{"id":24134,"date":"2021-03-11T00:03:11","date_gmt":"2021-03-10T16:03:11","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=24134"},"modified":"2021-07-19T08:35:53","modified_gmt":"2021-07-19T00:35:53","slug":"%e8%88%87%e7%99%8c%e7%b4%b0%e8%83%9e%e3%80%8c%e6%96%b7%e6%8d%a8%e9%9b%a2%e3%80%8d-%e6%9c%ac%e9%99%a2%e5%81%95%e4%b8%ad%e9%86%ab%e5%a4%a7%e5%90%88%e6%88%90%e8%83%9c%e8%82%bd%e5%88%86%e5%ad%90","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/24134\/","title":{"rendered":"\u8207\u764c\u7d30\u80de\u300c\u65b7\u6368\u96e2\u300d! \u672c\u9662\u5055\u4e2d\u91ab\u5927\u5408\u6210\u80dc\u80bd\u5206\u5b50 \u6709\u6548\u6291\u5236\u80f0\u81df\u764c\u7d30\u80de\u8f49\u79fb"},"content":{"rendered":"
\"\"

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\u80f0\u81df\u764c\u5b58\u6d3b\u7387\u4f4e\uff0c\u662f\u6538\u95dc\u5168\u4eba\u985e\u5065\u5eb7\u7684\u91cd\u5927\u8b70\u984c\u3002\u674e\u6587\u83ef\u9662\u58eb\u5e36\u9818\u7684\u7814\u7a76\u5718\u968a\u66fe\u65bc2015\u5e74\u767c\u73fe\uff0c\u80f0\u81df\u764c\u816b\u7624\u7d30\u80de\u7684\u7d30\u80de\u819c\u4e0a\u6703\u51fa\u73fe\u5927\u91cf\u53d7\u9ad4\uff08\u8a3b\u4e00\uff09\u300cIL-17RB\u300d\uff0c\u8207\u914d\u9ad4\u76f8\u4e92\u7d50\u5408\u5f8c\uff0c\u4fbf\u6703\u555f\u52d5\u4e00\u9023\u4e32\u53cd\u61c9\uff0c\u523a\u6fc0\u7d30\u80de\u589e\u751f\u6216\u8f49\u79fb\u3002\u5718\u968a\u64da\u6b64\u7814\u767c\u6297\u9ad4\u85e5\u7269\uff0c\u85c9\u7531\u6e1b\u5c11IL-17RB\u8207\u914d\u9ad4\u300cIL17B\u300d\u7d50\u5408\u6a5f\u6703\uff0c\u964d\u4f4e\u764c\u7d30\u80de\u8f49\u79fb\u6a5f\u7387\u3002\u947d\u7814\u80f0\u81df\u764c\u591a\u5e74\u3001\u540c\u6642\u4e5f\u662f\u5718\u968a\u6210\u54e1\u7684\u672c\u9662\u57fa\u56e0\u9ad4\u4e2d\u5fc3\u80e1\u6625\u7f8e\u52a9\u7814\u7a76\u54e1\u8868\u793a\uff0c\u7576\u6642\u5df2\u78ba\u8a8d\u53d7\u9ad4IL-17RB\u662f\u523a\u6fc0\u80f0\u81df\u764c\u7d30\u80de\u8f49\u79fb\u7684\u91cd\u8981\u56e0\u7d20\uff0c\u4f46\u4ecd\u4e0d\u6e05\u695a\u5206\u5b50\u5167\u90e8\u7684\u8a0a\u606f\u50b3\u905e\u6a5f\u5236\u3002\u5718\u968a\u53c3\u8003\u80ba\u764c\u300c\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08EGFR\uff09\u300d\uff08\u8a3b\u4e8c\uff09\u6291\u5236\u5291\u7684\u7814\u767c\u6b77\u7a0b\u5f8c\uff0c\u8a8d\u70ba\u6b64\u9805\u80f0\u81df\u764c\u7814\u7a76\u503c\u5f97\u6301\u7e8c\u63a8\u9032\uff0c\u4ee5\u9032\u4e00\u6b65\u6539\u5584\u80f0\u81df\u764c\u6cbb\u7642\u6548\u679c\u3002<\/p>\n

\u5f8c\u7e8c\u7814\u7a76\u767c\u73fe\uff0cIL-17RB\u4e0d\u50c5\u51fa\u73fe\u5728\u764c\u7d30\u80de\u4e0a\uff0c\u4e5f\u6703\u51fa\u73fe\u5728\u6b63\u5e38\u514d\u75ab\u8f14\u52a9\u578bT\u7d30\u80de\uff08Th2\uff09\u4e0a\uff0c\u800c\u4e14\u514d\u75ab\u7d30\u80de\u82e5\u7f3a\u4e4fIL-17RB\uff0c\u53cd\u800c\u5f71\u97ff\u514d\u75ab\u8a0a\u606f\u50b3\u905e\uff0c\u5c0e\u81f4\u4eba\u9ad4\u5bb9\u6613\u53d7\u5fae\u751f\u7269\u611f\u67d3\u3002\u56e0\u6b64\uff0c\u6700\u4f73\u6cbb\u7642\u65b9\u6cd5\u662f\u4e86\u89e3IL-17RB\u65bc\u764c\u7d30\u80de\u8207\u514d\u75ab\u7d30\u80de\u4e0a\u7684\u5dee\u7570\uff0c\u518d\u767c\u5c55\u6a19\u9776\u85e5\u7269\u3002\u5982\u6b64\u4e00\u4f86\uff0c\u53ef\u5728\u4e0d\u5f71\u97ff\u60a3\u8005\u514d\u75ab\u80fd\u529b\u7684\u524d\u63d0\u4e0b\uff0c\u540c\u6642\u9632\u7bc4\u764c\u7d30\u80de\u64f4\u6563\u3002<\/p>\n

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\u672c\u7814\u7a76\u8ad6\u6587\u70ba \u201cCharacterization of Initial Key Steps of IL-17 Receptor B Oncogenic Signaling for Targeted Therapy of Pancreatic Cancer\u201d\u3002\u7814\u7a76\u5718\u968a\u6210\u54e1\u6709\u672c\u9662\u674e\u6587\u83ef\u9662\u58eb\u3001\u80e1\u6625\u7f8e\u52a9\u7814\u7a76\u54e1\u548c\u6c88\u5bb6\u5be7\u526f\u7814\u7a76\u54e1\uff1b\u4e2d\u570b\u91ab\u85e5\u5927\u5b78\u5433\u6052\u7965\u52a9\u7406\u6559\u6388\uff1b\u81fa\u5927\u91ab\u9662\u7530\u90c1\u6587\u91ab\u5e2b\u3001\u5f35\u6bd3\u5ef7\u91ab\u5e2b\u3001\u7ae0\u660e\u73e0\u91ab\u5e2b\u548c\u912d\u6c38\u9298\u91ab\u5e2b\u3002<\/p>\n

\u8ad6\u6587\u5168\u6587\uff1ahttps:\/stm.sciencemag.org\/content\/13\/583\/eabc2823<\/a>\u3002<\/p>\n

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\u57161(\u7814\u7a76\u6210\u679c)\uff1a\u591a\u80dc\u80bd\u5206\u5b50\u7684\u4f5c\u7528\u793a\u610f\u5716
\u6b64\u5716\u5de6\u534a\u908a\u70ba\u6b63\u5e38\u514d\u75ab\u8f14\u52a9\u578bT\u7d30\u80de (Th2)\uff0c\u53d7\u9ad4IL-17RB\u5728\u6b64\u53ef\u4ee5\u50b3\u905e\u514d\u75ab\u53cd\u61c9\u8a0a\u865f\u3002\u6b64\u5716\u53f3\u534a\u908a\u70ba\u80f0\u81df\u764c\u7d30\u80de\uff0cIL-17RB\u5728\u764c\u7d30\u80de\u4e0a\u53cd\u800c\u6703\u53ec\u559a\u6fc0\u9176MLK4\uff0c\u555f\u52d5\u81f4\u764c\u53cd\u61c9\u3002\u7814\u7a76\u5718\u968a\u5408\u6210\u7684\u591a\u80dc\u80bd\u5206\u5b50\uff0c\u53ef\u8207\u6fc0\u9176MLK4\u7af6\u722d\uff0c\u963b\u6b62\u6fc0\u9176\u8207\u53d7\u9ad4IL-17RB\u7d50\u5408\uff0c\u85c9\u6b64\u963b\u65b7\u5f8c\u7e8c\u764c\u5316\u8a0a\u606f\u50b3\u905e\u3002<\/p><\/div>\n

\"\"

\u57162(\u539f\u7406\u89e3\u8aaa)\uff1aIL-17RB\u81f4\u764c\u8a0a\u606f\u50b3\u905e
\u5728\u764c\u7d30\u80de\u819c\u8868\u9762\uff0c\u53d7\u9ad4IL-17RB\u5927\u91cf\u51fa\u73fe\uff0c\u56e0\u6b64\u914d\u9ad4IL-17B\u7d50\u5408\u5f8c\u6703\u5f62\u6210\u540c\u8cea\u96d9\u805a\u9ad4\uff0c\u540c\u8cea\u96d9\u805a\u9ad4\u627e\u5230\u5f8c\uff0c\u5c31\u6703\u5728\u7d30\u80de\u5167\u90e8\u53ec\u559a\u6fc0\u9176MLK4\uff0c\u555f\u52d5\u81f4\u764c\u8a0a\u865f\uff0c\u50ac\u5316\u764c\u7d30\u80de\u589e\u751f\u53ca\u79fb\u8f49\u3002<\/p><\/div>\n

\n

\uff08\u8a3b\u4e00\uff09\u53d7\u9ad4(receptor)\u662f\u5b58\u5728\u65bc\u7d30\u80de\u819c\u4e0a\u7684\u86cb\u767d\u8cea\u5206\u5b50\uff0c\u53ef\u60f3\u50cf\u6210\u8a0a\u865f\u63a5\u53d7\u5668\u3002\u914d\u9ad4(ligand)\u5247\u662f\u53ef\u8207\u76f8\u5c0d\u61c9\u53d7\u9ad4\u7d50\u5408\u7684\u7269\u8cea\uff0c\u4f8b\u5982\u8377\u723e\u8499\u3001\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u3001\u85e5\u7269\u7b49\u3002\u53d7\u9ad4\u548c\u76f8\u5c0d\u61c9\u7684\u914d\u9ad4\u5b58\u5728\u9ad8\u5ea6\u5c08\u4e00\u6027\uff0c\u6709\u5982\u9396\u982d\u548c\u9470\u5319\uff0c\u552f\u6709\u9396\u5b54\u7b26\u5408\u624d\u80fd\u300c\u89e3\u9396\u300d\uff0c\u9032\u800c\u555f\u52d5\u53cd\u61c9\u3002\u7d30\u80de\u819c\u4e0a\u7684\u53d7\u9ad4\u300cIL-17RB\u300d\u5982\u679c\u9047\u898b\u914d\u9ad4\u300cIL-17B\u300d\uff0c\u4fbf\u6703\u5982\u9470\u5319\u89e3\u9396\u3127\u822c\u555f\u52d5\u53cd\u61c9\u3002\u300cIL-17RB\u300d\u540d\u7a31\u4e2d\u7684R\u6307\u7684\u5c31\u662f\u300creceptor\u300d\u3002<\/p>\n

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