{"id":32611,"date":"2023-10-05T00:12:37","date_gmt":"2023-10-04T16:12:37","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=32611"},"modified":"2023-10-05T04:21:14","modified_gmt":"2023-10-04T20:21:14","slug":"%e3%80%90%e5%b0%88%e6%ac%84%e3%80%91%e8%88%87%e7%9c%be%e4%b8%8d%e5%90%8c%e7%9a%84%e7%84%a1%e8%86%9c%e8%83%9e%e5%99%a8-%e4%b8%ad%e5%bf%83%e9%ab%94","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/32611\/","title":{"rendered":"\u3010\u5c08\u6b04\u3011\u8207\u773e\u4e0d\u540c\u7684\u7121\u819c\u80de\u5668\u2014\u2014\u4e2d\u5fc3\u9ad4"},"content":{"rendered":"<div class=\"auth-info\">\n<div class='one_fourth'>\n\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/10\/3-2_A.jpg\" alt=\"\u590f\u570b\u5f37\u526f\u7814\u7a76\u54e1\uff08\u672c\u9662\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240\uff09\" width=\"150\" height=\"150\" class=\"aligncenter size-full wp-image-32612\" \/>\n\t\t\t\t<\/div>\n<div class='three_fourth et_column_last'>\n\t\t\t\t\t\u4f5c\u8005\u590f\u570b\u5f37\u535a\u58eb\u65bc 2009 \u5e74\u81ea\u7f8e\u570b\u6d1b\u514b\u83f2\u52d2\u5927\u5b78\u53d6\u5f97\u535a\u58eb\u5b78\u4f4d\uff0c\u73fe\u70ba\u672c\u9662\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240\u526f\u7814\u7a76\u54e1\u3002\u71b1\u8877\u65bc\u63a2\u7d22\u751f\u7269\u5de8\u5206\u5b50\u7d50\u69cb\u4e4b\u7f8e\u8207\u5176\u80cc\u5f8c\u4e4b\u7d30\u80de\u751f\u7406\u610f\u7fa9\u3002\n\t\t\t\t<\/div><div class='clear'><\/div><\/div>\n<p>&nbsp;<\/p>\n<p>\u7d30\u80de\u70ba\u751f\u547d\u9ad4\u7684\u6700\u5c0f\u751f\u7269\u55ae\u4f4d\u3002\u7d30\u80de\u5167\u6301\u7e8c\u5730\u900f\u904e\u5404\u5f0f\u4e0d\u540c\u7684\u5316\u5b78\u53cd\u61c9\u7522\u751f\u9069\u7576\u7684\u751f\u5316\u7522\u7269\uff0c\u7528\u4ee5\u7dad\u6301\u7d30\u80de\u7684\u6d3b\u52d5\u3002\u79d1\u5b78\u5bb6\u65e9\u671f\u5229\u7528\u986f\u5fae\u93e1\u767c\u73fe\u7d30\u80de\u5167\u6709\u4e0d\u540c\u7684\u80de\u5668\uff0c\u4e26\u4e14\u9019\u4e9b\u7531\u8102\u8cea\u6240\u5305\u570d\u7684\u80de\u5668\u80fd\u5920\u5206\u9694\u51fa\u5404\u81ea\u7368\u7acb\u7684\u7a7a\u9593\uff0c\u8b93\u57f7\u884c\u7279\u5b9a\u53cd\u61c9\u7684\u76f8\u95dc\u751f\u7269\u5206\u5b50\uff08\u4f8b\u5982\uff1a\u86cb\u767d\u8cea\uff09\u80fd\u5920\u5171\u540c\u7fa4\u805a\u5728\u4e00\u5b9a\u7684\u7bc4\u570d\u5167\uff0c\u4f7f\u5f97\u7279\u5b9a\u7684\u5316\u5b78\u53cd\u61c9\u4fbf\u80fd\u767c\u751f\u5728\u9069\u7576\u7684\u6642\u9593\u8207\u5730\u9ede\uff0c\u4e26\u9032\u4e00\u6b65\u63d0\u9ad8\u5176\u53cd\u61c9\u6548\u7387\u3002\u4f8b\u5982\uff0c\u7c92\u7dda\u9ad4\u901a\u904e\u96d9\u5c64\u819c\u7d50\u69cb\u5c07\u4e0d\u540c\u86cb\u767d\u8cea\u9593\u9694\u5728\u4e0d\u540c\u7684\u5340\u57df\uff0c\u5be6\u73fe\u5c08\u4e00\u4e14\u9ad8\u6548\u7684\u547c\u5438\u4f5c\u7528\uff0c\u751f\u6210\u80fd\u91cf\u3002<\/p>\n<p>\u7136\u800c\uff0c\u79d1\u5b78\u5bb6\u8fd1\u5e74\u4f86\u767c\u73fe\u7d30\u80de\u5167\u8a31\u591a\u5f9e\u4e8b\u7279\u5b9a\u53cd\u61c9\u7684\u76f8\u95dc\u751f\u7269\u5206\u5b50\u80fd\u5920\u7fa4\u805a\u5728\u4e00\u8d77\uff0c\u4f46\u4e26\u4e0d\u9700\u8981\u7d30\u80de\u819c\u7684\u5b58\u5728\u3002\u9019\u73fe\u8c61\u4e3b\u8981\u85c9\u7531\u751f\u7269\u5206\u5b50\uff08\u4f8b\u5982\uff1a\u86cb\u767d\u8cea\uff09\u4e4b\u7269\u7406\u8207\u5316\u5b78\u7279\u6027\u7522\u751f\u6db2\u9ad4\u8207\u6db2\u9ad4\u4e4b\u76f8\u5206\u96e2\uff08Liquid-liquid phase separation\uff09\uff0c\u4f7f\u7279\u5b9a\u7684\u751f\u7269\u5206\u5b50\u80fd\u5920\u5f9e\u7d30\u80de\u8cea\u4e2d\u6210\u5343\u4e0a\u842c\u7684\u5176\u5b83\u5206\u5b50\u4e2d\u5206\u96e2\u4e26\u4e14\u805a\u96c6\uff0c\u5f62\u6210\u9ad8\u6fc3\u5ea6\u7684\u6db2\u6ef4\u72c0\u4e4b\u751f\u7269\u5206\u5b50\u805a\u96c6\u9ad4\uff08\u5716\u4e00 A\uff09<sup>1<\/sup>\u3002<\/p>\n<p><div id=\"attachment_21652\" style=\"width: 910px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21652\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/10\/3-2_1.jpg\" alt=\"\u3010\u5c08\u6b04\u3011\u8207\u773e\u4e0d\u540c\u7684\u7121\u819c\u80de\u5668\u2014\u2014\u4e2d\u5fc3\u9ad4\" width=\"900\" height=\"575\" class=\"aligncenter size-full wp-image-32615\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/10\/3-2_1.jpg 900w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/10\/3-2_1-300x192.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/10\/3-2_1-768x491.jpg 768w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">\u25b2\u5716\u4e00\uff1a<u>\u86cb\u767d\u8cea\u7684\u76f8\u5206\u96e2<\/u><br \/>\nA. \u86cb\u767d\u8cea\u900f\u904e\u7269\u7406\u53ca\u5316\u5b78\u4ea4\u4e92\u4f5c\u7528\u7522\u751f\u751f\u7269\u5206\u5b50\u805a\u96c6\u9ad4\u3002B. \u5c0f\u86cb\u767d\u8cea\u5206\u5b50\u805a\u96c6\u884c\u8f03\u5feb\u901f\u5e03\u6717\u904b\u52d5\u78b0\u649e\u878d\u5408\u6210\u5927\u86cb\u767d\u8cea\u6db2\u6ef4\u4e26\u4f34\u96a8\u5176\u5e03\u6717\u904b\u52d5\u80fd\u529b\u964d\u4f4e\u3002C. \u7d30\u80de\u5206\u88c2\u6642\u7d21\u9318\u9ad4\uff08\u767d\u8272\u7bad\u982d\uff09\u88ab\u5927\u91cf\u5fae\u7ba1\u5305\u570d\uff08\u7da0\u8272\uff1a\u5fae\u7ba1\uff1b\u85cd\u8272\uff1a\u67d3\u8272\u9ad4\uff09\u3002D. \u679c\u8805\u80da\u80ce\u7d30\u80de\u4e2d\u767c\u73fe\u7576\u4e0d\u5c0d\u7a31\u7d30\u80de\u5206\u88c2\u9032\u884c\u6642\uff0c\u5169\u7aef\u7684\u4e2d\u5fc3\u7c92\u5468\u570d\u7269\u8cea\u6709\u5927\u5c0f\u7684\u5dee\u7570\uff08\u85cd\u8272\uff1a\u4e2d\u5fc3\u7c92\u5468\u570d\u7269\u8cea\uff1b\u9ec3\u8272\uff1a\u4e2d\u5fc3\u7c92\uff09\u3002<\/p><\/div><br 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<sup>2<\/sup>\u3002\u5176\u4e2d\uff0c\u8ca0\u8cac\u7d30\u80de\u5167\u7d30\u80de\u9aa8\u67b6\u4e4b\u5fae\u7ba1\uff08microtubule\uff09\u751f\u5408\u6210\uff0c\u88ab\u7a31\u70ba\u5fae\u7ba1\u7d44\u7e54\u4e2d\u5fc3\u7684\u4e2d\u5fc3\u9ad4\uff08centrosome\uff09\u4fbf\u662f\u85c9\u7531\u76f8\u5206\u96e2\u73fe\u8c61\u8abf\u63a7\u5176\u8907\u88fd\u8207\u6210\u719f\u7684\u7121\u819c\u80de\u5668\u4e4b\u4e00\u3002\u4e2d\u5fc3\u9ad4\u7684\u5167\u90e8\u7531\u4e00\u7fa4\u7d50\u69cb\u86cb\u767d\u8cea\u7d44\u6210\u4e2d\u5fc3\u7c92\uff08centrioles\uff09\uff0c\u5176\u5916\u570d\u5247\u7531\u8a31\u591a\u7121\u5b9a\u5f62\u86cb\u767d\u8cea\u6240\u5305\u570d\uff0c\u5f62\u6210\u4e2d\u5fc3\u7c92\u5468\u570d\u7269\u8cea\uff08pericentriolar material, PCM\uff09\u3002<\/p>\n<p>\u7576\u7d30\u80de\u5c07\u9032\u884c\u7d30\u80de\u5206\u88c2\u6642\uff0c\u86cb\u767d\u8cea\u6703\u805a\u96c6\u81f3\u4e2d\u5fc3\u9ad4\u4e4b\u5468\u570d\u7269\u8cea\u5340\uff0c\u4f7f\u5f97\u5176\u9ad4\u7a4d\u589e\u5927\uff0c\u5f9e\u800c\u4fc3\u9032\u5fae\u7ba1\u4e4b\u751f\u5408\u6210\u4ee5\u5229\u7d21\u9318\u9ad4\u7684\u5f62\u6210\uff08\u5716\u4e00 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D\uff09\u3002<\/p>\n<p>\u800c\u5728\u7d30\u80de\u5206\u88c2\u968e\u6bb5\uff0c\u5927\u91cf\u7684\u86cb\u767d\u8cea\u300c\u805a\u96c6\u300d\u5230\u4e2d\u5fc3\u9ad4\uff0c\u9020\u6210\u5176\u9ad4\u7a4d\u64f4\u5f35\u4e26\u4f7f\u5176\u6210\u719f\uff0c\u4ee5\u5229\u57f7\u884c\u76f8\u95dc\u4e4b\u751f\u7269\u529f\u80fd <sup>4<\/sup>\u3002\u7136\u800c\uff0c\u9818\u57df\u5167\u5c0d\u65bc\u4e2d\u5fc3\u9ad4\u9019\u500b\u7121\u819c\u80de\u5668\u5982\u4f55\u300c\u805a\u96c6\u300d\u7279\u5b9a\u4e4b\u86cb\u767d\u8cea\u7684\u5206\u5b50\u6a5f\u5236\u3001\u4e2d\u5fc3\u9ad4\u6578\u91cf\u8207\u9ad4\u7a4d\u5982\u4f55\u7dad\u6301\u7684\u8abf\u63a7\u6a5f\u5236\u90fd\u4e26\u6c92\u6709\u5b9a\u8ad6\u3002\u76ee\u524d\u8a8d\u70ba\u662f\u85c9\u7531\u88ab\u52d5\u64f4\u6563\u4f5c\u7528\u548c\u5e03\u6717\u904b\u52d5\u4f7f\u76f8\u5206\u96e2\u7684\u4e2d\u5fc3\u9ad4\u86cb\u767d\u8cea\u7522\u751f\u805a\u96c6\u7684\u73fe\u8c61\u3002\u4f46\u662f\u50c5\u85c9\u7531\u9019\u5169\u7a2e\u7269\u7406\u73fe\u8c61\uff0c\u662f\u5426\u8db3\u5920\u8abf\u63a7\u4e2d\u5fc3\u9ad4\u6578\u91cf\u8207\u9ad4\u7a4d\uff0c\u4ee5\u53ca\u662f\u5426\u9084\u6709\u5176\u4ed6\u6a5f\u5236\u727d\u6d89\u5176\u4e2d\u90fd\u5c1a\u672a\u63ed\u793a\u3002<\/p>\n<p>\u7b46\u8005\u5be6\u9a57\u5ba4\u7684\u7814\u7a76\u4e3b\u984c\u4e4b\u4e00\uff0c\u5373\u63a2\u8a0e\u5fae\u7ba1\u5728\u4e2d\u5fc3\u9ad4\u64f4\u5f35\u8207\u6210\u719f\u4e2d\u6240\u626e\u6f14\u7684\u89d2\u8272\u3002\u5728\u904e\u53bb\u7684\u7814\u7a76\u6587\u737b\u4e2d\uff0c\u6709\u7814\u7a76\u5718\u968a\u8b49\u660e\u4e86\u4e2d\u5fc3\u9ad4\u4e2d\u7684\u652f\u67b6\u86cb\u767d\uff08Scaffolding protein\uff09\u6703\u8207\u7d21\u9318\u9ad4\u4e0a\u7684\u9a45\u52d5\u86cb\u767d\uff08Kinesin\uff09\u76f8\u4e92\u4f5c\u7528\uff0c\u5f9e\u800c\u9023\u63a5\u4e86\u4e2d\u5fc3\u9ad4\u8207\u7d21\u9318\u9ad4\uff0c\u4e26\u78ba\u4fdd\u7d21\u9318\u9ad4\u7d50\u69cb\u4e0a\u7684\u5b8c\u6574\u6027\uff08\u5716\u4e8c A\uff09<sup>5<\/sup>\u3002<\/p>\n<p><div id=\"attachment_21652\" style=\"width: 910px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21652\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/10\/3-2_2.jpg\" alt=\"\u3010\u5c08\u6b04\u3011\u8207\u773e\u4e0d\u540c\u7684\u7121\u819c\u80de\u5668\u2014\u2014\u4e2d\u5fc3\u9ad4\" width=\"900\" height=\"553\" class=\"aligncenter size-full wp-image-32616\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/10\/3-2_2.jpg 900w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/10\/3-2_2-300x184.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/10\/3-2_2-768x472.jpg 768w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">\u25b2\u5716\u4e8c\uff1a<u>\u4e2d\u5fc3\u9ad4\u652f\u67b6\u86cb\u767d\u8207\u9a45\u52d5\u86cb\u767d\u7684\u4ea4\u4e92\u4f5c\u7528<\/u><br \/>\nA. \u7d93\u7531\u514d\u75ab\u67d3\u8272\u7684\u6d77\u62c9\u7d30\u80de\u900f\u904e\u8d85\u9ad8\u89e3\u6790\u986f\u5fae\u93e1\u62cd\u651d\u7d50\u679c\uff08\u7d05\u8272\uff1a\u9a45\u52d5\u86cb\u767d\uff1b\u7da0\u8272\uff1a\u4e2d\u5fc3\u9ad4\u652f\u67b6\u86cb\u767d\uff09\u3002B. \u9a45\u52d5\u86cb\u767d\u4e3b\u52d5\u904b\u8f38\u652f\u67b6\u86cb\u767d\u5230\u5fae\u7ba1\u7684\u4e00\u7aef\uff08\u7d05\u8272\uff1a\u5fae\u7ba1\uff1b\u7da0\u8272\uff1a\u4e2d\u5fc3\u9ad4\u652f\u67b6\u86cb\u767d\uff09C. \u4e2d\u5fc3\u9ad4\u652f\u67b6\u86cb\u767d\uff08\u7da0\u8272\uff09\u5f62\u6210\u86cb\u767d\u8cea\u6db2\u6ef4\u3002D. \u5927\u91cf\u8868\u73fe\u4e2d\u5fc3\u9ad4\u652f\u67b6\u86cb\u767d\u5728\u6d77\u62c9\u7d30\u80de\u4e2d\u6703\u5f62\u6210\u86cb\u767d\u8cea\u805a\u96c6\u9ad4\uff08\u7da0\u8272\uff1a\u4e2d\u5fc3\u9ad4\u652f\u67b6\u86cb\u767d\uff1b\u85cd\u8272\uff1a\u67d3\u8272\u9ad4\uff09\u3002E. \u7406\u8ad6\u6a21\u578b\u793a\u610f\u5716<\/p><\/div><br \/>\n&nbsp;<\/p>\n<p>\u4ee5\u6b64\u7814\u7a76\u70ba\u69cb\u60f3\u57fa\u790e\uff0c\u7b46\u8005\u4e4b\u5be6\u9a57\u5ba4\u5229\u7528\u57fa\u56e0\u5254\u9664\u6280\u8853\uff08Knockdown\uff09\u964d\u4f4e\u7d30\u80de\u5167\u5176\u4e2d\u4e00\u7a2e\u9a45\u52d5\u86cb\u767d\u7684\u86cb\u767d\u91cf\u3002\u901a\u904e\u986f\u5fae\u93e1\u89c0\u5bdf\u9032\u4e00\u6b65\u767c\u73fe\uff0c\u5728\u7d30\u80de\u5206\u88c2\u904e\u7a0b\u4e2d\uff0c\u652f\u67b6\u86cb\u767d\u5728\u4e2d\u5fc3\u9ad4\u4e0a\u6578\u91cf\u4e5f\u76f8\u5c0d\u7684\u6e1b\u5c11\u3002\u9019\u500b\u7d50\u679c\u6307\u51fa\u9a45\u52d5\u86cb\u767d\u7684\u5b58\u5728\u8207\u4e2d\u5fc3\u9ad4\u4e2d\u652f\u67b6\u86cb\u767d\u6578\u91cf\u7684\u95dc\u806f\u6027\u3002\u7531\u65bc\u9a45\u52d5\u86cb\u767d\u80fd\u5920\u5728\u5fae\u7ba1\u4e0a\u651c\u5e36\u8ca8\u7269\u86cb\u767d\uff08Cargo proteins\uff09\u5f80\u76ee\u7684\u5730\u505a\u79fb\u52d5\uff0c\u56e0\u6b64\u672c\u7814\u7a76\u5718\u968a\u63d0\u51fa\u4e86\u5fae\u7ba1\u4f9d\u8cf4\u6027\u7684\u4e3b\u52d5\u904b\u8f38\u53ef\u80fd\u5728\u4e2d\u5fc3\u9ad4\u4e2d\u86cb\u767d\u8cea\u7684\u805a\u96c6\u626e\u6f14\u4e86\u91cd\u8981\u7684\u89d2\u8272\u3002<\/p>\n<p>\u70ba\u4e86\u9032\u4e00\u6b65\u63a2\u7a76\u9a45\u52d5\u86cb\u767d\u4e3b\u52d5\u904b\u8f38\u4e2d\u5fc3\u9ad4\u652f\u67b6\u86cb\u767d\u7684\u5206\u5b50\u6a5f\u5236\uff0c\u7814\u7a76\u5718\u968a\u7d14\u5316\u9ad8\u7d14\u5ea6\u7684\u91cd\u7d44\u86cb\u767d\uff0c\u4e26\u5229\u7528\u5168\u5167\u89d2\u53cd\u5c04\u87a2\u5149\u986f\u5fae\u93e1\u89c0\u5bdf\u767c\u73fe\uff0c\u7576\u6709\u63d0\u4f9b\u80fd\u91cf\uff08ATP\uff09\u60c5\u6cc1\u4e0b\uff0c\u9a45\u52d5\u86cb\u767d\u80fd\u5920\u4fc3\u4f7f\u5e36\u6709\u87a2\u5149\u6a19\u5b9a\u4e4b\u652f\u67b6\u86cb\u767d\u805a\u96c6\u5728\u5fae\u7ba1\u7684\u8ca0\u7aef\uff08\u5728\u5206\u88c2\u7d30\u80de\u4e2d\uff0c\u5fae\u7ba1\u8ca0\u7aef\u591a\u4f4d\u65bc\u7d21\u9318\u9ad4\u5169\u6975\uff0c\u4e26\u532f\u805a\u65bc\u4e2d\u5fc3\u9ad4\u4e4b\u5468\u570d\uff09\uff08\u5716\u4e8c B\uff09\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4e4b\u524d\u7684\u6587\u737b\u4e2d\u4e26\u672a\u63d0\u53ca\u9019\u9a45\u52d5\u86cb\u767d\u53ef\u4ee5\u5728\u5fae\u7ba1\u4e0a\u9032\u884c\u9577\u8ddd\u96e2\u4e14\u6709\u65b9\u5411\u6027\u7684\u79fb\u52d5\u3002\u56e0\u6b64\uff0c\u9019\u500b\u767c\u73fe\u4e5f\u540c\u6642\u63ed\u793a\u4e86\u4e2d\u5fc3\u9ad4\u652f\u67b6\u86cb\u767d\u80fd\u5920\u8abf\u63a7\u9a45\u52d5\u86cb\u767d\u7684\u904b\u8f38\u6d3b\u6027\u3002<\/p>\n<p>\u56e0\u6b64\uff0c\u672c\u7814\u7a76\u767c\u73fe\u7576\u9a45\u52d5\u86cb\u767d\u8207\u4e2d\u5fc3\u9ad4\u652f\u67b6\u86cb\u767d\u4f5c\u7528\u6642\uff0c\u6703\u4fc3\u4f7f\u9a45\u52d5\u86cb\u767d\u6301\u7e8c\u5730\u9032\u884c\u904b\u52d5\uff0c\u5c07\u652f\u67b6\u86cb\u767d\u5411\u5fae\u7ba1\u7684\u8ca0\u7aef\u79fb\u52d5\u7684\u73fe\u8c61\u3002\u9032\u4e00\u6b65\u767c\u73fe\u4e2d\u5fc3\u9ad4\u652f\u67b6\u86cb\u767d\u6703\u4ee5\u805a\u96c6\u9ad4\u7684\u5f62\u5f0f\u7531\u9a45\u52d5\u86cb\u767d\u4f86\u904b\u8f38\u3002\u5728\u9019\u904e\u7a0b\u4e2d\uff0c\u805a\u96c6\u9ad4\u6703\u767c\u751f\u9032\u4e00\u6b65\u805a\u96c6\u7684\u73fe\u8c61\uff0c\u6700\u5f8c\u5806\u7a4d\u65bc\u5fae\u7ba1\u7684\u8ca0\u7aef\u3002<\/p>\n<p>\u9019\u89c0\u5bdf\u986f\u793a\u4e86\u6b64\u805a\u96c6\u9ad4\u8207\u4e4b\u524d\u63d0\u5230\u76f8\u5206\u96e2\u73fe\u8c61\u6709\u9ad8\u5ea6\u7684\u76f8\u4f3c\u6027\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u7531\u65bc\u751f\u7269\u5206\u5b50\u805a\u96c6\u9ad4\u7684\u9ad8\u52d5\u614b\u7279\u6027\uff0c\u7576\u751f\u7269\u5206\u5b50\u805a\u96c6\u9ad4\u4e92\u76f8\u878d\u5408\u4e26\u5f62\u6210\u66f4\u5927\u9ad4\u7a4d\u4e4b\u805a\u96c6\u9ad4\uff0c\u7406\u8ad6\u4e0a\u4e5f\u6703\u96a8\u4e4b\u964d\u4f4e\u5176\u5e03\u6717\u904b\u52d5\u4e4b\u80fd\u529b\u8207\u88ab\u52d5\u904b\u8f38\u4e4b\u901f\u7387\u3002\u7136\u800c\uff0c\u4e2d\u5fc3\u9ad4\u652f\u67b6\u86cb\u767d\u805a\u96c6\u9ad4\u7684\u904b\u8f38\u901f\u7387\u4e26\u4e0d\u6703\u96a8\u8457\u805a\u96c6\u9ad4\u7684\u5927\u5c0f\u767c\u751f\u6539\u8b8a\uff0c\u6b64\u7279\u6027\u6709\u5229\u65bc\u76f8\u5c0d\u77ed\u6642\u9593\u5167\u4e2d\u5fc3\u9ad4\u64f4\u5f35\u8207\u6210\u719f\u7684\u9700\u8981\u3002<\/p>\n<p>\u7dda\u87f2\u7684\u4e2d\u5fc3\u9ad4\u652f\u67b6\u86cb\u767d\u5df2\u7d93\u88ab\u8b49\u660e\u80fd\u5920\u805a\u96c6\u6210\u6db2\u6ef4\u72c0\u4e4b\u751f\u7269\u5206\u5b50\u805a\u96c6\u9ad4 <sup>6<\/sup>\u3002\u70ba\u4e86\u80fd\u5920\u4e86\u89e3\u4eba\u985e\u7684\u4e2d\u5fc3\u9ad4\u652f\u67b6\u86cb\u767d\u662f\u5426\u5177\u6709\u76f8\u540c\u7684\u86cb\u767d\u7279\u6027\u3002\u7814\u7a76\u5718\u968a\u4f7f\u7528\u986f\u5fae\u93e1\u89c0\u5bdf\u9ad8\u7d14\u5ea6\u4e4b\u87a2\u5149\u6a19\u5b9a\u4e2d\u5fc3\u9ad4\u652f\u67b6\u86cb\u767d\uff0c\u767c\u73fe\u6b64\u86cb\u767d\u8cea\u540c\u6a23\u4e5f\u80fd\u5f62\u6210\u6db2\u6ef4\uff0c\u4e26\u4e14\u9a45\u52d5\u86cb\u767d\u4e5f\u6703\u6eb6\u5165\u9019\u6b64\u6db2\u6ef4\u4e2d\uff08\u5716\u4e8c C\uff09\u3002\u6709\u8da3\u7684\u662f\uff0c\u7576\u9a45\u52d5\u86cb\u767d\u9032\u5165\u4e2d\u5fc3\u9ad4\u652f\u67b6\u86cb\u767d\u7684\u6db2\u6ef4\uff0c\u6703\u4f7f\u5f97\u6db2\u6ef4\u7684\u6750\u6599\u7279\u6027\u8b8a\u5f97\u66f4\u52a0\u901a\u900f\u4e14\u9ad8\u52d5\u614b\u3002\u70ba\u4e86\u9a57\u8b49\u5728\u8a66\u7ba1\u4e2d\u89c0\u5bdf\u5230\u7684\u7d50\u679c\uff0c\u7814\u7a76\u5718\u968a\u9032\u4e00\u6b65\u5229\u7528\u5728\u7d30\u80de\u4e2d\u5927\u91cf\u8868\u9054\u87a2\u5149\u6a19\u5b9a\u7684\u652f\u67b6\u86cb\u767d\uff0c\u89c0\u5bdf\u5230\u652f\u67b6\u86cb\u767d\u7684\u78ba\u6703\u5728\u7d30\u80de\u4e2d\u5f62\u6210\u86cb\u767d\u8cea\u6db2\u6ef4\uff0c\u800c\u9a45\u52d5\u86cb\u767d\u7684\u5b58\u5728\u80fd\u5920\u63d0\u9ad8\u5176\u6d3b\u6027\uff08\u5716\u4e8c D\uff09\u3002<\/p>\n<p>\u7d30\u80de\u5167\u4e0d\u65b7\u767c\u751f\u8457\u5316\u5b78\u53cd\u61c9\uff0c\u4ee5\u7dad\u6301\u751f\u547d\u6d3b\u52d5\u3002\u70ba\u4e86\u7cbe\u78ba\u8abf\u63a7\u8907\u96dc\u7684\u751f\u5316\u53cd\u61c9\uff0c\u7d30\u80de\u5fc5\u9808\u5275\u9020\u7368\u7acb\u7684\u74b0\u5883\u4f86\u4fc3\u9032\u5404\u7a2e\u53cd\u61c9\u7684\u9032\u884c\uff0c\u5305\u62ec\u88ab\u78f7\u8102\u96d9\u5c64\u819c\u5305\u570d\u7684\u80de\u5668\uff0c\u548c\u900f\u904e\u76f8\u5206\u96e2\u73fe\u8c61\u5f62\u6210\u7684\u7121\u819c\u80de\u5668\u3002\u4e2d\u5fc3\u9ad4\u5728\u7d30\u80de\u9593\u671f\u8207\u7d30\u80de\u5206\u88c2\u904e\u7a0b\u4e2d\u626e\u6f14\u4e86\u91cd\u8981\u7684\u89d2\u8272\uff0c\u96d6\u7136\u5b78\u754c\u5c0d\u65bc\u4e2d\u5fc3\u9ad4\u7684\u529f\u80fd\uff08\u4f8b\u5982\uff1a\u8abf\u63a7\u5fae\u7ba1\u7684\u751f\u6210\uff09\u6709\u4e00\u5b9a\u7684\u4e86\u89e3\uff0c\u4f46\u5c0d\u4e2d\u5fc3\u9ad4\u5982\u4f55\u4ee5\u76f8\u5206\u96e2\u7684\u7279\u6027\u8907\u88fd\u8207\u64f4\u5f35\u6240\u77e5\u537b\u6709\u9650\u3002<\/p>\n<p>\u672c\u5be6\u9a57\u5ba4\u7279\u5225\u5c08\u6ce8\u65bc\u63a2\u7a76\u7d30\u80de\u9aa8\u67b6\u5fae\u7ba1\u5728\u7121\u819c\u80de\u5668\u4e2d\u5fc3\u9ad4\u64f4\u5f35\u4e2d\u7684\u529f\u80fd\uff0c\u4e26\u63d0\u51fa\u570d\u7e5e\u65bc\u4e2d\u5fc3\u9ad4\u7684\u5fae\u7ba1\u5728\u8abf\u7bc0\u4e2d\u5fc3\u9ad4\u7684\u6210\u719f\u904e\u7a0b\u4e2d\u767c\u63ee\u8457\u95dc\u9375\u4f5c\u7528\u4e4b\u7406\u8ad6\uff0c\u8aaa\u660e\u4e2d\u5fc3\u9ad4\u86cb\u767d\u8cea\u7684\u805a\u96c6\u9664\u4e86\u5229\u7528\u88ab\u52d5\u64f4\u6563\u4f5c\u7528\u5916\uff0c\u5fae\u7ba1\u8207\u9a45\u52d5\u86cb\u767d\u4e5f\u626e\u6f14\u8457\u91cd\u8981\u7684\u89d2\u8272\uff08\u5716\u4e8c E\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<hr>\n<ol>\n<li> Banani, S., Lee, H., Hyman, A. et al. 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Cell. 2017 Jun 1;169(6):1066-1077.e10.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; \u7d30\u80de\u70ba\u751f\u547d\u9ad4\u7684\u6700\u5c0f\u751f\u7269\u55ae\u4f4d\u3002\u7d30\u80de\u5167\u6301\u7e8c\u5730\u900f\u904e\u5404\u5f0f\u4e0d\u540c\u7684\u5316\u5b78\u53cd\u61c9\u7522\u751f\u9069\u7576\u7684\u751f\u5316\u7522\u7269\uff0c\u7528\u4ee5\u7dad\u6301\u7d30\u80de\u7684 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":32689,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[991,983],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/32611"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=32611"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/32611\/revisions"}],"predecessor-version":[{"id":32957,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/32611\/revisions\/32957"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/32689"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=32611"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=32611"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=32611"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}