{"id":28563,"date":"2022-09-08T00:13:15","date_gmt":"2022-09-07T16:13:15","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=28563"},"modified":"2022-09-08T00:29:25","modified_gmt":"2022-09-07T16:29:25","slug":"%e5%b0%8d%e6%8a%97%e6%80%a5%e6%80%a7%e9%aa%a8%e9%ab%93%e6%80%a7%e7%99%bd%e8%a1%80%e7%97%85%e4%b9%8b%e5%b6%84%e6%96%b0%e6%a8%99%e9%9d%b6%e6%b2%bb%e7%99%82","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/28563\/","title":{"rendered":"\u5c0d\u6297\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\u4e4b\u5d84\u65b0\u6a19\u9776\u6cbb\u7642"},"content":{"rendered":"<p>\u767d\u8840\u75c5\u80fd\u85c9\u7531\u5316\u7642\u7372\u5f97\u6539\u5584\uff0c\u4f46 MLL \u57fa\u56e0\u91cd\u6392 (MLL-r) \u767d\u8840\u75c5\u60a3\u8005\u5c0d\u65bc\u5316\u7642\u7684\u6210\u6548\u8207\u9810\u5f8c\u90fd\u4e0d\u4f73\u3002\u672c\u9662\u751f\u91ab\u6240\u7814\u7a76\u54e1\u694a\u745e\u5f6c\u5718\u968a\u7814\u7a76\u6307\u51fa\uff0cSCUBE1 \u65bc MLL-r \u767d\u8840\u75c5\u4e4b\u75c5\u7406\u529f\u80fd\u4e0a\u626e\u6f14\u95dc\u9375\u89d2\u8272\u3002SCUBE1 \u70ba FLT3 \u8f14\u53d7\u9ad4 (co-receptor)\uff0c\u80fd\u589e\u5f37 FLT3 \u914d\u9ad4\u8207\u53d7\u9ad4\u4e4b\u7d50\u5408\u80fd\u529b\uff0c\u6d3b\u5316\u4e0b\u6e38 LYN-AKT \u8a0a\u865f\uff0c\u9032\u800c\u4fc3\u4f7f\u8840\u764c\u7d30\u80de\u5b58\u6d3b\u8207\u589e\u751f\u3002<\/p>\n<p>\u7814\u7a76\u4e5f\u767c\u73fe\uff0c\u7576 SCUBE1 \u6297\u9ad4\u7d50\u5408\u6297\u6709\u7d72\u5206\u88c2\u85e5\u7269 MMAE\uff0c\u80fd\u6709\u6548\u6bd2\u6bba MLL-r \u8840\u764c\u7d30\u80de\uff0c\u6b64\u986f\u793a SCUBE1 \u6975\u5177\u6f5b\u529b\uff0c\u53ef\u4f5c\u70ba MLL-r \u767d\u8840\u75c5\u514d\u75ab\u6cbb\u7642\u4e4b\u6a19\u7684\u3002\u672c\u7814\u7a76\u6210\u679c\u5df2\u65bc\u4eca(2022) \u5e74 8 \u6708\u520a\u767b\u5728\u570b\u969b\u671f\u520a\u300a\u8840\u6db2\u5b78\u300b\uff08<em>Haematologica<\/em>\uff09\u3002<\/p>\n<p>\u7814\u7a76\u8aaa\u660e : <a href=\"https:\/www.ibms.sinica.edu.tw\/ch\/news\/2022-444.html\">https:\/www.ibms.sinica.edu.tw\/ch\/news\/2022-444.html<\/a><br \/>\n\u8ad6\u6587\u5168\u6587 : <a href=\"https:\/haematologica.org\/article\/view\/haematol.2022.281151\">https:\/haematologica.org\/article\/view\/haematol.2022.281151<\/a><\/p>\n<img loading=\"lazy\" decoding=\"async\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/09\/3-2.jpg\" alt=\"\u5c0d\u6297\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\u4e4b\u5d84\u65b0\u6a19\u9776\u6cbb\u7642\" width=\"836\" height=\"504\" class=\"alignnone size-full wp-image-28564\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/09\/3-2.jpg 836w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/09\/3-2-300x181.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/09\/3-2-768x463.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/09\/3-2-440x264.jpg 440w\" sizes=\"(max-width: 836px) 100vw, 836px\" \/>\n","protected":false},"excerpt":{"rendered":"<p>\u767d\u8840\u75c5\u80fd\u85c9\u7531\u5316\u7642\u7372\u5f97\u6539\u5584\uff0c\u4f46 MLL \u57fa\u56e0\u91cd\u6392 (MLL-r) \u767d\u8840\u75c5\u60a3\u8005\u5c0d\u65bc\u5316\u7642\u7684\u6210\u6548\u8207\u9810\u5f8c\u90fd\u4e0d\u4f73\u3002\u672c\u9662\u751f\u91ab [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":28565,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[988,984],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/28563"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=28563"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/28563\/revisions"}],"predecessor-version":[{"id":28622,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/28563\/revisions\/28622"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/28565"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=28563"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=28563"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=28563"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}