{"id":24848,"date":"2021-06-17T00:03:53","date_gmt":"2021-06-16T16:03:53","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=24848"},"modified":"2021-08-26T08:26:38","modified_gmt":"2021-08-26T00:26:38","slug":"%e3%80%90%e5%b0%88%e6%ac%84%e3%80%91%e7%9c%bc%e8%a6%8b%e7%82%ba%e6%86%91%ef%bc%8c%e5%88%a9%e7%94%a8%e5%bd%b1%e5%83%8f%e8%b3%aa%e8%ad%9c%e5%88%86%e6%9e%90-%e6%8e%a2%e7%b4%a2%e5%be%ae%e7%94%9f%e7%89%a9","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/24848\/","title":{"rendered":"\u3010\u5c08\u6b04\u3011\u773c\u898b\u70ba\u6191\uff0c\u5229\u7528\u5f71\u50cf\u8cea\u8b5c\u5206\u6790 \u63a2\u7d22\u5fae\u751f\u7269\u8207\u690d\u7269\u7684\u5316\u5b78\u4e16\u754c"},"content":{"rendered":"<p>\u4fd7\u8afa\u6709\u4e91\uff1a\u300c\u773c\u898b\u70ba\u6191\u300d\uff0c\u82f1\u6587\u5247\u8aaa\u201cSeeing is 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\/>\ncharge ratio, <em>m\/z<\/em>\uff09\u201d\uff0c\u7c21\u7a31\u70ba\u8cea\u8377\u6bd4\u3002\u5f71\u50cf\u8cea\u8b5c\u5c07\u4e00\u6a23\u54c1\u8868\u9762\u4e0a\u4e0d\u540c\u5206\u6790\u4f4d\u7f6e\u6240\u5f97\u7684\u96e2\u5b50\u8a0a\u865f\uff08\u8cea\u8377\u6bd4\uff09\u53ca\u8a0a\u865f\u5f37\u5ea6\uff0c\u900f\u904e\u96fb\u8166\u8edf\u9ad4\u8f49\u63db\u70ba\u5e73\u9762\u5716\u50cf\uff0c\u5373\u53ef\u5feb\u901f\u4e00\u89bd\u4e0d\u540c\u5206\u5b50\u91cf\u4e4b\u5206\u5b50\u5728\u6a23\u54c1\u8868\u9762\u7684\u5206\u5e03\u3002\u5728\u5404\u7a2e\u5f71\u50cf\u8cea\u8b5c\u5206\u6790\u6280\u8853\u4e2d\uff0c\u6700\u5ee3\u6cdb\u904b\u7528\u7684\u662f\u57fa\u8cea\u8f14\u52a9\u96f7\u5c04\u812b\u9644\u6e38\u96e2\u6cd5\uff08matrix-assisted laser desorption\/ionization\uff0c\u7c21\u7a31\u70baMALDI\uff09\uff0c\u5176\u5148\u5728\u6a23\u54c1\u8868\u9762\u5674\u7051\u8986\u84cb\u4e00\u5c64\u53ef\u4ee5\u5438\u6536\u96f7\u5c04\u80fd\u91cf\u7684\u57fa\u8cea\uff08\u901a\u5e38\u662f\u5c0f\u5206\u5b50\u6709\u6a5f\u9178\uff09\uff0c\u5373\u53ef\u5728\u96f7\u5c04\u6fc0\u767c\u4e0b\u5e6b\u52a9\u6a23\u54c1\u4e2d\u7684\u5206\u5b50\u812b\u9644\u5f62\u6210\u5e36\u96fb\u7684\u6c23\u9ad4\u96e2\u5b50\uff0c\u518d\u900f\u904e\u8cea\u8b5c\u5100\u5075\u6e2c\u5230\u8cea\u8377\u6bd4\u8a0a\u865f\u3002\u8fd1\u5e74\u4f86\uff0cMALDI\u5f71\u50cf\u8cea\u8b5c\u5df2\u5927\u91cf\u61c9\u7528\u65bc\u5206\u6790\u751f\u7269\u6a23\u54c1\u4e2d\u5404\u985e\u5c0f\u5206\u5b50\uff08\u4f8b\u5982\u80fa\u57fa\u9178\uff09\u53ca\u5927\u5206\u5b50\uff08\u4f8b\u5982\u86cb\u767d\u8cea\uff09\u7684\u7a7a\u9593\u5206\u5e03\u3002\uff08\u53c3\u8003\u8cc7\u65991\uff09<\/p>\n<p><strong>\u900f\u904e\u5f71\u50cf\u8cea\u8b5c\u5c0b\u627e\u65b0\u7a4e\u7684\u6297\u751f\u7d20\u4e26\u63a2\u7d22\u5fae\u751f\u7269\u9593\u7684\u5316\u5b78\u4ea4\u4e92\u4f5c\u7528<\/strong><\/p>\n<p>\u5fae\u751f\u7269\u662f\u91cd\u8981\u7684\u6297\u751f\u7d20\u4f86\u6e90\uff0c\u4eba\u985e\u6700\u65e9\u767c\u73fe\u4e14\u5ee3\u6cdb\u4f7f\u7528\u7684\u6297\u751f\u7d20\u2014\u9752\u9ef4\u7d20\uff08penicillin\uff0c\u6216\u8b6f\u70ba\u76e4\u5c3c\u897f\u6797\uff09\u5c31\u662f\u7531\u9752\u9ef4\u83cc\u6240\u751f\u7522\u7684\u4e00\u7a2e\u5c0f\u5206\u5b50\u4ee3\u8b1d\u7269\u3002\u53ef\u751f\u7522\u6297\u751f\u7d20\u7684\u5fae\u751f\u7269\u901a\u5e38\u6703\u5c07\u6297\u751f\u7d20\u7269\u8cea\u5206\u6ccc\u81f3\u5176\u751f\u9577\u5340\u57df\u7684\u5468\u570d\uff0c\u4ee5\u6291\u5236\u5468\u908a\u5176\u4ed6\u5fae\u751f\u7269\u7684\u751f\u9577\uff0c\u9019\u6642\uff0c\u5f71\u50cf\u8cea\u8b5c\u5c31\u6210\u4e86\u7528\u4f86\u5206\u6790\u83cc\u843d\u5468\u908a\u5316\u5b78\u5206\u5b50\u7684\u6709\u529b\u5de5\u5177\uff0c\u53ef\u5e6b\u52a9\u63a2\u52d8\u6f5b\u5728\u7684\u65b0\u7a4e\u6297\u751f\u7d20\uff1b\u6b64\u5916\uff0c\u7576\u5169\u7a2e\u4e0d\u540c\u5fae\u751f\u7269\u5171\u540c\u751f\u9577\u5728\u540c\u4e00\u7a7a\u9593\u6642\uff0c\u4ea6\u53ef\u5229\u7528\u5f71\u50cf\u8cea\u8b5c\u5f9e\u5206\u5b50\u8f49\u63db\u7684\u89c0\u9ede\u63a2\u7d22\u4e0d\u540c\u5fae\u751f\u7269\u4e4b\u9593\u662f\u5426\u767c\u751f\u4e86\u5316\u5b78\u4ea4\u4e92\u4f5c\u7528\u3002\uff08\u53c3\u8003\u8cc7\u65992-3\uff09<\/p>\n<p>\u6211\u5011\u5df2\u6210\u529f\u5229\u7528MALDI\u5f71\u50cf\u8cea\u8b5c\u5206\u6790\u4f5c\u70ba\u5c0b\u627e\u6f5b\u5728\u6297\u751f\u7d20\u7684\u7b56\u7565\u3002\u9996\u5148\u5c07\u5fae\u751f\u7269\u63a5\u7a2e\u751f\u9577\u65bc\u57f9\u990a\u76bf\u4e2d\uff0c\u518d\u85c9\u7531\u5075\u6e2c\u5fae\u751f\u7269\u83cc\u843d\u5468\u908a\u7684\u5c0f\u5206\u5b50\u4ee3\u8b1d\u7269\u7d44\u6210\u4e26\u6e2c\u8a66\u5404\u7279\u5b9a\u4ee3\u8b1d\u7269\u65cf\u7fa4\u7684\u6291\u83cc\u80fd\u529b\uff0c\u7be9\u9078\u767c\u73fe\u4e00\u682a\u6d77\u6d0b\u5f27\u83cc\uff08<em>Vibrio<\/em> sp.QWI-06\uff09\u53ef\u751f\u7522\u5c0d\u6297\u9b91\u6c0f\u4e0d\u52d5\u687f\u83cc \uff08<em>Acinetobacter baumannii<\/em>\uff0c\u91ab\u9662\u5167\u5e38\u898b\u7d30\u83cc\u611f\u67d3\u4e4b\u75c5\u539f\u83cc\uff09\u7684\u6297\u751f\u7d20\uff0c\u9032\u4e00\u6b65\u78ba\u8a8d\u5176\u5206\u5b50\u7d50\u69cb\u5f8c\u5f97\u77e5\u6b64\u7269\u8cea\u70ba\u4e00\u7cfb\u5217\u542b\u6709\u80fa\u57fa\u7684\u805a\u916e\u985e\u884d\u751f\u7269\uff08amino-polyketide derivatives\uff09\uff0c\u5c6c\u65bc\u65b0\u578b\u6297\u751f\u7d20\uff0c\u6545\u6b64\u6210\u679c\u5373\u70ba\u904b\u7528\u5f71\u50cf\u8cea\u8b5c\u5f9e\u5fae\u751f\u7269\u8cc7\u6e90\u4e2d\u63a2\u52d8\u5177\u85e5\u7528\u6f5b\u529b\u7269\u8cea\u7684\u5be6\u969b\u7bc4\u4f8b\u3002\uff08\u53c3\u8003\u8cc7\u65994\uff09<\/p>\n<p>\u6b64\u5916\uff0c\u6211\u5011\u4e5f\u85c9\u7531MALDI\u5f71\u50cf\u8cea\u8b5c\u5206\u6790\u767c\u73fe\u4e86\u4e00\u500b\u7d30\u83cc\u8207\u771f\u83cc\u9593\u7279\u6b8a\u7684\u5316\u5b78\u4ea4\u4e92\u4f5c\u7528\u3002\u5728\u6b64\u8a66\u9a57\u4e2d\uff0c\u6211\u5011\u5c07\u4f2f\u514b\u6c0f\u83cc\u5c6c\u7684\u7d30\u83cc \uff08<em>Burkholderia cenocepacia<\/em>\uff09\u8207\u6728\u5c64\u5b54\u83cc\u5c6c\u7684\u771f\u83cc\uff08<em>Phellinus noxius<\/em>\uff0c\u8910\u6839\u75c5\u83cc\uff0c\u70ba\u4e00\u7a2e\u690d\u7269\u75c5\u539f\u83cc\uff09\u5171\u540c\u57f9\u990a\u5728\u540c\u4e00\u500b\u57f9\u990a\u76bf\u4e2d\uff0c\u4e26\u6301\u7e8c\u89c0\u5bdf\u5b83\u5011\u7684\u751f\u9577\u60c5\u5f62\u3002\u4f2f\u514b\u6c0f\u83cc\u5c6c\u7684\u7d30\u83cc\u6703\u5206\u6ccc\u4e00\u7a2e\u53eb\u505apyochelin\u7684\u7269\u8cea\uff0c\u6b64\u7269\u8cea\u5177\u6709\u87af\u5408\u9435\u96e2\u5b50\u53ca\u6291\u5236\u771f\u83cc\u751f\u9577\u7684\u529f\u80fd\u3002\u5728\u57f9\u990a\u521d\u671f\uff0c\u6211\u5011\u78ba\u5be6\u770b\u5230\u8910\u6839\u75c5\u83cc\u5728\u4ea4\u754c\u8655\u7684\u751f\u9577\u6709\u53d7\u5230\u6291\u5236\uff0c\u7136\u800c\uff0c\u5230\u4e86\u57f9\u990a\u5f8c\u671f\uff0c\u6b64\u6291\u5236\u73fe\u8c61\u537b\u9010\u6f38\u6d88\u5931\u3002\u900f\u904e\u5f71\u50cf\u8cea\u8b5c\u5206\u6790\u83cc\u843d\u4ea4\u754c\u908a\u7de3\u7684\u5206\u5b50\u7d44\u6210\uff0c\u6211\u5011\u767c\u73fe\u9760\u8fd1\u8910\u6839\u75c5\u83cc\u4e00\u5074\u7684pyochelin\u8a0a\u865f\uff08<em>m\/z<\/em> 325\uff09\u8b8a\u5f31\uff0c\u53cd\u800c\u51fa\u73fe\u53e6\u4e00\u5206\u5b50\u7684\u8a0a\u865f\uff08<em>m\/z<\/em> 383\uff09\uff08\u5716\u4e00\uff09\uff0c\u85c9\u7531\u9032\u4e00\u6b65\u7684\u7d50\u69cb\u89e3\u6790\uff0c\u6211\u5011\u5f97\u77e5\u6b64\u5206\u5b50\u662f\u7d93\u904e\u8f49\u63db\u4fee\u98fe\u7684pyochelin\u7d50\u69cb\u985e\u4f3c\u7269\uff08pyochelin-GA\uff09\u3002\u8207pyochelin\u76f8\u6bd4\uff0c\u6b64\u8f49\u63db\u7522\u7269\u7684\u6297\u771f\u83cc\u6d3b\u6027\u8207\u87af\u5408\u9435\u96e2\u5b50\u7684\u80fd\u529b\u660e\u986f\u964d\u4f4e\uff0c\u8b93\u8910\u6839\u75c5\u83cc\u5f97\u4ee5\u7e7c\u7e8c\u751f\u9577\u3002\u6545\u6b64\u8a66\u9a57\u5229\u7528\u5f71\u50cf\u8cea\u8b5c\u63d0\u4f9b\u4e4b\u7dda\u7d22\uff0c\u767c\u73fe\u8910\u6839\u75c5\u83cc\u53ef\u80fd\u900f\u904e\u9175\u7d20\u50ac\u5316\u4e4b\u5316\u5b78\u8f49\u63db\u65b9\u5f0f\u505a\u70ba\u5c0d\u6297\u7d30\u83cc\u7522\u7269pyochelin\u7684\u89e3\u6bd2\u6a5f\u5236\u3002\uff08\u53c3\u8003\u8cc7\u65995\uff09<\/p>\n<div id=\"attachment_21652\" style=\"width: 1034px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21652\" class=\"aligncenter size-large wp-image-24850\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2021\/06\/3-1-1024x638.png\" alt=\"\" width=\"1024\" height=\"638\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2021\/06\/3-1-1024x638.png 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2021\/06\/3-1-300x187.png 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2021\/06\/3-1-768x478.png 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2021\/06\/3-1-400x250.png 400w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2021\/06\/3-1-1080x672.png 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2021\/06\/3-1.png 1386w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">\u5716\u4e00\u3001\u4ee5\u5f71\u50cf\u8cea\u8b5c\u5206\u6790\u5171\u540c\u57f9\u990a\u4e4b\u7d30\u83cc\uff08<em>Burkholderia cenocepacia<\/em>\uff09\u8207\u771f\u83cc\uff08<em>Phellinus noxius<\/em>\uff09\u767c\u73fe\u5230\u690d\u7269\u75c5\u539f\u771f\u83cc\u7684\u89e3\u6bd2\u6a5f\u5236\u3002<\/p><\/div>\n<p><strong>\u5f71\u50cf\u8cea\u8b5c\u5728\u690d\u7269\u5206\u6790\u7684\u767c\u5c55\u548c\u9650\u5236<\/strong><\/p>\n<p>\u690d\u7269\u662f\u4e0d\u53ef\u6216\u7f3a\u7684\u5929\u7136\u5316\u5b78\u8cc7\u6e90\uff0c\u8a31\u591a\u690d\u7269\u4ee3\u8b1d\u7269\u5177\u6709\u85e5\u7406\u6d3b\u6027\uff0c\u662f\u81e8\u5e8a\u85e5\u7269\u6216\u662f\u4fdd\u5065\u98df\u54c1\u7684\u91cd\u8981\u539f\u6599\u4f86\u6e90\uff0c\u65e5\u5e38\u751f\u6d3b\u4e5f\u6709\u8a31\u591a\u4f86\u81ea\u690d\u7269\u4ee3\u8b1d\u7269\u7684\u884d\u751f\u7522\u54c1\uff0c\u4f8b\u5982\u9999\u6599\u3001\u7cbe\u6cb9\u3001\u8272\u7d20\uff0c\u53ca\u71df\u990a\u6210\u5206\u7b49\u3002\u4e8b\u5be6\u4e0a\uff0c\u690d\u7269\u4e4b\u6240\u4ee5\u6703\u751f\u7522\u5404\u5f0f\u5404\u6a23\u7684\u4ee3\u8b1d\u7269\uff0c\u8ddf\u690d\u7269\u672c\u8eab\u7684\u751f\u9577\u767c\u80b2\u53ca\u9632\u79a6\u6709\u95dc\uff0c\u56e0\u6b64\uff0c\u7d04\u5f9e2005\u5e74\u958b\u59cb\uff0c\u5f71\u50cf\u8cea\u8b5c\u4e5f\u958b\u59cb\u61c9\u7528\u65bc\u5206\u6790\u690d\u7269\u4ee3\u8b1d\u7269\u5728\u690d\u7269\u7d44\u7e54\u4e2d\u7684\u7a7a\u9593\u5206\u5e03\uff0c\u85c9\u4ee5\u4e86\u89e3\u4ee3\u8b1d\u7269\u7684\u751f\u7406\u529f\u80fd\u53ca\u5176\u751f\u5408\u6210\u9014\u5f91\uff0c\u4f8b\u5982\u63a2\u8a0e\u5728\u53d7\u5230\u5916\u754c\u50b7\u5bb3\u4e4b\u5340\u57df\u662f\u5426\u6703\u51fa\u73fe\u7279\u5b9a\u7684\u4ee3\u8b1d\u7269\u4ee5\u5354\u52a9\u9632\u79a6\u6216\u4fee\u5fa9\u7d44\u7e54\uff0c\u4ee5\u53ca\u89c0\u6e2c\u540c\u4e00\u690d\u7269\u7d44\u7e54\u5340\u57df\u4e2d\u4ee3\u8b1d\u7269\u7d44\u6210\u7684\u52d5\u614b\u8b8a\u5316\u6216\u5206\u5e03\uff0c\u5e6b\u52a9\u9451\u5b9a\u7279\u5b9a\u4ee3\u8b1d\u7269\u751f\u5408\u6210\u9014\u5f91\u4e2d\u7684\u524d\u9a45\u7269\u53ca\u76f8\u95dc\u4ee3\u8b1d\u7522\u7269\u3002\uff08\u53c3\u8003\u8cc7\u65996\uff09<\/p>\n<p>\u7136\u800c\uff0c\u8207\u52d5\u7269\u7d44\u7e54\u5206\u6790\u76f8\u6bd4\uff0c\u5f71\u50cf\u8cea\u8b5c\u904b\u7528\u65bc\u690d\u7269\u9818\u57df\u7684\u76f8\u5c0d\u6bd4\u4f8b\u5247\u5c11\u4e86\u8a31\u591a\uff0c\u9664\u4e86\u52d5\u7269\u7d44\u7e54\u5206\u6790\u8f03\u80fd\u76f4\u63a5\u8ddf\u81e8\u5e8a\u91ab\u5b78\u8a3a\u65b7\u61c9\u7528\u9023\u7d50\u7684\u56e0\u7d20\u5916\uff0c\u690d\u7269\u672c\u8eab\u7684\u751f\u7406\u69cb\u9020\u4e5f\u662f\u5c0e\u81f4\u5f71\u50cf\u8cea\u8b5c\u8f03\u4e0d\u6613\u61c9\u7528\u65bc\u690d\u7269\u9818\u57df\u7684\u4e3b\u56e0\u4e4b\u4e00\u3002\u76f8\u8f03\u65bc\u52d5\u7269\u7d44\u7e54\uff0c\u5927\u90e8\u5206\u690d\u7269\u7d44\u7e54\u7d30\u80de\u7684\u5916\u570d\u591a\u4e86\u5169\u5c64\u7269\u7406\u6027\u7684\u5c4f\u969c\uff0c\u5305\u542b\u7d30\u80de\u58c1\u8207\u89d2\u8cea\u5c64 \uff08cuticle\uff09\uff0c\u5728\u5f71\u50cf\u8cea\u8b5c\u5206\u6790\u4e2d\u963b\u7919\u4e86\u690d\u7269\u7d44\u7e54\u5167\u90e8\u5206\u5b50\u7684\u812b\u9644\u53ca\u6e38\u96e2\u3002\u6b64\u5916\uff0c\u690d\u7269\u7d44\u7e54\u9ad8\u542b\u6c34\u91cf\u7684\u7279\u5fb5\u4e5f\u5c0e\u81f4\u5176\u7d44\u7e54\u5207\u7247\u7684\u88fd\u5099\u96e3\u5ea6\u63d0\u9ad8\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u76ee\u524d\u5f71\u50cf\u8cea\u8b5c\u7684\u4e3b\u6d41\u6280\u8853 \uff08MALDI\uff09\u9700\u8981\u5728\u6a23\u54c1\u4e0a\u5916\u52a0\u57fa\u8cea\uff0c\u800c\u9019\u4e9b\u57fa\u8cea\u901a\u5e38\u662f\u5c0f\u5206\u5b50\u6709\u6a5f\u9178\uff0c\u5176\u5206\u5b50\u91cf\u7bc4\u570d\u8207\u690d\u7269\u4ee3\u8b1d\u7269\u76f8\u4f3c\uff0c\u6703\u7522\u751f\u660e\u986f\u7684\u80cc\u666f\u5e72\u64fe\u8a0a\u865f\uff0c\u800c\u690d\u7269\u4ee3\u8b1d\u7269\u7684\u7a2e\u985e\u591a\u6a23\u6027\u76f8\u7576\u9ad8\uff0c\u53ef\u80fd\u6703\u8207\u80cc\u666f\u8a0a\u865f\u91cd\u758a\uff0c\u9019\u4e9b\u7d9c\u5408\u56e0\u7d20\u5e38\u5e38\u5c0e\u81f4\u5206\u6790\u7d50\u679c\u4e0d\u6613\u5224\u8b80\u3002\u56e0\u6b64\uff0c\u958b\u767c\u9069\u7528\u65bc\u690d\u7269\u4ee3\u8b1d\u7269\u5206\u6790\u7684\u5f71\u50cf\u8cea\u8b5c\u65b9\u6cd5\u5c07\u6709\u52a9\u65bc\u5f71\u50cf\u8cea\u8b5c\u5728\u690d\u7269\u9818\u57df\u7684\u61c9\u7528\u767c\u5c55\u3002<\/p>\n<p><strong>\u958b\u767c\u4e26\u904b\u7528\u65b0\u7684\u5f71\u50cf\u8cea\u8b5c\u65b9\u6cd5\u5206\u6790\u690d\u7269\u82b1\u74e3\u4e2d\u7684\u5c0f\u5206\u5b50\u4ee3\u8b1d\u7269<\/strong><\/p>\n<p>\u82e5\u60f3\u91dd\u5c0d\u690d\u7269\u4ee3\u8b1d\u7269\u9032\u884c\u5206\u6790\uff0c\u9996\u5148\u8981\u514b\u670d\u80cc\u666f\u8a0a\u865f\u5e72\u64fe\u7684\u554f\u984c\uff0c\u56e0\u6b64\u6211\u5011\u904b\u7528\u4e86\u8868\u9762\u8f14\u52a9\u96f7\u5c04\u812b\u9644\u6e38\u96e2\u6cd5\uff08surface-assisted laser desorption\/ionization\uff0c\u7c21\u7a31SALDI\uff09\uff0c\u6b64\u65b9\u6cd5\u7684\u7279\u9ede\u662f\u4e0d\u9700\u5916\u52a0\u57fa\u8cea\uff0c\u76f4\u63a5\u5c07\u6a23\u54c1\u7f6e\u65bc\u7279\u6b8a\u4ecb\u8cea\u7684\u8868\u9762\uff0c\u5373\u53ef\u5728\u96f7\u5c04\u6fc0\u767c\u4e0b\u4fc3\u4f7f\u6a23\u54c1\u5167\u5316\u5b78\u5206\u5b50\u7684\u812b\u9644\u53ca\u6e38\u96e2\u3002\u6211\u5011\u4ee5\u5e02\u552e\u7684\u91d1\u5c6c\u9226\u8584\u7247\u70ba\u539f\u6599\uff0c\u958b\u767c\u4e86\u4e00\u7a2e\u904b\u7528\u65bcSALDI\u7684\u65b0\u578b\u7279\u6b8a\u4ecb\u8cea\uff0c\u662f\u7d93\u904e\u5f37\u9e7c\u8755\u523b\u53ca\u5316\u5b78\u4fee\u98fe\uff0c\u8868\u9762\u5177\u6709\u5948\u7c73\u5b54\u9699\u7684\u4e8c\u6c27\u5316\u9226\u677f\u5b50\uff0c\u4e0d\u6703\u7522\u751f\u80cc\u666f\u8a0a\u865f\u5e72\u64fe\uff0c\u9069\u7528\u65bc\u5c0f\u5206\u5b50\u4ee3\u8b1d\u7269\u5206\u6790\u3002\u6211\u5011\u9078\u7528\u53ef\u4ee5\u751f\u7522\u6297\u764c\u85e5\u7269\u7684\u690d\u7269\u2014\u65e5\u65e5\u6625\u7684\u82b1\u74e3\u505a\u6e2c\u8a66\uff0c\u5148\u5c07\u82b1\u74e3\u5e73\u653e\u65bc\u4e8c\u6c27\u5316\u9226\u677f\u5b50\u4e0a\uff0c\u518d\u4ee5\u5e73\u53e3\u9257\u65bd\u52a0\u5916\u529b\u7684\u65b9\u5f0f\u4f7f\u82b1\u74e3\u5167\u7684\u7269\u8cea\u8f49\u5370\u81f3\u677f\u5b50\u8868\u9762\uff0c\u79fb\u9664\u82b1\u74e3\u6b98\u9ad4\u5f8c\u5373\u53ef\u9032\u884c\u5f71\u50cf\u8cea\u8b5c\u5206\u6790\uff0c\u4e26\u540c\u6642\u53bb\u9664\u4e86\u690d\u7269\u7d30\u80de\u58c1\u8207\u89d2\u8cea\u5c64\u7684\u5c4f\u969c\u3002\u5206\u6790\u7d50\u679c\u767c\u73fe\uff0c\u8207\u65e5\u65e5\u6625\u4e4b\u6297\u764c\u6210\u5206\u76f8\u95dc\u7684\u4ee3\u8b1d\u7269\uff08<em>m\/z<\/em> 349\u3001457\u3001793\uff09\u8a0a\u865f\u5f37\u5ea6\uff08\u76f8\u5c0d\u542b\u91cf\uff09\u5728\u4e0d\u540c\u5340\u57df\u6709\u9ad8\u4f4e\u8b8a\u5316\uff0c\u4ee3\u8868\u5176\u5728\u82b1\u74e3\u4e2d\u7684\u5206\u5e03\u6709\u6240\u4e0d\u540c\uff08\u5716\u4e8c\uff09\uff0c\u4e5f\u8b49\u5be6\u6211\u5011\u9019\u4e00\u5957\u65b0\u958b\u767c\u7684\u5f71\u50cf\u8cea\u8b5c\u65b9\u6cd5\u78ba\u5be6\u9069\u7528\u65bc\u63a2\u8a0e\u690d\u7269\u7d44\u7e54\u4e2d\u7684\u4ee3\u8b1d\u7269\u5206\u5e03\uff0c\u70ba\u690d\u7269\u9818\u57df\u7684\u5f71\u50cf\u8cea\u8b5c\u61c9\u7528\u63d0\u4f9b\u65b0\u7684\u5206\u6790\u7b56\u7565\u3002\uff08\u53c3\u8003\u8cc7\u65997\uff09<\/p>\n<p>\u672a\u4f86\uff0c\u6211\u5011\u671f\u8a31\u5f71\u50cf\u8cea\u8b5c\u5728\u52d5\u7269\u3001\u5fae\u751f\u7269\u6216\u690d\u7269\u5206\u6790\u4e0a\u7686\u80fd\u767c\u5149\u767c\u71b1\uff0c\u5e6b\u52a9\u4eba\u5011\u89e3\u7b54\u7279\u5b9a\u5206\u5b50\u5206\u5e03\u8207\u751f\u7406\u6216\u75c5\u7406\u4e0a\u7684\u95dc\u806f\uff0c\u4e26\u63a2\u52d8\u66f4\u591a\u6709\u52a9\u65bc\u8fb2\u696d\u7522\u696d\u61c9\u7528\u8207\u4eba\u985e\u5065\u5eb7\u7684\u5316\u5b78\u8cc7\u6e90\u3002<\/p>\n<div id=\"attachment_21652\" style=\"width: 996px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21652\" class=\"aligncenter size-large wp-image-24851\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2021\/06\/3-2-986x1024.png\" alt=\"\" width=\"986\" height=\"1024\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2021\/06\/3-2-986x1024.png 986w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2021\/06\/3-2-289x300.png 289w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2021\/06\/3-2-768x798.png 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2021\/06\/3-2-1080x1122.png 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2021\/06\/3-2.png 1387w\" sizes=\"(max-width: 986px) 100vw, 986px\" \/><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">\u5716\u4e8c\u3001\u5f71\u50cf\u8cea\u8b5c\u5206\u6790\u65e5\u65e5\u6625\u82b1\u74e3\u53ca\u5176\u6297\u764c\u6210\u5206\u4e4b\u751f\u5408\u6210\u524d\u9a45\u7269\u7684\u5206\u4f48\u3002<\/p><\/div>\n<p>\u53c3\u8003\u8cc7\u6599<br \/>\n1.Mass Spectrom Rev, 2016, 35, 147\u2013169. <a href=\"https:\/doi.org\/10.1002\/mas.21468\">https:\/doi.org\/10.1002\/mas.21468<\/a><br \/>\n2.Nat Prod Rep, 2014, 31, 739\u2013755. <a href=\"https:\/doi.org\/10.1039\/c3np70091g\">https:\/doi.org\/10.1039\/c3np70091g<\/a><br \/>\n3.J Nat Prod, 2018, 81, 1527\u20131533. <a href=\"https:\/doi.org\/10.1021\/acs.jnatprod.7b00866\">https:\/doi.org\/10.1021\/acs.jnatprod.7b00866<\/a><br \/>\n4.Sci Rep, 2015, 5, 12856. <a href=\"https:\/doi.org\/10.1038\/srep12856\">https:\/doi.org\/10.1038\/srep12856<\/a><br \/>\n5.ISME J, 2021. <a href=\"https:\/doi.org\/10.1038\/s41396-020-00871-0\">https:\/doi.org\/10.1038\/s41396-020-00871-0<\/a><br \/>\n6.Phytochem Rev, 2016, 15, 445\u2013488. <a href=\"https:\/doi.org\/10.1007\/s11101-015-9440-2\">https:\/doi.org\/10.1007\/s11101-015-9440-2<\/a><br \/>\n7.Plant J, 2021, 105, 1123\u20131133. <a href=\"https:\/doi.org\/10.1111\/tpj.15092\">https:\/doi.org\/10.1111\/tpj.15092<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4fd7\u8afa\u6709\u4e91\uff1a\u300c\u773c\u898b\u70ba\u6191\u300d\uff0c\u82f1\u6587\u5247\u8aaa\u201cSeeing is believing\u201d\uff0c\u5c07\u55ae\u8abf\u7684\u79d1\u5b78\u5206\u6790\u6578\u503c\u8f49\u63db\u70ba\u5e73\u6613\u8fd1\u4eba [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":24872,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[991,983],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/24848"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=24848"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/24848\/revisions"}],"predecessor-version":[{"id":24849,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/24848\/revisions\/24849"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/24872"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=24848"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=24848"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=24848"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}