{"id":24696,"date":"2021-06-03T00:03:48","date_gmt":"2021-06-02T16:03:48","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=24696"},"modified":"2021-09-30T11:34:50","modified_gmt":"2021-09-30T03:34:50","slug":"%e3%80%90%e6%bc%94%e8%ac%9b%e5%81%b4%e8%a8%98%e3%80%91%e3%80%8c%e5%a4%a7%e6%95%b8%e6%93%9a%e7%a7%91%e5%ad%b8%e8%ae%93%e6%96%b0%e5%86%a0%e7%97%85%e6%af%92%e7%8f%be%e5%bd%a2%e3%80%8d","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/24696\/","title":{"rendered":"\u3010\u6f14\u8b1b\u5074\u8a18\u3011\u300c\u5927\u6578\u64da\u79d1\u5b78\u8b93\u65b0\u51a0\u75c5\u6bd2\u73fe\u5f62\u300d"},"content":{"rendered":"

\u70ba\u63a8\u5ee3\u79d1\u666e\u77e5\u8b58\uff0c\u672c\u9662\u81ea94\u5e74\u8d77\uff0c\u6bcf\u5e74\u5b9a\u671f\u63a8\u85a6\u672c\u9662\u9662\u58eb\u6216\u7814\u7a76\u4eba\u54e1\u81f3\u9ad8\u4e2d\u6f14\u8b1b\uff0c\u8207\u5e74\u8f15\u5b78\u5b50\u4ea4\u6d41\u4e92\u52d5\uff0c\u4ee5\u6df1\u5165\u6dfa\u51fa\u7684\u65b9\u5f0f\u5206\u4eab\u5b78\u8853\u7814\u7a76\u6210\u679c\u3002<\/strong><\/p>\n

\u4eca\uff08110\uff09\u5e744\u67087\u65e5\uff0c\u672c\u9662\u7d71\u8a08\u79d1\u5b78\u7814\u7a76\u6240\u694a\u6b23\u6d32\u7814\u7a76\u54e1\u53d7\u9080\u524d\u5f80\u81fa\u5357\u4e00\u4e2d\uff0c\u64d4\u4efb\u7af9\u5712\u5b78\u8853\u8b1b\u5ea7\u4e3b\u8b1b\u4eba\uff0c\u4e3b\u8b1b\u300c\u5927\u6578\u64da\u79d1\u5b78\u8b93\u65b0\u51a0\u75c5\u6bd2\u73fe\u5f62\u300d\uff0c\u7531\u8a72\u6821\u4e00\u5e74\u7d1a\u5f90\u5146\u5ef7\u540c\u5b78\u64b0\u5beb\u5074\u8a18\u53ca\u5fc3\u5f97\uff0c\u5167\u5bb9\u5982\u4e0b\uff1a<\/strong><\/p>\n

\u5728COVID-19\u75ab\u60c5\u8086\u8650\u5168\u7403\u4e0b\uff0c\u8a31\u591a\u570b\u5bb6\u5206\u5225\u7814\u767c\u75ab\u82d7\uff0c\u4f46\u96a8\u8457\u75be\u75c5\u7684\u50b3\u64ad\u8207\u6d41\u884c\uff0c\u75c5\u6bd2\u958b\u59cb\u51fa\u73fe\u5404\u7a2e\u8b8a\u7570\u4e26\u7522\u751f\u4e0d\u540c\u7684\u57fa\u56e0\u9ad4\u3001\u751f\u7269\u7279\u5fb5\u3001\u578b\u614b\u3002\u800c\u694a\u7814\u7a76\u54e1\u8aaa\u660e\u4ed6\u8207\u7814\u7a76\u5718\u968a\u662f\u5982\u4f55\u904b\u7528\u5927\u6578\u64da\u79d1\u5b78\uff08Big data analysis\uff09\u5c07\u75c5\u6bd2\u5206\u985e\u3001\u8ffd\u8e64\uff0c\u4e26\u61c9\u7528\u6b64\u6280\u8853\u3002<\/p>\n

\uff08\u4e00\uff09\u70ba\u4f55\u9700\u8981\u5229\u7528\u5927\u6578\u64da\u79d1\u5b78\u5206\u6790\u548c\u8ffd\u8e64\u65b0\u51a0\u75c5\u6bd2\uff1f<\/p>\n

\u65b0\u51a0\u75c5\u6bd2\u7684\u907a\u50b3\u7269\u8cea\u70baRNA\uff0c\u4e14\u5bb9\u6613\u767c\u751f\u7a81\u8b8a\u3002\u5728\u4e16\u754c\u5404\u5730\u50b3\u64ad\u6642\u6703\u7522\u751f\u5404\u7a2e\u4e0d\u540c\u7684\u7a81\u8b8a\u7a2e\u5982\uff1a\u5357\u975e\u8b8a\u7a2e\u3001\u82f1\u570b\u8b8a\u7a2e\u7b49\uff0c\u800c\u4e0d\u540c\u7684\u8b8a\u7a2e\u6709\u4e0d\u540c\u7684\u57fa\u56e0\uff0c\u56e0\u6b64\u6709\u4e0d\u540c\u7684\u751f\u7269\u7279\u5fb5\u6216\u69cb\u9020\uff0c\u9032\u800c\u9020\u6210\u5728\u7fa4\u9ad4\u4e2d\u50b3\u67d3\u529b\u3001\u81f4\u6b7b\u7387\u53ca\u75c7\u72c0\u4e0d\u540c\u7684\u5f71\u97ff\u3002<\/p>\n

\u4ee5\u5728\u7fa4\u9ad4\u4e2d\u7684\u50b3\u67d3\u80fd\u529b\u70ba\u4f8b\uff0c\u75c5\u6bd2\u4fb5\u5165\u7d30\u80de\u6642\uff0c\u4ef0\u8cf4\u75c5\u6bd2\u8868\u9762\u7279\u7570\u6027\u9ad8\u7684\u523a\u7a81\u86cb\u767d\uff08Spike protein\uff09\u8207\u7d30\u80de\u8868\u9762\u7684\u8840\u7ba1\u6536\u7e2e\u7d20\u8f49\u5316\u91762\uff08Angiotensin-converting enzyme 2, ACE2\uff09\u7d50\u5408\uff08\u5716\u4e00\uff09\uff0c\u4e5f\u5c31\u662f\u5c07ACE2\u4f5c\u70ba\u53d7\u9ad4\u4fb5\u5165\u7d30\u80de\uff08\u5716\u4e8c\uff09\u3002\u85c9\u7531\u6b64\u65b9\u5f0f\uff0c\u88fd\u9020\u985e\u4f3c\u65bc\u75c5\u6bd2\u523a\u7a81\u86cb\u767d\u4e4b\u7269\u8cea\uff0c\u4fc3\u4f7f\u514d\u75ab\u53cd\u61c9\u767c\u751f\uff0c\u4e26\u5f15\u8d77\u5c08\u4e00\u6027\u9632\u79a6\uff0c\u5373\u75ab\u82d7\u7684\u4f5c\u7528\u65b9\u5f0f\u3002\u800c\u7576\u75c5\u6bd2\u767c\u751f\u8b8a\u7a2e\u6642\uff0c\u5176\u523a\u7a81\u86cb\u767d\u53ef\u80fd\u56e0\u6b64\u6539\u8b8a\uff0c\u800c\u964d\u4f4e\u5148\u524d\u6ce8\u5c04\u4e4b\u75ab\u82d7\u6240\u9020\u6210\u7684\u5c08\u4e00\u6027\u9632\u79a6\u529f\u6548\u3002<\/p>\n

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\u5716\u4e00\uff1a\u8840\u7ba1\u6536\u7e2e\u7d20\u8f49\u5316\u91762\uff08Angiotensin-converting enzyme 2, ACE2\uff09
\u8cc7\u6599\u4f86\u6e90\uff1aWikipedia. Structure of the ACE2 protein. (Dec.15, 2009)
Retrieved from https:\/en.wikipedia.org\/wiki\/File:Protein_ACE2_PDB_1r42.png<\/a><\/p><\/div>\n

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\u5716\u4e8c\uff1a\u65b0\u51a0\u75c5\u6bd2\u4fb5\u5165\u7d30\u80de\u904e\u7a0b
\u8cc7\u6599\u4f86\u6e90\uff1a\u300c\u7814\u4e4b\u6709\u7269\u300dhttps:\/research.sinica.edu.tw\/covid19-p3lab-academiasinica\/<\/a><\/p><\/div>\n

\u6545\u76f8\u540c\u7684\u75ab\u82d7\u5c0d\u65bc\u4e0d\u540c\u7684\u8b8a\u7a2e\u75c5\u6bd2\u5728\u4eba\u9ad4\u4e0a\u7684\u529f\u6548\u5177\u6709\u5dee\u7570\uff0c\u9700\u85c9\u7531\u75c5\u6bd2\u7684\u523a\u7a81\u86cb\u767d\u8a2d\u8a08\u75ab\u82d7\uff0c\u624d\u80fd\u9054\u5230\u6700\u4f73\u7684\u7642\u6548\u3002\u56e0\u6b64\u624d\u9808\u5c07\u65b0\u51a0\u75c5\u6bd2\u9032\u884c\u5206\u985e\uff0c\u4ee5\u5229\u8ffd\u8e64\u8207\u88fd\u9020\u75ab\u82d7\uff0c\u800c\u5927\u6578\u64da\u5206\u6790\u6070\u70ba\u59a5\u7576\u5206\u6790\u8b8a\u7a2e\u75c5\u6bd2\u9593\u7684\u89aa\u7de3\u95dc\u4fc2\u8207\u6f14\u5316\u6b77\u7a0b\uff0c\u65b9\u4fbf\u9032\u884c\u75c5\u6bd2\u8b8a\u7a2e\u8ffd\u8e64\u8207\u985e\u5225\u5206\u6790\u3002<\/p>\n

\uff08\u4e8c\uff09\u5982\u4f55\u53d6\u5f97\u5206\u6790\u65b0\u51a0\u75c5\u6bd2\u4e4b\u8cc7\u6599\u5eab\uff1f<\/p>\n

\u5206\u6790\u524d\uff0c\u5176\u4e2d\u4e00\u9805\u95dc\u9375\u8981\u7d20\u70ba\u5efa\u7acb\u8cc7\u6599\u5eab\u3002\u65b0\u51a0\u80ba\u708e\u75c5\u6bd2\u662fRNA\u75c5\u6bd2\uff0c\u6545\u5176\u907a\u50b3\u5bc6\u78bc\u7531\u56db\u7a2e\u9e7c\u57fa\u7d44\u6210\uff0c\u5206\u5225\u70ba\u817a\u560c\u5464\uff08Adenine, A\uff09\u3001\u8132\u5627\u5576\uff08Uracil, U\uff09\u3001\u9ce5\u560c\u5464\uff08Guanine, G\uff09\u3001\u80de\u5627\u5576\uff08Cytosine, C\uff09\u69cb\u6210\u3002\u65b0\u51a0\u75c5\u6bd2\u7684\u907a\u50b3\u5e8f\u5217\u4e2d\u5171\u6709\u7d0430,000\u500b\u9e7c\u57fa\u3002\u7576\u4e16\u754c\u5404\u5730\u7684\u91ab\u751f\u5728\u75c5\u60a3\u8eab\u4e0a\u63a1\u6aa2\u5f8c\uff0c\u5c07\u75c5\u6bd2\u7684\u907a\u50b3\u7269\u8cea\u5b9a\u5e8f\uff0c\u4e26\u7d93\u904e\u7be9\u6aa2\u5f8c\u4e0a\u50b3\u81f3\u5168\u7403\u5171\u4eab\u6d41\u611f\u6578\u64da\u5021\u8b70\u7d44\u7e54\uff08GISAID\uff09\uff0c\u4ee5\u516c\u958b\u4f86\u81ea\u4e16\u754c\u5404\u5730\u7684\u75c5\u6bd2\u5e8f\u5217\u8cc7\u8a0a\uff0c\u4f7f\u4e0d\u540c\u5be6\u9a57\u5ba4\u7686\u80fd\u9032\u884c\u75c5\u6bd2\u5e8f\u5217\u5206\u6790\u3002\u5728\u75ab\u60c5\u7206\u767c\u6700\u521d\uff0c\u50c5\u6709\u7d041,000\u7d44\u75c5\u6bd2\u5e8f\u5217\uff0c\u800c\u96a8\u8457\u75ab\u60c5\u8513\u5ef6\uff0c\u81f3\u4eca\u5df2\u7d2f\u8a08\u8d85\u8d8a\u4e00\u767e\u842c\u7d44\u75c5\u6bd2\u5e8f\u5217\u53ef\u4f9b\u5206\u6790\uff0c\u4f7f\u8cc7\u6599\u5eab\u66f4\u52a0\u9f4a\u5168\u3002<\/p>\n

\uff08\u4e09\uff09\u5982\u4f55\u6bd4\u8f03\u75c5\u6bd2\u89aa\u7de3\u95dc\u4fc2\u3001\u6b78\u985e\u53ca\u5efa\u7acb\u6f14\u5316\u6a39\uff1f<\/p>\n

\u9996\u5148\uff0c\u79d1\u5b78\u5bb6\u5c07\u5728\u4e2d\u570b\u6b66\u6f22\u63a1\u53d6\u5230\u7684\u6700\u521d\u75c5\u6bd2\u5e8f\u5217\u8a02\u70ba\u6b66\u6f22\u4e00\u865f\uff0c\u5c07\u5176\u4ed6\u75c5\u6bd230,000\u500b\u9e7c\u57fa\u8207\u5176\u9010\u4e00\u6bd4\u8f03\uff0c\u5c07\u4e0d\u540c\u8005\u5217\u70ba1\uff0c\u76f8\u540c\u8005\u5217\u70ba0\u3002\u5247\u6bcf\u4e00\u5247\u75c5\u6bd2\u5e8f\u5217\u53ef\u5f9730,000\u500b\u4e0d\u540c\u7684\u8b8a\u6578\u3002\u800c\u7d2f\u8a08\u81f3\u4eca\u7684\u8cc7\u6599\u5eab\uff0c\u8a72\u8cc7\u6599\u5c07\u8b8a\u70ba\u77e9\u9663\uff0c\u5c07\u5176\u77e9\u9663\u8996\u89ba\u5316\uff08\u5716\u4e09\uff09\uff0c\u6bcf\u985e\u578b\u4e2d\u7684\u76f4\u7dda\u70ba\u4e0d\u540c\u75c5\u6bd2\u682a\u9593\u76f8\u540c\u67d0\u7279\u5b9a\u57fa\u56e0\u8b8a\u7570\u9020\u6210\uff0c\u4e26\u53ef\u5206\u985e\u51fa\u516d\u5927\u985e\u75c5\u6bd2\u3002\u5982\u540c\u5728\u4e0b\u5716\u4e4b\u4e2d\u53ef\u77e5\u7b2c\u4e94\u985e\u75c5\u6bd2\u64c1\u6709\u5171\u540c\u7684\u907a\u50b3\u7279\u5fb5\u662f\u7de8\u865f1397\u8207\u7de8\u865f11083\u820728688\u4e4b\u9e7c\u57fa\u767c\u751f\u8b8a\u7570\uff1b\u800c\u7b2c\u56db\u985e\u75c5\u6bd2\u5247\u662f\u64c1\u6709\u5728\u7de8\u865f8782\u300117747\u300117858\u300118060\u300128144\u4e4b\u9e7c\u57fa\u907a\u50b3\u8b8a\u7570\u6240\u81f4\u3002<\/p>\n

\u5c071,932\u682a\u75c5\u6bd2\u682a\u4f9d\u64da\u5176\u57fa\u56e0\u5e8f\u5217\u5efa\u7acb\u89aa\u7de3\u95dc\u4fc2\u6a39\uff0c\u4e26\u5c07\u89aa\u7de3\u95dc\u4fc2\u6a39\u8207\u5df2\u8996\u89ba\u5316\u4e4b\u77e9\u9663\u5408\u4f75\u5f8c\uff0c\u767c\u73fe\u5169\u8005\u7d50\u679c\u5341\u5206\u543b\u5408\u3002\u800c\u4f9d\u7167\u5169\u8005\u4e92\u76f8\u6bd4\u5c0d\u5373\u53ef\u4f5c\u70ba\u8fa8\u8b58\u7a81\u8b8a\u7a2e\u4e4b\u4f9d\u64da\uff0c\u53ef\u660e\u78ba\u6b78\u985e\u51fa\u516d\u5927\u985e\u65b0\u51a0\u75c5\u6bd2\u7a81\u8b8a\u7a2e\u53ca\u5176\u4e9e\u7a2e\uff08\u5716\u56db\uff09\u3002\u5982\u5728\u7b2c\u516d\u578b\u7a81\u8b8a\u7a2e\u4e2d\u53ef\u767c\u73fe\u8b8a\u7570\u9e7c\u57fa\u7de8\u865f1059\u300125563\u7684\u4e9e\u8b8a\u7570\u7a2e\u548c\u8b8a\u7570\u9e7c\u57fa\u7de8\u865f28881\u300128882\u300128883\u7684\u4e9e\u8b8a\u7570\u7a2e\uff0c\u4f46\u9664\u6b64\u4e4b\u5916\u4ecd\u6709\u8a31\u591a\u4e0d\u540c\u75c5\u6bd2\u682a\u5177\u6709\u76f8\u540c\u7684\u9e7c\u57fa\u8b8a\u7570\uff0c\u537b\u672a\u88ab\u6b78\u985e\u70ba\u67d0\u4e9e\u7a2e\uff0c\u662f\u7531\u65bc\u4e9e\u7a2e\u7684\u5206\u985e\u4ecd\u8f03\u4f9d\u9760\u89aa\u7de3\u95dc\u4fc2\u6a39\u7684\u8fa8\u8b58\u3002<\/p>\n

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\u5716\u4e09\uff1aVariation matrix map and viral strain type.\uff08Yang. et al<\/em> 2020\uff09<\/p><\/div>\n

\u4f46\u5728\u5206\u6790\u8cc7\u6599\u6642\uff0c\u694a\u7814\u7a76\u54e1\u8207\u5176\u5718\u968a\u9762\u81e8\u4e86\u8cc7\u6599\u91cf\u904e\u5927\u7684\u56f0\u96e3\u3002\u570b\u5bb6\u9ad8\u901f\u7db2\u8def\u8207\u8a08\u7b97\u4e2d\u5fc3\u7121\u6cd5\u5206\u679038,248*30,000\u4e4b\u77e9\u9663\uff0c\u800c\u694a\u7814\u7a76\u54e1\u5247\u5229\u7528\u76f4\u63a5\u6bd4\u5c0d\u67d0\u7279\u5b9a\u57fa\u56e0\uff08\u5982\u4e0a\u8ff0\u53ef\u9451\u5b9a\u7a2e\u985e\u7684\u57fa\u56e0\uff0c\u5373\u4e0a\u5716\u4e2d\u4e0d\u540c\u57fa\u56e0\u70ba\u6240\u9023\u6210\u7684\u76f4\u7dda\uff09\uff0c\u4ee5\u53ca\u57fa\u56e0\u5e8f\u5217\u9593\u5169\u5169\u6bd4\u5c0d\u4ee5\u6e1b\u5c11\u8a08\u7b97\u91cf\u3002\u5728\u5f97\u5230\u5e7e\u4e4e\u76f8\u540c\u7684\u7814\u7a76\u6548\u679c\u524d\u63d0\u4e0b\uff0c\u5927\u5e45\u5ea6\u964d\u4f4e\u4e86\u5206\u6790\u6642\u9593\u3002\u900f\u904e\u4f7f\u7528\u4e0d\u540c\u7684\u5206\u6790\u65b9\u5f0f\uff0c\u5118\u7ba1\u5206\u6790\u6a23\u672c\u6578\u589e\u52a0\uff0c\u5206\u6790\u6642\u9593\u4ecd\u964d\u4f4e\uff08\u8868\u4e00\uff09\u3002<\/p>\n

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\u5716\u56db\uff1aMaximum parsimony dendrogram, variation matrix map and defined six types for 1,932 SARS-CoV-2 viral strains.\uff08Yang. et al<\/em> 2020\uff09<\/p><\/div>\n

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\u8868\u4e00\uff1aNumber and proportion of the SARS-CoV-2 strains in our defined six types.\uff08Yang. et al<\/em> 2020\uff09<\/p><\/div>\n

\uff08\u56db\uff09\u76ee\u524d\u4e16\u754c\u76db\u884c\u54ea\u4e00\u985e\u578b\u7a81\u8b8a\u7a2e\uff0c\u4ee5\u53ca\u5176\u57fa\u56e0\u7279\u5fb5\uff1f<\/p>\n

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\"\"

\u5716\u4e94\uff1aTemporal distributions of the six types.\uff08Yang. et al<\/em> 2020\uff09<\/p><\/div>\n

\u5fc3\u5f97<\/strong>
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