{"id":27277,"date":"2022-05-05T00:19:31","date_gmt":"2022-05-04T16:19:31","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=27277"},"modified":"2022-05-05T10:32:27","modified_gmt":"2022-05-05T02:32:27","slug":"%e3%80%90%e5%b0%88%e6%ac%84%e3%80%91%e5%a4%a7%e8%85%a6%e4%b9%9f%e5%96%9d%e3%80%8c%e8%a0%bb%e7%89%9b%e3%80%8d%ef%bc%8c%e8%ae%93%e9%81%8b%e4%bd%9c%e4%b8%8d%e5%81%9c%e6%ad%87%ef%bc%81","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/27277\/","title":{"rendered":"\u3010\u5c08\u6b04\u3011\u5927\u8166\u4e5f\u559d\u300c\u883b\u725b\u300d\uff0c\u8b93\u904b\u4f5c\u4e0d\u505c\u6b47\uff01"},"content":{"rendered":"<p>\u4f60\u662f\u5426\u66fe\u7d93\u554f\u904e\u5927\u8166\u300c\u4f60\u7d2f\u4e86\u55ce?\u300d\u70ba\u4f55\u5927\u8166\u7e3d\u80fd\u4e0d\u505c\u7684\u767c\u51fa\u5feb\u901f\u537b\u7cbe\u6e96\u7684\u6307\u4ee4\u5462\uff1f\u5927\u5bb6\u90fd\u7565\u77e5\u4f60\u6211\u7684\u5927\u8166\u662f\u7531\u8a31\u591a\u4e0d\u540c\u7684\u795e\u7d93\u7d30\u80de\u6240\u7d44\u6210\uff0c\u4f46\u771f\u5be6\u6578\u91cf\u662f\u591a\u5c11\uff1f\u7b54\u6848\u662f\u4e0a\u5343\u5104\u500b\uff01\u5f88\u96e3\u4ee5\u60f3\u50cf\u5427\uff1f<\/p>\n<p>\u6bcf\u4e00\u500b\u795e\u7d93\u7d30\u80de\u90fd\u6709\u8457\u975e\u5e38\u8207\u773e\u4e0d\u540c\u7684\u5916\u8868\uff0c\u5b83\u9577\u5f97\u5c31\u50cf\u4e00\u68f5\u6a39\uff0c\u6703\u5229\u7528\u6a39\u679d\u7684\u672b\u7aef\u628a\u5404\u500b\u795e\u7d93\u7d30\u80de\u4e32\u806f\u6210\u773e\u591a\u5f7c\u6b64\u4e0d\u540c\u7684\u8166\u8ff4\u8def\uff0c\u900f\u904e\u9019\u4e9b\u8ff4\u8def\u4e4b\u9593\u7684\u4ea4\u4e92\u50b3\u9054\u8a0a\u606f\u6216\u662f\u50b3\u9001\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\uff0c\u652f\u914d\u6211\u5011\u65e5\u5e38\u4e2d\u5404\u7a2e\u884c\u70ba\u3002\u6240\u4ee5\u5982\u4f55\u80fd\u6301\u7e8c\u4e0d\u505c\u5730\u628a\u8a0a\u865f\u5f9e\u4e00\u500b\u795e\u7d93\u7d30\u80de\u50b3\u5230\u53e6\u4e00\u500b\u795e\u7d93\u7d30\u80de\uff0c\u662f\u5927\u8166\u904b\u4f5c\u7684\u91cd\u8981\u95dc\u9375\u3002<\/p>\n<p>\u73fe\u5728\u4f60\u4e00\u5b9a\u8feb\u4e0d\u53ca\u5f85\u60f3\u77e5\u9053\u9019\u4e9b\u6a39\u679d\u4e4b\u9593\u5230\u5e95\u96b1\u85cf\u8457\u4ec0\u9ebc\u6a23\u7684\u79d8\u5bc6\uff1f\u7814\u7a76\u9a5a\u5947\u7684\u767c\u73fe\uff0c\u9019\u795e\u79d8\u9762\u7d17\u80cc\u5f8c\u5c45\u7136\u662f\u7531\u4e00\u7fa4\u7336\u5982\u300c\u5c0f\u73bb\u7483\u5f48\u73e0\u300d\u7684\u7269\u8cea\u5305\u8457\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\uff0c\u5b83\u5011\u80fd\u628a\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u4e1f\u51fa\u795e\u7d93\u7d30\u80de\u5916\uff0c\u63a5\u8457\u5c31\u80fd\u628a\u8a0a\u606f\u50b3\u7d66\u53e6\u4e00\u500b\u795e\u7d93\u7d30\u80de\u3002\u66f4\u610f\u60f3\u4e0d\u5230\u7684\u662f\uff0c\u5927\u8166\u597d\u50cf\u559d\u4e86\u63d0\u795e\u98f2\u6599\u4e00\u6a23\uff0c\u80fd\u5920\u5c07\u7528\u904e\u7684\u5f48\u73e0\u4e00\u76f4\u56de\u6536\u518d\u91cd\u8907\u5229\u7528\uff0c\u5982\u6b64\u4e00\u4f86\u5927\u8166\u5728\u91cb\u653e\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u4e0a\u5c31\u4e0d\u865e\u5331\u4e4f\u4e86\u3002\u4eca\u5929\u5c31\u8b93\u6211\u5011\u6253\u958b\u9019\u7f50\u300c\u883b\u725b\u300d\uff0c\u770b\u770b\u5b83\u70ba\u4ec0\u9ebc\u90a3\u9ebc\u300c\u725b\u300d\uff01<\/p>\n<p><strong>\u300c\u5c0f\u73bb\u7483\u5f48\u73e0\u7684\u7269\u8cea\u300d\u5176\u5be6\u662f\u795e\u7d93\u7279\u5316\u51fa\u7684\u300c\u7a81\u89f8\u5c0f\u6ce1\u300d<\/strong><\/p>\n<p>\u5982\u679c\u6211\u5011\u5f80\u7d30\u90e8\u89c0\u5bdf\uff08\u5716\u4e00\uff09\uff0c\u5728\u5927\u8166\u4e2d\uff0c\u4e32\u806f\u5728\u4e00\u8d77\u7684\u795e\u7d93\u7d30\u80de\u5927\u90e8\u5206\u975e\u76f4\u63a5\u76f8\u9023\uff0c\u6a39\u679d\u72c0\u7684\u795e\u7d93\u7d50\u69cb\u901a\u7a31\u4e4b\u70ba\u300c\u8ef8\u7a81\u300d\u8207\u300c\u6a39\u7a81\u300d\uff0c\u800c\u8ef8\u7a81\u7684\u672b\u7aef\u80fd\u8207\u4f86\u81ea\u65bc\u53e6\u4e00\u500b\u795e\u7d93\u7d30\u80de\u7684\u6a39\u7a81\u4e00\u540c\u5f62\u6210\u5e7e\u500b\u5fae\u7c73\u5927\u5c0f\u7684\u7279\u5316\u7d50\u69cb\uff0c\u6211\u5011\u7a31\u4e4b\u70ba\u300c\u7a81\u89f8\uff08Synapse\uff09\u300d\u3002\u8ef8\u7a81\u8207\u6a39\u7a81\u672b\u7aef\u5206\u5225\u5f62\u6210\u300c\u524d\u7a81\u89f8\u5340\u300d\u8207\u300c\u5f8c\u7a81\u89f8\u5340\u300d\uff0c\u9019\u4e4b\u9593\u6709\u8457\u5927\u7d0420\u523050\u5948\u7c73\u6975\u77ed\u7684\u8ddd\u96e2\u3002<\/p>\n<p>\u524d\u7a81\u89f8\u5340\u5132\u5b58\u8457\u8a31\u591a\u76f4\u5f91\u4ecb\u65bc30\u523050\u5948\u7c73\u5927\u5c0f\u8102\u8cea\u69cb\u6210\u7684\u300c\u7a81\u89f8\u5c0f\u6ce1\u300d\uff08Synaptic vesicle\uff09\uff0c\u5b83\u5c31\u662f\u6211\u4e0a\u8ff0\u63d0\u5230\u300c\u5c0f\u73bb\u7483\u5f48\u73e0\u7684\u7269\u8cea\u300d\u7684\u771f\u5be6\u8eab\u5206\uff0c\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u6703\u88ab\u5305\u9032\u7a81\u89f8\u5c0f\u6ce1\u5167\u3002\u795e\u7d93\u7d30\u80de\u8207\u5176\u4ed6\u7d30\u80de\u4e00\u6a23\uff0c\u7d30\u80de\u8868\u9762\u662f\u7531\u8102\u8cea\u819c\u72c0\u7269\u8cea\u6240\u69cb\u6210\uff0c\u795e\u7d93\u523a\u6fc0\u6703\u4fc3\u9032\u7a81\u89f8\u5c0f\u6ce1\u8207\u795e\u7d93\u7d30\u80de\u8868\u9762\u8102\u8cea\u819c\u878d\u5408\uff0c\u9032\u800c\u91cb\u653e\u6240\u5305\u542b\u7684\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\uff0c\u96a8\u5f8c\u53e6\u4e00\u500b\u795e\u7d93\u7d30\u80de\u5c31\u6703\u63a5\u6536\u50b3\u4f86\u7684\u8a0a\u606f\u3002<\/p>\n<div id=\"attachment_21652\" style=\"width: 912px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21652\" class=\"alignnone size-full wp-image-27278\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/3-1.png\" alt=\"\" width=\"902\" height=\"602\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/3-1.png 902w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/3-1-300x200.png 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/3-1-768x513.png 768w\" sizes=\"(max-width: 902px) 100vw, 902px\" \/><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">\u25b2\u5716\u4e00\uff1a\u795e\u7d93\u7d30\u80de\u900f\u904e\u7a81\u89f8\u50b3\u9001\u8a0a\u606f\u201c\u7a81\u89f8\u5c0f\u6ce1\u201d\u8b93\u5927\u8166\u91cb\u653e\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u8b8a\u7684\u96a8\u5fc3\u6240\u6b32\u4e86<\/p><\/div>\n<p>\u4e00\u500b\u5f88\u76f4\u89ba\u7684\u554f\u984c\u662f\uff0c\u70ba\u4f55\u9700\u8981\u5927\u8cbb\u5468\u7ae0\u628a\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u5148\u5305\u9032\u7a81\u89f8\u5c0f\u6ce1\u5167\u518d\u505a\u91cb\u653e\u5462\uff1f\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u4ee5\u80fa\u57fa\u9178\u3001\u591a\u80bd\u8207\u560c\u5464\u6240\u7d44\u6210\uff0c\u7686\u5728\u795e\u7d93\u7d30\u80de\u8cea\u4e2d\u751f\u6210\uff0c\u5df2\u77e5\u5b83\u5011\u5206\u5b50\u7684\u7279\u6027\u5c0e\u81f4\u7121\u6cd5\u76f4\u63a5\u7a7f\u900f\u7d30\u80de\u8868\u9762\u8102\u8cea\u819c\u800c\u88ab\u91cb\u653e\u51fa\u7d30\u80de\u5916\uff0c\u9019\u4e5f\u9020\u5c31\u300c\u7a81\u89f8\u5c0f\u6ce1\u300d\u7279\u5316\u800c\u751f\u4e86\uff01<\/p>\n<p>\u7a81\u89f8\u5c0f\u6ce1\u88fd\u9020\u65bc\u795e\u7d93\u7d30\u80de\u672c\u9ad4\uff0c\u63a5\u8457\u4e00\u8def\u9806\u8457\u5982\u9ad8\u901f\u516c\u8def\u4e00\u822c\u7684\u8ef8\u7a81\uff0c\u88ab\u904b\u9001\u5230\u524d\u7a81\u89f8\u5340\u66ab\u5b58\uff0c\u5b83\u5011\u80fd\u900f\u904e\u4e00\u500b\u81ea\u6211\u9178\u5316\u7684\u904e\u7a0b\u4f86\u555f\u52d5\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u704c\u5165\uff0c\u7336\u5982\u586b\u6eff\u5f48\u85e5\u4e00\u822c\u7684\u7a81\u89f8\u5c0f\u6ce1\u63a5\u8457\u88ab\u4e00\u6b65\u4e00\u6b65\u5f15\u5c0e\u5230\u7279\u5b9a\u91cb\u653e\u7684\u5730\u9ede\uff0c\u7a31\u4e4b\u70ba\u300c\u6fc0\u6d3b\u5340\u300d\u3002\u90a3\u8ab0\u4f86\u7576\u5c08\u696d\u7684\u5c0e\u904a\u5462\uff1f\u81ea1986\u5e74\u4ee5\u4f86\uff0cThomas C. S\u00fcdhof\u535a\u58eb\u70ba\u4e3b\u7684\u79d1\u5b78\u5bb6\u4e00\u540c\u52aa\u529b\u7684\u7814\u7a76\u767c\u73fe\uff0c\u7a81\u89f8\u5c0f\u6ce1\u81ea\u5df1\u6703\u651c\u5e36\u4e00\u4e9b\u86cb\u767d\u8cea\uff0c\u4f8b\u5982Rab\u8207SNARE\u7b49\u86cb\u767d\u8cea\uff0c\u900f\u904eRab\u8207\u7d30\u80de\u5fae\u7ba1\u904b\u8f38\u7cfb\u7d71\u7684\u4ea4\u4e92\u4f5c\u7528\uff0c\u628a\u7a81\u89f8\u5c0f\u6ce1\u5e36\u5230\u6fc0\u6d3b\u5340\u9644\u8fd1\uff0c\u63a5\u8457\u5229\u7528\u4f4d\u65bc\u7a81\u89f8\u5c0f\u6ce1\u4e0a\u7684SNARE\u86cb\u767d\u8207\u5ea7\u843d\u5728\u6fc0\u6d3b\u5340\u4e0a\u7684SNARE\u86cb\u767d\u7d50\u5408\u5f62\u6210\u86cb\u767d\u8907\u5408\u9ad4\uff0c\u7a81\u89f8\u5c0f\u6ce1\u5c31\u80fd\u5728\u6fc0\u6d3b\u5340\u5f85\u547d\u8457\u3002<\/p>\n<p>\u5728\u6fc0\u6d3b\u5340\u4e0a\uff0c\u795e\u7d93\u523a\u6fc0\u5c0e\u81f4\u9223\u96e2\u5b50\u901a\u9053\u6253\u958b\uff0c\u9223\u96e2\u5b50\u5c31\u9806\u5229\u7684\u5f9e\u795e\u7d93\u7d30\u80de\u5916\u5feb\u901f\u6d41\u5165\u7d30\u80de\u5167\uff0c\u9019\u6642\u9ad8\u6fc3\u5ea6\u7684\u9223\u96e2\u5b50\u505a\u4e86\u4e00\u4ef6\u5f88\u91cd\u8981\u7684\u4e8b\uff0c\u5b83\u6703\u8207\u7a81\u89f8\u5c0f\u6ce1\u4e0a\u7684Synaptotagmin\u86cb\u767d\u7d50\u5408\u800c\u6539\u8b8a\u6b64\u86cb\u767d\u7684\u69cb\u5f62\uff0c\u5982\u8b8a\u5f62\u91d1\u525b\u822c\u7684Synaptotagmin\u86cb\u767d\u53ef\u5927\u5927\u589e\u5f37SNARE\u86cb\u767d\u8907\u5408\u9ad4\u5167\u7684\u7d50\u5408\u529b\u9053\uff0c\u9032\u800c\u9a45\u4f7f\u7a81\u89f8\u5c0f\u6ce1\u8207\u7d30\u80de\u8868\u9762\u8102\u8cea\u819c\u9032\u884c\u878d\u5408\uff0c\u6574\u500b\u904e\u7a0b\u4e5f\u7a31\u4e4b\u70ba\u300c\u7a81\u89f8\u5c0f\u6ce1\u80de\u5410\u4f5c\u7528\u300d\u3002<\/p>\n<p>\u56e0\u6b64\u900f\u904e\u7a81\u89f8\u5c0f\u6ce1\uff0c\u5c31\u53ef\u8b93\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u7684\u91cb\u653e\u7dca\u7dca\u88ab\u795e\u7d93\u523a\u6fc0\u63a7\u5236\u8457\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u7a81\u89f8\u5c0f\u6ce1\u5177\u6709\u975e\u5e38\u56fa\u5b9a\u7684\u5927\u5c0f\uff0c\u53ef\u8b93\u5305\u9032\u6bcf\u4e00\u9846\u7a81\u89f8\u5c0f\u6ce1\u7684\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u5728\u6578\u91cf\u4e0a\u4e5f\u5f88\u4e00\u81f4\uff0c\u6240\u4ee5\u96a8\u8457\u795e\u7d93\u523a\u6fc0\u7684\u5f37\u5ea6\u8d8a\u5f37\uff0c\u7b49\u6bd4\u91cf\u7684\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u5c31\u80fd\u88ab\u91cb\u653e\u51fa\u53bb\u4e86\u3002\u6709\u7a81\u89f8\u5c0f\u6ce1\u5728\uff0c\u5927\u8166\u5728\u91cb\u653e\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u4e0a\uff0c\u771f\u7684\u80fd\u96a8\u300c\u795e\u7d93\u523a\u6fc0\u300d\u6240\u6b32\u4e86\uff0c\u7c21\u76f4\u662f\u9020\u7269\u8005\u7684\u7cbe\u5fc3\u5091\u4f5c\uff01Thomas C. S\u00fcdhof\u535a\u58eb\u8207\u5176\u4ed6\u5169\u4f4d\u79d1\u5b78\u5bb6\u57282013\u5e74\u4e00\u540c\u7372\u9812\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u548c\u91ab\u5b78\u734e\uff0c\u6b64\u6b8a\u69ae\u7528\u65bc\u611f\u8b1d\u4ed6\u5011\u5728\u95e1\u660e\u7d30\u80de\u5167\u819c\u904b\u8f38\u7cfb\u7d71\u7684\u904b\u884c\u6a5f\u5236\u5728\u4eba\u985e\u751f\u7406\u7dad\u6301\u4e0a\u6709\u6975\u5927\u8ca2\u737b\u3002<\/p>\n<p><strong>\u300c\u7a81\u89f8\u5c0f\u6ce1\u80de\u541e\u4f5c\u7528\u300d\u53c8\u662f\u4ec0\u9ebc\uff1f\u70ba\u4f55\u5b83\u80fd\u8b93\u80de\u5410\u4f5c\u7528\u76e1\u60c5\u7684\u767c\u63ee\uff1f<\/strong><\/p>\n<p>\u7a81\u89f8\u5c0f\u6ce1\u5f9e\u795e\u7d93\u7d30\u80de\u672c\u9ad4\u88fd\u9020\u51fa\u5f8c\uff0c\u6703\u4ee5\u5927\u6982\u5e73\u5747\u6bcf\u79d23\u5fae\u7c73\u7684\u904b\u8f38\u901f\u5ea6\u88ab\u904b\u5230\u524d\u7a81\u89f8\u5340\uff0c\u5927\u8166\u795e\u7d93\u8ef8\u7a81\u7d04\u83ab\u5e7e\u6beb\u7c73\u9577\uff0c\u63a8\u7b97\u9700\u5341\u5e7e\u5206\u9418\u624d\u80fd\u5230\u9054\u76ee\u7684\u5730\uff0c\u90a3\u5982\u50cf\u4e00\u516c\u5c3a\u9577\u7684\u5750\u9aa8\u795e\u7d93\u8ef8\u7a81\uff0c\u5c31\u8981\u82b1\u4e0a4\u5929\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5927\u8166\u795e\u7d93\u5f80\u5f80\u6703\u63a5\u6536\u5230\u4ecb\u65bc\u6bcf\u79d2\u5e7e\u5341\u5230\u5e7e\u767e\u4e0b\u7684\u523a\u6fc0\uff0c\u9810\u4f30\u5728\u77ed\u77ed\u5e7e\u79d2\u9023\u7e8c\u7684\u523a\u6fc0\u5f8c\uff0c\u5b58\u653e\u5728\u524d\u7a81\u89f8\u5340\u7684\u7a81\u89f8\u5c0f\u6ce1\u5c07\u6703\u5168\u90e8\u9032\u884c\u80de\u5410\u4f5c\u7528\uff0c\u4f46\u4e8b\u5be6\u4e0a\uff0c\u5927\u8166\u7e3d\u80fd\u4e00\u76f4\u904b\u4f5c\u8457\uff0c\u9019\u4e5f\u4ee3\u8868\u7a81\u89f8\u5c0f\u6ce1\u4e0d\u6703\u88ab\u7528\u5b8c\uff0c\u9019\u80cc\u5f8c\u795e\u5947\u7684\u6a5f\u5236\u70ba\u4f55\u5462\uff1f<\/p>\n<p>\u57281970\u5e74\u4ee3\uff0c\u7814\u7a76\u5b78\u5bb6\u5229\u7528\u96fb\u5b50\u986f\u5fae\u93e1\u89c0\u5bdf\u4f4d\u65bc\u9752\u86d9\u795e\u7d93\u8207\u808c\u8089\u9023\u63a5\u89f8\u6240\u751f\u6210\u7684\u524d\u7a81\u89f8\u5340\uff0c\u9996\u6b21\u767c\u73fe\u878d\u5408\u5f8c\u7684\u7a81\u89f8\u5c0f\u6ce1\u770b\u4f3c\u80fd\u5728\u6fc0\u6d3b\u5340\u5468\u570d\u88ab\u56de\u6536\u518d\u5f62\u6210\uff0c\u4e4b\u5f8c\u9019\u904e\u7a0b\u88ab\u7a31\u70ba\u300c\u7a81\u89f8\u5c0f\u6ce1\u80de\u541e\u4f5c\u7528\u300d\uff0c\u5b83\u5c31\u662f\u80fd\u8b93\u7a81\u89f8\u5c0f\u6ce1\u4e00\u76f4\u88ab\u5faa\u74b0\u5229\u7528\u7684\u795e\u79d8\u529b\u91cf\uff01\u5f9e\u6b64\u4ee5\u5f8c\uff0c\u96a8\u8457\u5404\u5f0f\u986f\u5fae\u93e1\u6280\u8853\u7684\u5feb\u901f\u6f14\u9032\u8207\u5404\u7a2e\u6a21\u5f0f\u751f\u7269\u7cfb\u7d71\uff08\u5305\u542b\u679c\u8805\u3001\u7dda\u87f2\u3001\u8001\u9f20\u7b49\uff09\u63a5\u8457\u6295\u5165\u7814\u7a76\u884c\u5217\u3002\u76f4\u5230\u76ee\u524d\uff0c\u5df2\u767c\u73fe\u6709\u56db\u7a2e\u6a21\u5f0f\u7684\u7a81\u89f8\u5c0f\u6ce1\u80de\u541e\u4f5c\u7528\uff0c\u5b83\u5011\u662f\u4f9d\u64da\u4e0d\u540c\u7684\u767c\u751f\u5730\u9ede\u3001\u4e0d\u540c\u7684\u767c\u751f\u6642\u9593\u3001\u4e0d\u540c\u7684\u80fd\u5f15\u767c\u5b83\u767c\u751f\u7684\u795e\u7d93\u523a\u6fc0\u5f37\u5ea6\u6240\u5206\u985e\uff08\u5716\u4e8c\uff09\u3002<\/p>\n<p>\u7b2c\u4e00\u7a2e\u6a21\u5f0f\uff1a\u7a81\u89f8\u5c0f\u6ce1\u80de\u5410\u5f8c\uff0c\u5728\u9084\u6c92\u6709\u5b8c\u5168\u878d\u5408\u7684\u72c0\u6cc1\u4e0b\u5c31\u8207\u7d30\u80de\u8102\u8cea\u819c\u5206\u96e2\u88ab\u56de\u6536\uff0c\u56de\u6536\u904e\u7a0b\u7d04\u4e00\u79d2\u9418\u5167\u5b8c\u6210\uff0c\u9867\u540d\u601d\u7fa9\u88ab\u547d\u540d\u70ba\u300c\u873b\u8713\u9ede\u6c34\u5f0f\u7684\u80de\u541e\u4f5c\u7528\u300d\u3002<br \/>\n\u7b2c\u4e8c\u7a2e\u6a21\u5f0f\uff1a\u7a81\u89f8\u5c0f\u6ce1\u80de\u5410\u5f8c\uff0c\u6703\u5b8c\u5168\u8207\u7d30\u80de\u8102\u8cea\u819c\u878d\u5408\uff0c\u7a81\u89f8\u5c0f\u6ce1\u56de\u6536\u767c\u751f\u53ea\u5728\u6fc0\u6d3b\u5340\u5468\u908a\u5340\u57df\uff0c\u904e\u7a0b\u4e2d\u7db2\u683c\u86cb\u767d\u8907\u5408\u9ad4\u6703\u5354\u52a9\u55ae\u4e00\u7a81\u89f8\u5c0f\u6ce1\u751f\u6210\uff0c\u5df2\u77e5\u56de\u6536\u904e\u7a0b\u8017\u6642\u5341\u5e7e\u79d2\u5230\u534a\u5206\u9418\u5b8c\u6210\uff0c\u9019\u6a21\u5f0f\u7a31\u4e4b\u70ba\u300c\u7db2\u683c\u86cb\u767d\u4ecb\u5c0e\u7684\u80de\u541e\u4f5c\u7528\u300d\u3002<br \/>\n\u7b2c\u4e09\u7a2e\u6a21\u5f0f\uff1a\u662f\u8fd1\u5e74\u4f86\u5c07\u5feb\u901f\u51b7\u51cd\u986f\u5fae\u6280\u8853\u7d50\u5408\u5149\u907a\u50b3\u5b78\u6280\u8853\u4e0b\u610f\u5916\u767c\u73fe\u7684\u65b0\u6a21\u5f0f\uff0c\u5b83\u53ea\u9700\u5e7e\u5341\u500b\u6beb\u79d2\u5c31\u53ef\u5728\u6fc0\u6d3b\u5340\u908a\u7de3\u5f62\u6210\u4e00\u500b\u7d04\u4e00\u767e\u5fae\u7c73\u5927\u5c0f\u7684\u5927\u6ce1\uff0c\u63a5\u8457\u900f\u904e\u7db2\u683c\u86cb\u767d\u4ecb\u5c0e\u7684\u80de\u541e\u4f5c\u7528\u751f\u6210\u55ae\u4e00\u7a81\u89f8\u5c0f\u6ce1\uff0c\u56e0\u6b64\u88ab\u547d\u540d\u70ba\u300c\u6975\u901f\u80de\u541e\u4f5c\u7528\u300d\u3002<br \/>\n\u7b2c\u56db\u7a2e\u6a21\u5f0f\uff1a\u53ea\u6703\u53d7\u5f37\u795e\u7d93\u523a\u6fc0\u8a98\u767c\uff0c\u767c\u751f\u65bc\u6fc0\u6d3b\u5340\u5468\u908a\u5340\u57df\uff0c\u5728\u5e7e\u79d2\u5167\u4e00\u6b21\u7684\u56de\u6536\u591a\u6578\u500b\u7a81\u89f8\u5c0f\u6ce1\uff0c\u5f62\u6210\u4e00\u500b\u5e7e\u767e\u5fae\u7c73\u5927\u5c0f\u7684\u5927\u6ce1\uff0c\u63a5\u8457\u4e5f\u900f\u904e\u7db2\u683c\u86cb\u767d\u4ecb\u5c0e\u7684\u80de\u541e\u4f5c\u7528\u751f\u6210\u55ae\u4e00\u7a81\u89f8\u5c0f\u6ce1\u6d3b\u6027\uff0c\u88ab\u7a31\u70ba\u300c\u795e\u7d93\u6d3b\u6027\u4f9d\u8cf4\u7684\u5927\u91cf\u80de\u541e\u4f5c\u7528\u300d\u3002<\/p>\n<p>\u76ee\u524d\u63a8\u6e2c\u591a\u7a2e\u6a21\u5f0f\u5171\u5b58\u53ef\u8b93\u4e0d\u540c\u6027\u8cea\u7684\u5927\u8166\u795e\u7d93\u7d30\u80de\u7528\u4f86\u61c9\u4ed8\u5404\u81ea\u7684\u7279\u6b8a\u9700\u6c42\u3002<\/p>\n<div id=\"attachment_21652\" style=\"width: 1034px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21652\" class=\"alignnone size-large wp-image-27279\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/3-2-1024x683.png\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/3-2-1024x683.png 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/3-2-300x200.png 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/3-2-768x512.png 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/3-2-1080x720.png 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/3-2.png 1255w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">\u5716\u4e8c\uff1a\u7a81\u89f8\u5c0f\u6ce1\u80de\u5410\u6a21\u5f0f\u3002\u9644\u5716\u662f\u5f9e\u6587\u737b\uff08Wu <em>et al., eLife<\/em>, 2014\uff09\u6539\u7de8<\/p><\/div>\n<p><strong>\u7a81\u89f8\u5c0f\u6ce1\u80de\u541e\u4f5c\u7528\u9084\u6709\u5176\u4ed6\u91cd\u8981\u4efb\u52d9<\/strong><\/p>\n<p>\u7a81\u89f8\u5c0f\u6ce1\u8868\u9762\u4e0d\u50cf\u5149\u6e9c\u6e9c\u7684\u73bb\u7483\u5f48\u73e0\u8868\u9762\uff0c\u6bcf\u4e00\u500b\u7a81\u89f8\u5c0f\u6ce1\u4e0a\u5176\u5be6\u662f\u88ab\u5404\u5f0f\u5404\u6a23\u7684\u86cb\u767d\u6240\u5360\u6eff\uff0c\u5927\u90e8\u5206\u7684\u86cb\u767d\u662f\u7528\u4f86\u5354\u52a9\u7a81\u89f8\u5c0f\u6ce1\u4f86\u57f7\u884c\u5b83\u7684\u529f\u80fd\uff0c\u4f46\u554f\u984c\u662f\uff0c\u7a81\u89f8\u5c0f\u6ce1\u80de\u5410\u5f8c\u4e5f\u6703\u5c07\u9019\u4e9b\u86cb\u767d\u6492\u5728\u6fc0\u6d3b\u5340\u4e0a\uff0c\u5f71\u97ff\u6fc0\u6d3b\u5340\u7684\u529f\u80fd\u3002\u6700\u65b0\u7684\u7814\u7a76\u4e5f\u767c\u73fe\uff0c\u53c3\u8207\u5728\u7a81\u89f8\u5c0f\u6ce1\u80de\u541e\u4f5c\u7528\u7684\u86cb\u767d\u4e5f\u80fd\u984d\u5916\u5354\u52a9\u6e05\u9664\u63a8\u7a4d\u7684\u7a81\u89f8\u5c0f\u6ce1\u86cb\u767d\uff0c\u9032\u800c\u8b93\u65b0\u4e00\u6ce2\u7684\u7a81\u89f8\u5c0f\u6ce1\u80de\u541e\u4f5c\u7528\u80fd\u9806\u5229\u5b8c\u6210\u3002\u9019\u4e5f\u518d\u6b21\u986f\u793a\u7a81\u89f8\u5c0f\u6ce1\u80de\u541e\u4f5c\u7528\u5c0d\u5927\u8166\u800c\u8a00\u662f\u4e0d\u53ef\u6216\u7f3a\u7684\u3002<\/p>\n<p><strong>\u7a81\u89f8\u5c0f\u6ce1\u80de\u541e\u4f5c\u7528\u767c\u751f\u7e3d\u662f\u7dca\u7dca\u8ddf\u5728\u80de\u5410\u4f5c\u7528\u5f8c<\/strong><\/p>\n<p>\u5f9e\u524d\u9762\u7a81\u89f8\u5c0f\u6ce1\u80de\u541e\u4f5c\u7528\u767c\u751f\u6642\u9593\u7684\u4ecb\u7d39\u4e2d\uff0c\u4f60\u61c9\u8a72\u548c\u5927\u90e8\u5206\u7684\u79d1\u5b78\u5bb6\u90fd\u89c0\u5bdf\u5230\u4e00\u500b\u5f88\u6709\u8da3\u7684\u73fe\u8c61\u4e86\u5427\uff01\u5c31\u662f\u4e0d\u7ba1\u4efb\u4f55\u6a21\u5f0f\u7684\u80de\u541e\u4f5c\u7528\u7e3d\u80fd\u5728\u80de\u5410\u4f5c\u7528\u767c\u751f\u5f8c\u88ab\u5373\u6642\u555f\u52d5\uff0c\u53ea\u662f\u4e0d\u540c\u6a21\u5f0f\u6240\u9700\u7684\u6642\u9593\u9577\u77ed\u4e0d\u4e00\u6a23\uff0c\u4f46\u4f60\u53ef\u4ee5\u60f3\u50cf\uff0c\u6709\u4e86\u80de\u541e\u4f5c\u7528\u7121\u7e2b\u63a5\u8ecc\u822c\u7684\u4e32\u806f\uff0c\u7a81\u89f8\u5c0f\u6ce1\u5c31\u53ef\u5373\u6642\u7684\u88ab\u56de\u6536\uff0c\u4ee5\u53ca\u65b0\u4e00\u6ce2\u7684\u7a81\u89f8\u5c0f\u6ce1\u80de\u5410\u4f5c\u7528\u80fd\u7dad\u6301\u5728\u9ad8\u6548\u7387\uff0c\u4f46\u53c3\u8207\u5728\u9019\u91cd\u8981\u904e\u7a0b\u7684\u5206\u5b50\u6a5f\u5236\u5c1a\u672a\u660e\u6717\u3002\u63a5\u4e0b\u4f86\u5c31\u4ecb\u7d39\u6211\u5be6\u9a57\u5ba4\u904e\u53bb\u5728\u9019\u65b9\u9762\u6240\u505a\u7684\u7814\u7a76\u8207\u6709\u8da3\u7684\u767c\u73fe\u3002<\/p>\n<p><strong>\u300c\u82b1\u300d\u96e2\u5b50\u901a\u9053\u86cb\u767d\u5e6b\u52a9\u7a81\u89f8\u5c0f\u6ce1\u80de\u5410\u8207\u80de\u541e\u4f5c\u7528\u300c\u652c\u7262\u7262\u300d<\/strong><\/p>\n<p>2006\u52302011\u5e74\u9593\uff0c\u7576\u7b46\u8005\u9084\u5728\u7f8e\u570b\u4f11\u58eb\u9813\u8c9d\u52d2\u91ab\u5b78\u9662\u5f9e\u4e8b\u535a\u58eb\u5f8c\u7814\u7a76\u6642\uff0c\u7576\u6642\u501f\u91cd\u679c\u8805\uff08Drosophila melanogaster\uff09\u6a21\u5f0f\u751f\u7269\u5728\u79d1\u5b78\u7814\u7a76\u4e0a\u7684\u5e7e\u5927\u512a\u52e2\uff1a\u679c\u8805\u8207\u4eba\u985e\u5927\u90e8\u5206\u7684\u57fa\u56e0\u529f\u80fd\u985e\u4f3c\u3001\u597d\u98fc\u990a\u3001\u751f\u6b96\u9031\u671f\u77ed\u3001\u500b\u9ad4\u5c0f\u53ef\u5728\u4e00\u5b9a\u56fa\u5b9a\u7a7a\u9593\u98fc\u990a\u5927\u91cf\u87f2\u9ad4\uff0c\u66f4\u91cd\u8981\u7684\u662f\uff0c\u8207\u8001\u9f20\u3001\u6591\u99ac\u9b5a\u76f8\u8f03\u4e4b\u4e0b\uff0c\u679c\u8805\u5177\u6700\u5b8c\u5099\u7684\u907a\u50b3\u5b78\u8207\u795e\u7d93\u751f\u7269\u5b78\u76f8\u95dc\u7684\u6280\u8853\u3002\u63a5\u8457\u6211\u5011\u9032\u884c\u4e86\u4e00\u500b\u91dd\u5c0d\u5e7e\u842c\u96bb\u679c\u8805\u7684\u5927\u898f\u6a21\u57fa\u56e0\u7a81\u8b8a\u7be9\u9078\u5be6\u9a57\uff0c\u6211\u5011\u7d66\u679c\u8805\u9935\u98df\u57fa\u56e0\u7a81\u8b8a\u5291\uff0c\u63a5\u4e0b\u4f86\u91cf\u6e2c\u9019\u4e9b\u7a81\u8b8a\u679c\u8805\u773c\u775b\u5c0d\u5149\u7684\u53cd\u61c9\uff0c\u9032\u800c\u7be9\u9078\u51fa\u4e00\u7fa4\u300c\u91cb\u653e\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u6709\u554f\u984c\u7684\u7a81\u8b8a\u679c\u8805\u682a\u300d\u3002<\/p>\n<p>\u679c\u8805\u8ddf\u4eba\u985e\u5f88\u50cf\uff0c\u5468\u908a\u904b\u52d5\u795e\u7d93\u6703\u8207\u808c\u8089\u767c\u80b2\u6210\u8fd1\u4f3c\u5927\u9215\u6263\u72c0\u7684\u524d\u7a81\u89f8\u5340\uff0c\u6709\u8da3\u7684\u662f\uff0c\u5176\u4e2d\u5e7e\u682a\u7a81\u8b8a\u679c\u8805\u7684\u524d\u7a81\u89f8\u5340\u6703\u767c\u80b2\u6210\u5f88\u4e0d\u4e00\u6a23\u7684\u578b\u614b\uff0c\u5f88\u50cf\u7dbb\u653e\u4e2d\u7684\u82b1\u6735\uff0c\u7576\u6211\u5011\u627e\u5230\u767c\u751f\u7a81\u8b8a\u7684\u57fa\u56e0\u5f8c\uff0c\u7d66\u4e86\u9019\u57fa\u56e0\u4e00\u500b\u597d\u8a18\u537b\u53c8\u5178\u96c5\u7684\u540d\u5b57\uff0d\uff0d\u82b1\uff08Flower\uff09\u3002<\/p>\n<p>\u7d9c\u5408\u7576\u6642\u5230\u73fe\u5728\u6211\u81ea\u5df1\u7684\u5be6\u9a57\u5ba4\u88e1\u6240\u505a\u7684\u7814\u7a76\u7d50\u679c\uff0c\u6211\u5011\u767c\u73fe\u7576\u795e\u7d93\u7d30\u80de\u9084\u6c92\u53d7\u4efb\u4f55\u523a\u6fc0\u524d\uff0c\u82b1\u86cb\u767d\u770b\u4f3c\u60a0\u60a0\u54c9\u54c9\u5ea7\u843d\u5728\u7a81\u89f8\u5c0f\u6ce1\u4e0a\uff08\u5716\u4e09\uff09\u3002\u6709\u8da3\u7684\u662f\uff0c\u96a8\u8457\u795e\u7d93\u53d7\u5230\u523a\u6fc0\uff0c\u7a81\u89f8\u5c0f\u6ce1\u8207\u7d30\u80de\u8102\u8cea\u819c\u878d\u5408\u7684\u540c\u6642\uff0c\u82b1\u86cb\u767d\u4e5f\u56e0\u6b64\u88ab\u300c\u8f49\u79fb\u300d\u5230\u6fc0\u6d3b\u5340\uff0c\u751a\u81f3\u5230\u5176\u5468\u908a\u5340\u57df\uff0c\u90a3\u6b63\u662f\u767c\u751f\u80de\u541e\u4f5c\u7528\u7684\u71b1\u9ede\u3002\u6b64\u6642\u6b64\u5730\u7684\u82b1\u86cb\u767d\u53ef\u5c07\u7db2\u683c\u86cb\u767d\u4ecb\u5c0e\u7684\u80de\u541e\u4f5c\u7528\u8a98\u767c\u4e86\u8d77\u4f86\u3002\u66f4\u795e\u5947\u7684\u662f\uff0c\u5728\u6fc0\u6d3b\u5340\u5468\u908a\u5340\u57df\u7684\u82b1\u86cb\u767d\u5c45\u7136\u9084\u80fd\u63a7\u5236\u53e6\u4e00\u6a21\u5f0f\u7684\u80de\u541e\u4f5c\u7528\uff0c\u4f46\u9019\u53ea\u6709\u7576\u795e\u7d93\u7d30\u80de\u53d7\u5f37\u523a\u6fc0\u5f8c\u624d\u6703\u767c\u751f\u3002<\/p>\n<p>\u6211\u5011\u8b49\u5be6\u82b1\u86cb\u767d\u4e5f\u5177\u6709\u96e2\u5b50\u901a\u9053\u7684\u529f\u80fd\uff0c\u53ef\u8b93\u9223\u96e2\u5b50\u901a\u900f\uff0c\u82b1\u86cb\u767d\u5c0d\u5f31\u7684\u795e\u7d93\u523a\u6fc0\u4e00\u9ede\u90fd\u4e0d\u70ba\u6240\u52d5\uff0c\u53ef\u662f\u5f37\u7684\u795e\u7d93\u523a\u6fc0\u537b\u80fd\u6d3b\u5316\u5b83\u7684\u96e2\u5b50\u901a\u9053\u529f\u80fd\uff0c\u6b64\u6642\u300c\u5fc3\u82b1\u6012\u653e\u300d\u7684\u82b1\u86cb\u767d\uff0c\u6703\u8fc5\u901f\u63d0\u5347\u524d\u7a81\u89f8\u5340\u5167\u7684\u9223\u96e2\u5b50\u6fc3\u5ea6\uff0c\u63a5\u8457\u4fc3\u9032\u795e\u7d93\u6d3b\u6027\u4f9d\u8cf4\u7684\u5927\u91cf\u80de\u541e\u4f5c\u7528\u7684\u767c\u751f\u3002\u7576\u7a81\u89f8\u5c0f\u6ce1\u80de\u541e\u4f5c\u7528\u555f\u52d5\u5f8c\uff0c\u80de\u541e\u4f5c\u7528\u6703\u628a\u82b1\u86cb\u767d\u56de\u6536\u5230\u65b0\u751f\u6210\u7684\u7a81\u89f8\u5c0f\u6ce1\u4e0a\uff0c\u5c31\u50cf\u9806\u624b\u95dc\u6389\u958b\u95dc\u4e00\u6a23\uff0c\u7d42\u6b62\u9019\u4e00\u6ce2\u7684\u80de\u541e\u4f5c\u7528\u3002\u6211\u5011\u63a8\u6e2c\u7a81\u89f8\u5c0f\u6ce1\u53ef\u4ee5\u5047\u300c\u82b1\u96e2\u5b50\u901a\u9053\u86cb\u767d\u300d\u4e4b\u624b\uff0c\u5c07\u7a81\u89f8\u5c0f\u6ce1\u80de\u5410\u8207\u80de\u541e\u4f5c\u7528\u300c\u652c\u7262\u7262\u300d\uff0c\u96a8\u5f8c\u4e5f\u63a7\u5236\u7a81\u89f8\u5c0f\u6ce1\u81ea\u5df1\u7684\u56de\u6536\u518d\u5229\u7528\uff0c\u9020\u5c31\u4e86\u4e00\u500b\u975e\u5e38\u7cbe\u7dfb\u7684\u4e32\u806f\u6a5f\u5236\u3002<\/p>\n<div id=\"attachment_21652\" style=\"width: 1034px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21652\" class=\"alignnone size-large wp-image-27280\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/3-3-1024x531.png\" alt=\"\" width=\"1024\" height=\"531\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/3-3-1024x531.png 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/3-3-300x156.png 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/3-3-768x399.png 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/3-3-1080x561.png 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/05\/3-3.png 1210w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">\u5716\u4e09\uff1a\u82b1\u9223\u96e2\u5b50\u901a\u9053\u86cb\u767d\u63a7\u5236\u7a81\u89f8\u5c0f\u6ce1\u80de\u5410\u8207\u80de\u541e\u4f5c\u7528\u4e32\u806f\u8207\u8a98\u767c\u7a81\u89f8\u5c0f\u6ce1\u80de\u541e\u4f5c\u7528\u3002VGCC\u70ba\u63a7\u5236\u7a81\u89f8\u5c0f\u6ce1\u80de\u5410\u4f5c\u7528\u7684\u9223\u96e2\u5b50\u901a\u9053\u86cb\u767d\u3002<\/p><\/div>\n<p><strong>\u795e\u79d8\u7684\u9762\u7d17\u53ea\u6380\u5230\u4e86\u4e00\u534a\uff01<\/strong><\/p>\n<p>\u81f3\u6b64\u9084\u5b58\u5728\u8a31\u591a\u7591\u60d1\u7b49\u5f85\u6211\u5011\u53bb\u63ed\u66c9\u7b54\u6848\u3002\u9996\u5148\uff0c\u4ee4\u4eba\u767e\u601d\u4e0d\u89e3\u7684\u554f\u984c\u662f\uff0c\u7a81\u89f8\u5c0f\u6ce1\u80de\u5410\u4f5c\u7528\u5f8c\uff0c\u6bcf\u500b\u7a81\u89f8\u5c0f\u6ce1\u6703\u628a\u5b83\u81ea\u8eab\u651c\u5e36\u5404\u5f0f\u5404\u6a23\u4e0d\u540c\u7a2e\u985e\u7684\u86cb\u767d\u6563\u843d\u5728\u6fc0\u6d3b\u5340\uff0c\u6b64\u6642\u5982\u4f55\u5728\u6975\u77ed\u7684\u6642\u9593\u5c07\u5b83\u5011\u7cbe\u6e96\u5730\u56de\u6536\u5230\u65b0\u751f\u7684\u7a81\u89f8\u5c0f\u6ce1\u4e0a\u5462\uff1f<\/p>\n<p>\u63a5\u8457\u662f\uff0c\u4e0d\u540c\u6a21\u5f0f\u7684\u7a81\u89f8\u5c0f\u6ce1\u80de\u541e\u4f5c\u7528\u4e0d\u50c5\u5728\u5f62\u6210\u6642\u9593\u4e0a\u6709\u5f88\u5927\u7684\u4e0d\u540c\u5916\uff0c\u800c\u4e14\u80fd\u767c\u751f\u5728\u4e0d\u540c\u7684\u524d\u7a81\u89f8\u5340\u57df\uff0c\u5206\u5b50\u6a5f\u5236\u53c8\u662f\u70ba\u4f55\u5462\uff1f\u5df2\u77e5\u4eba\u9ad4\u4e2d\u6709\u8457\u5404\u5f0f\u5404\u6a23\u4e0d\u540c\u7279\u6027\u7684\u795e\u7d93\u7d30\u80de\uff0c\u5b83\u5011\u5728\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u91cb\u653e\u7684\u7279\u6027\u4e0a\u4e5f\u5f88\u4e0d\u4e00\u6a23\uff0c\u662f\u5426\u9019\u7279\u7570\u6027\u662f\u7531\u65bc\u4e0d\u540c\u7a81\u89f8\u5c0f\u6ce1\u80de\u541e\u4f5c\u7528\u6a21\u5f0f\u5728\u4f7f\u7528\u7a0b\u5ea6\u4e0a\u4e0d\u4e00\u6a23\u6240\u5c0e\u81f4\u7684\u5462\uff1f<\/p>\n<p>\u5728\u4eba\u985e\u75be\u75c5\u4e0a\uff0c\u795e\u7d93\u7d30\u80de\u4e00\u65e6\u5728\u5e7c\u5152\u6642\u671f\u5230\u9752\u5c11\u5e74\u671f\u9593\u767c\u80b2\u5b8c\u6210\u5f8c\uff0c\u5c31\u6703\u4f34\u96a8\u8457\u6211\u5011\u4e00\u751f\uff0c\u8fd1\u5e74\u4f86\u8a31\u591a\u8b49\u64da\u5df2\u6307\u51fa\u6548\u7387\u8b8a\u5dee\u7684\u7a81\u89f8\u5c0f\u6ce1\u80de\u541e\u4f5c\u7528\u8207\u795e\u7d93\u75be\u75c5\u7684\u767c\u751f\u6709\u8457\u5bc6\u4e0d\u53ef\u5206\u7684\u95dc\u806f\u6027\uff0c\u4f46\u70ba\u4f55\u9019\u4e9b\u75be\u75c5\u6703\u5f15\u767c\u7a81\u89f8\u5c0f\u6ce1\u80de\u541e\u4f5c\u7528\u5931\u80fd\uff1f\u53e6\u4e00\u65b9\u9762\uff0c\u7a81\u89f8\u5c0f\u6ce1\u80de\u541e\u4f5c\u7528\u5931\u80fd\u5982\u4f55\u5f15\u8d77\u795e\u7d93\u9000\u5316\u7684\u5462\uff1f<\/p>\n<p>\u671f\u671b\u672a\u4f86\u80fd\u7834\u89e3\u4e0a\u8ff0\u554f\u984c\uff0c\u5f97\u5230\u7684\u7b54\u6848\u61c9\u53ef\u4fc3\u4f7f\u6211\u5011\u5c0d\u4eba\u8166\u932f\u7d9c\u8907\u96dc\u7684\u904b\u4f5c\u80fd\u66f4\u52a0\u77ad\u89e3\uff0c\u4ee5\u53ca\u5c0d\u65bc\u73fe\u5b58\u8a31\u591a\u68d8\u624b\u7684\u795e\u7d93\u75be\u75c5\u6cbb\u7642\u4e0a\uff0c\u63d0\u4f9b\u66f4\u597d\u7684\u826f\u65b9\u3002<\/p>\n<p>\u5ef6\u4f38\u95b1\u8b80<br \/>\n1.Li TN, Chen YJ, Wang YT, Lin HC, Lu TY, (Yao CK)* (2020-12) Elife 9, e60125 &#8220;A positive feedback loop between Flower and PI(4,5)P2 at periactive zones controls bulk endocytosis in <em>Drosophila<\/em>.&#8221;<br \/>\n2.Yao CK, Liu YT, Lee IC, Wang YT, Wu PY (2017-04) PLoS biology 15(4), e2000931 &#8220;A Ca2+ channel differentially regulates Clathrin-mediated and activity-dependent bulk endocytosis.&#8221;<br \/>\n3.Yao CK, Lin YQ, Ly CV, Ohyama T, Haueter CM, Moiseenkova-Bell VY, Wensel TG, Bellen HJ (2009) Cell 138(5), 947-960 &#8220;A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4f60\u662f\u5426\u66fe\u7d93\u554f\u904e\u5927\u8166\u300c\u4f60\u7d2f\u4e86\u55ce?\u300d\u70ba\u4f55\u5927\u8166\u7e3d\u80fd\u4e0d\u505c\u7684\u767c\u51fa\u5feb\u901f\u537b\u7cbe\u6e96\u7684\u6307\u4ee4\u5462\uff1f\u5927\u5bb6\u90fd\u7565\u77e5\u4f60\u6211\u7684\u5927\u8166\u662f\u7531\u8a31\u591a\u4e0d\u540c\u7684\u795e [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":27296,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[991,983],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/27277"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=27277"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/27277\/revisions"}],"predecessor-version":[{"id":27281,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/27277\/revisions\/27281"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/27296"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=27277"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=27277"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=27277"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}