{"id":30847,"date":"2023-03-23T00:18:02","date_gmt":"2023-03-22T16:18:02","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=30847"},"modified":"2023-04-20T00:43:34","modified_gmt":"2023-04-19T16:43:34","slug":"%e5%b0%8f%e5%b0%8f%e7%9a%84%e6%a0%b8%e7%b3%96%e6%a0%b8%e9%85%b8%e6%89%ae%e6%bc%94%e9%87%8d%e8%a6%81%e8%a7%92%e8%89%b2-%e8%84%8a%e9%ab%93%e6%80%a7%e8%82%8c%e8%82%89%e8%90%8e%e7%b8%ae%e7%97%87","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/30847\/","title":{"rendered":"\u5c0f\u5c0f\u7684\u6838\u7cd6\u6838\u9178\u626e\u6f14\u91cd\u8981\u89d2\u8272 \u2014 \u810a\u9ad3\u6027\u808c\u8089\u840e\u7e2e\u75c7\u7684\u634d\u885b\u6230\u58eb"},"content":{"rendered":"<p>\u672c\u9662\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240\u9673\u4fca\u5b89\u526f\u7814\u7a76\u54e1\u9818\u5c0e\u7684\u7814\u7a76\u5718\u968a\uff0c\u8207\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u9418\u80b2\u5fd7\u8b1b\u5ea7\u6559\u6388\u7814\u7a76\u5718\u968a\u5408\u4f5c\uff0c\u767c\u73fe\u4e00\u500b\u5fae\u578b\u6838\u7cd6\u6838\u9178\u5bb6\u65cf\u300cmicroRNA-34\u300d\u6216\u300cMiR34\u300d\u6703\u53c3\u8207\u810a\u9ad3\u6027\u808c\u8089\u840e\u7e2e\u75c7\uff08Spinal muscular atrophy, SMA\uff09\u7684\u75c5\u7a0b\u767c\u5c55\uff0c\u4e14\u6709\u6f5b\u529b\u4f5c\u70ba\u8a55\u4f30\u810a\u9ad3\u6027\u808c\u8089\u840e\u7e2e\u75c7\u6cbb\u7642\u7642\u6548\u7684\u81e8\u5e8a\u751f\u7269\u6a19\u8a18\u3002\u6b64\u4e00\u767c\u73fe\u70ba\u5c0f\u6838\u7cd6\u6838\u9178\u5982\u4f55\u5f71\u97ff SMA \u75c5\u7406\u8b8a\u5316\u63d0\u4f9b\u4e86\u5d84\u65b0\u7684\u898b\u89e3\uff0c\u4e26\u53ef\u70ba SMA \u7684\u6cbb\u7642\u5e36\u4f86\u66f4\u5468\u5168\u7684\u6cbb\u7642\u6548\u76ca\u3002\u6b64\u9805\u7814\u7a76\u8fd1\u671f\u5df2\u767c\u8868\u65bc\u570b\u969b\u671f\u520a\u300a\u5206\u5b50\u6cbb\u7642 &#8211; \u6838\u9178\u300b\uff08<em>Molecular Therapy &#8211; Nucleic Acids<\/em>\uff09\uff0c\u4e26\u5df2\u7533\u8acb\u7f8e\u570b\u5c08\u5229\u512a\u5148\u6b0a\u3002<\/p>\n<p>\u6b64\u7814\u7a76\u7372\u5f97\u672c\u9662\u3001\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u4ee5\u53ca\u9ad8\u91ab\u5927\u9644\u8a2d\u4e2d\u548c\u7d00\u5ff5\u91ab\u9662\u3001\u570b\u5bb6\u885b\u751f\u7814\u7a76\u9662\u3001\u570b\u5bb6\u79d1\u5b78\u53ca\u6280\u8853\u59d4\u54e1\u6703\u7684\u8cc7\u52a9\u3002<\/p>\n<p>\u7814\u7a76\u8aaa\u660e\uff1a <a href=\"https:\/www.imb.sinica.edu.tw\/en\/research\/publication_show.php?pid=230\">https:\/www.imb.sinica.edu.tw\/en\/research\/publication_show.php?pid=230<\/a><br \/>\n\u7814\u7a76\u8ad6\u6587\uff1a <a href=\"https:\/doi.org\/10.1016\/j.omtn.2023.03.005\">https:\/doi.org\/10.1016\/j.omtn.2023.03.005<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/03\/3-2.jpg\" alt=\"\u5c0f\u5c0f\u7684\u6838\u7cd6\u6838\u9178\u626e\u6f14\u91cd\u8981\u89d2\u8272 \u2014 \u810a\u9ad3\u6027\u808c\u8089\u840e\u7e2e\u75c7\u7684\u634d\u885b\u6230\u58eb\" width=\"796\" height=\"472\" class=\"aligncenter size-full wp-image-30849\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/03\/3-2.jpg 796w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/03\/3-2-300x178.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/03\/3-2-768x455.jpg 768w\" sizes=\"(max-width: 796px) 100vw, 796px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u672c\u9662\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240\u9673\u4fca\u5b89\u526f\u7814\u7a76\u54e1\u9818\u5c0e\u7684\u7814\u7a76\u5718\u968a\uff0c\u8207\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u9418\u80b2\u5fd7\u8b1b\u5ea7\u6559\u6388\u7814\u7a76\u5718\u968a\u5408\u4f5c\uff0c\u767c\u73fe\u4e00\u500b\u5fae\u578b\u6838\u7cd6\u6838\u9178 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":30851,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[988,984],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/30847"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=30847"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/30847\/revisions"}],"predecessor-version":[{"id":30863,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/30847\/revisions\/30863"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/30851"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=30847"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=30847"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=30847"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}