high level of platelet-derived extracellular vesicles (PLT-EVs) was found in COVID-19 patients, and PLT-EVs contribute to severe immunothrombosis via CLEC5A and TLR2. Thus, blockade of CLEC5A and TLR2 is a novel strategy to prevent SARS-CoV2-induced immunothrombosis.

Article Link:
https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-022-00832-z

For further information:
https://www.genomics.sinica.edu.tw/index.php/en/news/lastest-news/689-clec5a-tlr2-sars-cov-2