{"id":23513,"date":"2020-12-03T00:03:07","date_gmt":"2020-12-02T16:03:07","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=23513"},"modified":"2020-12-17T16:00:12","modified_gmt":"2020-12-17T08:00:12","slug":"%e6%9b%b4%e6%87%82%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%81%e7%a0%94%e7%a9%b6%e6%8f%aa%e5%87%ba%e7%96%be%e7%97%85%e6%83%a1%e5%8c%96%e7%9a%84%e8%9b%8b%e7%99%bd%e8%b3%aa%e5%b9%ab%e5%85%87","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/23513\/","title":{"rendered":"\u66f4\u61c2\u963f\u8332\u6d77\u9ed8\u75c7\uff01\u7814\u7a76\u63ea\u51fa\u75be\u75c5\u60e1\u5316\u7684\u86cb\u767d\u8cea\u5e6b\u5147"},"content":{"rendered":"
\"\"

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\u9673\u97fb\u5982\u8868\u793a\uff0c\u5168\u7403\u7d045,000\u842c\u540d\u5931\u667a\u75c7\u60a3\u8005\u4e4b\u4e2d\uff0c\u6709\u5c07\u8fd1\u516d\u3001\u4e03\u6210\u90fd\u662f\u963f\u8332\u6d77\u9ed8\u75c7\u75c5\u4eba\u3002\u75c5\u60a3\u7684\u8a18\u61b6\u529b\u3001\u8a9e\u8a00\u3001\u7a7a\u9593\u611f\u7b49\u8a8d\u77e5\u529f\u80fd\u6703\u9010\u6f38\u9000\u5316\u800c\u5f71\u97ff\u751f\u6d3b\u3002\u7136\u800c\uff0c\u76ee\u524d\u5c0d\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u79d1\u5b78\u8a8d\u8b58\uff0c\u5c1a\u672a\u80fd\u7814\u767c\u51fa\u6709\u6548\u7684\u6cbb\u7642\u85e5\u7269\u3002<\/p>\n

\u8166\u795e\u7d93\u76f8\u95dc\u75be\u75c5\u591a\u8d77\u56e0\u65bc\u5927\u8166\u56e4\u7a4d\u4e0d\u826f\u7684\u86cb\u767d\u8cea\u3002\u904e\u53bb\u7684\u79d1\u5b78\u5bb6\u8a8d\u70ba\uff0c\u963f\u8332\u6d77\u9ed8\u75c7\u8d77\u56e0\u65bc\u8166\u7d44\u7e54\u7121\u6cd5\u767c\u63ee\u6e05\u904b\u529f\u80fd\uff0c\u51fa\u73fe\u4e59\u578b\u985e\u6fb1\u7c89\u86cb\u767d\u8ceaA\u03b2\uff08Amyloid Beta\uff09\u53caTau\u86cb\u767d\u7684\u932f\u8aa4\u5806\u7a4d\u3001\u7e96\u7dad\u5316\u3002\u76f4\u5230\u8fd1\u5e74\uff0c\u958b\u59cb\u6709\u65b0\u7814\u7a76\u767c\u73fe\uff0c\u7d04\u670930%\u523057%\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\uff0c\u8166\u5167\u6709\u53e6\u4e00\u7a2e\u86cb\u767d\u8cea\u56e4\u7a4d\u2500\u2500TDP-43\uff0c\u800c\u9019\u4e9b\u60a3\u8005\u901a\u5e38\u6703\u6709\u66f4\u56b4\u91cd\u7684\u8a18\u61b6\u55aa\u5931\u53ca\u6d77\u99ac\u8ff4\u840e\u7e2e\u3002<\/p>\n

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\u672c\u7814\u7a76\u8d77\u59cb\u65bc\u5169\u4f4d\u535a\u58eb\u5f8c\u7814\u7a76\u5b78\u8005\u65bd\u8000\u7fd4\u8207\u675c\u73b2\u5afb\u535a\u58eb\uff0c\u81fa\u7063\u5927\u5b78\u751f\u6280\u7cfb\u5f35\u5a77\u5b87\u78a9\u58eb\u63a5\u8457\u52a0\u5165\u5718\u968a\u5354\u529b\u5b8c\u6210\u3002\u76ee\u524d\uff0c\u65bd\u8000\u7fd4\u662f\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u91ab\u5b78\u7cfb\u89e3\u5256\u5b78\u79d1\u52a9\u7406\u6559\u6388\uff0c\u675c\u73b2\u5afb\u535a\u58eb\u5247\u662f\u81fa\u7063\u5e2b\u7bc4\u5927\u5b78\u5316\u5b78\u7cfb\u52a9\u7406\u6559\u6388\u3002<\/p>\n

\u672c\u8ad6\u6587\u300cTDP-43 interacts with amyloid-\u03b2, inhibits fibrillization, and worsens pathology in a model of Alzheimer\u2019s disease\u300d\u53ef\u65bcNature Communications<\/em>\u7db2\u9801\u95b1\u8b80\uff0c\u8ad6\u6587\u5168\u6587\uff1ahttps:\/www.nature.com\/articles\/s41467-020-19786-7<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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