{"id":26686,"date":"2022-01-13T00:27:47","date_gmt":"2022-01-12T16:27:47","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=26686"},"modified":"2022-01-18T05:30:05","modified_gmt":"2022-01-17T21:30:05","slug":"pias1-variant-s510g-%e8%83%bd%e5%bb%b6%e7%b7%a9%e4%ba%a8%e4%b8%81%e9%a0%93%e8%88%9e%e8%b9%88%e7%97%87%e4%b9%8b%e7%99%bc%e7%97%85%e6%99%82%e9%96%93%e3%80%8d","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/26686\/","title":{"rendered":"PIAS1 <sup>S510G<\/sup> \u80fd\u5ef6\u7de9\u4ea8\u4e01\u9813\u821e\u8e48\u75c7\u4e4b\u767c\u75c5\u6642\u9593\u300d"},"content":{"rendered":"<p>\u4ea8\u4e01\u9813\u821e\u8e48\u75c7\uff08HD\uff09\u662f\u4e00\u7a2e\u805a\u9ea9\u91af\u80fa\uff08polyQ\uff09\u75be\u75c5\uff0cCAG\u4e09\u6838\u82f7\u9178\u91cd\u8907\u6578\u7684\u9577\u5ea6\u6c7a\u5b9a\u75c5\u4eba\u7684\u767c\u75c5\u5e74\u9f61\uff0cPIAS1S510G\u57fa\u56e0\u8abf\u98fe\u56e0\u5b50\u5247\u53ef\u8abf\u63a7\u6b64\u75be\u75c5\u7684\u767c\u75c5\u5e74\u9f61\u3002\u672c\u9662\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u7279\u8058\u7814\u7a76\u54e1\u9673\u5100\u838a\u5718\u968a\u9996\u6b21\u89e3\u958bPIAS1S510G\u5982\u4f55\u8abf\u63a7\u7a81\u8b8a\u4ea8\u4e01\u9813\u86cb\u767d\uff08mHtt\uff09\u7684\u5c0f\u6cdb\u7d20\u5316\u4fee\u98fe\uff0c\u6e1b\u5c11mHtt\u7684\u5806\u7a4d\uff0c\u80fd\u5ef6\u7de9\u767c\u75c5\u6642\u9593\u53ca\u75c5\u60c5\u56b4\u91cd\u6027\u3002\u672c\u7814\u7a76\u6210\u679c\u5df2\u65bc\u53bb\uff082021\uff09\u5e7412\u6708\u520a\u767b\u5728\u300a\u904b\u52d5\u969c\u7919\u300b\uff08<em>Movement Disorders<\/em>\uff09\u3002<\/p>\n<p>\u8ad6\u6587\u5168\u6587\uff1a<a href=\"https:\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.28896\">https:\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.28896<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-26687 aligncenter\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/01\/webimage-13-1024x615.jpg\" alt=\"\" width=\"1024\" height=\"615\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/01\/webimage-13-1024x615.jpg 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/01\/webimage-13-300x180.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/01\/webimage-13-768x462.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/01\/webimage-13-1080x649.jpg 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/01\/webimage-13-1280x768.jpg 1280w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/01\/webimage-13-627x376.jpg 627w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/01\/webimage-13-440x264.jpg 440w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2022\/01\/webimage-13.jpg 1396w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4ea8\u4e01\u9813\u821e\u8e48\u75c7\uff08HD\uff09\u662f\u4e00\u7a2e\u805a\u9ea9\u91af\u80fa\uff08polyQ\uff09\u75be\u75c5\uff0cCAG\u4e09\u6838\u82f7\u9178\u91cd\u8907\u6578\u7684\u9577\u5ea6\u6c7a\u5b9a\u75c5\u4eba\u7684\u767c\u75c5\u5e74\u9f61\uff0cPIAS1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":26687,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[988,984],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/26686"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=26686"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/26686\/revisions"}],"predecessor-version":[{"id":26688,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/26686\/revisions\/26688"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/26687"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=26686"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=26686"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=26686"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}