{"id":29449,"date":"2022-12-01T00:18:20","date_gmt":"2022-11-30T16:18:20","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=29449"},"modified":"2023-05-03T15:31:01","modified_gmt":"2023-05-03T07:31:01","slug":"mex3a-%e6%8a%91%e5%88%b6-p53-%e4%bb%8b%e5%b0%8e%e7%9a%84%e9%90%b5%e4%be%9d%e8%b3%b4%e5%9e%8b%e7%b4%b0%e8%83%9e%e6%ad%bb%e4%ba%a1%e4%bb%a5%e4%bf%83%e9%80%b2%e5%8d%b5%e5%b7%a2%e8%85%ab%e7%98%a4%e7%94%9f","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/29449\/","title":{"rendered":"MEX3A \u6291\u5236 p53 \u4ecb\u5c0e\u7684\u9435\u4f9d\u8cf4\u578b\u7d30\u80de\u6b7b\u4ea1\u4ee5\u4fc3\u9032\u5375\u5de2\u816b\u7624\u751f\u9577"},"content":{"rendered":"<p>\u5a66\u764c\u4e2d\uff0c\u5375\u5de2\u764c\u76db\u884c\u7387\u96d6\u4f4e\uff0c\u6b7b\u4ea1\u7387\u537b\u540d\u5217\u524d\u8305\uff0c\u4e94\u5e74\u5b58\u6d3b\u7387\u50c5 48.6%\u3002\u7279\u5225\u662f\u4e9e\u6d32\u76db\u884c\u3001\u5177\u6297\u764c\u57fa\u56e0 p53 \u7684\u5375\u5de2\u4eae\u7d30\u80de\u764c\uff0c\u5176\u9810\u5f8c\u5dee\u3001\u6297\u85e5\u6027\u53ca\u5fa9\u767c\u7387\u9ad8\u3002\u672c\u9662\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u52a9\u7814\u7a76\u54e1\u9ec3\u96ef\u83ef\u5718\u968a\u767c\u73fe\uff0cMEX3A \u80fd\u6291\u5236 p53 \u8abf\u63a7\u7684\u9435\u4f9d\u8cf4\u578b\u7d30\u80de\u6b7b\u4ea1\uff0c\u8b93\u764c\u7d30\u80de\u80fd\u58d3\u5236 p53 \u6297\u764c\u529f\u80fd\uff0c\u9032\u4e00\u6b65\u751f\u9577\u8207\u60e1\u5316\u3002\u672c\u7814\u7a76\u4e0d\u50c5\u95e1\u660e\u65b0\u7a4e\u7684\u764c\u5316\u5206\u5b50\u6a5f\u5236\uff0c\u4e26\u63d0\u4f9b\u6cbb\u7642 WT p53 \u5375\u5de2\u764c\u4e4b\u6cbb\u7642\u6a19\u7684\uff0c\u6210\u679c\u5df2\u520a\u767b\u65bc\u300a\u764c\u75c7\u7814\u7a76\u300b\uff08<em>Cancer Research<\/em>\uff09\u3002<\/p>\n<p>\u7814\u7a76\u8aaa\u660e\uff1a <a href=\"https:\/www.genomics.sinica.edu.tw\/index.php\/tw\/news\/lastest-news\/701-mex3a-p53\">https:\/www.genomics.sinica.edu.tw\/index.php\/tw\/news\/lastest-news\/701-mex3a-p53<\/a><br \/>\n\u8ad6\u6587\u5168\u6587\uff1a<a href=\"https:\/aacrjournals.org\/cancerres\/article\/doi\/10.1158\/0008-5472.CAN-22-1159\/710535\/MEX3A-mediates-p53-degradation-to-suppress\">https:\/aacrjournals.org\/cancerres\/article\/doi\/10.1158\/0008-5472.CAN-22-1159\/710535\/MEX3A-mediates-p53-degradation-to-suppress<\/a><\/p>\n<img loading=\"lazy\" decoding=\"async\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/11\/3-4-1024x617.jpg\" alt=\"MEX3A \u6291\u5236 p53 \u4ecb\u5c0e\u7684\u9435\u4f9d\u8cf4\u578b\u7d30\u80de\u6b7b\u4ea1\u4ee5\u4fc3\u9032\u5375\u5de2\u816b\u7624\u751f\u9577\" width=\"1024\" height=\"617\" class=\"aligncenter size-large wp-image-29450\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/11\/3-4-1024x617.jpg 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/11\/3-4-300x181.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/11\/3-4-768x463.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/11\/3-4-1080x651.jpg 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/11\/3-4-440x264.jpg 440w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/11\/3-4.jpg 1162w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\n","protected":false},"excerpt":{"rendered":"<p>\u5a66\u764c\u4e2d\uff0c\u5375\u5de2\u764c\u76db\u884c\u7387\u96d6\u4f4e\uff0c\u6b7b\u4ea1\u7387\u537b\u540d\u5217\u524d\u8305\uff0c\u4e94\u5e74\u5b58\u6d3b\u7387\u50c5 48.6%\u3002\u7279\u5225\u662f\u4e9e\u6d32\u76db\u884c\u3001\u5177\u6297\u764c\u57fa\u56e0 p53 \u7684\u5375 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":29451,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[988,984],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/29449"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=29449"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/29449\/revisions"}],"predecessor-version":[{"id":29530,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/29449\/revisions\/29530"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/29451"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=29449"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=29449"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=29449"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}