{"id":28558,"date":"2022-09-08T00:12:45","date_gmt":"2022-09-07T16:12:45","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=28558"},"modified":"2022-10-18T13:29:13","modified_gmt":"2022-10-18T05:29:13","slug":"%e3%80%90%e5%b0%88%e6%ac%84%e3%80%91%e5%b0%8b%e6%89%be%e6%bd%9b%e8%97%8f%e5%9c%a8%e5%9f%ba%e5%9b%a0%e9%ab%94%e6%b5%b7%e6%b4%8b%e4%b8%ad%e7%9a%84%e5%a4%a7%e7%a7%98%e5%af%b6%ef%bc%9a%e9%9d%9e%e5%85%b8","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/28558\/","title":{"rendered":"\u3010\u5c08\u6b04\u3011\u5c0b\u627e\u6f5b\u85cf\u5728\u57fa\u56e0\u9ad4\u6d77\u6d0b\u4e2d\u7684\u5927\u79d8\u5bf6\uff1a\u975e\u5178\u578b\u8f49\u8b6f\u86cb\u767d"},"content":{"rendered":"
\u751f\u7269\u57fa\u56e0\u9ad4\u4ee5 DNA \u7684\u5f62\u5f0f\u651c\u5e36\u907a\u50b3\u8a0a\u606f\uff0c\u751f\u7269\u6703\u9078\u64c7\u6027\u5730\u64f7\u53d6\u7279\u5b9a DNA \u7247\u6bb5\uff0c\u5c07\u5176\u8f49\u9304\u6210 RNA\uff0c\u518d\u5c07 RNA \u8f49\u8b6f\u6210\u86cb\u767d\u8cea\u3002\u800c\u5177\u6709\u751f\u7406\u529f\u80fd\u7684\u86cb\u767d\u8cea\u5247\u5728\u751f\u7269\u9ad4\u4e2d\u9032\u884c\u8457\u5404\u5f0f\u5404\u6a23\u7684\u53cd\u61c9\uff0c\u7dad\u6301\u751f\u7269\u9ad4\u7684\u751f\u7406\u6a5f\u80fd\u3002\u7531\u6b64\u53ef\u77e5\uff0c\u86cb\u767d\u8cea\u5c0d\u65bc\u751f\u7269\u9ad4\u7684\u91cd\u8981\u6027\u3002<\/p>\n
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\u85cf\u5bf6\u5716\uff1a\u5229\u7528\u6838\u91a3\u9ad4\u5b9a\u5e8f\u5206\u6790\u6280\u8853\u627e\u51fa\u8f49\u8b6f\u8d77\u59cb\u9ede<\/strong><\/p>\n \u60f3\u8981\u5728\u6c6a\u6d0b\u5927\u6d77\u4e2d\u5c0b\u5bf6\uff0c\u82e5\u80fd\u6709\u85cf\u5bf6\u5716\u60f3\u5fc5\u80fd\u4e8b\u534a\u529f\u500d\u3002<\/p>\n \u5728 2009 \u5e74\u4ee5\u4f86\uff0cIngolia \u8207 Gao \u535a\u58eb\u70ba\u4e3b\u7684\u79d1\u5b78\u5bb6\u5011\uff0c\u5efa\u7acb\u6838\u91a3\u9ad4\u5b9a\u5e8f\u5206\u6790\u6280\u8853\uff0c\u5229\u7528\u300clactimidomycin\uff08LTM\uff09\u8f49\u8b6f\u6291\u5236\u5291\u300d\uff0c\u6291\u5236\u8f49\u8b6f\u4f5c\u7528\u5728\u525b\u8d77\u59cb\u7684\u968e\u6bb5\uff0c\u8b93\u6838\u91a3\u9ad4\u7d2f\u7a4d\u5728\u8a0a\u606f RNA \u4e0a\u7684\u8f49\u8b6f\u8d77\u59cb\u4f4d\u7f6e\uff0c\u518d\u642d\u914d\u300cpuromycin\uff08PMY\uff09\u8f49\u8b6f\u6291\u5236\u5291\u300d\uff0c\u5c07\u5df2\u7d93\u9032\u5165\u8f49\u8b6f\u5ef6\u9577\u968e\u6bb5\u7684\u6838\u91a3\u9ad4\u89e3\u958b\uff0c\u8b93\u6838\u91a3\u9ad4\u53ea\u80fd\u4f54\u64da\u5728\u8f49\u8b6f\u8d77\u59cb\u4f4d\u7f6e\uff0c\u6700\u5f8c\u518d\u900f\u904e RNA \u5b9a\u5e8f\u627e\u51fa\u6838\u91a3\u9ad4\u6240\u4f54\u64da\u7684\u8f49\u8b6f\u8d77\u59cb\u5e8f\u5217\uff08\u5716\u4e00B\uff09\u3002\u300ccycloheximide\uff08CHX\uff09\u300d\u5247\u70ba\u53e6\u4e00\u7a2e\u8f49\u9304\u6291\u5236\u5291\uff0c\u53ef\u4ee5\u5c07\u8f49\u8b6f\u4f5c\u7528\u6291\u5236\u5728\u525b\u8d77\u59cb\u53ca\u5df2\u7d93\u9032\u5165\u8f49\u8b6f\u5ef6\u9577\u968e\u6bb5\u7684\u6838\u91a3\u9ad4\uff0c\u53ef\u4ee5\u5e6b\u52a9\u6211\u5011\u5b9a\u7fa9\u51fa\u6574\u9ad4\u7684\u8f49\u8b6f\u5340\u9593\uff08\u5716\u4e00C\uff09\u3002\u7d93\u7531 LTM \u8207 CHX \u5169\u8005\u8a0a\u865f\u6bd4\u8f03\uff0c\u53ef\u4ee5\u8b93\u6211\u5011\u66f4\u6e96\u78ba\u7684\u5b9a\u7fa9\u8a0a\u606f RNA \u4e0a\u7684\u8f49\u8b6f\u8d77\u59cb\u9ede\u8207\u8f49\u8b6f\u5340\u9593\u3002<\/p>\n \u900f\u904e\u6838\u91a3\u9ad4\u5b9a\u5e8f\u5206\u6790\u6280\u8853\uff0c\u79d1\u5b78\u5bb6\u5011\u767c\u73fe\uff0c\u5728\u54fa\u4e73\u985e\u52d5\u7269\u7d30\u80de\u4e2d\uff0c\u6709\u8a31\u591a\u8f49\u8b6f\u8d77\u59cb\u9ede\u4e26\u4e0d\u4f4d\u65bc\u5178\u578b\u5b9a\u7fa9\u7684\u8d77\u59cb\u4f4d\u7f6e\uff0c\u800c\u4e14\uff0c\u9664\u4e86\u8d77\u59cb\u65bc AUG \u5bc6\u78bc\u5b50\u4e4b\u5916\uff0c\u4e5f\u6703\u8d77\u59cb\u65bc\u8ddf AUG \u76f8\u5dee\u4e00\u500b\u6838\u9178\u7684\u5bc6\u78bc\u5b50\uff0c\u50cf\u662f CUG\u3001ACG \u7b49\u7b49\u3002\u6b64\u5916\uff0c\u8f49\u8b6f\u8d77\u59cb\u9ede\u7684\u4f4d\u7f6e\uff0c\u4e0d\u53ea\u6703\u4f4d\u65bc\u50b3\u7d71\u8a8d\u77e5\u7684\u7de8\u78bc\u5340\uff0c\u9084\u6703\u4f4d\u65bc 5 \u7aef\u8207 3 \u7aef\u975e\u7de8\u78bc\u5340\u3002<\/p>\n \u6700\u91cd\u8981\u7684\u662f\uff0c\u9019\u4e9b\u975e\u5178\u578b\u8d77\u59cb\u4f4d\u7f6e\u6240\u8f49\u8b6f\u7684\u86cb\u767d\u8cea\uff0c\u5728\u751f\u7269\u9ad4\u4e2d\u78ba\u5be6\u6703\u8868\u73fe\u51fa\u4f86\uff0c\u4e26\u4e14\u5177\u6709\u751f\u7406\u529f\u80fd\u3002\u4f8b\u5982\uff1a\u4fc3\u9032\u764c\u75c7\u7d30\u80de\u751f\u9577\u7684\u300cFGF2<\/em>\uff08fibroblast growth factor2<\/em>\uff09\u57fa\u56e0\u300d\u8207\u6291\u5236\u764c\u75c7\u7d30\u80de\u751f\u9577\u7684\u300cc-myc<\/em> \u57fa\u56e0\u300d\uff0c\u7686\u5177\u6709\u4e00\u500b\u4f4d\u5728 5 \u7aef\u975e\u7de8\u78bc\u5340\u7684 CUG \u975e\u5178\u578b\u8f49\u8b6f\u8d77\u59cb\u9ede\uff0c\u4e26\u4e14\u6703\u8f49\u8b6f\u51fa\u8207\u5178\u578b\u86cb\u767d\u8cea\u529f\u80fd\u76f8\u7570\u7684\u86cb\u767d\u8cea\u7570\u69cb\u9ad4\u3002<\/p>\n \u6709\u8da3\u7684\u662f\uff0c\u5916\u5728\u74b0\u5883\u7684\u523a\u6fc0\u6703\u6539\u8b8a\u8f49\u8b6f\u8d77\u59cb\u4f4d\u7f6e\uff0c\u9032\u800c\u8f49\u8b6f\u51fa\u529f\u80fd\u76f8\u7570\u7684\u86cb\u767d\u8cea\u3002\u4ee5\u300cMRPL18<\/em> \u57fa\u56e0\u300d\u70ba\u4f8b\uff0c\u7576\u7d30\u80de\u8655\u5728\u6b63\u5e38\u74b0\u5883\u6642\uff0cMRPL18<\/em> \u6703\u4f7f\u7528\u5178\u578b AUG \u8d77\u59cb\u9ede\u8f49\u8b6f\u86cb\u767d\u8cea\uff0c\u4e26\u4e14\u86cb\u767d\u8cea\u6703\u88ab\u50b3\u9001\u5230\u7c92\u817a\u9ad4\u5167\u7d44\u6210\u6838\u91a3\u9ad4\uff0c\u9032\u800c\u5e6b\u52a9\u86cb\u767d\u8cea\u7684\u5408\u6210\u3002\u4f46\u662f\uff0c\u82e5\u7d30\u80de\u8655\u5728\u9ad8\u6eab\u9006\u5883\u4e2d\uff0cMRPL18<\/em> \u57fa\u56e0\u5247\u6703\u4f7f\u7528\u4e0b\u6e38\u975e\u5178\u578b\u8f49\u8b6f\u8d77\u59cb\u9ede CUG \u8f49\u8b6f\u86cb\u767d\u8cea\uff0c\u4e26\u5c07\u6b64\u975e\u5178\u578b\u8f49\u8b6f\u86cb\u767d\u8cea\u9001\u81f3\u7d30\u80de\u8cea\u7d44\u6210\u7279\u6b8a\u5f62\u614b\u7684\u6838\u91a3\u9ad4\uff0c\u7528\u4f86\u5e6b\u52a9\u8f49\u8b6f HSP70 \u71b1\u4f11\u514b\u86cb\u767d\uff0c\u9032\u800c\u5e6b\u52a9\u7d30\u80de\u7dad\u6301\u9ad4\u5167\u74b0\u5883\u7684\u7a69\u5b9a\u4e26\u62b5\u6297\u9ad8\u6eab\u9006\u5883\u3002<\/p>\n \u7d9c\u5408\u4ee5\u4e0a\u7684\u7d50\u679c\uff0c\u6709\u4e86\u6838\u91a3\u9ad4\u5b9a\u5e8f\u5206\u6790\u6280\u8853\u9019\u5f35\u85cf\u5bf6\u5716\uff0c\u6211\u5011\u767c\u73fe\u4e86\u4e00\u7247\u6709\u5225\u4ee5\u5f80\u8a8d\u77e5\u7684\u65b0\u5927\u9678\uff0c\u5c0d\u65bc\u751f\u7269\u9ad4\u7684\u751f\u7406\u6a5f\u5236\u8207\u57fa\u56e0\u8f49\u8b6f\u7684\u8abf\u63a7\uff0c\u6709\u4e86\u66f4\u9032\u4e00\u6b65\u7684\u8a8d\u8b58\u3002<\/p>\n