{"id":6201,"date":"2018-06-21T00:00:40","date_gmt":"2018-06-20T16:00:40","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=6201"},"modified":"2021-08-12T15:27:35","modified_gmt":"2021-08-12T07:27:35","slug":"%e6%88%91%e5%80%91%e9%ab%94%e5%85%a7%e7%ab%9f%e7%84%b6%e4%bd%8f%e8%91%97%e5%89%aa%e6%8e%a5%e5%b8%ab%ef%bc%81%e9%84%ad%e6%b7%91%e7%8f%8d%e7%9a%84-rna-%e5%89%aa%e6%8e%a5%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/6201\/","title":{"rendered":"\u6211\u5011\u9ad4\u5167\u7adf\u7136\u4f4f\u8457\u526a\u63a5\u5e2b\uff01\u912d\u6dd1\u73cd\u7684 RNA \u526a\u63a5\u7814\u7a76"},"content":{"rendered":"
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\u4ec0\u9ebc\u662f RNA \u526a\u63a5<\/div>\n
<\/div>\n<\/div>\n<\/div>\n<\/div>\n
\u5982\u679c DNA \u662f\u96fb\u5f71\u5287\u672c\uff0c\u8a18\u8f09\u8457\u751f\u7269\u9ad4\u61c9\u8a72\u6f14\u51fa\u4ec0\u9ebc\u6a23\u7684\u96fb\u5f71\u3002 RNA \u5c31\u50cf\u4f9d\u5287\u672c\u62cd\u651d\u51fa\u4f86\u7684\u5f71\u7247\u7247\u6bb5\uff0c\u9700\u518d\u900f\u904e\u300c\u526a\u63a5\u300d\u624d\u80fd\u7d44\u6210\u5287\u60c5\u76f8\u7b26\u7684\u96fb\u5f71\uff0c\u800c\u7d30\u80de\u5167\u7684\u300c\u526a\u63a5\u5e2b\u5718\u968a\u300d\u5c31\u7531\u4e94\u500b\u5c0f\u6838\u6838\u91a3\u6838\u9178\u53ca\u591a\u7a2e\u86cb\u767d\u56e0\u5b50\u3001\u86cb\u767d\u8907\u5408\u9ad4\u5206\u5de5\u5408\u4f5c\u3002<\/div>\n
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\"\"<\/div>\n
\u4e2d\u7814\u9662\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240\u7684\u912d\u6dd1\u73cd\u9662\u58eb\uff0c\u8207\u5718\u968a\u900f\u904e\u5be6\u9a57\u767c\u73fe\u751f\u7269\u9ad4\u5167\u7684\u300c RNA \u526a\u63a5\u5e2b\u5718\u968a\u300d\u3002\u651d\u5f71\u2502\u5f35\u8a9e\u8fb0<\/div>\n
<\/div>\n
<\/div>\n
\u56de\u60f3\u56db\u5341\u5e74\u524d\uff0c\u912d\u6dd1\u73cd\u9084\u662f\u81fa\u7063\u5927\u5b78\u5316\u5b78\u7cfb\u7684\u5927\u56db\u751f\uff0c\u8ddf\u8457\u7f85\u9285\u58c1\u9662\u58eb\u505a\u5c08\u984c\u7814\u7a76\uff0c\u4ee5\u86c7\u6bd2\u86cb\u767d\u70ba\u6750\u6599\u3002\u300c\u9019\u8ddf\u4f5c\u5316\u5b78\u5be6\u9a57\u5f88\u4e0d\u4e00\u6a23\uff0c\u611f\u89ba\u8ddf\u751f\u547d\u6bd4\u8f03\u6709\u9023\u7d50\uff0c\u6709\u5f88\u591a\u81ea\u7136\u5967\u79d8\u7b49\u5f85\u88ab\u958b\u767c\uff01\u300d\u912d\u6dd1\u73cd\u56de\u60f3\u559c\u6b61\u4e0a\u751f\u5316\u5be6\u9a57\u7684\u65e5\u5b50\u3002<\/div>\n
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\u56db\u5341\u5e74\u904e\u53bb\uff0c\u912d\u6dd1\u73cd\u4ecd\u6295\u8eab\u65bc\u57fa\u790e\u7814\u7a76\uff0c\u53ea\u662f\u5c0d\u8c61\u4e0d\u518d\u662f\u86c7\u6bd2\u86cb\u767d\uff0c\u800c\u662f\u751f\u7269\u9ad4\u5167 RNA \u526a\u63a5\u7684\u5967\u79d8\u3002<\/p>\n

\"\"<\/p>\n

\u767c\u751f\u5728\u4f60\u6211\u9ad4\u5167\u7684\u300c\u526a\u63a5\u300d<\/b><\/strong><\/h2>\n

\u96fb\u5f71\u526a\u63a5\u6559\u7236 Walter Murch \u66fe\u8aaa\uff1a\u300c\u6700\u597d\u7684\u526a\u63a5\uff0c\u662f\u50cf\u7728\u773c\u4e00\u6a23\u81ea\u7136\u300d\uff0c\u800c\u5728\u81ea\u7136\u754c\u4e2d\uff0c\u7728\u773c\u4e00\u77ac\u9593\u3001\u751a\u81f3\u6bd4\u7728\u773c\u66f4\u5feb\u7684\u77ac\u9593\uff0c\u751f\u7269\u9ad4\u5167\u4e5f\u6709\u8a31\u591a\u300c RNA \u526a\u63a5\u300d\u6b63\u5728\u904b\u884c\u3002<\/p>\n

\u77ad\u89e3 RNA \u526a\u63a5\u4e4b\u524d\uff0c\u6211\u5011\u5148\u5c0d\u751f\u7269\u7684\u4e2d\u5fc3\u5b9a\u5f8b<\/a>\u00a0(Central Dogma)\u2500\u2500\u300c\u5f9e DNA \u5230\u86cb\u767d\u8cea\u300d\u9019\u904e\u7a0b\u6709\u500b\u6982\u5ff5\uff1a\"\"DNA \u6703\u5148\u8f49\u9304\u6210 RNA \uff0c\u518d\u526a\u63a5\u52a0\u5de5\u70ba\u6210\u719f mRNA\uff0c\u4e26\u9001\u53bb\u7d30\u80de\u8cea\u88fd\u9020\u86cb\u767d\u8cea\u3002(\u5716\u4e2d\u526a\u5200\u70ba RNA \u526a\u63a5\u7684\u793a\u610f\u4f4d\u7f6e\u3002)
\n\u5716\u8aaa\u8a2d\u8a08\u2502\u6797\u5a77\u5afb\u3001\u5f35\u8a9e\u8fb0<\/p>\n

\u4eba\u9ad4\u4e2d\u6709\u5404\u7a2e\u86cb\u767d\u8cea\u53c3\u8207\u5404\u7a2e\u529f\u80fd\uff0c\u4f8b\u5982\u4ee3\u8b1d\u4f5c\u7528\u3001\u8abf\u7bc0\u808c\u8089\u6536\u7e2e\u3001\u514d\u75ab\u53cd\u61c9\u7b49\u7b49\uff0c\u800c\u5404\u7a2e\u86cb\u767d\u8cea\u7684\u529f\u80fd\u88ab\u300c\u7de8\u78bc\u300d\u65bc\u6700\u6e90\u982d\u7684 DNA \u57fa\u56e0\u7247\u6bb5\u3002\u6700\u6e90\u982d\u7684 DNA \u57fa\u56e0\u7247\u6bb5\uff0c\u53ef\u7d30\u5206\u70ba\u5169\u7a2e\u5340\u6bb5\uff1a\u8868\u73fe\u5b50<\/a>(\u6216\u7a31\u5916\u986f\u5b50, Exon) \u3001\u4ecb\u5165\u5b50<\/a>(\u6216\u7a31\u5167\u542b\u5b50, Intron) \u3002<\/p>\n

\"\"DNA \u57fa\u56e0\u7247\u6bb5\uff0c\u5206\u70ba\u8868\u73fe\u5b50 (Exon) \u548c\u4ecb\u5165\u5b50 (Intron)\u3002
\n\u8cc7\u6599\u4f86\u6e90\u2502\u912d\u6dd1\u73cd \u5716\u8aaa\u91cd\u88fd\u2502\u6797\u5a77\u5afb\u3001\u5f35\u8a9e\u8fb0<\/p>\n<\/div>\n

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\u300c\u8868\u73fe\u5b50\u300d\u65bc RNA \u526a\u63a5\u6642\u6703\u88ab\u300c\u7559\u4e0b\u300d\uff0c\u800c\u300c\u4ecb\u5165\u5b50\u300d\u6703\u5728 RNA \u526a\u63a5\u6642\u88ab\u300c\u6368\u53bb\u300d\u3002\u4fdd\u7559\u7684\u8868\u73fe\u5b50\u88ab\u7d44\u6210\u4e00\u6bb5 mRNA \u907a\u50b3\u8a0a\u606f\uff0c\u4e26\u4f9d\u6b64 mRNA \u907a\u50b3\u8a0a\u606f\u88fd\u9020\u51fa\u5c0d\u61c9\u7684\u86cb\u767d\u8cea\uff0c\u86cb\u767d\u8cea\u518d\u65bc\u751f\u7269\u9ad4\u5167\u767c\u63ee\u61c9\u6709\u7684\u529f\u80fd\u3002<\/p>\n<\/div>\n<\/div>\n

\"RNARNA \u526a\u63a5\u904e\u7a0b\u4e2d\uff0c\u7531\u6838\u9178\u53ca\u86cb\u767d\u56e0\u5b50\u7d44\u6210\u7684\u300c\u526a\u63a5\u9ad4\u300d\uff0c\u6703\u526a\u4e0b\u4e0d\u9700\u8981\u7684\u4ecb\u5165\u5b50\u3001\u7d44\u88dd\u88ab\u4fdd\u7559\u7684\u8868\u73fe\u5b50\u3002
\n\u8cc7\u6599\u4f86\u6e90\u2502\u912d\u6dd1\u73cd \u5716\u8aaa\u91cd\u88fd\u2502\u6797\u5a77\u5afb\u3001\u5f35\u8a9e\u8fb0<\/p>\n
\n
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<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\u4eba\u9ad4\u4e2d\u6240\u6709\u7684\u8868\u73fe\u5b50\uff0c\u4e5f\u5c31\u662f\u80fd\u5920\u88fd\u9020\u86cb\u767d\u8cea\u7684\u57fa\u56e0\u7de8\u78bc\uff0c\u5176\u5be6\u53ea\u4f54\u4eba\u9ad4\u57fa\u56e0\u9ad4\u7e3d\u9577\u5ea6 1.5% \u3002\u70ba\u4ec0\u9ebc\u9019\u9ebc\u5c11\u7684\u57fa\u56e0\uff0c\u537b\u80fd\u7d44\u5408\u51fa\u4eba\u9ad4\u4e2d\u90a3\u9ebc\u591a\u7a2e\u8907\u96dc\u7684\u86cb\u767d\u8cea\uff1f\u53c8\u6216\u8005\uff0c\u70ba\u4ec0\u9ebc\u6709\u4e9b\u60c5\u6cc1\u4e0b\uff0c \u8868\u73fe\u5b50\u7684 DNA \u5e8f\u5217\u660e\u660e\u7121\u7570\u5e38\uff0c\u537b\u7522\u51fa\u5947\u602a\u7684\u86cb\u767d\u8cea\uff0c\u5c0e\u81f4\u751f\u7406\u7570\u5e38\u6216\u907a\u50b3\u6027\u75be\u75c5\uff1f<\/div>\n
<\/div>\n
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\u5967\u79d8\u5728\u65bc\u300c RNA \u526a\u63a5\u300d\u662f\u5426\u6b63\u78ba\u904b\u4f5c\uff1a\u526a\u6389\u4e0d\u8981\u7684\u4ecb\u5165\u5b50\uff0c\u4e26\u4fdd\u7559\u3001\u7d44\u88dd\u9700\u8981\u7684\u8868\u73fe\u5b50\u3002<\/strong><\/h4>\n<\/div>\n<\/blockquote>\n

\u300c\u6368\u300d\u8207\u300c\u7559\u300d\u7684\u7cbe\u6e96<\/b><\/strong><\/h2>\n

\u300c\u96fb\u5f71\u526a\u63a5\uff0c\u4e3b\u8981\u662f\u900f\u904e\u300e\u6e1b\u6cd5\u300f\u4f86\u9054\u6210\u7684\u4e00\u9580\u85dd\u8853\uff0c\u5426\u6c7a\u90a3\u4e9b\u5c0d\u6700\u7d42\u6210\u679c\u7121\u7528\u7684\u5143\u7d20\u3002\u9019\u500b\u5f62\u5f0f\u4e0d\u53ea\u662f\u7531\u4fdd\u7559\u4e86\u4ec0\u9ebc\u4f86\u6c7a\u5b9a\uff0c\u88ab\u522a\u9664\u4e86\u4ec0\u9ebc\u4e5f\u540c\u7b49\u91cd\u8981\u3002\u300d\u2014\u2014\u300a\u526a\u63a5\u5e2b\u4e4b\u8def\u300b\u4f5c\u8005 Justin Chang \u3002<\/p>\n

\u9019\u500b\u5fc3\u6cd5\u4e0d\u55ae\u6307\u96fb\u5f71\u526a\u63a5\uff0c\u751f\u7269\u9ad4\u5167\u7684 RNA \u526a\u63a5\u4e5f\u662f\u3002\u6211\u5011\u53ef\u8a66\u8457\u5c07 RNA \u526a\u63a5\u52a0\u5de5\u6210 mRNA \u7684\u904e\u7a0b\uff0c\u60f3\u50cf\u6210\u4e0b\u5716\u3002<\/p>\n

\"\"\u7531\u6838\u9178\u53ca\u591a\u7a2e\u86cb\u767d\u56e0\u5b50\u7d44\u6210\u7684\u526a\u63a5\u9ad4 (Spliceosome)\uff0c\u5c31\u50cf\u751f\u7269\u9ad4\u5167\u7684\u96fb\u5f71\u526a\u63a5\u5718\u968a\u3002
\n\u5716\u8aaa\u8a2d\u8a08\u2502\u6797\u5a77\u5afb\u3001\u5f35\u8a9e\u8fb0<\/p>\n

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RNA \u57fa\u56e0\u7247\u6bb5\uff0c\u662f\u6839\u64da DNA \u96fb\u5f71\u8173\u672c\u62cd\u651d\u51fa\u4f86\u7684\u5f71\u7247\u7247\u6bb5\uff0c\u800c\u526a\u63a5\u9ad4 (Spliceosome) \u5c31\u50cf\u751f\u7269\u9ad4\u5167\u7684\u526a\u63a5\u5e2b\u5718\u968a\uff0c\u5c07\u9700\u8981\u7684\u5f71\u7247\u7247\u6bb5\u7559\u4e0b\u4f86\u7d44\u88dd\u3001\u8aaa\u6210\u6709\u610f\u7fa9\u7684\u6545\u4e8b\u60c5\u7bc0\uff0c\u800c\u4e0d\u9700\u8981\u7684\u93e1\u982d\u756b\u9762\uff0c\u5c31\u5982\u540c\u88ab\u526a\u53bb\u7684\u4ecb\u5165\u5b50\u3002<\/p>\n

\u82e5\u67d0\u4e00\u6b65\u9a5f\u526a\u932f\uff0c\u5c11\u4e86\u3001\u6216\u591a\u4e86\u4e00\u6bb5\u5f71\u7247\u7247\u6bb5\uff0c\u96fb\u5f71\u60c5\u7bc0\u5c31\u6703\u8b93\u4eba\u6eff\u982d\u554f\u865f\u3002\u60c5\u7bc0\u932f\u8aa4\u7684\u96fb\u5f71\uff0c\u5982\u540c\u6700\u7d42\u7522\u51fa\u7684\u932f\u8aa4\u86cb\u767d\u8cea\uff0c\u8b93\u9ad4\u5167\u751f\u7406\u6a5f\u5236\u4e5f\u6eff\u982d\u554f\u865f\uff0c\u5c0e\u81f4\u751f\u7406\u7570\u5e38\u6216\u907a\u50b3\u6027\u75be\u75c5\u3002<\/p>\n<\/div>\n<\/div>\n

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\u5efa\u69cb RNA \u526a\u63a5\u8def\u5f91<\/b><\/strong><\/h2>\n

\u8981\u77ad\u89e3 RNA \u526a\u63a5\u54ea\u88e1\u51fa\u932f\uff0c\u9700\u5148\u900f\u5fb9\u77ad\u89e3\u526a\u63a5\u8def\u5f91\u3002\u912d\u6dd1\u73cd\u5718\u968a\u4ee5\u9175\u6bcd\u83cc\u70ba\u6a21\u5f0f\u7cfb\u7d71\uff0c\u900f\u904e\u5be6\u9a57\u62c6\u89e3 RNA \u526a\u63a5\u52a0\u5de5\u6210\u70ba mRNA \u7684\u6b65\u9a5f\uff0c\u627e\u51fa\u662f\u54ea\u4e9b\u300c\u526a\u63a5\u5e2b\u2500\u2500\u86cb\u767d\u56e0\u5b50\u3001\u86cb\u767d\u8907\u5408\u9ad4\u300d\u53c3\u8207\u5176\u4e2d\u3002<\/p>\n

\u9175\u6bcd\u83cc\u9019\u7a2e\u55ae\u7d30\u80de\u751f\u7269\uff0c\u6709\u8fa6\u6cd5\u5e6b\u52a9\u77ad\u89e3\u4eba\u9ad4\u55ce\uff1f\u912d\u6dd1\u73cd\u8aaa\u660e\uff0cRNA \u526a\u63a5\u662f\u771f\u6838\u751f\u7269\u9ad4\u5167\u4e00\u500b\u57fa\u672c\u7684\u751f\u5316\u53cd\u61c9\uff0c\u5728\u5404\u7a2e\u751f\u7269\u4e2d\u6a5f\u5236\u5927\u81f4\u76f8\u4f3c\u3002\u96d6\u7136\u4eba\u9ad4\u6bd4\u9175\u6bcd\u83cc\u8907\u96dc\u5f88\u591a\uff0c\u4f46\u4eba\u9ad4\u7684\u57fa\u56e0\u6578\u91cf\u5176\u5be6\u53ea\u6709\u9175\u6bcd\u83cc\u7684\u56db\u500d\u3002<\/p>\n<\/div>\n

\n

\u9ad8\u7b49\u751f\u7269\u9ad4\u5167\uff0c\u4e00\u6bb5\u57fa\u56e0\u7de8\u78bc\u505a\u51fa\u4e0d\u53ea\u4e00\u7a2e\u86cb\u767d\u8cea\uff0c\u5c31\u662f\u5229\u7528\u300c\u526a\u63a5\u300d\u6392\u5217\u7d44\u5408\u4f86\u9054\u6210\u3002<\/strong><\/h4>\n<\/blockquote>\n

\u591a\u5e74\u4f86\u7684\u52aa\u529b\uff0c\u7d50\u5408\u5176\u4ed6\u7814\u7a76\u5718\u968a\u63d0\u4f9b\u7684\u8cc7\u8a0a\uff0c\u5c0d\u526a\u63a5\u8def\u5f91\u7684\u8a8d\u77e5\u6574\u5408\u65bc\u4e0b\u5716\u5448\u73fe\u3002\u7c21\u55ae\u4f86\u8aaa\uff0cRNA \u526a\u63a5\u904e\u7a0b\u53ef\u5206\u70ba\u56db\u500b\u968e\u6bb5\uff1a\u7d44\u88dd\u3001\u6d3b\u5316\u3001\u50ac\u5316\u3001\u62c6\u89e3\u3002\u904e\u7a0b\u4e2d\uff0c\u7531\u4e94\u500b\u5c0f\u6838\u6838\u91a3\u6838\u9178\u53ca\u591a\u7a2e\u86cb\u767d\u56e0\u5b50\u7d44\u6210\u526a\u63a5\u5e2b\u5718\u968a\uff0c\u64d4\u7db1\u526a\u63a5\u4efb\u52d9\u3002<\/p>\n

\"\"
\nRNA \u526a\u63a5\u8def\u5f91\u3002
\n\u8cc7\u6599\u4f86\u6e90\u2502\u912d\u6dd1\u73cd \u5716\u8aaa\u91cd\u88fd\u2502\u6797\u5a77\u5afb\u3001\u5f35\u8a9e\u8fb0<\/p>\n<\/div>\n

\n
\n

\u5728 RNA \u526a\u63a5\u904e\u7a0b\u4e2d\uff0c\u6709\u4e9b\u86cb\u767d\u56e0\u5b50\u8ca0\u8cac\u5c07\u8981\u88ab\u7d44\u88dd\u7684\u8868\u73fe\u5b50\u62c9\u8fd1\u4e00\u9ede\uff0c\u6709\u4e9b\u86cb\u767d\u8907\u5408\u9ad4(\u4f8b\u5982 NTC) \u8ca0\u8cac\u6d3b\u5316\u7d50\u69cb\u3001\u50ac\u5316\u526a\u63a5\u53cd\u61c9\u3002\u6709\u4e9b\u86cb\u767d\u8907\u5408\u9ad4(\u4f8b\u5982 NTR) \u8ca0\u8cac\u62c6\u89e3\u7d50\u69cb\uff0c\u8b93\u86cb\u767d\u56e0\u5b50\u53ef\u4ee5\u91cd\u65b0\u53c3\u8207\u4e00\u6b21\u526a\u63a5\u8f2a\u8ff4\u3002<\/p>\n

\u5176\u4e2d\u7684 NTC\u3001NTR \u86cb\u767d\u8907\u5408\u9ad4\uff0c\u548c Cwc22\u3001Cwc24\u3001Cwc25\u3001Yju2 \u7b49\u86cb\u767d\u56e0\u5b50\uff0c\u4e00\u958b\u59cb\u6c92\u4eba\u77e5\u9053\u5b83\u5011\u7684\u5b58\u5728\u8207\u529f\u80fd\uff0c\u76f4\u5230\u912d\u6dd1\u73cd\u5718\u968a\u900f\u904e\u751f\u5316\u5be6\u9a57\uff0c\u4e00\u4e00\u62c6\u89e3 RNA \u526a\u63a5\u6b65\u9a5f\uff0c\u624d\u767c\u73fe\u9019\u4e9b\u53c3\u8207\u53cd\u61c9\u7684\u300c\u526a\u63a5\u5e2b\u5718\u968a\u300d\u3002<\/p>\n

\u81ea\u7136\u60c5\u6cc1\u4e0b\uff0c\u751f\u7269\u9ad4\u5167\u7684\u526a\u63a5\u904e\u7a0b\u6709\u53ef\u80fd\u6703\u51fa\u932f\uff0c\u4f8b\u5982\uff0c\u7576\u526a\u63a5\u86cb\u767d\u56e0\u5b50\u90fd\u88ab\u5957\u7262\u5728 RNA \u57fa\u56e0\u7247\u6bb5\u4e0a\uff0c\u5c0e\u81f4\u65b0\u7684 RNA \u6c92\u6709\u4eba\u624b\u4f86\u526a\u63a5\uff0c\u5c31\u6703\u5c0d\u7d30\u80de\u7522\u751f\u4e0d\u826f\u5f71\u97ff\u3002\u53ef\u4ee5\u60f3\u50cf\u6210\uff0c\u7576\u526a\u63a5\u5e2b\u5718\u968a\u5168\u90fd\u5361\u5728\u540c\u4e00\u500b\u96fb\u5f71\u5c08\u6848\u3001\u767d\u8cbb\u529f\u592b\uff0c\u5c31\u62d6\u7d2f\u4e86\u5f8c\u7e8c\u65b0\u96fb\u5f71\u7684\u526a\u63a5\u9032\u5ea6\u3002<\/p>\n<\/div>\n<\/div>\n

\n
\n

RNA \u526a\u63a5\u7814\u7a76 \u672a\u5b8c\u5f85\u7e8c<\/b><\/strong><\/h2>\n

\u53cd\u8986\u7684\u751f\u5316\u5be6\u9a57\u64cd\u4f5c\uff0c\u4ed4\u7d30\u5075\u6e2c\u5be6\u9a57\u7522\u7269\u7684\u8b8a\u5316\uff0c\u4e26\u904b\u7528\u60f3\u50cf\u529b\u63a8\u8ad6\u8b8a\u5316\u7684\u539f\u56e0\u3002\u96d6\u7136\u8017\u6642\u8cbb\u529b\uff0c\u912d\u6dd1\u73cd\u8a8d\u70ba\uff1a\u300c\u5be6\u9a57\u7a0b\u5e8f\u5fc5\u9808\u5f88\u624e\u5be6\uff0c\u624d\u80fd\u7372\u5f97\u78ba\u5be6\u7684\u7d50\u679c \u3002\u5f88\u591a\u6642\u5019\u5be6\u9a57\u6703\u78b0\u5230\u74f6\u9838\uff0c\u7121\u6cd5\u7834\u89e3\u3002\u4f46\u7576\u60f3\u4e86\u5f88\u4e45\u7d42\u65bc\u60f3\u901a\u4e86\uff0c\u662f\u505a\u7814\u7a76\u6700\u958b\u5fc3\u7684\u6642\u5019\uff01\u300d<\/p>\n

\u4e0d\u5c11\u907a\u50b3\u6027\u75be\u75c5\u8ddf RNA \u526a\u63a5\u6709\u95dc\uff0c\u4f46\u8981\u4ee5\u6b64\u767c\u5c55\u85e5\u7269\uff0c\u5fc5\u9808\u5fb9\u5e95\u4e86\u89e3 RNA \u526a\u63a5\u9014\u5f91\u7684\u6a5f\u5236\uff0c\u624d\u80fd\u5c0d\u75c7\u4e0b\u85e5\u3002\u5f88\u4ee4\u4eba\u632f\u596e\u7684\uff0c 2016 \u5e74\u5e95\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40 (FDA) \u6279\u51c6\u4e86\u4e00\u500b\u6cbb\u7642\u810a\u9ad3\u6027\u808c\u8089\u840e\u7e2e\u75c7 (SMA) \u7684\u85e5\uff0c\u53ef\u4ee5\u77ef\u6b63\u8abf\u63a7\u75c5\u60a3\u904b\u52d5\u795e\u7d93\u5143\u86cb\u767d\u8cea\u7684 RNA \u526a\u63a5\u7570\u5e38\u3002\u912d\u6dd1\u73cd\u63d0\u5230\uff0c\u6b64\u5916\u570b\u5718\u968a\u5728\u9019\u65b9\u9762\u4e0d\u653e\u68c4\u5730\u7814\u7a76\u4e86\u4e8c\u5341\u591a\u5e74\uff0c\u4e26\u651c\u624b\u751f\u6280\u516c\u53f8\u3001\u85e5\u5ee0\u5408\u4f5c\u958b\u767c\u65b0\u85e5\u3002<\/p>\n

\u570b\u969b\u4e0a\u9664\u4e86\u810a\u9ad3\u6027\u808c\u8089\u840e\u7e2e\u75c7 (SMA) \u85e5\u7269\u7814\u767c\u6210\u529f\u7684\u6fc0\u52f5\uff0cRNA \u526a\u63a5\u7814\u7a76\u4e5f\u7167\u9032\u53e6\u4e00\u9053\u66d9\u5149\u3002<\/p>\n

\u4ee5\u524d\u662f\u900f\u904e\u751f\u5316\u5be6\u9a57\u4f86\u300c\u63a8\u8ad6\u300d RNA \u526a\u63a5\u9014\u5f91\u3002\u8fd1\u5e74\u7531\u65bc\u51b7\u51cd\u96fb\u5b50\u986f\u5fae\u93e1\u6280\u8853\u7684\u5927\u7cbe\u9032\uff0c\u89e3\u51fa\u4e86\u526a\u63a5\u8907\u5408\u9ad4\u7684\u8907\u96dc\u7d50\u69cb\uff0c\u53ef\u4ee5\u770b\u5230\u526a\u63a5\u9014\u5f91\u4e0d\u540c\u968e\u6bb5\u7684\u526a\u63a5\u9ad4\u7d50\u69cb\u7d30\u5fae\u7684\u90e8\u4efd\uff0c\u76f8\u7576\u65bc\u76f4\u63a5\u300c\u770b\u898b\u300dRNA \u526a\u63a5\u904e\u7a0b\uff0c\u4e5f\u61c9\u8b49\u904e\u53bb\u7684\u5be6\u9a57\u63a8\u8ad6\u3002\u9019\u4ee4\u7814\u7a76\u4eba\u54e1\u5011\u5167\u5fc3\u72c2\u559c\uff0c\u56e0\u70ba\u526a\u63a5\u9ad4\u7684\u7d50\u69cb\u65e2\u8907\u96dc\u53c8\u4e0d\u7a69\u5b9a\uff0c\u904e\u53bb\u5f88\u96e3\u60f3\u50cf\u5176\u7d50\u69cb\u80fd\u8f15\u6613\u89e3\u51fa\u4f86\u3002<\/p>\n

\u300c\u5f88\u591a\u9019\u500b\u9818\u57df\u7684\u5275\u59cb\u5143\u8001\uff0c\u73fe\u90fd\u5df2\u516b\u5341\u591a\u6b72\uff0c\u6c92\u60f3\u5230\u6709\u751f\u4e4b\u5e74\u53ef\u4ee5\u89aa\u773c\u770b\u5230\u9019\u4e9b\u7d50\u69cb\uff0c\u4ed6\u5011\u90fd\u5f88\u958b\u5fc3\uff01\u300d\u8aaa\u8457\u9019\u6bb5\u8a71\u7684\u912d\u6dd1\u73cd\uff0c\u773c\u4e2d\u4e5f\u5e36\u8457\u671f\u5f85\u3002<\/p>\n<\/div>\n<\/div>\n

\n

\u96d6\u7136\u591a\u77ad\u89e3\u4e86\u5f88\u591a\uff0c\u4f46\u9084\u6709\u5f88\u591a\u9700\u8981\u88ab\u77ad\u89e3\uff0c\u6240\u4ee5\u6211\u5011\u5c31\u5728\u9019\u500b\u9818\u57df\u7e7c\u7e8c\u505a\u3002<\/strong><\/h4>\n<\/blockquote>\n

RNA \u526a\u63a5\u6b63\u767c\u751f\u5728\u4f60\u6211\u9ad4\u5167\uff0c\u6b64\u9818\u57df\u96d6\u5df2\u7d2f\u7a4d\u4e0d\u5c11\u7814\u7a76\u767c\u73fe\uff0c\u4f46\u9084\u6709\u5f88\u591a\u9700\u8981\u88ab\u63a2\u7a76\u3002\u591a\u77ad\u89e3\u5b83\u5011\u4e00\u4e9b\uff0c\u5c31\u7d66\u6211\u5011\u66f4\u591a\u6a5f\u6703\u53bb\u5c0d\u4ed8\u56e0\u526a\u63a5\u7f3a\u5931\u6240\u9020\u6210\u7684\u75be\u75c5\u3002<\/p>\n

\u66f4\u591a\u7cbe\u91c7\u6587\u7ae0\uff0c\u8acb\u898b\u300c\u7814\u4e4b\u6709\u7269\u300d\u7db2\u9801\uff1ahttp:\/research.sinica.edu.tw\/<\/a><\/em><\/strong><\/h3>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u4ec0\u9ebc\u662f RNA \u526a\u63a5 \u5982\u679c DNA \u662f\u96fb\u5f71\u5287\u672c\uff0c\u8a18\u8f09\u8457\u751f\u7269\u9ad4\u61c9\u8a72\u6f14\u51fa\u4ec0\u9ebc\u6a23\u7684\u96fb\u5f71\u3002 RNA \u5c31\u50cf\u4f9d\u5287\u672c\u62cd\u651d\u51fa\u4f86 […]<\/p>\n","protected":false},"author":1,"featured_media":6228,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/6201"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=6201"}],"version-history":[{"count":5,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/6201\/revisions"}],"predecessor-version":[{"id":24467,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/6201\/revisions\/24467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/6228"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=6201"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=6201"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=6201"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}