{"id":32658,"date":"2023-10-05T00:21:14","date_gmt":"2023-10-04T16:21:14","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=32658"},"modified":"2023-10-12T08:51:06","modified_gmt":"2023-10-12T00:51:06","slug":"%e7%94%9f%e9%86%ab%e6%89%80%e8%83%a1%e5%93%b2%e9%8a%98%e5%89%af%e7%a0%94%e7%a9%b6%e5%93%a1%e7%a0%94%e7%a9%b6%e5%9c%98%e9%9a%8a-%e7%8d%b2%e9%a0%92%e9%a6%96%e5%b1%86%e3%80%8cmrna-%e5%89%8d%e7%9e%bb","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/32658\/","title":{"rendered":"\u751f\u91ab\u6240\u80e1\u54f2\u9298\u526f\u7814\u7a76\u54e1\u7814\u7a76\u5718\u968a \u7372\u9812\u9996\u5c46\u300cmRNA \u524d\u77bb\u65b0\u5275\u734e\u300d"},"content":{"rendered":"

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\n <\/p>\n

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\n\u30fb \u672c\u9662\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u80e1\u54f2\u9298\u526f\u7814\u7a76\u54e1\u5718\u968a\uff1a Noninflammatory immune cell-targeted mRNA delivery for immunotherapy
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\n\u30fb \u78d0\u77f3\u91ab\u85e5\u751f\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff1a Preclinical safety and efficacy evaluation of a novel dendritic cell targeting Low-Sugar Universal mRNA Vaccine against Influenza
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\u7372\u734e\u8cc7\u8a0a<\/strong><\/p>\n

\u4e2d\u592e\u7814\u7a76\u9662\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u80e1\u54f2\u9298\u5718\u968a\uff1a<\/strong>\u63d0\u51fa\u65b0\u8208\u7684 mRNA \u5948\u7c73\u7c92\u5b50\u6280\u8853\uff0c\u9032\u884c\uff34\u7d30\u80de\u7de8\u8f2f\u9032\u884c\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u3002\u5176\u6280\u8853\u53ef\u671b\u89e3\u6c7a mRNA \u8f09\u9ad4\u7684\u514d\u75ab\u539f\u6027\u4ee5\u53ca\u5176\u4e0d\u4f73\u7684\u7d30\u80de\u6a19\u7684\u50b3\u905e\u6548\u6027\uff0c\u63d0\u5347\u975c\u8108\u6ce8\u5c04\u6027\u7684 mRNA \u85e5\u7269\u958b\u767c\u3002<\/p>\n

\u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78\u751f\u91ab\u5de5\u7a0b\u7814\u7a76\u6240\u9673\u51a0\u5b87\u5be6\u9a57\u5ba4\uff1a<\/strong>\u6240\u7814\u767c\u7684\u4eff\u751f\u5668\u5b98\u6676\u7247\u80fd\u6a21\u64ec\u4eba\u9ad4\u80ba\u90e8\u7d44\u7e54\u548c\u5438\u5165\u6027\u8a66\u9a57\u7684\u53cd\u61c9\uff0c\u5c07\u53ef\u70ba Moderna \u7684\u65b0\u578b mRNA- \u8102\u8cea\u5948\u7c73\u6280\u8853\u767c\u5c55\u5e36\u4f86\u6377\u5f91\uff0c\u6e96\u78ba\u5730\u8a55\u4f30\u5438\u5165\u6027\u85e5\u7269\u7684\u6f5b\u529b\u4ee5\u52a0\u901f\u85e5\u7269\u7814\u767c\uff0c\u4e26\u6e1b\u5c11\u958b\u767c\u7684\u98a8\u96aa\u548c\u6210\u672c\u3002<\/p>\n

\u78d0\u77f3\u91ab\u85e5\u751f\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff1a<\/strong>\u4f4e\u91a3\u5ee3\u6548 mRNA \u6d41\u611f\u75ab\u82d7\u8a08\u5283\uff0c\u662f\u91dd\u5c0d\u9ad8\u5ea6\u8b8a\u7570\u7684\u6d41\u611f\u75c5\u6bd2\uff0c\u671f\u671b\u5728\u7fa4\u9ad4\u8a98\u767c\u5ee3\u6cdb\u7684\u514d\u75ab\u4fdd\u8b77\u529b\uff0c\u4ee5\u964d\u4f4e\u91cd\u75c7\u6b7b\u4ea1\u6a5f\u7387\uff0c\u4e26\u6e1b\u4f4e\u6bcf\u5e74\u91cd\u8907\u65bd\u6253\u7684\u9700\u8981\uff0c\u540c\u6a23\u7684\u6280\u8853\u5c07\u4f86\u53ef\u671b\u5ee3\u6cdb\u61c9\u7528\u5728\u5404\u7a2e\u6d41\u884c\u6027\u75c5\u6bd2\u611f\u67d3\u75be\u75c5\u3002<\/p>\n

\u570b\u7acb\u6e05\u83ef\u5927\u5b78\u5316\u5b78\u5de5\u7a0b\u5b78\u7cfb\u5b8b\u4fe1\u6587\u5be6\u9a57\u5ba4\uff1a<\/strong>\u4ee5 \u03b2 -glucans \u505a\u70ba\u514d\u75ab\u4f50\u5291\u53ca\u4fdd\u8b77\u5291\u8207 mRNA \u6df7\u5408\u5f62\u6210\u8907\u5408\u7269\uff0c\u7d93\u5fae\u6d41\u9053\u8207\u8102\u8cea\u5f62\u6210\u4e00\u53e3\u670d\u6297\u816b\u7624\u75ab\u82d7\uff0c\u539f\u7406\u70ba \u03b2-glucans \u80fd\u5f37\u5316\u75ab\u82d7\u7684\u6d3b\u5316\u6548\u679c\uff0c\u4fc3\u4f7f\u5176\u9077\u5f99\u81f3\u8178\u7e6b\u819c\u6dcb\u5df4\u7d50\u523a\u6fc0 T \u7d30\u80de\uff0c\u5f15\u8d77\u5c08\u4e00\u6027\u7684\u5f8c\u5929\u514d\u75ab\u53cd\u61c9\u4ee5\u6291\u5236\u816b\u7624\u7684\u751f\u9577\u3002<\/p>\n

\u5de5\u696d\u6280\u8853\u7814\u7a76\u9662\u751f\u91ab\u8207\u91ab\u6750\u7814\u7a76\u6240\u912d\u6dd1\u73cd\u5718\u968a\uff1a<\/strong>\u958b\u767c\u7684\u65b0\u8102\u8cea LNP \u5df2\u5728\u521d\u7d1a T \u7d30\u80de\u4e2d\u5c55\u793a\u51fa\u5353\u8d8a\u7684\u8f49\u67d3\u6548\u80fd\uff0c\u8d85\u8d8a\u5546\u696d\u5957\u4ef6\u548c\u81e8\u5e8a\u4f7f\u7528\u7684\u914d\u65b9\u3002\u7576\u8207\u8f49\u67d3\u589e\u5f37\u5291\u7d50\u5408\u4f7f\u7528\u6642\uff0c\u5718\u968a\u7684\u65b0\u578b LNP \u4e5f\u5728\u521d\u7d1a NK \u7d30\u80de\u4e2d\u5c55\u73fe\u826f\u597d\u7684\u8f49\u67d3\u6548\u679c\u3002\u6700\u7d42\u76ee\u6a19\u662f\u5275\u5efa\u4e00\u5957\u5168\u9762\u7684 LNP \u5de5\u5177\uff0c\u7528\u65bc\u514d\u75ab\u7d30\u80de\u5de5\u7a0b\u4e2d\u7684\u6838\u9178\u50b3\u905e\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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