{"id":27586,"date":"2022-06-16T00:08:38","date_gmt":"2022-06-15T16:08:38","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=27586"},"modified":"2022-10-19T14:16:38","modified_gmt":"2022-10-19T06:16:38","slug":"%e3%80%90%e5%b0%88%e6%ac%84%e3%80%91%e7%a5%9e%e7%b6%93%e5%85%83%e7%94%9f%e9%95%b7%e9%8c%90%e7%9a%84%e5%a4%9a%e9%87%8d%e5%ae%87%e5%ae%99","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/27586\/","title":{"rendered":"\u3010\u5c08\u6b04\u3011\u795e\u7d93\u5143\u751f\u9577\u9310\u7684\u591a\u91cd\u5b87\u5b99"},"content":{"rendered":"

\u300c\u6211\u6709\u5e78\u7b2c\u4e00\u6b21\u770b\u5230\u751f\u9577\u4e2d\u7684\u795e\u7d93\u5143\u8ef8\u7a81\u6709\u500b\u5947\u5999\u7684\u672b\u68a2\u7d50\u69cb\u3002\u5728\u6211\u81ea\u5df1\u88fd\u5099\u7684\u96de\u80da\u80ce\u810a\u9ad3\u5207\u7247\u4e2d\uff0c\u9019\u500b\u672b\u68a2\u770b\u8d77\u4f86\u5c31\u50cf\u500b\u5145\u6eff\u539f\u751f\u8cea\u7684\u9310\u9ad4\uff0c\u9032\u884c\u8457\u8b8a\u5f62\u87f2\u5f0f\u7684\u79fb\u52d5\u3002\u53ef\u5c07\u5b83\u6bd4\u64ec\u4f5c\u4e00\u500b\u6d3b\u7684\u653b\u57ce\u9318\uff0c\u67d4\u8edf\u800c\u9748\u6d3b\uff0c\u5b83\u524d\u9032\uff0c\u4fbf\u53ef\u6a5f\u68b0\u6027\u5730\u63a8\u958b\u64cb\u5728\u5b83\u7684\u8def\u5f91\u4e0a\u7684\u963b\u7919\uff0c\u76f4\u5230\u62b5\u9054\u5728\u5b83\u5916\u570d\u7684\u7d42\u9ede\u3002\u9019\u500b\u5947\u7279\u7684\u7aef\u9ede\u9310\u7bc0\uff0c\u6211\u8981\u5c07\u5b83\u547d\u540d\u70ba\u300e\u751f\u9577\u9310\u300f\u3002\u300d–Santiago Ramon y Cajal, Recollections of My Life, 1989.<\/p>\n

\"\u3010\u5c08\u6b04\u3011\u795e\u7d93\u5143\u751f\u9577\u9310\u7684\u591a\u91cd\u5b87\u5b99\"

\u25b2\u5229\u7528AI\u5e73\u53f0Midjournal\u7e6a\u88fd\u7684\u795e\u7d93\u5143<\/p><\/div>\n

\u795e\u7d93\u79d1\u5b78\u4e4b\u7236 Ramon y Cajal\u5229\u7528\u4e00\u822c\u5149\u5b78\u986f\u5fae\u93e1\uff0c\u5c07\u56fa\u5b9a\u5f8c\u7684\u795e\u7d93\u7d44\u7e54\u6a23\u672c\u5229\u7528\u9ad8\u723e\u57fa\u67d3\u8272\u6cd5\u67d3\u8272\uff0c\u8ddd\u4eca\u767e\u5e74\u524d\uff0c\u9996\u6b21\u63cf\u8ff0\u5230\u8ef8\u7a81\u8207\u6a39\u7a81\u5c16\u7aef\u7684\u7279\u6b8a\u7d50\u69cb\u4e26\u5c07\u5176\u7a31\u70ba\u300c\u751f\u9577\u9310\u300d(Ramon y Cajal, 1890, 1911, 1929)\u3002Cajal\u7684\u85dd\u8853\u5929\u8ce6\uff0c\u5c07\u986f\u5fae\u93e1\u4e0b\u6240\u770b\u5230\u7684\u795e\u7d93\u7cfb\u7d71\u8f49\u5316\u70ba\u975e\u5e38\u7cbe\u78ba\u7684\u5716\u756b\uff0c\u6e05\u695a\u5730\u756b\u51fa\u8166\u7d44\u7e54\u5167\u5c64\u5c64\u758a\u758a\u795e\u7d93\u9023\u7d50\u7684\u67b6\u69cb\u3002\u4e14\u4ed6\u50c5\u5f9e\u975c\u614b\u5716\u50cf\u5c31\u80fd\u63a8\u6572\u51fa\u6b21\u7d30\u80de\u7d50\u69cb\u4e00\u7cfb\u5217\u7684\u52d5\u614b\u529f\u80fd\uff0c\u662f\u5148\u77e5\u822c\u7684\u5b58\u5728\u3002\u96a8\u5f8cRoss Granville Harrison\u767c\u660e\u4e86\u80fd\u5c07\u7d44\u7e54\u7d30\u80de\u5206\u96e2\u4e26\u5728\u6d3b\u9ad4\u5916\u57f9\u990a\u7684\u6280\u8853\uff0c\u6210\u70ba\u9996\u4f4d\u89c0\u6e2c\u6d3b\u7684\u751f\u9577\u9310\u884c\u70ba\u7684\u79d1\u5b78\u5bb6\u3002Harrison\u89c0\u5bdf\u5230\u751f\u9577\u9310\u5728\u7d44\u7e54\u57f9\u990a\u76bf\u4e2d\u6301\u7e8c\u79fb\u52d5\uff0c\u4e0d\u65b7\u5c40\u90e8\u5ef6\u4f38\u8207\u6536\u7e2e\uff0c\u6b63\u5982\u540cCajal\u63a8\u6e2c\u7684\u90a3\u6a23\uff0c\u9019\u500b\u5947\u5999\u7684\u9310\u5f62\u7aef\u9ede\u7684\u78ba\u662f\u5c6c\u65bc\u6b63\u5728\u5f80\u524d\u751f\u9577\u4e2d\u7684\u8ef8\u7a81\u7684\u4e00\u90e8\u5206\u3002\u9664\u4e86\u5c0d\u751f\u9577\u9310\u7684\u63cf\u8ff0\u4e4b\u5916\uff0cCajal\u9996\u5148\u8a8d\u5b9a\u795e\u7d93\u5143\u5c31\u662f\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u7684\u6700\u57fa\u672c\u5143\u4ef6\uff0c\u9084\u767c\u73fe\u4e86\u7a81\u89f8\uff08synapse\uff09\uff0c\u4e5f\u65b7\u8a00\u795e\u7d93\u5143\u7684\u578b\u614b\u8207\u529f\u80fd\u5177\u6709\u6975\u6027\uff1a\u795e\u7d93\u7cfb\u7d71\u7684\u8a0a\u606f\u50b3\u905e\u61c9\u8a72\u662f\u7531\u7d30\u80de\u672c\u9ad4\u6216\u6a39\u7a81\u63a5\u6536\uff0c\u7531\u9577\u8ef8\u7a81\u6295\u905e\u51fa\u53bb\u3002\u800c\u9019\u4e9b\u9810\u8a00\u6210\u70ba\u795e\u7d93\u7d30\u80de\u5b78\u5bb6\u7684\u7814\u7a76\u7d20\u6750\uff0c\u524d\u4ec6\u5f8c\u7e7c\u4ee5\u66f4\u9ad8\u968e\u7684\u5100\u5668\u6216\u66f4\u7cbe\u78ba\u7684\u5be6\u9a57\u65b9\u6cd5\uff0c\u60f3\u61c9\u8b49Cajal\u7684\u7406\u8ad6\u3002\u73fe\u4eca\u7684\u795e\u7d93\u7d30\u80de\u5b78\u5bb6\u7684\u78ba\u64c1\u6709Cajal\u6642\u4ee3\u805e\u6240\u672a\u805e\u7684\u57fa\u56e0\u5716\u8b5c\uff0c\u5206\u5b50\u514b\u9686\uff0c\u751f\u7269\u5316\u5b78\u53cd\u61c9\uff0c\u548c\u8d85\u9ad8\u89e3\u6790\u5ea6\u87a2\u5149\u5f71\u50cf\u7b49\u7814\u7a76\u6280\u8853\u8207\u77e5\u8b58\uff0c\u4f46\u6211\u5011\u76ee\u524d\u4ecd\u7136\u9084\u8ffd\u8d95\u8457Cajal\u5c0d\u300c\u653b\u57ce\u9310\u300d\uff08battering ram\uff09\u7684\u60f3\u50cf\u3002\u5118\u7ba1\u79d1\u5b78\u5bb6\u5011\u66f4\u559c\u6b61\u5728\u81ea\u7136\u754c\u4e2d\u5c0b\u627e\u7c21\u55ae\u4e14\u53cd\u8986\u51fa\u73fe\u7684\u4e3b\u984c\uff0c\u4f46\u751f\u9577\u9310\u975e\u5e38\u8907\u96dc\uff0c\u6240\u6709\u7684\u751f\u9577\u9310\u90fd\u4e0d\u76e1\u76f8\u540c\uff0c\u4e26\u4e14\u5728\u795e\u7d93\u767c\u80b2\u904e\u7a0b\u4e2d\u6709\u591a\u7a2e\u9014\u5f91\u53ef\u4ee5\u76f8\u4e92\u5354\u8abf\u751f\u9577\u9310\u7684\u884c\u70ba\u3002\u5c31\u5982\u540c\u5929\u4e0a\u7e41\u661f\u904b\u884c\u7684\u898f\u5247\uff0cCajal\u70ba\u6211\u5011\u63cf\u7e6a\u4e86\u4e0d\u540c\u661f\u7cfb\u7684\u6a23\u8c8c\uff0c\u751a\u81f3\u9810\u6e2c\u51fa\u661f\u9ad4\u79fb\u52d5\u7684\u8ecc\u8de1\uff0c\u53ea\u662f\u4e00\u767e\u5e74\u5f8c\uff0c\u79d1\u5b78\u5bb6\u5011\u662f\u5426\u63a8\u5c0e\u51fa\u5c6c\u65bc\u795e\u7d93\u79d1\u5b78\u7684\u91cd\u529b\u5834\u516c\u5f0f\u4e86\u5462\uff1f\u7c21\u77ed\u7684\u7b54\u6848\u662f\uff0c\u9084\u6c92\u3002\u4f46\u6211\u5011\u4ea6\u975e\u5168\u7121\u9032\u6b65\uff0c\u53ea\u662f\u5076\u800c\u8ff7\u5931\u5728\u795e\u7d93\u7d30\u80de\u751f\u9577\u7684\u591a\u91cd\u5b87\u5b99\u3002\u56e0\u6b64\u5728\u9019\u6b21\u7684\u5c08\u6587\u88e1\uff0c\u8b93\u6211\u5011\u8a66\u8457\u89e3\u91cbCajal\u9019\u6700\u521d\u7684\u89c0\u5bdf\uff1a\u67d4\u8edf\u800c\u9748\u6d3b\u7684\u751f\u9577\u9310\uff0c\u4f55\u4ee5\u653b\u57ce\uff1f<\/p>\n

\u5728\u6d3b\u9ad4\u5916\u5747\u8cea\u7684\u74b0\u5883\u4e0b\uff0c\u8d77\u521d\u7d30\u80de\u770b\u4f3c\u7121\u76ee\u7684\u7684\u6f2b\u6b65\uff0c\u7d66\u5b83\u4e00\u4e9b\u8a98\u56e0\uff0c\u5b83\u5c31\u6703\u986f\u73fe\u51fa\u4e00\u4e9b\u672c\u6027\u3002R.G.Harrison\u7cfb\u7d71\u6027\u7684\u5229\u7528\u5169\u68f2\u985e\uff08\u5982\u9752\u86d9\uff09\u7684\u795e\u7d93\u6bcd\u7d30\u80de\u4f86\u7814\u7a76\u7d30\u80de\u5728\u4e0d\u540c\u4ecb\u8cea\u4e0a\u7684\u884c\u70ba\uff0c\u5f88\u5feb\u5730\u4ed6\u4fbf\u767c\u73fe\uff0c\u7d30\u80de\u7e3d\u662f\u7dca\u8cbc\u8457\u56fa\u614b\u7684\u8868\u9762\u6500\u722c\u3002Harrison\u7a31\u9019\u6a23\u7684\u884c\u70ba\u70ba\u300ccontact guidance\u300d\u3002\u6bd4\u5982\u8aaa\u5728\u6df7\u8457\u8718\u86db\u7d72\u7684\u61f8\u6d6e\u57f9\u990a\u6ef4\u88e1\uff0c\u795e\u7d93\u6bcd\u7d30\u80de\u53ea\u9078\u64c7\u9ecf\u9644\u5728\u8718\u86db\u7d72\u4e0a\uff0c\u4e26\u6cbf\u8457\u7d30\u7d72\u5ef6\u5c55\u3002\u96a8\u5f8c Paul Alfred Weiss\u4e5f\u6ce8\u610f\u5230\u7d30\u80de\u7e3d\u662f\u6cbf\u8457\u73bb\u7483\u8868\u9762\u7684\u523b\u75d5\u751f\u9577\u3002\u4f46\u7d30\u80de\u4e26\u975e\u6beb\u7121\u9078\u64c7\u5730\u9ecf\u8457\u5728\u74b0\u5883\u5468\u906d\u7684\u4efb\u4f55\u56fa\u614b\u8868\u9762\uff0c\u771f\u6b63\u8d77\u95dc\u9375\u4f5c\u7528\u7684\u662f\u7d30\u80de\u819c\u4e0a\u7684\u53d7\u9ad4\u662f\u5426\u8207\u56fa\u614b\u8868\u9762\u7522\u751f\u4ea4\u4e92\u4f5c\u7528\u800c\u6d3b\u5316\u3002\u6d3b\u5316\u5f8c\u7684\u53d7\u9ad4\u5f15\u767c\u7d30\u80de\u819c\u4e0b\u7684\u9ecf\u9644\u86cb\u767d\u9ad4\u805a\u96c6\uff0c\u555f\u52d5\u9023\u4e32\u7684\u751f\u5316\u53cd\u61c9\uff0c\u4fc3\u4f7f\u7d30\u80de\u9aa8\u67b6\u7522\u751f\u8b8a\u5316\uff0c\u4e5f\u6539\u8b8a\u4e86\u7d30\u80de\u819c\u7684\u5f35\u529b\u3002\u63a5\u8457\u5df2\u6d3b\u5316\u7684\u53d7\u9ad4\u4fbf\u96a8\u8457\u7d30\u80de\u819c\u5167\u541e\u53cd\u61c9\u9032\u7d30\u80de\u5167\u800c\u5931\u6548\uff0c\u89e3\u9664\u5c40\u90e8\u7684\u53cd\u61c9\u3002\u5728\u7d30\u80de\u63a2\u7d22\u8868\u9762\u74b0\u5883\u6642\uff0c\u7d30\u80de\u819c\u4e0a\u6bcf\u500b\u53d7\u9ad4\u7686\u9032\u884c\u8457\u9019\u6a23\u7684\u5faa\u74b0\uff0c\u52d5\u614b\u7684\u7dad\u6301\u8457\u7d30\u80de\u5c0d\u5468\u570d\u74b0\u5883\u7684\u654f\u611f\u6027\uff0c\u6642\u6642\u5075\u6e2c\u8457\u5728\u884c\u9032\u8def\u5f91\u4e0a\u7684\u5404\u7a2e\u8b8a\u5316\uff0c\u800c\u975e\u6b7b\u9ecf\u65bc\u4ecb\u8cea\u8868\u9762\u3002<\/p>\n

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\n\u70ba\u751f\u9577\u9310\u8a8d\u8b58\u7684\u4ea4\u901a\u865f\u8a8c\u6216\u8def\u6a19\u3002\u4f46\u4e5f\u56e0\u70ba\u57f9\u990a\u5728\u6d3b\u9ad4\u5916\u786c\u4ecb\u8cea\u7684\u751f\u9577\u9310\u8207\u8edf\u7d44\u7e54\u88e1\u7684\u751f\u9577\u9310\uff0c\u4e0d\u5fc5\u7136\u5229\u7528\u76f8\u540c\u7684\u4f5c\u7528\u6a5f\u5236\u4f86\u4e3b\u5c0e\u8ef8\u7a81\u751f\u9577\uff0c\u9019\u4f7f\u5f97\u6211\u5011\u5728\u89e3\u8b80\u76f8\u95dc\u7814\u7a76\u7d50\u679c\u9700\u8981\u66f4\u52a0\u5c0f\u5fc3\u3002<\/p>\n

\u751f\u9577\u9310\u9577\u5728\u6d3b\u9ad4\u5916\u57f9\u990a\u76e4\u4e0a\u7684\u5f62\u72c0\u5c31\u50cf\u96bb\u6b63\u5728\u5f48\u92fc\u7434\u7684\u624b\uff0c\u5f35\u958b\u7684\u624b\u638c\uff0c\u7528\u6307\u5c16\u4ee5\u5fae\u5c0f\u7684\u529b\u91cf\u4f46\u6975\u5feb\u7684\u901f\u5ea6\u4ea4\u66ff\u5f48\u594f\u3002\u795e\u7d93\u8ef8\u7a81\u5411\u524d\u79fb\u52d5\u3001\u7e2e\u56de\uff0c\u6539\u8b8a\u65b9\u5411\u8207\u518d\u751f\u7686\u9700\u8981\u85c9\u7531\u6539\u8b8a\u7d30\u80de\u9aa8\u67b6\u7684\u52d5\u614b\u4f86\u57f7\u884c\uff0c\u795e\u7d93\u7d30\u80de\u5b78\u5bb6\u5c0d\u5f15\u767c\u6b64\u985e\u4e8b\u4ef6\u7684\u74b0\u5883\u56e0\u7d20\u4ee5\u53ca\u5982\u4f55\u5c07\u9019\u4e9b\u9023\u4e32\u7684\u751f\u5316\u53cd\u61c9\u8f49\u5316\u70ba\u300c\u6a5f\u68b0\u529b\u300d\u65bd\u52a0\u5728\u5176\u751f\u9577\u74b0\u5883\u4e0a\u4e5f\u975e\u5e38\u611f\u8208\u8da3\u3002\u79d1\u5b78\u5bb6\u5011\u666e\u904d\u8a8d\u70ba\uff0c\u7121\u8ad6\u4f55\u7a2e\u7d30\u80de\u8a0a\u606f\u50b3\u905e\uff0c\u6700\u7d42\u5fc5\u9808\u81f3\u5c11\u5c0d\u751f\u9577\u9310\u5167\u7684\u808c\u52d5\u86cb\u767d(actin)\u6216\u5fae\u7ba1(microtubule)\u7d30\u80de\u9aa8\u67b6\u9663\u5217\u7522\u751f\u90e8\u5206\u6539\u8b8a\u3002\u808c\u52d5\u86cb\u767d\u7d72\u548c\u5fae\u7ba1\u88ab\u914d\u7f6e\u6210\u5bc6\u96c6\u4e14\u9ad8\u5ea6\u6709\u5e8f\u7684\u9663\u5217\uff0c\u808c\u52d5\u86cb\u767d\u7d72\u9ad8\u5ea6\u96c6\u4e2d\u5728\u751f\u9577\u9310\u7684\u524d\u7de3\uff0c\u662f\u7d72\u72c0\u507d\u8db3 (filopodia)\u8207\u7247\u72c0\u507d\u8db3(lamellipodia)\u7684\u6838\u5fc3\u7d50\u69cb\u3002\u4e0d\u7ba1\u662f\u808c\u7403\u86cb\u767d(myosin)\u7684\u6536\u7e2e\u6027\u6216\u662f\u808c\u52d5\u86cb\u767d\u7d72\uff08F-actin)\u7684\u7d44\u88dd\u548c\u62c6\u5378\u52d5\u614b\u90fd\u53ef\u53c3\u8207\u6539\u8b8a\u751f\u9577\u9310\u5f62\u614b\u548c\u884c\u70ba\u3002\u5fae\u7ba1\u4e5f\u96a8\u6642\u8655\u65bc\u540c\u6b65\u9032\u884c\u7d44\u88dd\u548c\u62c6\u5378\u7684\u52d5\u614b\u5e73\u8861\u72c0\u614b\uff0c\u6cbf\u8457\u9577\u8ef8\u7a81\u5f62\u6210\u7dfb\u5bc6\u7684\u5fae\u7ba1\u675f\uff0c\u5ef6\u4f38\u5230\u751f\u9577\u9310\u4e2d\u4ee5\u300c\u9047\u5230\u300d\u7dfb\u5bc6\u7684\u808c\u52d5\u86cb\u767d\u7d30\u80de\u9aa8\u67b6\u3002\u4e8b\u5be6\u4e0a\uff0c\u7814\u7a76\u9019\u4e09\u7a2e\u7d30\u80de\u9aa8\u67b6\u7cfb\u7d71\u5982\u4f55\u76f8\u4e92\u7d50\u5408\u53ef\u80fd\u662f\u7406\u89e3\u751f\u9577\u9310\u5982\u4f55\u79fb\u52d5\u524d\u5f80\u9060\u65b9\u7684\u95dc\u9375\u3002<\/p>\n

\u82e5\u4ee5\u7d30\u80de\u9aa8\u67b6\u86cb\u767d\u7684\u7a2e\u985e\u8207\u67b6\u69cb\u4f86\u5b9a\u7fa9\uff0c\u751f\u9577\u9310\u53ef\u5206\u70ba\u4e09\u500b\u4e9e\u5340\uff1a1\uff09\u4e2d\u592e\u57df\uff08C-domain\uff09\uff0c\u4f4d\u65bc\u6216\u9760\u8fd1\u8ef8\u7a81\u8ef8\u7684\u672b\u7aef\uff0c\u4e3b\u8981\u7531\u5fae\u7ba1\u675f\u7d44\u6210\uff1b2\uff09\u5916\u570d\u57df\uff08P-domain\uff09\uff0c\u5206\u4f48\u5728\u751f\u9577\u9310\u6700\u524d\u7de3\u7684\u5468\u570d\uff0c\u4e3b\u8981\u7531\u808c\u52d5\u86cb\u767d\u7d72\u7d44\u6210\uff1b3) \u904e\u6e21\u5340 (T-zone)\uff0c\u4ee3\u8868C\u548cP\u57df\u4e4b\u9593\u7684\u63a5\u53e3\uff0c\u805a\u96c6\u8457\u5fae\u7ba1-\u808c\u52d5\u86cb\u767d\u4ea4\u806f\u5206\u5b50\uff0c\u4f8b\u5982\u975e\u808c\u8089\u808c\u7403\u86cb\u767dII(non-muscle myosinII;NMII)\u548c\u767c\u80b2\u8abf\u7bc0\u5206\u5b50\u8166\u86cb\u767d(drebrin)\u3002\u9019\u6a23\u7279\u5225\u7684\u67b6\u69cb\u975e\u5e38\u985e\u4f3c\u65bc\u4eba\u985e\u7684\u624b\u90e8\u7d50\u69cb\uff1aC-domain\u662f\u524d\u81c2\u6a48\u9aa8\u672b\u68a2\uff0cT-zone\u662f\u8155\u9aa8\u8207\u624b\u8155\u95dc\u7bc0\uff0cP-domain\u5247\u662f\u624b\u6307\u3002\u73fe\u4eca\u666e\u904d\u501f\u7528\u7e96\u7dad\u6bcd\u7d30\u80de\u4e0a\u7d93\u5178\u7684\u808c\u52d5\u86cb\u767d\u7d72\u9006\u884c\u8dd1\u6b65\u6a5f\u6a21\u578b\uff08retrograde treadmill model)\u4f86\u8aaa\u660e\u5982\u4f55\u85c9\u7531\u808c\u52d5\u86cb\u767d-\u808c\u7403\u86cb\u767d\u7cfb\u7d71\uff0c\u4f7f\u8ef8\u7a81\u672b\u68a2\u7522\u751f\u5169\u7a2e\u985e\u578b\u7684\u6a5f\u68b0\u529b\uff1a1\uff09\u7531 T-zone\u4e2d\u7684\u808c\u52d5\u86cb\u767d\u5f27(actin arc) NMII\u9a45\u52d5\u7684\u6536\u7e2e\u529b\uff0c\u548c 2\uff09\u7531 P-domain \u4e2d\u7684 F-\u808c\u52d5\u86cb\u767d\u805a\u5408\u6240\u9a45\u52d5\u7684\u63a8\u529b\u3002\u6240\u8b02\u7684\u9006\u884c\u8dd1\u6b65\u6a5f\u6307\u7684\u662f\u539f\u672c\u8207NMII\u7d50\u5408\u6703\u8b93\u808c\u52d5\u86cb\u767d\u7d72\u5411\u5f8c\u9006\u884c\uff0c\u4f46\u7576\u7d30\u80de\u819c\u4e0a\u7684\u6574\u5408\u7d20-\u8cbc\u9644\u86cb\u767d\u9ad4\uff08Integrin-focal adhesion complex\uff09\u9257\u4f4f\u808c\u52d5\u86cb\u767d\u7d72\u6642\uff0c\u808c\u52d5\u86cb\u767d\u7d72\u589e\u52a0\u5411\u524d\u805a\u5408\u7684\u6548\u7387\uff0c\u4e26\u4e14\u539f\u672c\u808c\u7403\u86cb\u767d\u5411\u5f8c\u7684\u62c9\u52d5\u808c\u52d5\u86cb\u767d\u7d72\u7684\u62c9\u529b\uff0c\u53cd\u800c\u8f49\u63db\u6210\u5c07\u56fa\u5b9a\u808c\u52d5\u86cb\u767d\u7d72\u7684\u652f\u9ede\u5f80\u524d\u63a8\u7684\u63a8\u529b\uff08\u985e\u4f3c\u6211\u5011\u7528\u624b\u6307\u982d\u64a5\u52d5\u6ed1\u9f20\u6efe\u8f2a\u7684\u52d5\u4f5c\uff09\u3002<\/p>\n

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