{"id":23300,"date":"2020-11-05T00:03:20","date_gmt":"2020-11-04T16:03:20","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=23300"},"modified":"2021-08-26T08:50:18","modified_gmt":"2021-08-26T00:50:18","slug":"%e3%80%90%e5%b0%88%e6%ac%84%e3%80%91%e9%81%ba%e5%82%b3%e5%b7%a5%e7%a8%8b%e5%b8%ab%ef%bc%9a%e8%be%b2%e6%a1%bf%e8%8f%8c%e7%9a%84%e7%ab%b6%e7%88%ad%e8%88%87%e8%87%b4%e7%97%85%e6%a9%9f%e5%88%b6","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/23300\/","title":{"rendered":"\u3010\u5c08\u6b04\u3011\u907a\u50b3\u5de5\u7a0b\u5e2b\uff1a\u8fb2\u687f\u83cc\u7684\u7af6\u722d\u8207\u81f4\u75c5\u6a5f\u5236"},"content":{"rendered":"

\u690d\u7269\u8207\u4eba\u4e00\u6a23\uff0c\u6703\u88ab\u5404\u5f0f\u5404\u6a23\u7684\u75c5\u539f\u611f\u67d3\u800c\u751f\u75c5\u3002\u5176\u4e2d\uff0c\u8fb2\u687f\u83cc\uff08Agrobacterium tumefaciens<\/em>\uff09\u53ef\u8aaa\u662f\u6700\u70ba\u8072\u540d\u9060\u64ad\u7684\u690d\u7269\u75c5\u539f\u83cc\u4e4b\u4e00\u3002\u9019\u7a2e\u7d30\u83cc\u666e\u904d\u751f\u6d3b\u5728\u571f\u58e4\u4e2d\uff0c\u5728\u9047\u5230\u9069\u5408\u7684\u690d\u7269\u5bbf\u4e3b\u6642\u6703\u5165\u4fb5\u690d\u7269\uff0c\u9020\u6210\u690d\u7269\u7d30\u80de\u589e\u751f\u5f62\u6210\u816b\u7624\uff0c\u7a31\u70ba\u764c\u816b\u75c5\uff08crown gall disease\uff09\u3002\u9019\u500b\u690d\u7269\u7684\u816b\u7624\u5b9b\u82e5\u8fb2\u687f\u83cc\u7684\u8c6a\u5b85\uff0c\u4e0d\u53ea\u63d0\u4f9b\u4f4f\u5bbf\u9084\u9644\u8d08\u5b83\u611b\u5403\u7684\u990a\u5206\uff0c\u8b93\u8fb2\u687f\u83cc\u5728\u9019\u88e1\u589e\u751f\u7e41\u6b96\u3002\u7a76\u7adf\u8fb2\u687f\u83cc\u662f\u5982\u4f55\u6210\u70ba\u6210\u529f\u7684\u690d\u7269\u75c5\u539f\u83cc\uff0c\u5728\u6fc0\u70c8\u7684\u7af6\u722d\u74b0\u5883\u4e2d\u812b\u7a4e\u800c\u51fa\u3001\u5f81\u670d\u5bbf\u4e3b\u4e56\u4e56\u807d\u8a71\uff1f\u800c\u79d1\u5b78\u5bb6\u5011\u53c8\u5982\u4f55\u5316\u5371\u6a5f\u70ba\u8f49\u6a5f\uff0c\u5c07\u9019\u96bb\u7d30\u83cc\u8b8a\u6210\u5f37\u800c\u6709\u529b\u7684\u907a\u50b3\u5de5\u7a0b\u5e2b\u5462\uff1f<\/p>\n

\u770b\u4e0d\u898b\u7684\u7d30\u83cc\u5927\u6df7\u6230\u2500\u2500\u8fb2\u687f\u83cc\u7684\u7af6\u722d\u7be9\u9078\u6a5f\u5236<\/strong><\/p>\n

\u89ac\u89a6\u80a5\u7f8e\u591a\u6c41\u7684\u690d\u7269\u7684\u53ef\u4e0d\u53ea\u6709\u8fb2\u687f\u83cc\u9019\u7a2e\u7d30\u83cc\uff0c\u4e8b\u5be6\u4e0a\uff0c\u81ea\u7136\u754c\u4e2d\u5145\u65a5\u8457\u5404\u5f0f\u5404\u6a23\u7684\u5fae\u751f\u7269\u3002\u9019\u4e9b\u5fae\u751f\u7269\u6709\u6642\u5408\u4f5c\u6709\u6642\u7af6\u722d\uff0c\u7121\u8ad6\u662f\u571f\u58e4\u3001\u6c34\u57df\u9084\u662f\u751f\u7269\u9ad4\u5167\uff0c\u5728\u6211\u5011\u770b\u4e0d\u5230\u7684\u5fae\u89c0\u4e16\u754c\u4e2d\u6642\u6642\u523b\u523b\u90fd\u4e0a\u6f14\u8457\u5edd\u6bba\u6232\u78bc\uff0c\u8fb2\u687f\u83cc\u7576\u7136\u4e5f\u7121\u6cd5\u7f6e\u8eab\u4e8b\u5916\u3002<\/p>\n

\u6c5f\u6e56\u5728\u8d70\uff0c\u6b66\u5668\u8981\u6709\u3002\u7d30\u83cc\u5011\u70ba\u4e86\u6c42\u751f\u5b58\uff0c\u6f14\u5316\u51fa\u5404\u5f0f\u5404\u6a23\u7684\u6b66\u5668\u4f86\u61c9\u4ed8\u4e0d\u540c\u7684\u7af6\u722d\u5c0d\u624b\uff0c\u7b2c\u516d\u578b\u5206\u6ccc\u7cfb\u7d71(Type VI secretion system, T6SS)\u4fbf\u662f\u5176\u4e2d\u4e00\u7a2e\u7528\u65bc\u7d30\u83cc\u9593\u5167\u9b25\u7684\u6b66\u5668\u3002\u5728\u96fb\u5b50\u986f\u5fae\u93e1\u4e0b\u53ef\u4ee5\u770b\u51faT6SS\u662f\u7531\u8a31\u591a\u86cb\u767d\u8cea\u7d44\u88dd\u800c\u6210\u50cf\u662f\u91dd\u7b52\u4e00\u6a23\u7684\u69cb\u9020\uff0c\u7528\u4f86\u523a\u5165\u5176\u4ed6\u7d30\u83cc\u4e4b\u4e2d\uff0c\u5c07\u6548\u61c9\u5206\u5b50(effector)\u9001\u5165\u4ee5\u6bba\u6b7b\u6216\u6291\u5236\u7af6\u722d\u8005\u7684\u751f\u9577\uff0c\u4ee5\u589e\u9032\u81ea\u5df1\u7684\u751f\u9577\u6216\u7af6\u722d\u512a\u52e2\u3002<\/p>\n

\u6253\u4ed7\u5167\u9b25\u53ef\u662f\u4ef6\u50b7\u795e\u8017\u6642\u7684\u4e8b\u60c5\uff0c\u8fb2\u687f\u83cc\u7684\u8cc7\u6e90\u6709\u9650\uff0c\u8a72\u5982\u4f55\u6c7a\u5b9a\u4ec0\u9ebc\u6642\u5019\u8a72\u7aef\u69cd\u6253\u4ed7\u3001\u4ec0\u9ebc\u6642\u5019\u53c8\u61c9\u8a72\u653e\u4e0b\u6b66\u5668\u990a\u7cbe\u84c4\u92b3\u5462\uff1f\u900f\u904e\u5728\u8fb2\u687f\u83ccC58\u83cc\u682aT6SS\u7684\u6df1\u5165\u7814\u7a76\uff0c\u6211\u5011\u767c\u73feC58\u83cc\u682a\u6703\u88fd\u9020\u4e00\u500b\u53eb\u4f5cTde\u7684\u6548\u61c9\u5206\u5b50\uff0cTde\u662f\u5177\u6709\u5206\u89e3DNA\u80fd\u529b\u7684\u6bba\u83cc\u6bd2\u7d20\uff0c\u6703\u7531\u5ea7\u843d\u5728T6SS\u91dd\u7b52\u5c16\u7aef\u7684\u86cb\u767d\u8ceaVgrG\u6240\u651c\u5e36\uff0c\u518d\u6ce8\u5c04\u5165\u6575\u83cc\u4e4b\u4e2d[1][2]\u3002\u800cTde\u548cVgrG\u9019\u5169\u500b\u86cb\u767d\u8cea\u7684\u7d50\u5408\u5c31\u50cf\u662f\u958b\u706b\u8a0a\u865f\u4e00\u822c\uff0c\u6703\u555f\u52d5\u7d30\u83cc\u5feb\u901f\u7d44\u88ddT6SS\u4e26\u5c07\u9019\u4e9b\u6bba\u83cc\u6bd2\u7d20\u9001\u5165\u76ee\u6a19\u7d30\u83cc\u4e4b\u4e2d[3]\u3002<\/p>\n

\u6709\u4e86\u653b\u64ca\u8a0a\u865f\uff0c\u9084\u8981\u64d4\u5fc3\u5b50\u5f48\u4e0d\u9577\u773c\uff0c\u5728\u4e00\u5718\u6df7\u6230\u4e4b\u4e2d\u8981\u662f\u8aa4\u50b7\u53cb\u8ecd\u53ef\u5c31\u5f97\u4e0d\u511f\u5931\u4e86\u3002\u90a3\u9ebc\uff0c\u8fb2\u687f\u83cc\u662f\u5426\u80fd\u5920\u8fa8\u8b58\u6575\u6211\uff0c\u8b93\u81ea\u5df1\u7684\u6b66\u5668\u4e0d\u8981\u50b7\u5bb3\u5230\u968a\u53cb\u5462\uff1f\u672c\u7814\u7a76\u5718\u968a\u5229\u7528\u4e0d\u540c\u4f86\u6e90\u7684\u8fb2\u687f\u83cc\u83cc\u682a\u5728\u690d\u7269\u9ad4\u4e2d\u5169\u5169\u7af6\u722d\uff0c\u4e26\u4e14\u5206\u6790\u5b83\u5011\u4e4b\u9593\u7684\u89aa\u7de3\u95dc\u4fc2\uff0c\u767c\u73fe\u8fb2\u687f\u83cc\u50be\u5411\u5c0d\u81ea\u5df1\u7684\u300c\u719f\u4eba\u300d\u7db2\u958b\u4e00\u9762\u2500\u2500\u5b83\u5011\u5c0d\u65bc\u89aa\u7de3\u95dc\u4fc2\u76f8\u8fd1\u7684\u83cc\u682a\u7684\u6bba\u50b7\u529b\u8f03\u5f31[4]\uff0c\u4f46\u5c0d\u89aa\u7de3\u95dc\u4fc2\u8f03\u9060\u7684\u8fb2\u687f\u83cc\u83cc\u682a\u6216\u975e\u8fb2\u687f\u83cc\u7684\u7d30\u83cc\u5982\u5927\u8178\u687f\u83cc(Escherichia coli<\/em>)\u5c31\u5c55\u73fe\u8f03\u5f37\u7684\u6bba\u50b7\u529b\u3002\u6709\u8da3\u7684\u662f\uff0c\u4e0d\u540c\u7684\u5927\u8178\u687f\u83cc\u83cc\u682a\u9762\u5c0d\u8fb2\u687f\u83cc\u7684T6SS\u653b\u64ca\u4e5f\u6703\u5c55\u73fe\u4e0d\u540c\u7684\u50b7\u4ea1\u7a0b\u5ea6\u3002\u85c9\u7531\u8b93\u8fb2\u687f\u83cc\u653b\u64ca\u4e0d\u540c\u7684\u5927\u8178\u687f\u83cc\u7a81\u8b8a\u682a\u7684\u5be6\u9a57\uff0c\u672c\u7814\u7a76\u5718\u968a\u767c\u73fe\u6709\u5e7e\u682a\u5927\u8178\u687f\u83cc\u7a81\u8b8a\u682a\u53ef\u62b5\u6297\u8fb2\u687f\u83ccT6SS\u7684\u6bba\u50b7\u529b\u2500\u2500\u4e5f\u5c31\u662f\u8aaa\u64c1\u6709\u9019\u4e9b\u57fa\u56e0\u7522\u7269\u7684\u7684\u5927\u8178\u687f\u83cc\u6703\u66f4\u5bb9\u6613\u88ab\u8fb2\u687f\u83cc\u7684T6SS\u653b\u64ca\u6bba\u6b7b\u3002\u9019\u8868\u793a\u9019\u4e9b\u5927\u8178\u687f\u83cc\u7684\u57fa\u56e0\u7522\u7269\u53ef\u80fd\u88ab\u8fb2\u687f\u83cc\u7528\u4f86\u589e\u9032T6SS\u7684\u653b\u64ca\u80fd\u529b\u6216\u6bba\u83cc\u6bd2\u7d20\u7684\u6bba\u50b7\u529b[5]\u3002\u53ef\u898b\u8fb2\u687f\u83cc\u5728\u9019\u5834\u5927\u6df7\u6230\u4e2d\u773c\u775b\u53ef\u4eae\u8457\u5462\uff01\u4e0d\u53ea\u53ef\u4ee5\u5340\u5225\u540c\u985e\u6216\u7570\u5df1\uff0c\u4e5f\u80fd\u5920\u501f\u5200\u6bba\u4eba\uff0c\u6436\u596a\u6575\u8ecd\u7684\u8cc7\u6e90\u4f86\u6210\u5c31\u81ea\u8eab\u7684\u52dd\u5229\u3002<\/p>\n

\u4f60\u7684\u8d85\u80fd\u529b\u5c31\u662f\u6211\u7684\u8d85\u80fd\u529b\u2500\u2500\u8fb2\u687f\u83cc\u8f49\u57fa\u56e0\u6a5f\u5236\u53ca\u5176\u61c9\u7528<\/strong><\/p>\n

\u7576\u8fb2\u687f\u83cc\u7d42\u65bc\u5f9e\u7af6\u722d\u6fc0\u70c8\u7684\u7d30\u83cc\u5167\u9b25\u4e2d\u5b58\u6d3b\u4e26\u5faa\u8457\u690d\u7269\u6240\u91cb\u51fa\u7684\u7269\u8cea\u627e\u5230\u5922\u5bd0\u4ee5\u6c42\u7684\u5bbf\u4e3b\u6642\uff0c\u5b83\u6703\u638f\u51fa\u53e6\u5916\u4e00\u628a\u69cd\u2500\u2500\u7b2c\u56db\u578b\u5206\u6ccc\u7cfb\u7d71(Type IV secretion system, T4SS)\uff0c\u9019\u500b\u6b66\u5668\u53ef\u4ee5\u7528\u4f86\u300c\u6d17\u8166\u300d\u5b83\u7684\u5bbf\u4e3b\uff0c\u8b93\u5bbf\u4e3b\u5011\u5fc3\u7518\u60c5\u9858\u5730\u4f9b\u5403\u4f9b\u4f4f\u3002<\/p>\n

\u8fb2\u687f\u83cc\u80fd\u5920\u5982\u6b64\u9a19\u5403\u9a19\u559d\u7684\u7955\u5bc6\u5c31\u5728\u4e00\u500b\u7368\u7acb\u65bc\u67d3\u8272\u9ad4\u4e4b\u5916\u7684\u816b\u7624\u8a98\u767c\u8cea\u9ad4(Tumor-inducing plasmid, Ti plasmid)\uff0c\u5728\u690d\u7269\u5bbf\u4e3b\u5206\u5b50\u8a0a\u606f\u7684\u523a\u6fc0\u4e4b\u4e0b\uff0c\u9019\u500b\u816b\u7624\u8a98\u767c\u8cea\u9ad4\u4e0a\u7684\u4e00\u7fa4\u57fa\u56e0\u53ef\u4ee5\u505a\u51fa\u7d44\u6210T4SS\u7684\u96f6\u4ef6\u53ca\u5176\u4ed6\u80fd\u5354\u52a9\u81f4\u75c5\u7684\u86cb\u767d\u8cea\uff0c\u9084\u6703\u5c07\u81ea\u5df1\u7684\u5176\u4e2d\u4e00\u500b\u7247\u6bb5\u900f\u904eT4SS\u9001\u9032\u5bbf\u4e3b\u7684\u7d30\u80de\u88e1\u9762\u3002\u79d1\u5b78\u5bb6\u5011\u5c07\u9019\u500b\u6703\u88ab\u8f49\u79fb\u7684DNA\u7247\u6bb5\u5b9a\u7fa9\u70ba\u8f49\u79fbDNA (transferred DNA, T-DNA)\u3002\u8f49\u79fbDNA\u5728\u9032\u5165\u690d\u7269\u7d30\u80de\u4e4b\u5f8c\u6703\u5d4c\u5165\u690d\u7269\u7d30\u80de\u6838\u7684\u67d3\u8272\u9ad4\u4e2d\uff0c\u56e0\u70ba\u9019\u6bb5DNA\u5e8f\u5217\u4e2d\u5305\u542b\u4e86\u88fd\u9020\u690d\u7269\u8377\u723e\u8499\u4ee5\u53ca\u7d30\u83cc\u5c08\u5c6c\u990a\u5206\u7684\u57fa\u56e0\uff0c\u6240\u4ee5\u6703\u8a98\u5c0e\u690d\u7269\u7d30\u80de\u4e0d\u65b7\u5206\u88c2\u589e\u751f\u8b8a\u6210\u816b\u7624\uff0c\u4e5f\u88fd\u9020\u4e86\u8fb2\u687f\u83cc\u559c\u6b61\u7684\u990a\u5206[6]\u3002<\/p>\n

\u9b54\u9ad8\u4e00\u5c3a\uff0c\u9053\u9ad8\u4e00\u4e08\u3002\u79d1\u5b78\u5bb6\u5c0d\u8fb2\u687f\u83cc\u7684\u816b\u7624\u8a98\u767c\u8cea\u9ad4\u52d5\u4e86\u4e9b\u624b\u8173\uff0c\u5c07\u8fb2\u687f\u83cc\u539f\u672c\u8981\u9001\u5165\u690d\u7269\u7684\u8f49\u79fbDNA\u57fa\u56e0\u79fb\u82b1\u63a5\u6728\uff0c\u63db\u6210\u81ea\u5df1\u60f3\u9001\u5165\u690d\u7269\u7684\u57fa\u56e0\u5e8f\u5217\uff0c\u4fbf\u53ef\u4ee5\u5229\u7528\u8fb2\u687f\u83cc\u7684\u7279\u6027\u88fd\u4f5c\u51fa\u6703\u8868\u73fe\u7279\u5b9a\u57fa\u56e0\u7522\u7269\u7684\u690d\u7269\u3002\u9664\u4e86\u7528\u65bc\u88fd\u4f5c\u8f49\u57fa\u56e0\u4f5c\u7269\u5916\uff0c\u5728\u79d1\u5b78\u7814\u7a76\u4e0a\u4e5f\u53ef\u4ee5\u7528\u4f86\u7814\u7a76\u690d\u7269\u57fa\u56e0\u7684\u529f\u80fd\u3002\u4f8b\u5982\uff0c\u5229\u7528\u8fb2\u687f\u83cc\u6703\u5c07\u8f49\u79fbDNA\u96a8\u6a5f\u63d2\u5165\u690d\u7269\u57fa\u56e0\u7d44\u7684\u7279\u6027\uff0c\u8fb2\u687f\u83cc\u53ef\u4ee5\u7528\u4f86\u88fd\u4f5c\u5177\u6709\u4e0d\u540c\u57fa\u56e0\u88ab\u7834\u58de\u7684\u690d\u7269\u7a81\u8b8a\u682a\uff0c\u4e5f\u80fd\u5920\u53cd\u904e\u4f86\u5229\u7528\u8f49\u79fbDNA\u651c\u5e36\u7279\u5b9a\u6838\u9178\u5e8f\u5217\uff0c\u4ee5\u75c5\u6bd2\u8a98\u5c0e\u4e4b\u57fa\u56e0\u975c\u9ed8(virus-induced gene silencing)\u539f\u7406\u8b93\u7279\u5b9a\u7684\u690d\u7269\u57fa\u56e0\u8868\u73fe\u4e0b\u964d\u3002\u9019\u4e9b\u5de5\u5177\u8b93\u79d1\u5b78\u5bb6\u5f97\u4ee5\u89c0\u5bdf\u690d\u7269\u5177\u6709\u6216\u8005\u7f3a\u4e4f\u67d0\u4e9b\u57fa\u56e0\u7684\u6642\u5019\u8868\u73fe\u7684\u6027\u72c0\uff0c\u5c0d\u65bc\u79d1\u7814\u767c\u5c55\u529f\u4e0d\u53ef\u6c92\u3002<\/p>\n

\u591a\u5e74\u4f86\uff0c\u8a31\u591a\u79d1\u5b78\u5bb6\u81f4\u529b\u65bc\u6539\u826f\u8207\u7814\u767c\u8fb2\u687f\u83cc\u57fa\u56e0\u8f49\u6b96\u7684\u65b9\u5f0f\uff0c\u9664\u4e86\u5e0c\u671b\u80fd\u5920\u66f4\u7a69\u5b9a\u6709\u6548\u7387\u5730\u88fd\u4f5c\u8f49\u57fa\u56e0\u690d\u7269\u5916\uff0c\u4e5f\u958b\u767c\u80fd\u5920\u7e2e\u77ed\u5be6\u9a57\u6642\u9593\u3001\u589e\u52a0\u6a23\u672c\u6578\u91cf\u7684\u7814\u7a76\u5de5\u5177\u3002\u5176\u4e2d\uff0c\u672c\u7814\u7a76\u5718\u968a\u6240\u958b\u767c\u7684AGROBEST\u65b9\u6cd5\u53ef\u4ee5\u540c\u6642\u611f\u67d3\u5927\u91cf\u690d\u7269\u5e7c\u82d7\u5feb\u901f\u9032\u884c\u8fb2\u687f\u83cc\u57fa\u56e0\u8f49\u6b96\u3002\u900f\u904e\u9019\u500b\u9ad8\u901a\u91cf\u611f\u67d3\u5be6\u9a57\uff0c\u79d1\u5b78\u5bb6\u5011\u80fd\u5920\u66f4\u6709\u6548\u7387\u5730\u5f97\u5230\u8fb2\u687f\u83cc\u8f49\u6b96\u7684\u57fa\u56e0\u8868\u73fe\u7d50\u679c\uff0c\u52a0\u901f\u7814\u7a76\u9032\u7a0b[7]\u3002<\/p>\n

\u5c31\u50cf\u662f\u4eba\u9ad4\u514d\u75ab\u53cd\u61c9\u61c2\u5f97\u5c0d\u6297\u5916\u4f86\u75c5\u83cc\uff0c\u690d\u7269\u9762\u5c0d\u8fb2\u687f\u83cc\u81ea\u7136\u4e5f\u4e0d\u6703\u4e56\u4e56\u5c31\u7bc4\uff0c\u9019\u4f7f\u5f97\u5229\u7528\u8fb2\u687f\u83cc\u9032\u884c\u57fa\u56e0\u8f49\u6b96\u7684\u65b9\u5f0f\u9047\u5230\u74f6\u9838\u3002\u8981\u5982\u4f55\u9a19\u904e\u690d\u7269\u3001\u589e\u52a0\u8fb2\u687f\u83cc\u57fa\u56e0\u8f49\u690d\u6210\u529f\u7387\u4e00\u76f4\u662f\u500b\u5f85\u89e3\u7684\u96e3\u984c\u3002\u672c\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u7576AGROBEST\u5be6\u9a57\u4e2d\u4ee5\u7de9\u885d\u6db2\u7dad\u6301\u9178\u9e7c\u503c\u5728pH 5.5\u7684\u6642\u5019\u53ef\u4ee5\u9054\u5230\u6700\u4f73\u7684\u8f49\u57fa\u56e0\u6548\u7387\uff0c\u5176\u4e2d\u539f\u7406\u662f\u56e0\u70ba\u7a69\u5b9a\u7684pH\u503c\u6703\u6291\u5236\u690d\u7269\u7d30\u80de\u651d\u53d6\u9223\u96e2\u5b50\uff0c\u9032\u800c\u6291\u5236\u690d\u7269\u7684\u514d\u75ab\u53cd\u61c9[8]\u3002<\/p>\n

\u96d9\u9762\u8fb2\u687f\u83cc\u2500\u2500\u5f9e\u690d\u7269\u816b\u7624\u75c5\u539f\u83cc\u5316\u8eab\u70ba\u907a\u50b3\u5de5\u7a0b\u5e2b<\/strong><\/p>\n

19\u4e16\u7d00\u521d\u671f\u8b49\u660e\u8fb2\u687f\u83cc\u70ba\u9020\u6210\u764c\u816b\u75c5\u7684\u5143\u5147\u6642\uff0c\u8ab0\u4e5f\u6c92\u60f3\u5230\u9019\u4e9b\u4ee4\u4eba\u982d\u75bc\u7684\u7d30\u83cc\u5982\u4eca\u6703\u6416\u8eab\u4e00\u8b8a\u6210\u70ba\u690d\u7269\u79d1\u5b78\u7814\u7a76\u53ca\u8fb2\u696d\u79d1\u6280\u4e0d\u53ef\u6216\u7f3a\u7684\u5de5\u5177\uff0c\u9019\u4e5f\u8b49\u660e\u63a2\u7d22\u5967\u5999\u751f\u547d\u73fe\u8c61\u53ca\u57fa\u790e\u7814\u7a76\u7684\u91cd\u8981\u6027\u3002\u900f\u904e\u5c0d\u5176\u7368\u7279\u7684\u8de8\u754c\u907a\u50b3\u7269\u8cea\u8f49\u79fb\u7684\u5206\u5b50\u6a5f\u5236\u7814\u7a76\uff0c\u4ee5\u53ca\u4e0d\u65b7\u6539\u826f\u4f7f\u7528\u65b9\u5f0f\u53ca\u64f4\u5c55\u5176\u61c9\u7528\uff0c\u6211\u5011\u671f\u8a31\u9019\u500b\u5de5\u5177\u5728\u672a\u4f86\u80fd\u5920\u66f4\u52a0\u6210\u719f\u8207\u65b9\u4fbf\uff0c\u70ba\u79d1\u5b78\u7814\u7a76\u53ca\u793e\u6703\u5e36\u4f86\u66f4\u591a\u798f\u7949\u3002<\/p>\n

\"\"

\u5716\u4e00\u3001\u8fb2\u687f\u83cc\u751f\u5b58\u7af6\u722d\u53ca\u611f\u67d3\u690d\u7269\u5bbf\u4e3b\u7684\u7b56\u7565
\u8fb2\u687f\u83cc\u8eab\u61f7\u4e0d\u540c\u7684\u6b66\u5668\uff0c\u5728\u9762\u5c0d\u4e0d\u540c\u7684\u74b0\u5883\u548c\u63a5\u89f8\u5c0d\u8c61\u5247\u6703\u555f\u52d5\u4e0d\u540c\u7684\u56e0\u61c9\u7b56\u7565\u3002\u7576\u9762\u5c0d\u6575\u8ecd\u6642\u6703\u806f\u5408\u76df\u8ecd\u4e00\u8d77\u555f\u52d5\u7b2c\u516d\u578b\u5206\u6ccc\u7cfb\u7d71(T6SS)\u6bba\u83cc\u6b66\u5668\u4f86\u634d\u885b\u81ea\u5df1\u65cf\u7fa4\u7684\u751f\u5b58\u7a7a\u9593\uff0c\u9047\u5230\u5408\u9069\u7684\u690d\u7269\u5bbf\u4e3b\u6642\u5247\u8d95\u5feb\u88fd\u9020\u81f4\u75c5\u86cb\u767d\u8cea\uff0c\u5408\u529b\u904b\u9001\u8f49\u79fbDNA\uff0c\u7d93\u7531\u7b2c\u56db\u578b\u5206\u6ccc\u7cfb\u7d71(T4SS)\u901a\u9053\u904b\u9001\u5230\u690d\u7269\u7d30\u80de\u5167\uff0c\u8a98\u5c0e\u690d\u7269\u7522\u751f\u816b\u7624\u4f9b\u5176\u5c45\u4f4f\u7e41\u6b96\u3002<\/p><\/div>\n

\u6df1\u5165\u95b1\u8b80<\/strong><\/p>\n

1.Ma LS, Hachani A, Lin JS, Filloux A*, and Lai EM* (2014) Agrobacterium tumefaciens<\/em> deploys a superfamily of type VI secretion DNase effectors as weapons for interbacterial competition in planta. Cell Host & Microbe.<\/em> 16(1):94-104. doi: 10.1016\/j.chom.2014.06.002. https:\/ipmb.sinica.edu.tw\/ch\/activities\/highlights\/140.
\n2.Bondage D, Lin JS, Ma LS, Kuo CH, and Lai EM* (2016) VgrG C-terminus confers the type VI effector transport specificity and is required for binding with PAAR and adaptor-effector complex. Proc Natl Acad Sci<\/em> U S A. 2016 Jul 5:113(27):E3931-40. doi: 10.1073\/pnas.1600428113. https:\/ipmb.sinica.edu.tw\/ch\/activities\/highlights\/65.
\n3.Wu CF#, Lien YW#, Bondage D, Lin JS, Pilhofer M, Shih YL, Chang JH, Lai EM*. (2020) Effector loading onto the VgrG carrier activates type VI secretion system assembly. EMBO Rep.<\/em> 2020 Jan 7;21(1):e47961. doi: 10.15252\/embr.201947961. https:\/ipmb.sinica.edu.tw\/ch\/activities\/highlights\/374.
\n4.Wu CF, Santos MNM, Cho ST, Chang HH, Tsai YM, Smith DA, Kuo CH*, Chang JH*, Lai EM* (2019) Plant pathogenic Agrobacterium tumefaciens<\/em> strains have diverse type VI effector-immunity pairs and vary in in planta<\/em> competitiveness. Mol Plant-Microbe Interact.<\/em> Mar 4. doi: 10.1094\/MPMI-01-19-0021-R. https:\/ipmb.sinica.edu.tw\/ch\/activities\/highlights\/362.
\n5.Lin HH, Yu M, Sriramoju MK, Hsu ST, Liu CT*, and Lai EM* (2020) A high-throughput interbacterial competition screen identifies ClpAP in enhancing recipient susceptibility to type VI secretion system-mediated attack by Agrobacterium tumefaciens. Front. Microbiol.<\/em> doi: 10.3389\/fmicb.2019.03077. https:\/ipmb.sinica.edu.tw\/ch\/activities\/highlights\/378.
\n6.Hwang HH*, Yu M, and Lai EM*. (2017) Agrobacterium<\/em>-mediated plant transformation: biology and applications. The Arabidopsis Book<\/em> 15: e0186. USA: American Society of Plant Biologists.: e0186. doi: 10.1199\/tab.0186.
\n7.Wu HY, Liu KH, Wang YC, Wu JF, Chiu WL, Chen CY, Wu SH, Sheen J, and Lai EM.* (2014) AGROBEST: an efficient Agrobacterium<\/em>-mediated transient expression method for versatile gene function analysis in Arabidopsis<\/em> seedlings. Plant Methods.<\/em> Jun 18;10:19. doi: 10.1186\/1746-4811-10-19. https:\/ipmb.sinica.edu.tw\/ch\/activities\/highlights\/143.
\n8.Wang YC#, Yu M#, Shih PY, Wu HY, Lai EM* (2018) Stable pH suppresses defense signaling and is the key to enhance Agrobacterium<\/em>-mediated transient expression in Arabidopsis seedlings. Sci Rep<\/em> 8(1):17071. doi: 10.1038\/s41598-018-34949-9. https:\/ipmb.sinica.edu.tw\/ch\/activities\/highlights\/340.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u690d\u7269\u8207\u4eba\u4e00\u6a23\uff0c\u6703\u88ab\u5404\u5f0f\u5404\u6a23\u7684\u75c5\u539f\u611f\u67d3\u800c\u751f\u75c5\u3002\u5176\u4e2d\uff0c\u8fb2\u687f\u83cc\uff08Agrobacterium tumefaciens\uff09 […]<\/p>\n","protected":false},"author":1,"featured_media":23303,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[991,983],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/23300"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=23300"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/23300\/revisions"}],"predecessor-version":[{"id":23307,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/23300\/revisions\/23307"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/23303"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=23300"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=23300"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=23300"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}