{"id":23948,"date":"2021-01-28T00:03:00","date_gmt":"2021-01-27T16:03:00","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=23948"},"modified":"2021-09-30T11:39:09","modified_gmt":"2021-09-30T03:39:09","slug":"%e5%90%84%e5%9c%8b%e9%a9%9a%e7%88%86%e6%96%b0%e5%86%a0%e7%97%85%e6%af%92%e8%ae%8a%e7%a8%ae%ef%bc%81%e4%b8%ad%e7%a0%94%e9%99%a2%e6%8c%81%e7%ba%8c%e8%bf%bd%e8%b9%a4%e7%97%85%e6%af%92%e8%ae%8a%e7%95%b0","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/23948\/","title":{"rendered":"\u5404\u570b\u9a5a\u7206\u65b0\u51a0\u75c5\u6bd2\u8b8a\u7a2e\uff01\u4e2d\u7814\u9662\u6301\u7e8c\u8ffd\u8e64\u75c5\u6bd2\u8b8a\u7570"},"content":{"rendered":"<p><strong>\u8ffd\u8e64\u65b0\u51a0\u75c5\u6bd2\u7a81\u8b8a<\/strong><\/p>\n<p>\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\uff08SARS-CoV-2\uff09\u8db3\u8de1\u904d\u5e03\u5168\u7403\uff0c\u5728\u50b3\u64ad\u904e\u7a0b\u4e2d\u4e00\u518d\u51fa\u73fe\u65b0\u7684\u7a81\u8b8a\u7a2e\uff0c\u8b93\u9632\u75ab\u5de5\u4f5c\u8207\u7814\u7a76\u5747\u56f0\u96e3\u91cd\u91cd\u3002\u4e2d\u592e\u7814\u7a76\u9662\u5ed6\u4fca\u667a\u9662\u9577\u7d44\u7e54\u7814\u7a76\u5718\u968a\uff0c\u6839\u64da\u5168\u7403\u5171\u4eab\u6d41\u611f\u6578\u64da\u5021\u8b70\u7d44\u7e54 GISAID \u8cc7\u6599\uff0c\u5206\u6790\u4e09\u5341\u842c\u7b46\u4ee5\u4e0a\u7684\u75c5\u6bd2\u57fa\u56e0\u5e8f\u5217\u6a23\u672c\u8cc7\u6599\uff0c\u5c07\u75c5\u6bd2\u5283\u5206\u70ba\u516d\u5927\u985e\u578b\uff0c\u5176\u4e2d\u300c\u7b2c\u516d\u578b\u300d\u4f54\u76ee\u524d\u6d41\u50b3\u75c5\u6bd2\u985e\u578b\u7684 99%\u3002\u65e5\u524d\uff0c\u4e2d\u7814\u9662\u4e5f\u6210\u7acb\u300c\u75c5\u6bd2\u8b8a\u7570\u5168\u7403\u5373\u6642\u76e3\u6e2c\u7db2\u300d\u5206\u4eab\u8cc7\u6599\uff0c\u8b93\u5168\u4e16\u754c\u5747\u80fd\u5373\u6642\u8ffd\u8e64\u75c5\u6bd2\u8b8a\u7570\u3002<\/p>\n<p><strong>\u7a81\u8b8a\uff0c\u5230\u5e95\u600e\u9ebc\u8b8a\uff1f<\/strong><\/p>\n<p>COVID-19 \u75ab\u60c5\u81ea 2019 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class=\"wp-caption-text\">\u65b0\u51a0\u75c5\u6bd2\u5728\u7a7f\u900f\u5f0f\u96fb\u5b50\u986f\u5fae\u93e1\u4e0b\u73fe\u5f62\uff0c\u53ef\u898b\u75c5\u6bd2\u8868\u73fe\u7a81\u8d77\u7684\u68d8\u51a0\u3002\u56e0\u65b0\u51a0\u75c5\u6bd2\u662f RNA \u75c5\u6bd2\uff0c\u7a81\u8b8a\u901f\u5ea6\u5feb\u3002\u4e2d\u7814\u9662\u5718\u968a\u5c07\u76ee\u524d\u65b0\u51a0\u75c5\u6bd2\u8b8a\u7570\u5206\u70ba\u516d\u5927\u985e\u578b\uff0c\u76ee\u524d\u5168\u7403\u6d41\u50b3\u7684\u5e7e\u4e4e\u90fd\u662f\u7b2c\u516d\u985e\u578b\u75c5\u6bd2\uff0c\u672a\u4f86\u5718\u968a\u5c07\u6301\u7e8c\u8ffd\u8e64\u75c5\u6bd2\u8b8a\u7570\u3002<br \/>\u5716\u2502\u7dad\u57fa\u767e\u79d1<\/p><\/div>\n<p>\u751f\u7269\u5b78\u4e2d\u7684\u7a81\u8b8a\uff08mutation\uff09\u4e00\u8a5e\uff0c\u6307\u7684\u662f\u7d30\u80de\u6838\u88e1\u7684\u907a\u50b3\u7269\u8cea\u767c\u751f\u6539\u8b8a\uff0c\u53ef\u80fd\u662f DNA 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\u75c5\u6bd2\u7a81\u8b8a\uff0c\u6bd4\u4f60\u60f3\u5f97\u5bb9\u6613\uff01<\/strong><\/p>\n<p>\u300c\u65b0\u51a0\u75c5\u6bd2\u7684\u907a\u50b3\u7269\u8cea\u662f\u55ae\u80a1\u7684 RNA \uff08ribonucleic acid\uff09\uff0cRNA \u7d50\u69cb\u4e0d\u592a\u7a69\u5b9a\u3002\u300d\u672c\u6b21\u7814\u7a76\u5718\u968a\u7684\u694a\u6b23\u6d32\u7814\u7a76\u54e1\u5e6b\u8b80\u8005\u5283\u91cd\u9ede\u3002\u76f8\u8f03\u65bc\u907a\u50b3\u7269\u8cea\u70ba DNA \u7684\u75c5\u6bd2\uff0cRNA \u75c5\u6bd2\u5728\u8907\u88fd\u907a\u50b3\u7269\u8cea (RNA) \u7684\u904e\u7a0b\uff0c\u66f4\u52a0\u5bb9\u6613\u7a81\u8b8a\uff0c\u5982\u9700\u8981\u5e74\u5e74\u9078\u682a\u7684\u6d41\u611f\u75c5\u6bd2\u5373\u70ba RNA \u75c5\u6bd2\u3002<\/p>\n<p style=\"text-align: center;\"><strong>\u65b0\u51a0\u75c5\u6bd2\u96d6\u7136\u6709\u6821\u5c0d\u9176\u3001\u7a81\u8b8a\u901f\u5ea6\u6bd4\u6d41\u611f\u75c5\u6bd2\u7a0d\u6162\uff0c\u4f46\u7a81\u8b8a\u901f\u5ea6\u4ecd\u9ad8\u3002<\/strong><\/p>\n<p>\u9762\u5c0d\u65b0\u51a0\u75c5\u6bd2\u4e0d\u65b7\u5192\u51fa\u7684\u8b8a\u7a2e\uff0c\u4e2d\u7814\u9662\u7814\u7a76\u5718\u968a\u5f9e\u6700\u5e38\u898b\u7684\u7a81\u8b8a \u2014 \u55ae\u4e00\u6838\u82f7\u9178\u8b8a\u7570\uff08single-nucleotide variantion, SNV\uff09\u8457\u624b\u7814\u7a76\u3002\u7814\u7a76\u4eba\u54e1\u7d50\u5408\u75c5\u6bd2\u8b8a\u7570\u5206\u6790\u8207\u5206\u985e\u6a39\u5206\u6790\u5169\u7a2e\u65b9\u6cd5\uff0c\u8457\u624b\u5206\u6790\u5f9e\u5168\u7403\u5171\u4eab\u6d41\u611f\u6578\u64da\u5021\u8b70\u7d44\u7e54\uff08GISAID\uff09\u53d6\u5f97\u7684 1932 \u682a\u75c5\u6bd2\u57fa\u56e0\u5e8f\u5217\u6a23\u672c\u3002<\/p>\n<p>\u75c5\u6bd2\u8b8a\u7570\u767c\u751f\u4f4d\u7f6e\u8207\u983b\u7387\u65b9\u9762\uff0c\u5247\u4ee5\u4e2d\u7814\u9662\u7d71\u8a08\u79d1\u5b78\u7814\u7a76\u6240\u9673\u541b\u539a\u6240\u9577\u7684\u7d71\u8a08\u77e9\u9663\u8996\u89ba\u5316\uff0c\u89e3\u6790\u65b0\u51a0\u75c5\u6bd2\u8fd1\u4e09\u842c\u500b\u6838\u82f7\u9178\u7684 RNA \u5e8f\u5217\u4e2d\uff0c\u5404\u500b\u6838\u82f7\u9178\u8b8a\u7570\u4e4b\u9593\u7684\u95dc\u806f\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u4f7f\u7528\u4e00\u7a2e\u7d71\u8a08\u5206\u985e\u6a39\u548c\u56db\u7a2e\u89aa\u7de3\u95dc\u4fc2\u6a39\uff0c\u4f86\u77ad\u89e3\u5404\u75c5\u6bd2\u682a\u4e4b\u9593\u7684\u8ddd\u96e2\u8207\u89aa\u7de3\u95dc\u4fc2\u3002\u300c\u5404\u570b\u4e0a\u50b3\u7684\u75c5\u6bd2\u682a\u6a23\u672c\u8cc7\u6599\u90fd\u6703\u9644\u8a3b\u6536\u6a23\u6642\u9593\uff0c\u4e5f\u591a\u5c11\u8f14\u52a9\u89aa\u7de3\u6a39\u8a55\u5224\u5b9a\u6f14\u5316\u524d\u5f8c\u95dc\u4fc2\u7684\u53c3\u8003\u3002\u300d\u694a\u6b23\u6d32\u88dc\u5145\u3002<\/p>\n<p><strong>14 \u500b\u5370\u8a18\uff0c\u5feb\u901f\u5206\u985e\u516d\u5927\u75c5\u6bd2<\/strong><\/p>\n<p>\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u76ee\u524d\u4e16\u754c\u4e0a\u7684\u75c5\u6bd2\u682a\u53ef\u4ee5\u88ab\u5206\u6210\u516d\u5927\u578b\uff0c\u6bcf\u4e00\u578b\u90fd\u6709\u4e00\u7d44\u81ea\u5df1\u7368\u7279\u7684\u55ae\u4e00\u6838\u82f7\u9178\u8b8a\u7570\uff08SNV\uff09\u4f4d\u9ede\uff0c\u9019\u6a23\u7684 SNV \u4f4d\u9ede\u5370\u8a18\u5171\u6709 14 \u500b\u3002\u7814\u7a76\u5718\u968a\u5728\u516d\u5343\u682a\u3001\u4e09\u842c\u591a\u682a\u4ee5\u53ca\u4e09\u5341\u842c\u682a\u7b49\uff0c\u5e7e\u6b21\u64f4\u5927\u6a23\u672c\u6578\u7684\u75c5\u6bd2\u5206\u6790\u4e2d\u90fd\u80fd\u5f97\u5230\u91cd\u8907\u7684\u9a57\u8b49\u3002<\/p>\n<div id=\"attachment_21652\" style=\"width: 1034px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" aria-describedby=\"caption-attachment-21652\" src=\"https:\/research.sinica.edu.tw\/wp-content\/uploads\/2021\/01\/hsin-chou-yang-02.jpg\" alt=\"\" width=\"1024\" \/><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">\u4e0a\u5716\u70ba\u65b0\u51a0\u75c5\u6bd2\u516d\u5927\u578b\u7684\u7a81\u8b8a\u4f4d\u9ede\uff0c\u6bcf\u4e00\u6a6b\u689d\u4ee3\u8868\u67d0\u4e00\u578b\u7684 RNA \u5e8f\u5217\uff0c\u5411\u4e0b\u7684\u5340\u584a\u70ba\u7a81\u8b8a\u7684\u55ae\u4e00\u6838\u82f7\u9178\u8b8a\u7570 (SNV) \u4f4d\u9ede\u6240\u5ea7\u843d\u7684\u57fa\u56e0\u3002\u76ee\u524d\u4e16\u754c\u4e0a\u7684\u75c5\u6bd2\u682a\u53ef\u4ee5\u88ab\u5206\u6210\u516d\u5927\u578b\uff0c\u6bcf\u4e00\u578b\u90fd\u6709\u4e00\u7d44\u81ea\u5df1\u7368\u7279\u7684 SNV \u4f4d\u9ede\uff0c\u9019\u6a23\u7684 SNV \u4f4d\u9ede\u5370\u8a18\u5171\u6709 14 \u500b\u3002<br \/>\u5716\u2502\u694a\u6b23\u6d32<\/p><\/div>\n<p>\u300c\u672a\u4f86\u4e0d\u7528\u518d\u770b\u5b8c\u6574\u75c5\u6bd2\u57fa\u56e0\u9ad4\uff0c\u53ea\u8981\u91dd\u5c0d\u65b0\u6a23\u672c\u6aa2\u67e5\u9019 14 \u500b SNV \u5370\u8a18\uff0c\u5c31\u53ef\u4ee5\u5728\u5e7e\u5206\u9418\u5167\u5c07\u65b0\u75c5\u6bd2\u682a\u5206\u985e\u6b78\u6a94\u3002\u300d\u694a\u6b23\u6d32\u6307\u51fa\u3002\u539f\u672c\u7684\u5206\u6790\u65b9\u6cd5\u662f\u5c07\u75c5\u6bd2\u682a\u6a23\u672c\u7684 RNA 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style=\"text-align: center;\"><strong>\u4e2d\u7814\u9662\u5718\u968a\u50c5\u7528 14 \u500b SNV \u5370\u8a18\uff0c\u7528\u4e00\u5c0d\u4e00\u5e8f\u5217\u6392\u6bd4\uff08Pairwise Alignment\uff09\u548c\u6587\u5b57\u63a2\u52d8\uff08Text Mining\uff09\u5169\u7a2e\u65b9\u6cd5\uff0c\u5e7e\u4e4e\u53ea\u8981\u5e7e\u5206\u9418\u5c31\u80fd\u5b8c\u6210\u5206\u985e\uff0c\u4e14\u6b63\u78ba\u7387\u5206\u5225\u662f\u767e\u5206\u4e4b 100 \u8207 98 \u4ee5\u4e0a\u3002<\/strong><\/p>\n<p>&nbsp;<\/p>\n<h2 style=\"text-align: center;\"><strong>\u6b32\u700f\u89bd\u5b8c\u6574\u7cbe\u91c7\u6587\u7ae0\uff0c\u8acb\u81f3\u7814\u4e4b\u6709\u7269\u5b98\u7db2\uff1a<\/strong><\/h2>\n<h2 style=\"text-align: center;\"><a href=\"https:\/research.sinica.edu.tw\/sinica-sars-cov-2-variation\/\"><em>https:\/research.sinica.edu.tw\/sinica-sars-cov-2-variation\/<\/em><\/a><\/h2>\n<h2 style=\"text-align: center;\"><strong>\uff08\u8d95\u5feb\u9ede\u9032\u4f86\u5594\uff01\u9084\u6709\u66f4\u591a\u7cbe\u91c7\u5716\u6587\uff01\uff09<\/strong><\/h2>\n","protected":false},"excerpt":{"rendered":"<p>\u8ffd\u8e64\u65b0\u51a0\u75c5\u6bd2\u7a81\u8b8a \u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\uff08SARS-CoV-2\uff09\u8db3\u8de1\u904d\u5e03\u5168\u7403\uff0c\u5728\u50b3\u64ad\u904e\u7a0b\u4e2d\u4e00\u518d\u51fa\u73fe\u65b0\u7684\u7a81\u8b8a\u7a2e\uff0c\u8b93\u9632\u75ab\u5de5\u4f5c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":23950,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/23948"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=23948"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/23948\/revisions"}],"predecessor-version":[{"id":23949,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/23948\/revisions\/23949"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/23950"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=23948"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=23948"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=23948"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}