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The circles Part II: investigating causal relationship between genetic variants and circular RNA expression in autism

By integrating RNA-sequencing with genotype data from autistic brains, the research team led by Dr. Trees-Juen Chuang’s group at Genomics Research center, Academia Sinica assessed expression quantitative trait loci of circRNAs (circQTLs) that cis-regulate expression of nearby circRNAs and trans-regulate expression of distant genes (trans-eGenes) simultaneously. The study provided the...(more)

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Ketogenic Gene Therapy Allows Heart Regeneration and Rejuvenation

Heart disease is the leading cause of death worldwide, with myocardial infarction (heart attack) being the most common cause. Heart transplantation is still the optimal treatment for the disease, but there are insufficient donors to meet the demands. In mammals, including humans, cardiac muscle cells (cardiomyocytes) cannot keep dividing and...(more)

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