The research team from Genomic Research Center was inspired by pyrrolidine-based alkaloid AN9 and bicyclic alkaloid swainsonine to design a hybrid skeleton to generate potential candidate scaffolds, followed by structural diversity called “Natural product-inspired combinatorial chemistry” (NPICC) to rapidly prepare this indolizidine-based molecular library. The team discovered a compound named ACK900, which is not only an effective α-hGMII inhibitor but also a selective inhibitor. Further animal studies showed it is a promising anticancer agent. These research results are published in Chemical Science, the flagship journal of The Royal Society of Chemistry, and recommended by its Reviewers as one of the HOT Chemical Science articles published in 2022.

Article:https://pubs.rsc.org/en/content/articlelanding/2022/sc/d1sc05894k