{"id":6042,"date":"2018-06-21T00:04:34","date_gmt":"2018-06-20T16:04:34","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=6042"},"modified":"2020-12-31T14:23:36","modified_gmt":"2020-12-31T06:23:36","slug":"%e8%87%aa%e5%b7%b1%e7%9a%84%e5%93%81%e8%b3%aa%e8%87%aa%e5%b7%b1%e7%ae%a1%ef%bc%81-%e7%99%bc%e7%8f%be%e8%9b%8b%e7%99%bd%e8%b3%aa%e5%93%81%e7%ae%a1%e6%a9%9f%e5%88%b6-%e5%8f%af%e6%9c%9b%e5%b0%8d%e7%94%9f","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/6042\/","title":{"rendered":"\u81ea\u5df1\u7684\u54c1\u8cea\u81ea\u5df1\u7ba1\uff01 \u767c\u73fe\u86cb\u767d\u8cea\u54c1\u7ba1\u6a5f\u5236 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Cell<\/em>\uff09<\/strong>\uff0c\u540c\u6642\u7372\u9078\u70ba\u8a72\u671f\u520a\u7576\u671f\u4e4b\u91cd\u9ede\u8ad6\u6587\uff0c\u4e26\u4ee5\u5c08\u6587\u4ecb\u7d39\u3002<\/p>\n<p>\u86cb\u767d\u8cea\u70ba\u7d30\u80de\u57f7\u884c\u751f\u7406\u529f\u80fd\u7684\u91cd\u8981\u5143\u4ef6\uff0c\u4eba\u9ad4\u7d30\u80de\u4e2d\u5373\u6709\u4e0a\u842c\u7a2e\u7684\u86cb\u767d\u8cea\uff0c\u9019\u4e9b\u86cb\u767d\u8cea\u53ef\u80fd\u56e0\u88fd\u7a0b\u7455\u75b5\u6216\u74b0\u5883\u523a\u6fc0\u7522\u751f\u7f3a\u9677\uff0c\u800c\u6709\u7f3a\u9677\u7684\u86cb\u767d\u8cea\u4ea6\u53ef\u80fd\u5f71\u97ff\u5176\u4ed6\u6b63\u5e38\u86cb\u767d\u8cea\u7684\u904b\u4f5c\uff0c\u9032\u800c\u5371\u5bb3\u7d30\u80de\uff0c\u751a\u81f3\u6574\u500b\u751f\u7269\u9ad4\u3002<\/p>\n<p>\u300c\u86cb\u767d\u8cea\u54c1\u7ba1\u964d\u89e3\u300d\u6a5f\u5236\u5373\uff1a\u5177\u54c1\u7ba1\u529f\u80fd\u7684\u86cb\u767d\u8cea\u5c07\u7f3a\u9677\u86cb\u767d\u964d\u89e3\uff08\u5206\u89e3\u6210\u5c0f\u7247\u6bb5\uff09\u6210\u7121\u5bb3\u7684\u80dc\u80bd\u6216\u80fa\u57fa\u9178\uff0c\u9032\u800c\u7dad\u6301\u7d30\u80de\u5065\u5eb7\u3002\u7136\u800c\uff0c\u4eba\u9ad4\u4e2d\u537b\u53ea\u6709\u5c11\u6578\u86cb\u767d\u8cea\u5177\u6709\u54c1\u7ba1\u529f\u80fd\u3002\u9019\u4e9b\u5177\u54c1\u7ba1\u529f\u80fd\u7684\u86cb\u767d\u8cea\u662f\u5982\u4f55\u5728\u96e3\u4ee5\u8a08\u6578\u7684\u7f3a\u9677\u6a23\u614b\u4e2d\uff0c\u7cbe\u6e96\u5730\u8fa8\u8a8d\u51fa\u7279\u5fb5\u3001\u63ea\u51fa\u6709\u7f3a\u9677\u86cb\u767d\uff1f\u662f\u672c\u6b21\u7814\u7a76\u5718\u968a\u7279\u5225\u95dc\u6ce8\u7684\u8b70\u984c\u3002<\/p>\n<p>\u984f\u96ea\u742a\u526f\u7814\u7a76\u54e1\u65bc2008\u5e74\u5efa\u7acb\u300c\u5168\u86cb\u767d\u8cea\u7a69\u5b9a\u5ea6\u76e3\u6e2c\u7cfb\u7d71\u300d\uff08Global Protein Stability, GPS\uff09\uff0c\u53ef\u540c\u6642\u5075\u6e2c\u7d30\u80de\u4e2d\u4e0a\u842c\u500b\u86cb\u767d\u8cea\u7684\u7a69\u5b9a\u5ea6\u3002\u900f\u904e\u6b64\u9805\u6280\u8853\uff0c2015\u5e74\u7814\u7a76\u5718\u968a\u5c31\u5148\u5728\u7852\u86cb\u767d\u7684\u7814\u7a76\u4e2d\u767c\u73fe\uff0c\u86cb\u767d\u8ceaCRL2\u5177\u6709\u86cb\u767d\u8cea\u54c1\u7ba1\u7684\u529f\u80fd\u3002\u672c\u6b21\u7814\u7a76\u5718\u968a\u6cbf\u7528\u6b64\u9805\u6280\u8853\uff0c\u9032\u4e00\u6b65\u638c\u63e1CRL2\u7684\u54c1\u7ba1\u6a5f\u5236\u3002<\/p>\n<p>\u7814\u7a76\u767c\u73fe\uff0cCRL2\u53ef\u900f\u904e\u591a\u7a2e\u53d7\u5668\u7684\u8f49\u63db\uff0c\u5feb\u901f\u4e14\u6e96\u78ba\u5730\u8fa8\u8b58\u7f3a\u9677\u86cb\u767d\u5c3e\u7aef\u7684\u7279\u5b9a\u77ed\u80dc\u80bd\uff0c\u9032\u800c\u5c07\u8a72\u86cb\u767d\u8cea\u6a19\u8a18\u3001\u6e05\u9664\u3002\u9019\u4e9b\u7279\u5b9a\u77ed\u80dc\u80bd\u7d04\u75316\u523010\u500b\u80fa\u57fa\u9178\u7d44\u6210\uff08\u5982\u9644\u5716\uff09\uff0c\u800c\u4e0d\u540c\u5e8f\u5217\u7684\u77ed\u80dc\u80bd\u4e5f\u5f15\u5c0e\u4e0d\u540c\u964d\u89e3\u901f\u5ea6\u3002\u6b64\u7814\u7a76\u6210\u679c\u5c07\u8abf\u63a7\u86cb\u767d\u8cea\u964d\u89e3\u901f\u7387\u7684\u6e96\u78ba\u5ea6\u5927\u5927\u63d0\u9ad8\uff0c\u53ef\u671b\u70ba\u86cb\u767d\u8cea\u751f\u7269\u5de5\u7a0b\u7684\u61c9\u7528\u5e36\u4f86\u65b0\u7684\u5951\u6a5f\u3002<\/p>\n<div id=\"attachment_6043\" style=\"width: 381px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-6043\" class=\" wp-image-6043\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/06\/1-2.jpg\" alt=\"\" width=\"371\" height=\"371\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/06\/1-2.jpg 468w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/06\/1-2-150x150.jpg 150w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/06\/1-2-300x300.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/06\/1-2-440x440.jpg 440w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/06\/1-2-180x180.jpg 180w\" sizes=\"(max-width: 371px) 100vw, 371px\" \/><p id=\"caption-attachment-6043\" class=\"wp-caption-text\">CRL2\u53c3\u8207\u7684\u86cb\u767d\u8cea\u964d\u89e3\u6a5f\u5236\u8207\u5176\u8fa8\u8a8d\u7684\u7279\u5b9a\u77ed\u80dc\u80bd\u7279\u5fb5<\/p><\/div>\n<p>\u9664\u4e86\u91dd\u5c0d\u7f3a\u9677\u86cb\u767d\uff0c\u7814\u7a76\u5718\u968a\u4e5f\u767c\u73fe\u86cb\u767d\u8ceaCRL2\u7684\u54c1\u7ba1\u6a5f\u5236\u5c0d\u6b63\u5e38\u4f46\u5e36\u6709\u5c3e\u7aef\u964d\u89e3\u8a0a\u865f\u86cb\u767d\u4e5f\u9069\u7528\uff0c\u7531\u6b64\u53ef\u77e5\uff0c\u4efb\u4f55\u86cb\u767d\u8cea\u53ea\u8981\u63a5\u4e0a\u9019\u4e9b\u77ed\u80dc\u80bd\uff0c\u5c31\u6703\u88abCRL2\u5feb\u901f\u4e14\u6e96\u78ba\u5730\u8fa8\u8b58\u3001\u6a19\u8a18\uff0c\u9032\u800c\u88ab\u964d\u89e3\u6e05\u9664\u3002\u76ee\u524d\uff0c\u7814\u7a76\u5718\u968a\u5df2\u8457\u624b\u6aa2\u9a57\u6b64\u964d\u89e3\u6a5f\u5236\u7684\u5176\u4ed6\u751f\u7406\u529f\u80fd\u53ca\u5c0d\u86cb\u767d\u8cea\u7684\u6574\u9ad4\u5f71\u97ff\u3002<\/p>\n<p>\u6b64\u8ad6\u6587\u7b2c\u4e00\u4f5c\u8005\u70ba\u570b\u7acb\u81fa\u7063\u5927\u5b78\u751f\u547d\u79d1\u5b78\u9662\u57fa\u56e0\u9ad4\u8207\u7cfb\u7d71\u751f\u7269\u5b78\u5b78\u4f4d\u5b78\u7a0b\u535a\u58eb\u751f\u6797\u79c0\u5a1f\u3002\u984f\u96ea\u742a\u5be6\u9a57\u5ba4\u7684\u7814\u7a76\u662f\u7531\u4e2d\u7814\u9662\u524d\u77bb\u8a08\u756b\u8207\u79d1\u6280\u90e8\u5c08\u984c\u8a08\u756b\u7684\u7d93\u8cbb\u6240\u652f\u6301\u3002<\/p>\n<p>\u8ad6\u6587\u7db2\u5740\uff1a<a href=\"https:\/www.cell.com\/molecular-cell\/abstract\/S1097-2765(18)30276-4\">https:\/www.cell.com\/molecular-cell\/abstract\/S1097-2765(18)30276-4<\/a><\/p>\n<p>\uff08\u79d8\u66f8\u8655\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4eba\u985e\u7684\u8a31\u591a\u75be\u75c5\u8af8\u5982\u8001\u5316\u3001\u9000\u5316\u6027\u795e\u7d93\u75be\u75c5\u53ca\u764c\u75c7\u7b49\uff0c\u90fd\u548c\u86cb\u767d\u8cea\u7684\u7f3a\u9677\u6709\u95dc\u3002\u70ba\u4e86\u9664\u53bb\u7f3a\u9677\u86cb\u767d\uff0c\u7d30\u80de\u6703\u900f\u904e\u54c1\u7ba1\u964d\u89e3\u6a5f\u5236 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":6244,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/6042"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=6042"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/6042\/revisions"}],"predecessor-version":[{"id":6044,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/6042\/revisions\/6044"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/6244"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=6042"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=6042"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=6042"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}