{"id":27411,"date":"2022-06-02T00:16:15","date_gmt":"2022-06-01T16:16:15","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=27411"},"modified":"2022-06-02T00:59:09","modified_gmt":"2022-06-01T16:59:09","slug":"%e8%87%aa%e9%96%89%e7%97%87%e7%aa%81%e8%ae%8a%e5%bd%b1%e9%9f%bf%e7%aa%81%e8%a7%b8%e8%9b%8b%e7%99%bd%e5%88%86%e5%ad%90%e7%9a%84%e6%b6%b2%e7%9b%b8%e5%88%86%e9%9b%a2%ef%bc%88llps%ef%bc%89","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/27411\/","title":{"rendered":"\u81ea\u9589\u75c7\u7a81\u8b8a\u5f71\u97ff\u7a81\u89f8\u86cb\u767d\u5206\u5b50\u7684\u6db2\u76f8\u5206\u96e2\uff08LLPS\uff09"},"content":{"rendered":"<p>\u672c\u9662\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240\u859b\u4e00\u860b\u7279\u8058\u7814\u7a76\u54e1\u3001\u590f\u570b\u5f37\u526f\u7814\u7a76\u54e1\u3001\u738b\u5ef7\u65b9\u7814\u7a76\u54e1\u7684\u5be6\u9a57\u5ba4\u5408\u4f5c\uff0c\u9996\u6b21\u63ed\u793a\u4e86\u81ea\u9589\u75c7\u8b5c\u7cfb\u969c\u7919\uff08ASD\uff09\u76f8\u95dc\u7684\u7a81\u8b8a\u53ef\u4ee5\u6539\u8b8a\u7a81\u89f8\u86cb\u767d\u7684\u6db2\u76f8\u5206\u96e2\uff0c\u4e26\u4e14\u8a3c\u660e\u7a81\u89f8\u523a\u6fc0\u6240\u91cb\u653e\u7684\u92c5\uff0c\u53ef\u4ee5\u8abf\u7bc0ASD\u76f8\u95dc\u7a81\u89f8\u86cb\u767d\u7684\u6db2\u9ad4-\u51dd\u81a0\u76f8\u8b8a\u3002Cortactin\u7d50\u5408\u86cb\u767d2\uff08CTTNBP2\uff09\u662f\u4e00\u7a2eASD\u81f4\u75c5\u57fa\u56e0\uff0c\u5229\u7528\u5176C\u7aef\u7121\u5e8f\u5340\u57df\uff0cCTTNBP2\u53ef\u7d93\u6db2\u76f8\u5206\u96e2\u5728\u7a81\u89f8\u5f62\u6210\u51dd\u96c6\u7269\uff0c\u4e26\u53ef\u548c\u53e6\u4e00\u81ea\u9589\u75c7\u5206\u5b50SHANK3\u5728\u7a81\u89f8\u5171\u51dd\u96c6\u3002\u6b64\u5916\uff0c\u92c5\u7d50\u5408CTTNBP2\u7684N\u7aef\uff0c\u4fc3\u9032\u9ad8\u968e\u7d44\u88dd\uff0c\u5b83\u6703\u589e\u5f37 CTTNBP2\u51dd\u805a\u7269\u7684\u7a69\u5b9a\u6027\u548c\u51dd\u96c6\u5728\u7a81\u89f8\u3002\u81ea\u9589\u75c7\u76f8\u95dc\u7a81\u8b8a\u6703\u6539\u8b8aCTTNBP2\u7684\u51dd\u805a\u7269\u5f62\u6210\u548c\u7a81\u89f8\u51dd\u96c6\uff0c\u4e26\u640d\u5bb3\u5c0f\u9f20\u7684\u793e\u4ea4\u884c\u70ba\uff0c\u9019\u4e9b\u90fd\u53ef\u4ee5\u901a\u904e\u88dc\u92c5\u5f97\u5230\u6539\u5584\u3002\u9019\u9805\u7814\u7a76\u6210\u679c\u5df2\u65bc2022\u5e745\u670813 \u65e5\u767c\u8868\u5728\u300a\u81ea\u7136\u901a\u8a0a\u300b\uff08<em>Nature Communication<\/em>\uff09\u4e0a\u3002<\/p>\n<p>\u8ad6\u6587\u5168\u6587\uff1a<a href=\"https:\/www.nature.com\/articles\/s41467-022-30353-0\">https:\/www.nature.com\/articles\/s41467-022-30353-0<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-27412 aligncenter\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/webimage-10-1-1024x615.jpg\" alt=\"\" width=\"1024\" height=\"615\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/webimage-10-1-1024x615.jpg 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/webimage-10-1-300x180.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/webimage-10-1-768x462.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/webimage-10-1-1080x649.jpg 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/webimage-10-1-1280x768.jpg 1280w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/webimage-10-1-627x376.jpg 627w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/webimage-10-1-440x264.jpg 440w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/webimage-10-1.jpg 1396w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u672c\u9662\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240\u859b\u4e00\u860b\u7279\u8058\u7814\u7a76\u54e1\u3001\u590f\u570b\u5f37\u526f\u7814\u7a76\u54e1\u3001\u738b\u5ef7\u65b9\u7814\u7a76\u54e1\u7684\u5be6\u9a57\u5ba4\u5408\u4f5c\uff0c\u9996\u6b21\u63ed\u793a\u4e86\u81ea\u9589\u75c7\u8b5c\u7cfb\u969c\u7919\uff08ASD [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":27412,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[988,984],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/27411"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=27411"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/27411\/revisions"}],"predecessor-version":[{"id":27881,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/27411\/revisions\/27881"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/27412"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=27411"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=27411"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=27411"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}