{"id":31631,"date":"2023-06-15T00:19:55","date_gmt":"2023-06-14T16:19:55","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=31631"},"modified":"2023-06-15T00:20:38","modified_gmt":"2023-06-14T16:20:38","slug":"%e6%9c%ac%e9%99%a2%e8%88%87%e8%8e%ab%e5%be%b7%e7%b4%8d%e7%b0%bd%e7%bd%b2%e5%90%88%e4%bd%9c%e6%84%8f%e5%90%91%e6%9b%b8%e5%8a%a0%e9%80%9f-mrna-%e7%a0%94%e7%a9%b6-%e5%85%b1%e6%8e%a8%e5%89%8d%e7%9e%bb","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/31631\/","title":{"rendered":"\u672c\u9662\u8207\u83ab\u5fb7\u7d0d\u7c3d\u7f72\u5408\u4f5c\u610f\u5411\u66f8\u52a0\u901f mRNA \u7814\u7a76 \u5171\u63a8\u524d\u77bb\u65b0\u5275\u734e \u9f13\u52f5\u6311\u6230\u751f\u91ab\u95dc\u9375\u8b70\u984c"},"content":{"rendered":"<p>\u672c\u9662\u65bc\u672c\uff082023\uff09\u5e74 6 \u6708 1 \u65e5\u5ba3\u5e03\u8207\u83ab\u5fb7\u7d0d\uff08ModernaTx\uff09\u53ca\u83ab\u5fb7\u7d0d\u53f0\u7063\uff08Moderna Taiwan\uff09\u7c3d\u7f72\u5408\u4f5c\u610f\u5411\u66f8\uff0c\u5efa\u7acb\u7b56\u7565\u5408\u4f5c\u95dc\u4fc2\uff0c\u96d9\u65b9\u5c07\u7d50\u5408\u7814\u767c\u8207\u8f14\u5c0e\u8cc7\u6e90\uff0c\u52a0\u901f\u570b\u5167 mRNA \u6280\u8853\u7684\u767c\u5c55\uff0c\u57f9\u80b2\u76f8\u95dc\u7814\u7a76\u4eba\u624d\uff0c\u4e26\u5171\u540c\u767c\u8d77 mRNA \u524d\u77bb\u65b0\u5275\u734e\u8a08\u756b\uff0c\u5ee3\u9080\u81fa\u7063\u512a\u79c0\u7684\u7814\u7a76\u5718\u968a\u53c3\u8207\u8a55\u9078\u3002<\/p>\n<div id=\"attachment_21652\" style=\"width: 1034px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21652\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/06\/1-1-1024x538.jpg\" alt=\"\u672c\u9662\u8207\u83ab\u5fb7\u7d0d\u7c3d\u7f72\u5408\u4f5c\u610f\u5411\u66f8\u52a0\u901f mRNA \u7814\u7a76 \u5171\u63a8\u524d\u77bb\u65b0\u5275\u734e \u9f13\u52f5\u6311\u6230\u751f\u91ab\u95dc\u9375\u8b70\u984c\" width=\"1024\" height=\"538\" class=\"aligncenter size-large wp-image-31633\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/06\/1-1-1024x538.jpg 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/06\/1-1-300x158.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/06\/1-1-768x403.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/06\/1-1-1536x806.jpg 1536w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/06\/1-1-1080x567.jpg 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/06\/1-1.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">\u25b2\uff08\u5de6\u81f3\u53f3\uff09\u5433\u6f22\u5fe0\u4e3b\u4efb\u3001\u5510\u5802\u526f\u9662\u9577\u3001\u9ec3\u7fca\u7fa4\u7e3d\u7d93\u7406\u66a8\u79d1\u5b78\u9577\u3001\u674e\u5b9c\u771f\u7e3d\u7d93\u7406<\/p><\/div>\n<p><strong>\u672c\u9662\u8207\u83ab\u5fb7\u7d0d\u7c3d\u8a02\u5408\u4f5c\u610f\u5411\u66f8 \u52a0\u901f mRNA \u7814\u7a76<\/strong><\/p>\n<p>\u672c\u6b21\u5408\u4f5c\u610f\u5411\u66f8\u7531\u672c\u9662\u5510\u5802\u526f\u9662\u9577\u3001\u751f\u91ab\u8f49\u8b6f\u7814\u7a76\u4e2d\u5fc3\u5433\u6f22\u5fe0\u4e3b\u4efb\uff0c\u8207\u83ab\u5fb7\u7d0d\u57fa\u56e0\uff08Moderna Genomics\uff09\u9ec3\u7fca\u7fa4\u7e3d\u7d93\u7406\u66a8\u79d1\u5b78\u9577\u3001\u83ab\u5fb7\u7d0d\u53f0\u7063\u674e\u5b9c\u771f\u7e3d\u7d93\u7406\u5171\u540c\u7c3d\u7f72\u3002\u5167\u5bb9\u5f37\u8abf\u4e09\u500b\u4e3b\u8981\u65b9\u5411\uff1a\u4e00\u3001\u5efa\u7acb\u81fa\u7063 mRNA \u5275\u65b0\u7814\u767c\u5e73\u53f0\uff0c\u63d0\u4f9b\u65b0\u5275\u516c\u53f8\u5c55\u793a\u53ca\u4ea4\u6d41\u6a5f\u6703\uff1b\u4e8c\u3001\u9078\u5b9a mRNA \u6280\u8853\u7684\u524d\u77bb\u6027\u4e3b\u984c\uff0c\u5171\u540c\u63d0\u4f9b\u8cc7\u6e90\u4ee5\u52a0\u901f\u7814\u767c\u9032\u7a0b\uff1b\u4e09\u3001\u63d0\u4f9b\u5718\u968a\u66f4\u591a\u570b\u969b\u5316\u7684\u6a5f\u6703\u3002<\/p>\n<p>2019 \u5e74\u5e95\u65b0\u51a0\u80ba\u708e\u75ab\u60c5\u5e2d\u6372\u5168\u7403\uff0c\u65b0\u8208\u7684 mRNA \u75ab\u82d7\u5354\u52a9\u5404\u570b\u53d6\u5f97\u826f\u597d\u7684\u6297\u75ab\u6210\u679c\uff0c\u4e26\u4f7f mRNA \u751f\u91ab\u6280\u8853\u5ee3\u70ba\u4e16\u4eba\u6240\u77e5\u3002\u5510\u5802\u526f\u9662\u9577\u8868\u793a\uff0c\u672c\u9662\u5728 2020 \u5e74\u5e95\u5373\u7d44\u6210\u9996\u652f mRNA \u75ab\u82d7\u7814\u767c\u5718\u968a\uff0c\u4e26\u4ee5\u85e5\u54c1\u512a\u826f\u88fd\u9020\u4f5c\u696d\u898f\u7bc4\uff08GMP\uff09\u7684\u7cbe\u795e\u898f\u5283\u5efa\u7f6e\u6838\u5fc3\u8a2d\u65bd\u2500\u2500\u300cmRNA \u5148\u5c0e\u7814\u7a76\u8a2d\u65bd\u300d\uff0c\u4ee5\u4f9b\u61c9\u65e9\u671f\u81e8\u5e8a\u8a66\u9a57\u6240\u9700\u7684 mRNA \u75ab\u82d7\uff0c\u540c\u6642\u4e5f\u7a4d\u6975\u5ef6\u652c\u7814\u767c\u8207\u6280\u8853\u7684\u4eba\u624d\uff0c\u52a0\u901f\u767c\u5c55 mRNA \u6280\u8853\uff0c\u4f86\u61c9\u5c0d\u5df2\u77e5\u53ca\u672a\u77e5\u7684\u75be\u75c5\uff0c\u300cmRNA \u5148\u5c0e\u7814\u7a76\u8a2d\u65bd\u300d\u9810\u8a08\u4eca\u5e74\u5e95\u5b8c\u6210\u5834\u57df\u9a57\u8b49\uff0c2024 \u5e74\u958b\u59cb\u63a5\u53d7\u7522\u696d\u53ca\u5b78\u7814\u754c\u5c0f\u578b\u8a66\u91cf\u7522\u3002<\/p>\n<p>\u8f49\u8b6f\u4e2d\u5fc3\u5433\u6f22\u5fe0\u4e3b\u4efb\u6307\u51fa\uff0c\u570b\u5bb6\u751f\u6280\u7814\u7a76\u5712\u5340\u8fd1\u5e74\u7a4d\u6975\u5fb5\u9078\u7814\u7a76\u8a08\u756b\u5718\u968a\u9032\u99d0\uff0c\u9396\u5b9a\u5177\u793e\u6703\u91cd\u8981\u6027\u3001\u61c9\u7528\u6f5b\u529b\u53ca\u9069\u5408\u7531\u516c\u5171\u8cc7\u91d1\u6295\u5165\u7684\u968a\u4f0d\u3002\u672c\u9662\u7279\u5225\u5efa\u7f6e\u5c08\u696d\u7d1a\u7684\u6838\u5fc3\u8a2d\u65bd\uff0c\u4ee5\u5354\u52a9\u5275\u65b0\u5718\u968a\u9032\u884c\u52a0\u503c\u5be6\u9a57\uff0c\u4e26\u52a0\u901f\u7814\u767c\u6642\u7a0b\u3002\u5712\u5340\u4f5c\u70ba\u81fa\u7063\u751f\u91ab\u65b0\u5275\u7684\u6416\u7c43\uff0c\u81f4\u529b\u65bc\u5354\u52a9\u7814\u767c\u5718\u968a\u4e32\u63a5\u570b\u5167\u5916\u8cc7\u6e90\u3002\u901a\u904e\u672c\u6b21\u8207\u83ab\u5fb7\u7d0d\u7684\u5408\u4f5c\uff0c\u5718\u968a\u53ef\u671b\u5728\u5712\u5340\u53d6\u5f97\u66f4\u591a\u767b\u4e0a\u570b\u969b\u751f\u91ab\u821e\u53f0\u7684\u6a5f\u6703\u3002<\/p>\n<p>\u83ab\u5fb7\u7d0d\u57fa\u56e0\u9ec3\u7fca\u7fa4\u7e3d\u7d93\u7406\u66a8\u79d1\u5b78\u9577\u4f5c\u70ba\u83ab\u5fb7\u7d0d\u7e3d\u90e8\u7684\u4ee3\u8868\uff0c\u7279\u5730\u4f86\u81fa\u53c3\u8207\u7c3d\u7f72\u5100\u5f0f\u3002\u9ec3\u7fca\u7fa4\u8868\u793a\uff0c\u751f\u91ab\u7522\u696d\u7684\u57f9\u690d\u9700\u8981\u9577\u671f\u6295\u8cc7\uff0c\u671f\u5f85\u900f\u904e\u7522\u7814\u5408\u4f5c\u8a08\u756b\u62cb\u78da\u5f15\u7389\uff0c\u9f13\u52f5\u66f4\u591a\u81fa\u7063\u79d1\u7814\u5148\u9032\u52a0\u5165 mRNA \u7814\u7a76\u9818\u57df\u3001\u958b\u767c\u7121\u9650\u61c9\u7528\u6f5b\u529b\u3002<\/p>\n<p>\u83ab\u5fb7\u7d0d\u53f0\u7063\u674e\u5b9c\u771f\u7e3d\u7d93\u7406\u6307\u51fa\uff0c\u81fa\u7063\u4ee5\u5b8c\u5584\u91ab\u7642\u9ad4\u5236\uff0c\u591a\u5143\u7522\u696d\u4eba\u624d\u3001\u79d1\u5b78\u5bb6\u8207\u7814\u7a76\u6a5f\u69cb\uff0c\u4ee5\u53ca\u751f\u6280\u5275\u65b0\u80fd\u91cf\u8209\u4e16\u805e\u540d\u3002\u8207\u672c\u9662\u7684\u5408\u4f5c\u5c07\u6709\u52a9\u767c\u6398 mRNA \u66f4\u591a\u7684\u61c9\u7528\u53ef\u80fd\uff0c\u5c0b\u627e\u89e3\u6c7a\u5168\u7403\u9762\u81e8\u7684\u91ab\u7642\u7167\u8b77\u6311\u6230\u7684\u5275\u65b0\u89e3\u65b9\uff0c\u7a81\u7834\u76ee\u524d\u75be\u75c5\u9810\u9632\u53ca\u81e8\u5e8a\u6cbb\u7642\u7586\u754c\u3002<\/p>\n<p><strong>mRNA \u524d\u77bb\u65b0\u5275\u734e\u958b\u653e\u5fb5\u4ef6<\/strong><\/p>\n<p>\u6b64\u5916\uff0c\u672c\u9662\u8207\u83ab\u5fb7\u7d0d\u53f0\u7063\u4ea6\u651c\u624b\u5171\u540c\u8209\u8fa6\u300cmRNA \u524d\u77bb\u65b0\u5275\u734e\u300d\u8a08\u756b\uff0c\u5fb5\u6848\u9818\u57df\u5c07\u91dd\u5c0d\u4ee5\u4e0b\u4e94\u5927\u6cbb\u7642\u9818\u57df\uff1a\u50b3\u67d3\u75c5\uff08Infectious diseases\uff09\u3001\u514d\u75ab\u816b\u7624\uff08Immuno-oncology\uff09\u3001\u7f55\u898b\u75be\u75c5\uff08Rare diseases\uff09\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\uff08Cardiovascular diseases\uff09\u3001\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\uff08Autoimmune diseases\uff09\u3002\u6bcf\u7d44\u7372\u9078\u5718\u9ad4\uff0f\u500b\u4eba\u53ef\u4ee5\u7372\u5f97\u65b0\u81fa\u5e6350\u842c\u5143\u7814\u7a76\u734e\u91d1\uff0c\u4e26\u80fd\u5920\u7372\u5f97\u83ab\u5fb7\u7d0d\u53f0\u7063\u7684\u4e00\u5c0d\u4e00\u696d\u5e2b\u8f14\u5c0e\u6a5f\u6703\u3002<\/p>\n<p>\u5433\u6f22\u5fe0\u4e3b\u4efb\u8868\u793a\uff0cmRNA \u6280\u8853\u5728\u5168\u7403\u751f\u7269\u6280\u8853\u9818\u57df\u4e2d\u626e\u6f14\u8457\u91cd\u8981\u7684\u89d2\u8272\uff0c\u5728\u7d93\u6b77\u4e86\u65b0\u51a0\u75ab\u60c5\u7684\u8003\u9a57\u4ee5\u53ca\u5176\u4ed6\u591a\u500b\u75be\u75c5\u9818\u57df\u7684\u5be6\u9a57\u5f8c\uff0c\u672c\u9662\u8207\u83ab\u5fb7\u7d0d\u7684 mRNA \u6280\u8853\u65e5\u76ca\u6210\u719f\u3002\u9019\u6b21\u7684\u5408\u4f5c\u610f\u5411\u66f8\u5c07\u4fc3\u9032\u96d9\u65b9\u76f8\u95dc\u7814\u7a76\u9818\u57df\u9593\u7684\u4ea4\u6d41\u8207\u5408\u4f5c\uff0c\u5e6b\u52a9\u7814\u7a76\u4eba\u624d\u8207\u570b\u969b\u4e0a\u6700\u65b0\u7684\u751f\u7269\u91ab\u5b78\u6280\u8853\u63a5\u8ecc\uff0c\u5275\u9020\u66f4\u591a\u63a5\u8ecc\u4e16\u754c\u821e\u53f0\u7684\u6a5f\u6703\u3002<\/p>\n<p>2023 \u5e74\u9996\u5c46\u8a08\u756b\u5c07\u65bc 6 \u6708 9 \u65e5\u8d77\u6b63\u5f0f\u5c55\u958b\uff0c\u6b61\u8fce\u5168\u570b\u79d1\u7814\u5718\u968a\u8e34\u8e8d\u53c3\u8207\u63d0\u6848\uff0c\u5fb5\u4ef6\u6d3b\u52d5\u5c07\u5f9e\u6d3b\u52d5\u516c\u544a\u65e5\u81f3 7 \u6708 31 \u65e5\u4e0b\u5348 5 \u6642\u6574\u6b62\u3002\u8a73\u7d30\u7af6\u8cfd\u76f8\u95dc\u8cc7\u8a0a\u6703\u516c\u5e03\u65bc\u672c\u9662\u570b\u5bb6\u751f\u6280\u7814\u7a76\u5712\u5340\u5b98\u65b9\u7db2\u7ad9\uff0c\u6b61\u8fce\u6709\u610f\u9858\u5831\u540d\u8005\u4e0a\u7db2\u67e5\u8a62\u3002<\/p>\n<p><strong>\u95dc\u65bc\u4e2d\u592e\u7814\u7a76\u9662<\/strong><\/p>\n<p>\u672c\u9662\u5275\u7acb\u65bc 1928 \u5e74\uff0c\u70ba\u4e2d\u83ef\u6c11\u570b\u5b78\u8853\u7814\u7a76\u6700\u9ad8\u6a5f\u95dc\uff0c\u63a8\u884c\u4eba\u6587\u53ca\u79d1\u5b78\u7814\u7a76\uff0c\u4e26\u80a9\u8ca0\u6307\u5c0e\u3001\u806f\u7d61\u53ca\u734e\u52f5\u5b78\u8853\u7814\u7a76\u4ee5\u53ca\u57f9\u990a\u9ad8\u7d1a\u5b78\u8853\u7814\u7a76\u4eba\u624d\u4e4b\u4efb\u52d9\u3002\u70ba\u517c\u9867\u81ea\u7136\u79d1\u5b78\u53ca\u4eba\u6587\u8207\u793e\u6703\u79d1\u5b78\u4e4b\u5747\u8861\u767c\u5c55\uff0c\u4e2d\u7814\u9662\u5206\u70ba\u6578\u7406\u79d1\u5b78\u3001\u751f\u547d\u79d1\u5b78\u3001\u4eba\u6587\u53ca\u793e\u6703\u79d1\u5b78\u4e09\u5b78\u7d44\uff0c\u8a2d\u6709 24 \u500b\u7814\u7a76\u6240\u53ca 8 \u500b\u7814\u7a76\u4e2d\u5fc3\u3002\u53e6\u8a2d\u6709\u8a55\u8b70\u6703\u3001\u5b78\u8853\u8aee\u8a62\u7e3d\u6703\u53ca\u9662\u672c\u90e8\uff0c\u8ca0\u8cac\u8b70\u5b9a\u672c\u9662\u5b78\u8853\u8a08\u756b\u3001\u4fc3\u9032\u570b\u5167\u5916\u5b78\u8853\u5408\u4f5c\u53ca\u5b78\u8853\u884c\u653f\u5de5\u4f5c\u3002\u672c\u9662\u9662\u52d9\u767c\u5c55\u7684\u4e09\u9805\u76ee\u6a19\uff0c\u70ba\u300c\u6210\u5c31\u5168\u7403\u9802\u5c16\u7814\u7a76\u300d\u3001\u300c\u5584\u76e1\u793e\u6703\u95dc\u9375\u8cac\u4efb\u300d\uff0c\u4ee5\u53ca\u300c\u5ef6\u652c\u57f9\u80b2\u5353\u8d8a\u4eba\u624d\u300d\u3002\u900f\u904e\u805a\u7126\u95dc\u9375\u8b70\u984c\uff0c\u671f\u4ee5\u5b78\u8853\u7814\u7a76\u7684\u89d2\u5ea6\u8ca2\u737b\u793e\u6703\uff0c\u540c\u6642\u4ea6\u7a4d\u6975\u5ef6\u652c\u3001\u5168\u529b\u57f9\u80b2\u7814\u7a76\u4eba\u624d\uff0c\u4ee5\u9020\u5c31\u5353\u8d8a\u70ba\u5b97\u65e8\u3002\u82e5\u8981\u77ad\u89e3\u66f4\u591a\uff0c\u8acb\u9020\u8a2a <a href=\"https:\/www.sinica.edu.tw\/ch\" rel=\"noopener\" target=\"_blank\">https:\/www.sinica.edu.tw\/ch<\/a>\u3002<\/p>\n<p><strong>\u95dc\u65bc\u83ab\u5fb7\u7d0d<\/strong><\/p>\n<p>\u6210\u7acb\u5341\u591a\u5e74\u4f86\uff0c\u5df2\u5f9e\u63a8\u52d5\u4fe1\u4f7f\u6838\u91a3\u6838\u9178\uff08mRNA\uff09\u9818\u57df\u8a08\u756b\u7684\u7814\u7a76\u968e\u6bb5\u516c\u53f8\uff0c\u8f49\u578b\u70ba\u4e00\u5bb6\u4f01\u696d\uff0c\u64c1\u6709\u6a6b\u8de8\u4e03\u7a2e\u6a21\u7d44\u7684\u5404\u7a2e\u75ab\u82d7\u548c\u6cbb\u7642\u81e8\u5e8a\u7d44\u5408\u3001\u5728\u5305\u542b mRNA 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