{"id":25076,"date":"2021-07-29T00:03:08","date_gmt":"2021-07-28T16:03:08","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=25076"},"modified":"2021-09-30T11:30:25","modified_gmt":"2021-09-30T03:30:25","slug":"%e3%80%90%e5%b0%88%e6%ac%84%e3%80%91%e5%9f%ba%e5%9b%a0%e9%ab%94%e7%a0%94%e7%a9%b6%e4%b8%ad%e5%bf%83%e6%96%b0%e5%86%a0%e8%82%ba%e7%82%8e-%ef%bc%88covid-19%ef%bc%89%e9%98%b2%e7%96%ab%e7%9b%b8%e9%97%9c","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/25076\/","title":{"rendered":"\u3010\u5c08\u6b04\u3011\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3COVID-19\u9632\u75ab\u76f8\u95dc\u6210\u679c"},"content":{"rendered":"

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\u3010\u65b0\u51a0\u80ba\u708e\u7684\u9810\u9632\u3011<\/strong><\/p>\n

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\u3010\u65b0\u51a0\u80ba\u708e\u7684\u6cbb\u7642\u3011<\/strong><\/p>\n

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COVID-19\u75ab\u60c5\u5728\u5168\u4e16\u754c\u5df2\u7d93\u5ef6\u71d2\u591a\u6642\uff0c\u4e14\u65b0\u7684\u7a81\u8b8a\u7a2e\u6301\u7e8c\u51fa\u73fe\uff0c\u5404\u570b\u7a4d\u6975\u6295\u5165\u85e5\u7269\u958b\u767c\u3002\u7f8e\u570b\u5409\u5229\u5fb7\u79d1\u5b78\u516c\u53f8\uff08Gilead Sciences, Inc.\uff09\u7814\u767c\u7684\u6297\u75c5\u6bd2\u85e5\u7269\u300c\u745e\u5fb7\u897f\u97cb\u300d\uff0c\u76f8\u7e7c\u7372\u5f97\u7f8e\u570b\u3001\u65e5\u672c\u548c\u6b50\u6d32\u5404\u570b\u6279\u51c6\uff0c\u6210\u70ba\u5168\u7403\u7b2c\u4e00\u500b\u7372\u8b49\u7528\u65bc\u6cbb\u7642\u300c\u65b0\u51a0\u80ba\u708e\u300d\u7684\u85e5\u7269\uff0c\u81fa\u7063\u98df\u85e5\u7f72\u4e5f\u6279\u51c6\u6709\u689d\u4ef6\u4e0a\u5e02\u3002<\/p>\n

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\u7814\u7a76\u7d50\u679c\u986f\u793a\u9019\u9805\u300c\u4e00\u934b\u5316\u300d\u4e0d\u5c0d\u7a31\u50ac\u5316\u53cd\u61c9\uff0c\u4e0d\u50c5\u5c07\u539f\u5148\u4e00\u534a\u5fc5\u9808\u5ee2\u68c4\u7684\u78f7\u9178\u916f\u7570\u69cb\u7269\uff0c\u5168\u6578\u8f49\u63db\u6210\u53ef\u4f9b\u7e7c\u7e8c\u53cd\u61c9\u7684\u4e2d\u9593\u9ad4\uff0c\u800c\u4e14\u5c07\u5408\u6210\u300c\u745e\u5fb7\u897f\u97cb\u300d\u6700\u5f8c\u4e8c\u6b65\u7684\u7e3d\u7522\u7387\u5f9e48.3%\u63d0\u5347\u523070%\uff0c\u52a0\u4e0a\u56de\u6536\u7684\u50ac\u5316\u5291\u53ef\u4ee5\u91cd\u8907\u4f7f\u7528\uff0c\u61c9\u53ef\u5927\u5e45\u964d\u4f4e\u300c\u745e\u5fb7\u897f\u97cb\u300d\u7684\u88fd\u9020\u6210\u672c \uff08\u57162A\uff09\u3002<\/p>\n

\u2022\u91dd\u5c0d\u65b0\u51a0\u80ba\u708e\u75c5\u6bd2\u4ee5\u53ca\u5176\u8b8a\u7570\u682a\u7684\u55ae\u91a3\u5316\u68d8\u3000\u7a81\u86cb\u767d\u75ab\u82d7<\/p>\n

\u7531\u65bcSARS-CoV-2\u8b8a\u7a2e\u80fd\u529b\u8d85\u5f37\uff0c\u4e14\u50b3\u64ad\u80fd\u529b\u4e5f\u96a8\u4e4b\u589e\u5f37\uff0c\u9084\u6709\u53ef\u80fd\u5927\u5927\u5f71\u97ff\u73fe\u884c\u75ab\u82d7\u6548\u529b\u3002\u7531\u91ce\u751f\u578b\u7a81\u8b8a\u6210D614\u5230alpha\u3001beta\u3001gamma\u3001delta\u53cadelta plus\uff0c\u6642\u81f3\u4eca\u65e5\u96d6\u5df2\u6709\u8a31\u591aCOVID-19\u75ab\u82d7\u53ef\u4f9b\u4f7f\u7528\uff0c\u4f46\u6975\u6709\u53ef\u80fd\u64fa\u812b\u7576\u524d\u75ab\u82d7\u8a98\u767c\u7684\u4fdd\u8b77\uff0c\u8b93\u5df2\u7d93\u63a5\u7a2e\u75ab\u82d7\u7684\u4eba\u4ecd\u7136\u6709\u518d\u88ab\u611f\u67d3\u7684\u53ef\u80fd\u6027\u3002\u5982\u4f55\u8b93\u75ab\u82d7\u5177\u5099\u61c9\u4ed8\u8b8a\u7a2e\u75c5\u6bd2\u7684\u80fd\u529b\uff0c\u7522\u751f\u5b8c\u6574\u7684\u4fdd\u8b77\uff0c\u662f\u7576\u524d\u6025\u9700\u89e3\u6c7a\u7684\u96e3\u984c\u3002<\/p>\n

\u68d8\u7a81\u91a3\u86cb\u767d\u662f\u6240\u6709\u65b0\u51a0\u75ab\u82d7\u4e2d\u6700\u91cd\u8981\u7684\u86cb\u767d\u8cea\uff0c\u4e26\u900f\u904e\u8207\u4eba\u985eACE2\u53d7\u9ad4\u7d50\u5408\u9032\u5165\u7d30\u80de\uff0c\u800c\u81f3\u4eca\u5e7e\u4e4e\u6240\u6709COVID-19\u75ab\u82d7\u6240\u4f7f\u7528\u7684\u6297\u539f\uff0c\u7686\u4ee5\u68d8\u7a81\u86cb\u767d\u70ba\u76ee\u6a19\u3002\u7531\u7fc1\u555f\u60e0\u7279\u8058\u7814\u7a76\u54e1\u53ca\u99ac\u5fb9\u7814\u7a76\u54e1\u9818\u8ecd\u4e4b\u7814\u7a76\u5718\u968a\uff0c\u5176\u7814\u7a76\u7d50\u679c\u986f\u793a\u68d8\u7a81\u86cb\u767d\u8868\u9762\u91a3\u57fa\u5316\u7a0b\u5ea6\u5f88\u9ad8\uff0c\u4e14\u805a\u91a3\u8986\u84cb\u7684\u6297\u539f\u8f03\u5c11\u7a81\u8b8a\uff0c\u6545\u5176\u6240\u80fd\u8a98\u767c\u7684\u514d\u75ab\u53cd\u61c9\u6975\u5177\u75ab\u82d7\u958b\u767c\u6f5b\u529b\u3002<\/p>\n

\u7814\u7a76\u5718\u968a\u5f9e\u767c\u5c55\u5ee3\u6548\u6d41\u611f\u75ab\u82d7\u6240\u7d2f\u7a4d\u7684\u7d93\u9a57\u8457\u624b\uff0c\u767c\u73fe\u68d8\u7a81\u86cb\u767d\u8868\u9762\u91a3\u5316\u7684\u591a\u5be1\u5c0d\u75c5\u6bd2\u548c\u6297\u9ad4\u7684\u7d50\u5408\u529b\u6709\u91cd\u5927\u7684\u5f71\u97ff\u3002\u82e5\u79fb\u9664\u75c5\u6bd2\u8868\u9762\u4e0a\u6703\u5e72\u64fe\u8fa8\u8b58\u7684\u91a3\uff0c\u9732\u51fa\u66f4\u591a\u53ef\u4f9b\u8fa8\u8a8d\u7684\u7279\u5fb5\uff0c\u5c31\u80fd\u5920\u8b93\u75ab\u82d7\u589e\u52a0\u66f4\u591a\u7684\u514d\u75ab\u53cd\u61c9\uff0c\u6210\u70ba\u5ee3\u6548\u6297\u65b0\u51a0\u75ab\u82d7\u3002<\/p>\n

\u7814\u7a76\u5718\u968a\u904b\u7528\u5c08\u6709\u7684\u91a3\u86cb\u767d\u5de5\u7a0b\uff0c\u79fb\u9664\u75ab\u82d7\u68d8\u7a81\u86cb\u767d\u8868\u9762\u6703\u5e72\u64fe\u8fa8\u8b58\u7684\u91a3\uff0c\u958b\u767c\u51fa\u55ae\u91a3\u5316\u68d8\u7a81\u86cb\u767d\u75ab\u82d7Smg\uff0c\u900f\u904e\u5c0f\u9f20\u52d5\u7269\u6a21\u578b\u9a57\u8b49\uff0c\u7d50\u679c\u986f\u793aSmg\u75ab\u82d7\u6bd4\u50b3\u7d71\u75ab\u82d7\u53ef\u8a98\u767c2.1\u500d\u7684IgG\u6548\u50f9\uff0c\u4e26\u767c\u73fe\u53ef\u4ee5\u4fc3\u9032Th1\u7d30\u80de\u514d\u75ab\u53cd\u61c9\uff0c\u7522\u751f\u8f03\u9ad8\u91cf\u7684IFN-\u03b3\uff08\u57162B\uff09\u3002\u4e14\u5728\u8f15\u75c7\u6216\u662f\u91cd\u75c7\u52d5\u7269\u6a21\u578b\u4e2d\uff0c\u767c\u73feSmg\u86cb\u767d\u75ab\u82d7\u4e0d\u53ea\u5728SARS-CoV-2\u539f\u59cb\u682a\u4e0a\u63d0\u4f9b\u66f4\u597d\u4fdd\u8b77\u4e4b\u5916\uff0c\u53ef\u7dad\u6301\u5c0f\u9f20\u7684\u9ad4\u91cd\u3001\u589e\u52a0\u5b58\u6d3b\u7387\u3001\u964d\u4f4e\u80ba\u90e8\u75c5\u6bd2\u91cf\u3001\u4e26\u589e\u52a0\u8840\u6e05\u4e2d\u4e2d\u548c\u6297\u9ad4\u91cf\u3002\u6b64\u5916\uff0c\u7814\u7a76\u5718\u968a\u9032\u4e00\u6b65\u7814\u7a76\u6b64\u55ae\u91a3\u5316\u68d8\u7a81\u86cb\u767d\u75ab\u82d7\u5c0d\u65b0\u51a0\u75c5\u6bd2\u8b8a\u7570\u682a\u4e4b\u4fdd\u8b77\u6548\u529b\uff0c\u5229\u7528\u611f\u67d3D614G\u3001alpha\u3001beta\u3001gamma\u7a81\u8b8a\u682a\u7684\u52d5\u7269\u6a21\u5f0f\u9032\u884c\u8a66\u9a57\uff0c\u767c\u73fe\u63a5\u7a2eSmg\u75ab\u82d7\u7684\u5c0f\u9f20\uff0c\u6bd4\u63a5\u7a2e\u50b3\u7d71\u75ab\u82d7\u7522\u751f\u7684IgG\u6548\u50f9\u9ad8\u51fa2\u500d\u81f33.4\u500d\uff08\u57162B\uff09\u3002\u672c\u7814\u7a76\u6240\u7814\u767c\u51fa\u4e4b\u55ae\u91a3\u5316\u86cb\u767d\u75ab\u82d7\u5177\u6709\u5ee3\u6548\u7684\u6297\u65b0\u51a0\u75c5\u6bd2\u6548\u679c\u3002<\/p>\n

Figure legend<\/strong><\/p>\n

\"\"

\u57161A\u3001\u767d\u6241\u8c46\u4e2d\u8403\u53d6\u51fa\u4f86\u7684FRIL\u86cb\u767d\uff0c\u53ef\u4ee5\u6291\u5236\u591a\u7a2e\u6d41\u611f\u75c5\u6bd2\u548c\u65b0\u51a0\u75c5\u6bd2<\/strong>\uff1b\u57161B\u3001\u5009\u9f20\u52d5\u7269\u5be6\u9a57\u9a57\u8b495\u7a2e\u85e5\u7269\u53ef\u6e1b\u5c11\u8001\u9f20\u80ba\u90e8\u7684\u75c5\u6bd2\u91cf\u4e4b\u6d3b\u6027\uff0c\u4e14\u4e0d\u6703\u9020\u6210\u9ad4\u91cd\u6e1b\u8f15\u4e4b\u526f\u4f5c\u7528<\/p><\/div>\n

\"\"

\u57162A\u3001\u7d50\u5408\u4e0d\u5c0d\u7a31\u50ac\u5316\u548c\u9178\u6027\u53bb\u4fdd\u8b77\u7684\u300c\u4e00\u934b\u5316\u300d\u53cd\u61c9\u7b56\u7565\uff0c\u5927\u5e45\u63d0\u9ad8\u300c\u745e\u5fb7\u897f\u97cb\u300d\u7684\u7522\u7387\uff1b\uff0c\u5716 2B caption: \u4ee5\u5169\u7a2e\u52d5\u7269\u6a21\u578b\u5be6\u9a57\u9a57\u8b49Smg\u75ab\u82d7\u5177\u6709\u5ee3\u6548\u7684\u6297\u65b0\u51a0\u75c5\u6bd2\u6548\u679c<\/p><\/div>\n

\n

\u53c3\u8003\u6587\u737b\uff1a<\/strong>
\n1.Liu YM; Shahed-Al-Mahmud M; Chen X; Chen TH; Liao KS; Lo JM; Wu YM; Ho MC; Wu CY; Wong CH; Jan JT; Ma C, A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2. Cell Rep<\/em>, 2020, 32(6), 108016.<\/p>\n

2.Jan JT; Cheng TJR; Juang YP; Ma HH; Wu YT; Yang WB; Cheng CW; Chen X; Chou TH; Shie JJ; Cheng WC; Chein RJ; Mao SS; Liang PH; Ma C; Hung SC; Wong CH, Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection. Proc Natl Acad Sci US<\/em>A, 2021, 118 (5), e2021579118.<\/p>\n

3.Daniel O\u2019Day, 2020, 6.29, An Open Letter from Daniel O\u2019Day, Chairman & CEO, Gilead Sciences. https:\/stories.gilead.com\/articles\/an-open-letter-from-daniel-oday-june-29<\/p>\n

4.Gannedi V; Villuri, BK; Reddy SN; Ku CC; Wong CH; Hung SC, Practical Remdesivir Synthesis through One-Pot Organocatalyzed Asymmetric (S)-P-Phosphoramidation. J Org Chem<\/em>, 2021, 86(7):4977-4985.<\/p>\n

5.Liao HY; Huang HY; Chen X; Cheng CW; Wang SW; Shahed-Al-Mahmud M; Chen TH; Lo JM; Liu YM; Ma HH; Chang YH; Tsai CY; Huang PY; Chang SY; Chao TL; Kao HC; Tsai YM; Chen YH; Chen CY; Lee KC; Wu CY; Jan JT; Lin KI; Cheng TJR; Ma C; Wong CH, Impact of Glycosylation on SARS-CoV-2 Infection and Broadly Protective Vaccine Design. bioRxiv<\/em>, 2021.05.25.445523.<\/p>\n","protected":false},"excerpt":{"rendered":"

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