\u767d\u8840\u75c5\u80fd\u85c9\u7531\u5316\u7642\u7372\u5f97\u6539\u5584\uff0c\u4f46 MLL \u57fa\u56e0\u91cd\u6392 (MLL-r) \u767d\u8840\u75c5\u60a3\u8005\u5c0d\u65bc\u5316\u7642\u7684\u6210\u6548\u8207\u9810\u5f8c\u90fd\u4e0d\u4f73\u3002\u672c\u9662\u751f\u91ab\u6240\u7814\u7a76\u54e1\u694a\u745e\u5f6c\u5718\u968a\u7814\u7a76\u6307\u51fa\uff0cSCUBE1 \u65bc MLL-r \u767d\u8840\u75c5\u4e4b\u75c5\u7406\u529f\u80fd\u4e0a\u626e\u6f14\u95dc\u9375\u89d2\u8272\u3002SCUBE1 \u70ba FLT3 \u8f14\u53d7\u9ad4 (co-receptor)\uff0c\u80fd\u589e\u5f37 FLT3 \u914d\u9ad4\u8207\u53d7\u9ad4\u4e4b\u7d50\u5408\u80fd\u529b\uff0c\u6d3b\u5316\u4e0b\u6e38 LYN-AKT \u8a0a\u865f\uff0c\u9032\u800c\u4fc3\u4f7f\u8840\u764c\u7d30\u80de\u5b58\u6d3b\u8207\u589e\u751f\u3002<\/p>\n
\u7814\u7a76\u4e5f\u767c\u73fe\uff0c\u7576 SCUBE1 \u6297\u9ad4\u7d50\u5408\u6297\u6709\u7d72\u5206\u88c2\u85e5\u7269 MMAE\uff0c\u80fd\u6709\u6548\u6bd2\u6bba MLL-r \u8840\u764c\u7d30\u80de\uff0c\u6b64\u986f\u793a SCUBE1 \u6975\u5177\u6f5b\u529b\uff0c\u53ef\u4f5c\u70ba MLL-r \u767d\u8840\u75c5\u514d\u75ab\u6cbb\u7642\u4e4b\u6a19\u7684\u3002\u672c\u7814\u7a76\u6210\u679c\u5df2\u65bc\u4eca(2022) \u5e74 8 \u6708\u520a\u767b\u5728\u570b\u969b\u671f\u520a\u300a\u8840\u6db2\u5b78\u300b\uff08Haematologica<\/em>\uff09\u3002<\/p>\n
\u7814\u7a76\u8aaa\u660e : https:\/www.ibms.sinica.edu.tw\/ch\/news\/2022-444.html<\/a>
\n\u8ad6\u6587\u5168\u6587 : https:\/haematologica.org\/article\/view\/haematol.2022.281151<\/a><\/p>\n\n","protected":false},"excerpt":{"rendered":"