{"id":28797,"date":"2022-10-06T00:17:13","date_gmt":"2022-10-05T16:17:13","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=28797"},"modified":"2022-10-06T08:54:03","modified_gmt":"2022-10-06T00:54:03","slug":"%e6%a4%8d%e7%89%a9%e5%80%8d%e5%8d%8a%e8%90%9c%e5%85%a7%e9%85%afdeoxyelephantopin%ef%bc%88det%ef%bc%89%e5%92%8c%e5%85%b6%e6%96%b0%e7%a9%8e%e8%a1%8d%e7%94%9f%e7%89%a9-%e6%9c%89%e5%8a%a9%e6%8a%91","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/28797\/","title":{"rendered":"\u690d\u7269\u500d\u534a\u841c\u5167\u916fdeoxyelephantopin\uff08DET\uff09\u548c\u5176\u65b0\u7a4e\u884d\u751f\u7269 \u6709\u52a9\u6291\u5236\u85e5\u6027\u654f\u611f\u6216\u6297\u85e5\u6027 BRAF<sup>V600E<\/sup> \u9ed1\u8272\u7d20\u7624\u751f\u9577"},"content":{"rendered":"<p>\u9ed1\u8272\u7d20\u7624\u662f\u6700\u81f4\u547d\u6027\u7684\u76ae\u819a\u764c\u5f62\u5f0f\uff0c\u8d85\u904e 50% \u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5e36\u6709 BRAF<sup>V600E<\/sup> \u7a81\u8b8a\uff0c\u4f46\u5927\u90e8\u5206\u60a3\u8005\u5728\u4ee5 BRAF<sup>V600E<\/sup> \u6291\u5236\u5291\u85e5\u7269\uff08\u5982\uff1avemurafenib\uff09\u6cbb\u7642\u5f8c\uff0c\u6703\u7522\u751f\u6297\u85e5\u6027\u3001\u526f\u4f5c\u7528\u4e26\u5fa9\u767c\u3002\u672c\u9662\u8fb2\u751f\u4e2d\u5fc3\u7279\u8058\u7814\u7a76\u54e1\u5f90\u9e97\u82ac\u5718\u968a\u767c\u73fe\uff0c\u690d\u7269\u500d\u534a\u841c\u5167\u916f\u300c\u53bb\u6c27\u5730\u81bd\u8349\u7d20\u300d\uff08DET\uff09\u8207\u5176\u7d50\u69cb\u4fee\u98fe\u4e4b\u884d\u751f\u7269 DETD-35\uff0c\u70ba GPX4 \u9175\u7d20\u6291\u5236\u5291\u4ee5\u53ca\u9435\u4f9d\u8cf4\u578b\u7d30\u80de\u6b7b\u4ea1\uff08ferroptosis\uff09\u7684\u8a98\u5c0e\u5291\u3002\u85c9\u7531\u9019\u4e9b\u65b0\u7a4e\u4e4b\u4f5c\u7528\u6a5f\u5236\uff0c\u53ef\u6709\u6548\u8abf\u63a7\u53ca\u9006\u8f49 vemurafenib \u5728\u6297\u85e5\u6027\u9ed1\u8272\u7d20\u7624\u7d30\u80de\u4e2d\u7570\u5e38\u589e\u52a0\u4e4b\u521d\u7d1a\u8207\u8102\u8cea\u4ee3\u8b1d\u7269\u8cea\uff0c\u4e26\u589e\u52a0\u6297\u85e5\u6027\u816b\u7624\u5c0d vemurafenib \u85e5\u7269\u7684\u654f\u611f\u5ea6\u3002DET \u548c DETD-35 \u53ef\u767c\u5c55\u70ba\u6cbb\u7642 BRAF<sup>V600E<\/sup> \u9ed1\u8272\u7d20\u7624\u4e4b\u85e5\u7269\u6216\u4f50\u5291\uff0c\u6210\u679c\u5df2\u65bc\u4eca\uff082022\uff09\u5e74\u520a\u767b\u5728\u300a\u85e5\u7406\u5b78\u7814\u7a76\u300b\uff08<em>Pharmacological Research<\/em>\uff09\u3002<\/p>\n<p>\u7814\u7a76\u8aaa\u660e\uff1a<br \/>\n<a href=\"https:\/abrc.sinica.edu.tw\/ch\/view.php?aid=6268&#038;wid=2\">https:\/abrc.sinica.edu.tw\/ch\/view.php?aid=6268&#038;wid=2<\/a><\/p>\n<p>\u8ad6\u6587\u5168\u6587\uff1a<br \/>\n<a href=\"https:\/pubmed.ncbi.nlm.nih.gov\/35231572\/\">https:\/pubmed.ncbi.nlm.nih.gov\/35231572\/<\/a><\/p>\n<div id=\"attachment_21652\" style=\"width: 810px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" aria-describedby=\"caption-attachment-21652\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/10\/3-1-1.jpg\" alt=\"\u690d\u7269\u500d\u534a\u841c\u5167\u916fdeoxyelephantopin\uff08DET\uff09\u548c\u5176\u65b0\u7a4e\u884d\u751f\u7269 \u6709\u52a9\u6291\u5236\u85e5\u6027\u654f\u611f\u6216\u6297\u85e5\u6027 BRAF<sup><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">V600E<\/sup> \u9ed1\u8272\u7d20\u7624\u751f\u9577&#8221; width=&#8221;800&#8243; height=&#8221;311&#8243; class=&#8221;alignnone size-full wp-image-28798&#8243; \/><\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u9ed1\u8272\u7d20\u7624\u662f\u6700\u81f4\u547d\u6027\u7684\u76ae\u819a\u764c\u5f62\u5f0f\uff0c\u8d85\u904e 50% \u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5e36\u6709 BRAFV600E \u7a81\u8b8a\uff0c\u4f46\u5927\u90e8\u5206\u60a3\u8005\u5728\u4ee5  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":28799,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[988,984],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/28797"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=28797"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/28797\/revisions"}],"predecessor-version":[{"id":28888,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/28797\/revisions\/28888"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/28799"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=28797"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=28797"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=28797"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}