Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the HTT gene. A work in Movement Disorders conducted by Dr. Yijuang Chern’s group, at the Institute of Biomedical Sciences, demonstrated that during HD progression, the level of the Translin-associated protein X (TRAX, a scaffold protein that mediates miRNA degradation) was markedly enhanced in the brain of patients and mice with HD. Such TRAX upregulation is protective in HD, because genetic downregulation of TRAX in the brain of HD mice altered the miRNA-mRNA network and accelerated disease progression.

For further information: https://www.ibms.sinica.edu.tw/en/news/2022-443.html
Article link: https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.29174