{"id":23393,"date":"2020-11-19T00:03:36","date_gmt":"2020-11-18T16:03:36","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=23393"},"modified":"2020-12-23T13:56:45","modified_gmt":"2020-12-23T05:56:45","slug":"%e7%99%8c%e7%97%87%e7%82%ba%e4%bd%95%e6%83%a1%e5%8c%96%ef%bc%9f%e6%9c%ac%e9%99%a2%e7%a0%b4%e8%a7%a3%e9%97%9c%e9%8d%b5%e6%a9%9f%e5%88%b6-%e9%a6%96%e5%89%b5%e6%96%b0%e6%8a%97%e9%ab%94%e5%8a%a9%e5%85%8d","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/23393\/","title":{"rendered":"\u764c\u75c7\u70ba\u4f55\u60e1\u5316\uff1f\u672c\u9662\u7834\u89e3\u95dc\u9375\u6a5f\u5236 \u9996\u5275\u65b0\u6297\u9ad4\u52a9\u514d\u75ab\u6cbb\u7642"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-23503\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/11\/\u7db2\u9801\u7528\u571655-08-1024x615.jpg\" alt=\"\" width=\"1024\" height=\"615\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/11\/\u7db2\u9801\u7528\u571655-08-1024x615.jpg 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/11\/\u7db2\u9801\u7528\u571655-08-300x180.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/11\/\u7db2\u9801\u7528\u571655-08-768x461.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/11\/\u7db2\u9801\u7528\u571655-08-1536x923.jpg 1536w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/11\/\u7db2\u9801\u7528\u571655-08-2048x1230.jpg 2048w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/11\/\u7db2\u9801\u7528\u571655-08-1080x649.jpg 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/11\/\u7db2\u9801\u7528\u571655-08-1280x768.jpg 1280w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/11\/\u7db2\u9801\u7528\u571655-08-627x376.jpg 627w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/11\/\u7db2\u9801\u7528\u571655-08-440x264.jpg 440w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p>\n<p>\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u53ef\u671b\u66f4\u7cbe\u6e96\uff01\u5728\u764c\u75c7\u7814\u7a76\u4e2d\uff0c\u4e0a\u76ae\u7d30\u80de\u9ecf\u9644\u5206\u5b50\uff08EpCAM\uff09\u88ab\u5ee3\u6cdb\u8a8d\u70ba\u662f\u8fa8\u8a8d\u764c\u7d30\u80de\u7684\u91cd\u8981\u6a19\u7684\u3002\u8fd1\u671f\uff0c\u672c\u9662\u7d30\u80de\u8207\u500b\u9ad4\u751f\u7269\u7814\u7a76\u6240\u7279\u8058\u7814\u7a76\u54e1\u517c\u4efb\u751f\u91ab\u8f49\u8b6f\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u5433\u6f22\u5fe0\u7684\u7814\u7a76\u5718\u968a\u767c\u8868\u4e86\u4e00\u9805\u7814\u7a76\u6210\u679c\uff0c\u89e3\u958bEpCAM\u5982\u4f55\u4fc3\u9032\u764c\u7d30\u80de\u751f\u9577\uff0c\u4ee5\u53ca\u5982\u4f55\u4e2d\u6b62\u9019\u9805\u6a5f\u5236\u4e4b\u8b0e\u3002\u5718\u968a\u7814\u767c\u7684\u65b0\u6297\u9ad4EpAb2-6\u5c0d\u764c\u75c7\u7684\u8a3a\u65b7\u3001\u6a19\u9776\u6cbb\u7642\u53ca\u9020\u5f71\u90fd\u6df1\u5177\u767c\u5c55\u6f5b\u529b\uff0c\u8fd1\u671f\u5df2\u520a\u767b\u5728\u570b\u969b\u671f\u520a\u300a\u764c\u75c7\u7814\u7a76\u300b\uff08<em>Cancer Research<\/em>\uff09\u3002<\/p>\n<p>EpCAM\u662f\u4e00\u7a2e\u5728\u7d30\u80de\u819c\u4e0a\u7684\u86cb\u767d\u8cea\uff0c\u5e38\u898b\u65bc\u4e0a\u76ae\u7d44\u7e54\u548c\u5927\u91cf\u8868\u9054\u65bc\u60e1\u6027\u816b\u7624\u4e2d\uff0c\u8207\u7d30\u80de\u9ecf\u9644\u3001\u9077\u79fb\u3001\u589e\u6b96\u3001\u5206\u5316\u53ca\u816b\u7624\u767c\u751f\u3001\u9032\u5c55\u6709\u95dc\u3002\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u5b83\u6703\u900f\u904e\u8a0a\u606f\u50b3\u905e\u4f86\u7a69\u5b9aPD-L1\u7684\u86cb\u767d\uff1b\u800cPD-L1\u6b63\u662f\u4f7f\u816b\u7624\u7d30\u80de\u5f97\u4ee5\u9003\u812b\u8eab\u9ad4\u514d\u75ab\u7cfb\u7d71\u76e3\u63a7\u3001\u5c0e\u81f4\u764c\u75c7\u60e1\u5316\u7684\u86cb\u767d\u8cea\uff01\u76ee\u524d\uff0c\u5df2\u8b49\u5be6\u53ea\u8981\u6291\u5236\u514d\u75ab\u6aa2\u67e5\u9ede\u86cb\u767d\uff08\u4f8b\u5982 PD-1 \u6216CTLA-4\uff09\u5c31\u80fd\u6709\u6548\u6cbb\u7642\u764c\u75c7\uff0c\u9019\u4e5f\u5c31\u662f2018\u5e74\u7372\u5f97\u8afe\u8c9d\u723e\u751f\u7406\u91ab\u5b78\u734e\u80af\u5b9a\u3001\u5728\u91ab\u5b78\u754c\u5099\u53d7\u91cd\u8996\u7684\u300c\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u300d\u3002<\/p>\n<p>\u70ba\u4e86\u80fd\u7cbe\u6e96\u8fa8\u8b58\u51fa\u764c\u7d30\u80de\u819c\u4e0a\u7684EpCAM\uff0c\u7814\u7a76\u5718\u968a\u7814\u767c\u51fa\u76f8\u5c0d\u61c9\u7684\u4e2d\u548c\u6027\u55ae\u682a\u6297\u9ad4EpAb2-6\uff0c\u53ef\u6291\u5236EpCAM\u7684\u8a0a\u606f\u50b3\u905e\u529f\u80fd\u3001\u964d\u4f4e\u764c\u7d30\u80de\u4e2dPD-L1\u86cb\u767d\u7684\u8868\u73fe\uff0c\u9032\u800c\u5c0e\u81f4\u816b\u7624\u7d30\u80de\u6b7b\u4ea1\u53ca\u6d3b\u5316T\u7d30\u80de\u6bba\u6b7b\u764c\u7d30\u80de\u7684\u80fd\u529b\u3002\u5728\u5927\u8178\u764c\u7684\u52d5\u7269\u5be6\u9a57\u4e2d\uff0cEpAb2-6\u5c55\u73fe\u4e86\u7d55\u4f73\u7684\u816b\u7624\u6291\u5236\u80fd\u529b\u53ca\u5927\u5e45\u63d0\u5347\u5c0f\u9f20\u7684\u5b58\u6d3b\u7387\u3002\u6b64\u5916\uff0c\u5728\u80ba\u764c\u7684\u52d5\u7269\u5be6\u9a57\u540c\u6642\u4f7f\u7528EpAb2-6 \u548cPD-L1\u6297\u9ad4Atezolizumab\u7684\u300c\u806f\u5408\u7642\u6cd5\u300d\uff0c\u53ef\u6709\u6548\u6291\u5236\u816b\u7624\u7684\u751f\u9577\u3002\u9019\u4e9b\u767c\u73fe\u4e0d\u50c5\u66f4\u6df1\u5165\u5256\u6790EpCAM\u4fc3\u4f7f\u764c\u75c7\u60e1\u5316\u7684\u5206\u5b50\u6a5f\u5236\uff0c\u5c0d\u672a\u4f86\u81e8\u5e8a\u4e0a\u6cbb\u7642EpCAM\u904e\u91cf\u8868\u73fe\u7684\u764c\u75c7\uff0c\u4e5f\u63d0\u4f9b\u4e86\u7d50\u5408\u514d\u75ab\u7642\u6cd5\u7684\u65b0\u7b56\u7565\u3002<\/p>\n<p>\u5433\u6f22\u5fe0\u8868\u793a\uff1a\u300cEpCAM\u53ef\u898b\u65bc\u8a31\u591a\u7a2e\u764c\u7d30\u80de\uff0c\u5982\uff1a\u5927\u8178\u764c\u3001\u80ba\u764c\u3001\u53e3\u8154\u764c\u3001\u80f0\u81df\u764c\u7b49\uff0c\u56e0\u6b64\uff0c\u53ef\u4ee5\u9810\u898b\u9019\u9805\u7814\u7a76\u6210\u679c\u672a\u4f86\u5c07\u88ab\u5ee3\u6cdb\u61c9\u7528\u5728\u5404\u7a2e\u4e0d\u540c\u7684\u764c\u75c7\u8a3a\u65b7\u548c\u6cbb\u7642\u3002\u300d\u7d93\u5be6\u9a57\u8b49\u5be6\uff0c\u9019\u7a2e\u4e2d\u548c\u6027\u6297\u9ad4EpAb2-6\u80fd\u8207\u591a\u7a2e\u764c\u7d30\u80de\u7684EpCAM\u7d50\u5408\uff0c\u4e5f\u80fd\u6709\u6548\u6291\u5236\u816b\u7624\u7684\u751f\u9577\u548c\u8f49\u79fb\uff0c\u5ef6\u9577\u5c0f\u9f20\u58fd\u547d\u3002\u76ee\u524d\uff0c\u6b64\u4eba\u985e\u5316\u4e2d\u548c\u6027\u6297\u9ad4EpAb2-6\u5728\u764c\u75c7\u7684\u8a3a\u65b7\u3001\u6a19\u9776\u6cbb\u7642\u53ca\u9020\u5f71\u7684\u61c9\u7528\uff0c\u6df1\u5177\u767c\u5c55\u6f5b\u529b\uff0c\u5df2\u53d6\u5f97\u4e16\u754c\u591a\u570b\u7684\u5c08\u5229\uff0c\u4e26\u7372\u79d1\u6280\u90e8\u50f9\u5275\u8a08\u756b5,000\u842c\u5143\u7684\u652f\u6301\uff0c\u6210\u7acb\u65b0\u5275\u516c\u53f8\u9032\u99d0\u570b\u5bb6\u751f\u6280\u7814\u7a76\u5712\u5340\uff0c\u672a\u4f86\u53ef\u671b\u5316\u7814\u70ba\u7528\uff0c\u9020\u798f\u4eba\u7fa4\u3002<\/p>\n<p>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cEpCAM\u5c0d\u4eba\u9ad4\u4e26\u975e\u53ea\u6709\u8ca0\u9762\u5f71\u97ff\u3002\u5728\u4e00\u7cfb\u5217\u958b\u5275\u6027\u7684\u7814\u7a76\u4e2d\uff0c\u5433\u6f22\u5fe0\u5718\u968a\u767c\u73fe\u5b83\u5176\u5be6\u5c0d\u4eba\u9ad4\u7684\u5e79\u7d30\u80de\u6709\u6b63\u9762\u7684\u5e6b\u52a9\u3002\u4f8b\u5982\uff1aEpCAM\u6703\u9ad8\u5ea6\u8868\u73fe\u5728\u672a\u5206\u5316\u7684\u4eba\u985e\u80da\u80ce\u5e79\u7d30\u80de\uff0c\u53ef\u76f4\u63a5\u8abf\u63a7\u591a\u80fd\u57fa\u56e0\uff0c\u5e6b\u52a9\u7dad\u6301\u80da\u80ce\u5e79\u7d30\u80de\u7684\u591a\u80fd\u6027\u3002\u6b64\u5916\uff0c\u7814\u7a76\u5718\u968a\u4e5f\u900f\u904eEpCAM\uff0c\u63a8\u9032\u4e862012\u5e74\u8afe\u8c9d\u723e\u5f97\u4e3b\u5c71\u4e2d\u4f38\u5f4c\u7684\u7814\u7a76\u6210\u679c\u3002\u539f\u672c\uff0c\u4f7f\u7e96\u7dad\u6bcd\u7d30\u80de\u91cd\u7de8\u7a0b\u6210\u70ba\u8a98\u5c0e\u578b\u591a\u80fd\u5e79\u7d30\u80de\u9700\u89814\u500b\u5c71\u4e2d\u4f38\u5f4c\u56e0\u5b50\uff0c\u4f46\u6709\u4e86EpCAM\uff0c\u53ea\u97001\u500b\u5c71\u4e2d\u4f38\u5f4c\u56e0\u5b50\u5373\u53ef\u6210\u529f\uff1b\u800c\u5718\u968a\u4e5f\u767c\u73feEpCAM\u5c0d\u9aa8\u982d\u7684\u751f\u6210\u4ea6\u6709\u5e6b\u52a9\u3002\u7e3d\u800c\u8a00\u4e4b\uff0c\u9019\u4e9b\u7814\u7a76\u6210\u679c\u6709\u52a9\u65bc\u958b\u767c\u66f4\u9ad8\u6548\u7684\u91cd\u7de8\u7a0b\u7b56\u7565\u53ca\u7dad\u6301\u5e79\u7d30\u80de\u7684\u591a\u80fd\u6027\uff0c\u4ee3\u8868EpCAM\u86cb\u767d\u4e5f\u53ef\u61c9\u7528\u5728\u5e79\u7d30\u80de\u7684\u7814\u7a76\u3001\u7d44\u7e54\u5de5\u7a0b\u6216\u518d\u751f\u91ab\u5b78\u7b49\u3002<\/p>\n<p>\u672c\u7814\u7a76\u8ad6\u6587\uff1cEpCAM signaling promotes tumor progression and protein stability of PD-L1 through the EGFR pathway\uff1e\u5df2\u65bc2020\u5e7411\u670816\u65e5\u6b63\u5f0f\u767c\u8868\u3002\u7814\u7a76\u5718\u968a\u6709\u5433\u6f22\u5fe0\u7279\u8058\u7814\u7a76\u54e1\u53ca2\u4f4d\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff1a\u78a9\u58eb\u751f\u9673\u7693\u5e74\u8207\u6881\u525b\u8c6a\u535a\u58eb\u3002<\/p>\n<p>\u8ad6\u6587\u5168\u6587\uff1a<a href=\"https:\/cancerres.aacrjournals.org\/content\/80\/22\/5035\">https:\/cancerres.aacrjournals.org\/content\/80\/22\/5035<\/a>\u3002<\/p>\n<div id=\"attachment_21652\" style=\"width: 904px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21652\" class=\"aligncenter size-full wp-image-23395\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/11\/1\u7576\u671f\u7126\u9ede_\u764c\u75c7\u70ba\u4f55\u60e1\u5316-2.jpg\" alt=\"\" width=\"894\" height=\"979\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/11\/1\u7576\u671f\u7126\u9ede_\u764c\u75c7\u70ba\u4f55\u60e1\u5316-2.jpg 894w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/11\/1\u7576\u671f\u7126\u9ede_\u764c\u75c7\u70ba\u4f55\u60e1\u5316-2-274x300.jpg 274w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/11\/1\u7576\u671f\u7126\u9ede_\u764c\u75c7\u70ba\u4f55\u60e1\u5316-2-768x841.jpg 768w\" sizes=\"(max-width: 894px) 100vw, 894px\" \/><p id=\"caption-attachment-21652\" 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