{"id":28567,"date":"2022-09-08T00:14:21","date_gmt":"2022-09-07T16:14:21","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=28567"},"modified":"2022-09-08T00:29:25","modified_gmt":"2022-09-07T16:29:25","slug":"trax-%e8%97%89%e7%94%b1%e8%aa%bf%e6%8e%a7%e5%be%ae%e6%a0%b8%e7%b3%96%e6%a0%b8%e9%85%b8-%e9%80%b2%e8%80%8c%e5%bd%b1%e9%9f%bf%e4%ba%a8%e4%b8%81%e9%a0%93%e6%b0%8f%e8%88%9e%e8%b9%88%e7%97%87%e7%9a%84","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/28567\/","title":{"rendered":"TRAX \u85c9\u7531\u8abf\u63a7\u5fae\u6838\u7cd6\u6838\u9178 \u9032\u800c\u5f71\u97ff\u4ea8\u4e01\u9813\u6c0f\u821e\u8e48\u75c7\u7684\u75c5\u7a0b\u767c\u5c55"},"content":{"rendered":"<p>\u4ea8\u4e01\u9813\u821e\u8e48\u75c7\uff08HD\uff09\u662f\u4e00\u7a2e\u907a\u50b3\u6027\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\uff0c\u7531\u65bc CAG \u4e09\u6838\u82f7\u9178\u91cd\u8907\u5e8f\u5217\u5728 huntingtin \u57fa\u56e0\u64f4\u589e\uff0c\u9032\u800c\u640d\u5bb3\u591a\u7a2e\u7d30\u80de\u6a5f\u5236\u4e26\u5c0e\u81f4\u795e\u7d93\u9000\u5316\u3002TRAX\uff08Translin-associated protein X\uff09\u5df2\u77e5\u80fd\u8abf\u63a7 miRNA \u964d\u89e3\u3002\u672c\u9662\u751f\u91ab\u6240\u7279\u8058\u7814\u7a76\u54e1\u9673\u5100\u838a\u5718\u968a\u767c\u73fe\uff0c\u7576 HD \u767c\u75c5\u6642\uff0cTRAX \u5728 HD \u60a3\u8005\u548c HD \u5c0f\u9f20\u8166\u4e2d\u7684\u8868\u73fe\u91cf\u90fd\u6709\u660e\u986f\u589e\u5f37\u3002\u672c\u7bc7\u7814\u7a76\u8b49\u5be6 TRAX \u5c0d HD \u5177\u6709\u4fdd\u8b77\u4f5c\u7528\uff0c\u6291\u5236 TRAX \u6703\u6539\u8b8a HD \u5c0f\u9f20\u8166\u4e2d miRNA-mRNA \u7684\u8abf\u63a7\uff0c\u4e26\u52a0\u901f HD \u5c0f\u9f20\u767c\u75c5\u3002\u7814\u7a76\u6210\u679c\u65bc\u4eca\uff082022\uff09\u5e74 8 \u6708\u520a\u767b\u5728\u300a\u904b\u52d5\u969c\u7919\u300b\uff08<em>Movement Disorders<\/em>\uff09\u3002<\/p>\n<p>\u7814\u7a76\u8aaa\u660e\uff1a <a href=\"https:\/www.ibms.sinica.edu.tw\/ch\/news\/2022-443.html\">https:\/www.ibms.sinica.edu.tw\/ch\/news\/2022-443.html<\/a><br \/>\n\u8ad6\u6587\u5168\u6587\uff1a <a href=\"https:\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.29174\">https:\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.29174<\/a><\/p>\n<img loading=\"lazy\" decoding=\"async\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/09\/3-1.jpg\" alt=\"TRAX \u85c9\u7531\u8abf\u63a7\u5fae\u6838\u7cd6\u6838\u9178 \u9032\u800c\u5f71\u97ff\u4ea8\u4e01\u9813\u6c0f\u821e\u8e48\u75c7\u7684\u75c5\u7a0b\u767c\u5c55\" width=\"836\" height=\"504\" class=\"alignnone size-full wp-image-28568\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/09\/3-1.jpg 836w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/09\/3-1-300x181.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/09\/3-1-768x463.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/09\/3-1-440x264.jpg 440w\" sizes=\"(max-width: 836px) 100vw, 836px\" \/>\n","protected":false},"excerpt":{"rendered":"<p>\u4ea8\u4e01\u9813\u821e\u8e48\u75c7\uff08HD\uff09\u662f\u4e00\u7a2e\u907a\u50b3\u6027\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\uff0c\u7531\u65bc CAG \u4e09\u6838\u82f7\u9178\u91cd\u8907\u5e8f\u5217\u5728 huntingtin \u57fa\u56e0\u64f4 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":28569,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[988,984],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/28567"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=28567"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/28567\/revisions"}],"predecessor-version":[{"id":28638,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/28567\/revisions\/28638"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/28569"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=28567"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=28567"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=28567"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}