{"id":23796,"date":"2020-12-31T00:03:52","date_gmt":"2020-12-30T16:03:52","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=23796"},"modified":"2021-09-30T11:41:49","modified_gmt":"2021-09-30T03:41:49","slug":"%e3%80%8c%e5%85%a8%e7%90%83%e7%ac%ac%e4%b8%80%e6%ac%a1%e5%ae%8c%e6%95%b4%e5%89%96%e6%9e%90%e6%9d%b1%e4%ba%9e%e8%82%ba%e7%99%8c%e6%88%90%e5%9b%a0%ef%bc%81%e3%80%8d%e9%99%b3%e7%8e%89%e5%a6%82%e8%88%87","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/23796\/","title":{"rendered":"\u300c\u5168\u7403\u7b2c\u4e00\u6b21\u5b8c\u6574\u5256\u6790\u6771\u4e9e\u80ba\u764c\u6210\u56e0\uff01\u300d\u9673\u7389\u5982\u8207\u81fa\u7f8e\u764c\u75c7\u767b\u6708\u8a08\u756b"},"content":{"rendered":"<p><strong>\u81fa\u7063\u764c\u75c7\u767b\u6708\u8a08\u756b<\/strong><\/p>\n<p>\u6771\u4e9e\u7684\u80ba\u764c\u60a3\u8005\u8207\u6b50\u7f8e\u5927\u4e0d\u540c\uff0c\u904e\u534a\u70ba\u4e0d\u5438\u83f8\u8005\uff0c\u800c\u4e14\u5973\u6027\u6bd4\u7537\u6027\u591a\u3002\u4e2d\u7814\u9662\u5316\u5b78\u7814\u7a76\u6240\u9673\u7389\u5982\u6240\u9577\u9818\u5c0e\u7684\u300c\u81fa\u7063\u764c\u75c7\u767b\u6708\u8a08\u756b\u300d\uff0c\u8207\u81fa\u7063\u5927\u5b78\u3001\u81fa\u5317\u91ab\u5b78\u5927\u5b78\u3001\u81fa\u4e2d\u69ae\u7e3d\u7684\u91ab\u5e2b\u5408\u4f5c\uff0c\u627e\u51fa\u4e0d\u5438\u83f8\u80ba\u764c\u53ef\u80fd\u7684\u81f4\u75c5\u6a5f\u8f49\uff0c\u70ba\u5168\u4e16\u754c\u7b2c\u4e00\u500b\u5b8c\u6574\u5256\u6790\u6771\u4e9e\u80ba\u764c\u7684\u7814\u7a76\uff0c\u6210\u679c\u767c\u8868\u5728 2020 \u5e74 7 \u6708\u300a\u7d30\u80de\u300b(Cell)\uff0c\u4e26\u767b\u4e0a\u7576\u671f\u5c01\u9762\uff0c\u5728\u773e\u591a\u65b0\u51a0\u80ba\u708e\u7814\u7a76\u4e2d\u6bba\u51fa\u91cd\u570d\uff0c\u975e\u5e38\u4e0d\u7c21\u55ae\u3002\u66f4\u503c\u5f97\u7a31\u9053\u7684\u662f\uff0c\u5979\u5982\u4f55\u5728\u5176\u4e2d\u6574\u5408\u81fa\u7063\u5404\u9818\u57df\u5c08\u5bb6\u5b78\u8005\uff0c\u9f4a\u5fc3\u4fc3\u6210\u6b64\u9805\u81fa\u7063\u764c\u75c7\u7814\u7a76\u7684\u95dc\u9375\u7a81\u7834\uff1f\u4e00\u8d77\u4f86\u807d\u807d\u9673\u7389\u5982\u5f9e\u4e0d\u8a2d\u9650\u3001\u6709\u7b11\u6709\u6dda\u7684\u7814\u7a76\u4e4b\u65c5\u3002<\/p>\n<p><strong>\u5f9e\u4f86\u6c92\u60f3\u904e\u2026\u2026<\/strong><\/p>\n<p>\u300c\u8aaa\u5be6\u8a71\uff0c\u6211\u5f9e\u4f86\u6c92\u6709\u5922\u60f3\u904e\u767b\u4e0a\u9019\u7a2e\u671f\u520a\uff0c\u300d\u9673\u7389\u5982\u8aaa\uff1a\u300c\u56e0\u70ba\u6211\u662f\u5316\u5b78\u9818\u57df\u7684\u3002\u300d\u9019\u4f4d\u4e2d\u7814\u9662\u5316\u5b78\u6240\u6210\u7acb 92 \u5e74\u4ee5\u4f86\u7b2c\u4e00\u4f4d\u5973\u6240\u9577\uff0c\u535a\u58eb\u73ed\u5b78\u7684\u662f\u7269\u7406\u5316\u5b78\uff0c\u5c08\u9577\u662f\u8a2d\u8a08\u8cea\u8b5c\u5100\u53ca\u7814\u7a76\u5206\u5b50\u9375\u80fd\uff0c\u5230\u4e2d\u7814\u9662\u4e4b\u524d\uff0c\u5f9e\u4f86\u6c92\u7814\u7a76\u904e\u57fa\u56e0\u3001\u86cb\u767d\u8cea\uff0c\u537b\u610f\u5916\u6210\u70ba\u81fa\u7f8e\u764c\u75c7\u7814\u7a76\u5408\u4f5c\u7684\u91cd\u8981\u63a8\u624b\u3002<\/p>\n<p>2020 \u5e74 7 \u6708\uff0c\u9673\u7389\u5982\u6240\u9577\u9818\u5c0e\u300c\u81fa\u7063\u764c\u75c7\u767b\u6708\u8a08\u756b\u300d\uff0c\u5229\u7528\u6df1\u5ea6\u86cb\u767d\u8cea\u57fa\u56e0\u9ad4\u6280\u8853\u548c\u591a\u9ad4\u5b78\u6578\u64da\u6574\u5408\u5206\u6790\uff0c\u89e3\u6790\u81fa\u7063\u4e0d\u5438\u83f8\u75c5\u4eba\u8207\u897f\u65b9\u4e0d\u540c\u7684\u57fa\u56e0\u7a81\u8b8a\u7279\u5fb5\u3001\u5c0b\u627e\u5167\u751f\u6027\u8207\u5916\u5728\u74b0\u5883\u81f4\u75c5\u6a5f\u8f49\uff0c\u4e26\u767c\u73fe\u764c\u75c7\u65e9\u671f\u51fa\u73fe\u7684\u985e\u665a\u671f\u5206\u5b50\u7279\u5fb5\uff0c\u70ba\u5168\u4e16\u754c\u7b2c\u4e00\u500b\u5b8c\u6574\u5256\u6790\u6771\u4e9e\u80ba\u764c\u7684\u7814\u7a76\u3002\u7814\u7a76\u8ad6\u6587\u5df2\u767c\u8868\u65bc\u9802\u5c16\u671f\u520a\u300a\u7d30\u80de\u300b(Cell)\uff0c\u4e26\u69ae\u767b\u7576\u671f\u5c01\u9762\u3002(\u7814\u7a76\u8a73\u60c5\u8acb\u898b\u7814\u4e4b\u6709\u7269\u53e6\u4e00\u597d\u6587\u3008\u80ba\u764c\u60a3\u8005\u534a\u6578\u4e0d\u66fe\u5438\u83f8\uff1f\u5973\u751f\u6bd4\u7537\u751f\u5bb9\u6613\u7f79\u764c\uff1f\u627e\u5230\u81fa\u7063\u4eba\u80ba\u764c\u95dc\u9375\u6210\u56e0\u3009)<\/p>\n<div 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\/>\u5716\u2502\u4e2d\u7814\u9662\u79d8\u66f8\u8655<\/p><\/div>\n<p>\u5176\u5be6\u9673\u7389\u5982\u7684\u4e0d\u8a2d\u9650\u4eba\u751f\uff0c\u672c\u5c31\u662f\u4e00\u95dc\u53c8\u4e00\u95dc\u7684\u300c\u5f9e\u4f86\u6c92\u60f3\u904e\u300d\u3002\u5728\u7f8e\u570b\u53d6\u5f97\u535a\u58eb\u5b78\u4f4d\u4e4b\u5f8c\uff0c\u9673\u7389\u5982\u8209\u5bb6\u56de\u5230\u81fa\u7063\uff0c\u96d6\u7136\u5f88\u559c\u6b61\u52d5\u624b\u505a\u5be6\u9a57\uff0c\u4f46\u4e00\u958b\u59cb\u4e26\u6c92\u6709\u60f3\u8981\u505a\u7814\u7a76\uff0c\u4e5f\u4e0d\u89ba\u5f97\u81ea\u5df1\u9069\u5408\u8d70\u7814\u7a76\u7684\u8def\u5b50\u3002<\/p>\n<p>\u56e0\u7de3\u969b\u6703\u4f86\u5230\u4e2d\u7814\u9662\uff0c\u6700\u521d\u5169\u5e74\uff0c\u9673\u7389\u5982\u539f\u672c\u4ee5\u70ba\u6bcf\u5929\u7684\u5de5\u4f5c\u5c31\u662f\u7e6a\u6a5f\u68b0\u5716\u3001\u8a2d\u8a08\u8cea\u8b5c\u5100\u3001\u5e6b\u5fd9\u540c\u4e8b\u5206\u6790\u4ed6\u5011\u5408\u6210\u7684\u5206\u5b50\uff0c\u4f46\u65e5\u5b50\u4e45\u4e86\uff0c\u89ba\u5f97\u81ea\u5df1\u4e00\u4e8b\u7121\u6210\uff0c\u611f\u5230\u5f88\u8ff7\u832b\u3002\u5f8c\u4f86\u5728\u540c\u4e8b\u7684\u5efa\u8b70\u4e0b\uff0c\u8f49\u63db\u5230\u5206\u6790\u751f\u5316\u5206\u5b50\uff0c\u5f9e DNA \u5206\u6790\u505a\u8d77\u3002<\/p>\n<p>\u300c\u4f46\u6162\u6162\u7684\uff0c\u6211\u53c8\u89ba\u5f97 DNA \u5206\u6790\u6280\u8853\u65e5\u8da8\u6210\u719f\uff0c\u53ea\u6709 ATCG \u56db\u7a2e\u9e7c\u57fa\uff0c\u6c92\u6709\u592a\u5927\u767c\u5c55\u7a7a\u9593\u3002\u300d\u65bc\u662f\u9673\u7389\u5982\u8f49\u800c\u6311\u6230\u86cb\u767d\u8cea\uff0c\u8dd1\u53bb\u5b78\u7fd2\u7528\u300c\u4e8c\u7dad\u81a0\u9ad4\u96fb\u6cf3\u300d\u5206\u6790\u86cb\u767d\u8cea\u3002\u505a\u8457\u505a\u8457\uff0c\u5979\u53c8\u767c\u73fe\u9019\u7a2e\u65b9\u6cd5\u6709\u5f88\u5927\u7684\u9650\u5236\uff0c\u4e00\u6b21\u53ea\u80fd\u770b\u5230\u5e7e\u5341\u500b\u86cb\u767d\u8cea\uff0c\u4f46\u4eba\u985e\u86cb\u767d\u8cea\u6210\u5343\u4e0a\u842c\u3002\u5979\u6c7a\u5b9a\u5229\u7528\u8cea\u8b5c\u5100\u958b\u767c\u66f4\u597d\u7684\u86cb\u767d\u8cea\u5206\u6790\u6cd5\u3002\u800c\u9019\u4e00\u8f49\u5ff5\uff0c\u4eba\u751f\u98a8\u666f\u5927\u4e0d\u540c\u3002<\/p>\n<p><strong>\u805e\u540d\u4e16\u754c\u7684\u819c\u86cb\u767d\u8cea\u9ad4\u5206\u6790<\/strong><\/p>\n<p>\u9673\u7389\u5982\u6311\u9078\u4e86\u819c\u86cb\u767d\u8cea\u9ad4\u4f5c\u70ba\u4e3b\u984c\uff0c\u300c\u90a3\u6642\u5019\u771f\u662f\u521d\u751f\u4e4b\u72a2\uff0c\u60f3\u8aaa\u7d30\u80de\u4e0a\u6700\u91cd\u8981\u7684\u5206\u5b50\u5c31\u662f\u7d30\u80de\u819c\u86cb\u767d\u8cea\u9ad4\u4e86\uff0c\u7d50\u679c\uff0c\u90a3\u662f\u5168\u4e16\u754c\u6700\u96e3\u7684\u4e3b\u984c\u4e4b\u4e00\uff01\u300d\u9673\u7389\u5982\u7b11\u8457\u8aaa\u3002<\/p>\n<div id=\"attachment_21652\" style=\"width: 1034px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" aria-describedby=\"caption-attachment-21652\" src=\"https:\/research.sinica.edu.tw\/wp-content\/uploads\/2020\/12\/yu-ju-chen-02-.jpg\" alt=\"\" width=\"1024\" \/><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">\u7d30\u80de\u819c\u4e0a\u542b\u6709\u5927\u91cf\u7684\u819c\u86cb\u767d\u8cea(\u4eba\u9ad4\u5167\u81f3\u5c11\u6709 8000 \u7a2e)\uff0c\u819c\u86cb\u767d\u8cea\u8abf\u63a7\u4e86\u5f88\u591a\u91cd\u8981\u7684\u7d30\u80de\u529f\u80fd\uff0c\u4f8b\u5982\u901a\u9053\u86cb\u767d\u53ef\u8ca0\u8cac\u7d30\u80de\u9593\u7269\u8cea\u904b\u8f38\uff0c\u91a3\u86cb\u767d\u53ef\u63d0\u4f9b\u514d\u75ab\u7cfb\u7d71\u8fa8\u8b58\u81ea\u8eab\u548c\u5916\u4f86\u7d30\u80de\uff0c\u5176\u4ed6\u819c\u86cb\u767d\u8cea\u7684\u529f\u80fd\u9084\u5305\u62ec\u8a0a\u606f\u63a5\u6536\u3001\u50ac\u5316\u53cd\u61c9\u7b49\u7b49\u3002<br \/>\u9673\u7389\u5982\u5718\u968a\u4ee5\u8cea\u8b5c\u5100\u5168\u9762\u6027\u5b9a\u91cf\u819c\u86cb\u767d\u9ad4\uff0c\u53ef\u5e6b\u52a9\u79d1\u5b78\u5bb6\u4e86\u89e3\u8207\u819c\u86cb\u767d\u8cea\u76f8\u95dc\u75be\u75c5\u7684\u539f\u7406\uff0c\u958b\u767c\u75be\u75c5\u6aa2\u6e2c\u6216\u662f\u85e5\u7269\u6a19\u9776\u86cb\u767d\u8cea\u3002\u4ee5\u764c\u75c7\u70ba\u4f8b\uff0c\u73fe\u5728\u4f7f\u7528\u7684\u764c\u75c7\u6a19\u8b58\u5206\u5b50(biomarker)\u5927\u591a\u6578\u5c31\u662f\u819c\u86cb\u767d\u8cea\u3002<br \/>\u5716\u2502iStock<\/p><\/div>\n<p>\u819c\u86cb\u767d\u4e0d\u6127\u70ba\u86cb\u767d\u8cea\u754c\u7684\u6b7b\u4ea1\u4e4b\u7d44\uff0c\u9673\u7389\u5982\u7684\u5be6\u9a57\u5ba4\u6301\u7e8c\u56db\u5e74\u591a\u6c92\u6709\u4efb\u4f55\u6210\u679c\u3002\u9762\u5c0d\u9019\u6a23\u7684\u96e3\u95dc\uff0c\u5979\u537b\u8aaa\uff1a\u300c\u9084\u597d\uff0c\u6211\u7684\u500b\u6027\u5c31\u662f\u4e0d\u6b7b\u5fc3\uff0c\u4e0d\u6b7b\u5fc3\uff0c\u4e00\u76f4\u505a\u505a\u505a\u2026\u2026\u300d\u6240\u5e78\u7b2c\u4e00\u500b\u535a\u73ed\u5b78\u751f\u548c\u52a9\u7406\u5011\uff0c\u8ddf\u5979\u4e00\u6a23\u4e0d\u670d\u8f38\uff0c\u7d42\u65bc\u5b8c\u6210\u4e86\u5be6\u9a57\uff0c\u4e5f\u8b93\u9673\u7389\u5982\u7684\u5be6\u9a57\u5ba4\u95d6\u51fa\u4e86\u540d\u865f\u3002<\/p>\n<p>\u73fe\u5728\uff0c\u819c\u86cb\u767d\u8cea\u9ad4\u5206\u6790\u6210\u4e86\u5979\u5be6\u9a57\u5ba4\u7684\u6838\u5fc3\u6280\u8853\u4e4b\u4e00\uff0c\u805e\u540d\u5168\u4e16\u754c\u3002\u53bb\u5e74\uff082019 \u5e74\uff09\u9673\u7389\u5982\u4ee5\u4e00\u500b\u5316\u5b78\u80cc\u666f\u7684\u7814\u7a76\u8005\uff0c\u7576\u9078\u4e86\u300c\u4eba\u985e\u86cb\u767d\u9ad4\u7d44\u7e54\u300d(Human Proteome Organization, HUPO)\u7684\u7406\u4e8b\u9577\uff08HUPO President-Elect\uff09\uff0c\u5c07\u65bc 2021 \u5e74\u6b63\u5f0f\u4e0a\u4efb\u3002HUPO \u662f\u570b\u969b\u6027\u6700\u5927\u7684\u86cb\u767d\u8cea\u9ad4\u5b78\u8853\u7d44\u7e54\uff0c\u5728\u86cb\u767d\u8cea\u9ad4\u5b78\uf9b4\u57df\u5177\u6709\uf9b4\u5c0e\u6027\u7684\u5730\u4f4d\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2 style=\"text-align: center;\"><strong>\u6b32\u700f\u89bd\u5b8c\u6574\u7cbe\u91c7\u6587\u7ae0\uff0c\u8acb\u81f3\u7814\u4e4b\u6709\u7269\u5b98\u7db2\uff1a<\/strong><\/h2>\n<h2 style=\"text-align: center;\"><a href=\"https:\/research.sinica.edu.tw\/cancer-moonshot-yu-ju-chen\/\"><em>https:\/research.sinica.edu.tw\/cancer-moonshot-yu-ju-chen\/<\/em><\/a><\/h2>\n<h2 style=\"text-align: center;\"><strong>\uff08\u8d95\u5feb\u9ede\u9032\u4f86\u5594\uff01\u9084\u6709\u66f4\u591a\u7cbe\u91c7\u5716\u6587\uff01\uff09<\/strong><\/h2>\n","protected":false},"excerpt":{"rendered":"<p>\u81fa\u7063\u764c\u75c7\u767b\u6708\u8a08\u756b \u6771\u4e9e\u7684\u80ba\u764c\u60a3\u8005\u8207\u6b50\u7f8e\u5927\u4e0d\u540c\uff0c\u904e\u534a\u70ba\u4e0d\u5438\u83f8\u8005\uff0c\u800c\u4e14\u5973\u6027\u6bd4\u7537\u6027\u591a\u3002\u4e2d\u7814\u9662\u5316\u5b78\u7814\u7a76\u6240\u9673\u7389\u5982\u6240\u9577\u9818\u5c0e [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":23797,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/23796"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=23796"}],"version-history":[{"count":0,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/23796\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/23797"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=23796"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=23796"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=23796"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}