{"id":23186,"date":"2020-10-22T00:03:08","date_gmt":"2020-10-21T16:03:08","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=23186"},"modified":"2021-09-30T11:44:31","modified_gmt":"2021-09-30T03:44:31","slug":"%e9%9a%a8%e5%bf%83%e6%89%80%e6%ac%b2%e7%b7%a8%e8%bc%af%e4%ba%ba%e9%ab%94%e5%9f%ba%e5%9b%a0%e7%9a%84%e6%99%82%e4%bb%a3%e4%be%86%e4%ba%86%ef%bc%9f%e5%b0%88%e8%a8%aa%e5%87%8c%e5%98%89%e9%b4%bb","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/23186\/","title":{"rendered":"\u96a8\u5fc3\u6240\u6b32\u7de8\u8f2f\u4eba\u9ad4\u57fa\u56e0\u7684\u6642\u4ee3\u4f86\u4e86\uff1f\u5c08\u8a2a\u51cc\u5609\u9d3b"},"content":{"rendered":"<p><strong>\u4eba\u9ad4\u57fa\u56e0\u7de8\u8f2f\u7684\u73fe\u6cc1\u8207\u672a\u4f86<\/strong><\/p>\n<p>2020 \u5e74\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u51fa\u7210\uff0c\u57fa\u56e0\u7de8\u8f2f\u6280\u8853 CRISPR \u767c\u660e\u8005&#8211;\u73cd\u59ae\u4f5b\uff0e\u9053\u7d0d (Jennifer A. Doudna) \u4ee5\u53ca\u57c3\u99ac\u7d10\u57c3\u723e\uff0e\u5f6d\u8482\u8036 (Emmanuelle Charpentier) \u5169\u4f4d\u5973\u79d1\u5b78\u5bb6\u540c\u6458\u6842\u51a0\uff01\u57fa\u56e0\u795e\u526a CRISPR \u5b9b\u5982\u79d1\u6280\u9b54\u6212\uff0c\u5a01\u529b\u6a6b\u6383\u5168\u7403\uff0c\u5927\u591a\u6578\u79d1\u5b78\u5bb6\u7a4d\u6975\u7528\u5b83\u6539\u826f\u7269\u7a2e\uff0c\u751a\u81f3\u4eba\u985e\u81ea\u8eab\u3002\u4f46\uff0c\u7de8\u8f2f\u4eba\u9ad4\u57fa\u56e0\u5df2\u7d93\u5b89\u5168\uff0c\u6beb\u7121\u526f\u4f5c\u7528\u55ce\uff1f\u4e2d\u7814\u9662\u751f\u7269\u5316\u5b78\u7814\u7a76\u6240\u52a9\u7814\u7a76\u54e1\u51cc\u5609\u9d3b\uff0c\u66fe\u5728\u672c\u6b21\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u73cd\u59ae\u4f5b\uff0e\u9053\u7d0d\u535a\u58eb\u7684\u5be6\u9a57\u5ba4\u5de5\u4f5c\uff0c\u898b\u8b49 CRISPR \u7814\u7a76\u7684\u7206\u70b8\u6027\u7a81\u7834\uff0c\u4e5f\u6df1\u77e5\u57fa\u56e0\u7de8\u8f2f\u7684\u6280\u8853\u8207\u502b\u7406\u754c\u7dda\u3002\u6bd4\u8d77\u62ff\u8d77 CRISPR \u795e\u526a\u6539\u9020\u4eba\u985e\uff0c\u4ed6\u66f4\u60f3\u628a\u9019\u628a\u526a\u5200\u6539\u5f97\u66f4\u5b89\u5168\u3002<\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" src=\"https:\/research.sinica.edu.tw\/img\/team\/58.svg\" alt=\"\u554f\" width=\"45\" height=\"54\" \/>\u60a8\u662f\u4eba\u9ad4\u57fa\u56e0\u7de8\u8f2f\u7684\u5c08\u5bb6\uff0c\u53bb\u5e74\u767c\u751f\u57fa\u56e0\u7de8\u8f2f\u5bf6\u5bf6\u7684\u722d\u8b70\uff0c\u60a8\u600e\u9ebc\u770b?<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/research.sinica.edu.tw\/img\/talker\/55.svg\" alt=\"\u7b54\" width=\"45\" height=\"54\" \/>\u300c\u57fa\u56e0\u7de8\u8f2f\u5bf6\u5bf6\u4e8b\u4ef6\u300d\u662f\u4e2d\u570b\u751f\u7269\u5b78\u5bb6\u8cc0\u5efa\u594e\u548c\u4ed6\u7684\u5718\u968a\uff0c\u5229\u7528 CRISPR \u6280\u8853\uff0c\u4fee\u6539\u4eba\u985e\u53d7\u7cbe\u5375\u7684 CCR5 \u57fa\u56e0\uff0c\u76ee\u7684\u662f\u8b93\u80da\u80ce\u5728\u767c\u80b2\u904e\u7a0b\u4e2d\u5c0d\u611b\u6ecb\u75c5\u6bd2\u514d\u75ab\u3002<\/p>\n<p>2018 \u5e74 11 \u6708\uff0c\u8cc0\u5efa\u594e\u5ba3\u7a31\uff1a\u5df2\u6709\u4e00\u5c0d\u57fa\u56e0\u7d93\u904e\u7de8\u8f2f\u7684\u96d9\u80de\u80ce\u59ca\u59b9\u8a95\u751f\u3002\u9019\u5c0d\u59ca\u59b9\u7684\u7236\u89aa\u662f\u611b\u6ecb\u75c5\u5e36\u539f\u8005\uff0c\u4f46\u5169\u59ca\u59b9\u51fa\u751f\u5f8c\u8b49\u5be6\u5747\u672a\u611f\u67d3\u611b\u6ecb\u3002<\/p>\n<div id=\"attachment_21652\" style=\"width: 1034px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" aria-describedby=\"caption-attachment-21652\" src=\"https:\/research.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/lin-chia-hung2.jpg\" alt=\"\" width=\"1024\" \/><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">\u7576\u7236\u6bcd\u6709\u4e00\u65b9\u662f\u611b\u6ecb\u5e36\u539f\u8005\uff0c\u80da\u80ce\u767c\u80b2\u7684\u904e\u7a0b\u4e2d\u5c31\u53ef\u80fd\u6703\u611f\u67d3\u611b\u6ecb\u75c5\u6bd2\u3002\u8cc0\u5efa\u594e\u5ba3\u7a31\uff0c\u7d93\u7531\u526a\u9664 CCR5 \u57fa\u56e0\uff0c\u53ef\u4ee5\u8b93\u80da\u80ce\u5c0d\u611b\u6ecb\u75c5\u6bd2\u514d\u75ab\u3002<br \/>\u793a\u610f\u5716\u4f86\u6e90\u2502iStock<\/p><\/div>\n<p><strong><img loading=\"lazy\" decoding=\"async\" src=\"https:\/research.sinica.edu.tw\/img\/team\/58.svg\" alt=\"\u554f\" width=\"45\" height=\"54\" \/>\u5bf6\u5bf6\u4e0d\u6703\u611f\u67d3\u611b\u6ecb\uff0c\u807d\u8d77\u4f86\u5f88\u68d2\u554a\uff0c\u70ba\u4ec0\u9ebc\u5168\u4e16\u754c\u79d1\u5b78\u5bb6\u90fd\u8df3\u8173\uff1f<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/research.sinica.edu.tw\/img\/talker\/55.svg\" alt=\"\u7b54\" width=\"45\" height=\"54\" \/>\u4e3b\u8981\u539f\u56e0\u6709\u4e09\uff1a<\/p>\n<p>\u4e00\u3001\u9019\u500b\u5be6\u9a57\u662f\u6c92\u6709\u5fc5\u8981\u7684\u5192\u96aa\uff01\u7576\u592b\u59bb\u4e00\u65b9\u611f\u67d3\u611b\u6ecb\u75c5\uff0c\u53c8\u60f3\u8981\u751f\u4e0b\u5065\u5eb7\u5bf6\u5bf6\uff0c\u53ef\u4ee5\u6709\u66f4\u597d\u3001\u66f4\u5b89\u5168\u7684\u91ab\u7642\u65b9\u6848\uff0c\u4e0d\u9700\u8981\u9032\u884c\u98a8\u96aa\u9084\u5f88\u5927\u7684\u57fa\u56e0\u7de8\u8f2f\u3002<\/p>\n<p>\u4e8c\u3001\u9019\u6b21\u57fa\u56e0\u7de8\u8f2f\u7684\u96d9\u80de\u80ce\uff0c\u53ea\u6709\u4e00\u500b\u5be6\u9a57\u6210\u529f\uff0c\u53e6\u4e00\u9846\u53d7\u7cbe\u5375\u96d6\u7136\u4e5f\u653e\u5165 CRISPR \uff0c\u537b\u6c92\u6709\u5207\u6389 CCR5 \u57fa\u56e0\u3002\u4f46\u662f\uff0c\u8cc0\u5efa\u594e\u7adf\u5c07\u9019\u9846\u5be6\u9a57\u5931\u6557\u7684\u53d7\u7cbe\u5375\uff0c\u4e5f\u653e\u5230\u6bcd\u9ad4\u5b55\u80b2\uff0c\u9019\u8b93\u79d1\u5b78\u754c\u7121\u6cd5\u63a5\u53d7\uff01<\/p>\n<p>\u56e0\u70ba\u9019\u9846\u5931\u6557\u7684\u53d7\u7cbe\u5375\uff0c\u4e0d\u4f46\u6c92\u6709\u9054\u5230\u6297\u611b\u6ecb\u7684\u91ab\u7642\u521d\u8877\uff0c\u51fa\u751f\u7684\u5bf6\u5bf6\u9084\u5fc5\u9808\u627f\u53d7\u5de8\u5927\u7684\u98a8\u96aa\u3002\u5982\u679c CRISPR \u526a\u5230\u5176\u4ed6\u57fa\u56e0\uff0c\u53ef\u80fd\u70ba\u9019\u500b\u65b0\u751f\u547d\u5e36\u4f86\u96e3\u4ee5\u627f\u53d7\u7684\u5f8c\u679c\u3002<\/p>\n<p>\u4e09\u3001\u96d6\u7136\u5254\u9664\u57fa\u56e0 CCR5 \u53ef\u80fd\u62b5\u6297\u611b\u6ecb\u75c5\u6bd2\uff0c\u4f46\u9019\u500b\u57fa\u56e0\u6703\u4e0d\u6703\u6709\u5176\u4ed6\u91cd\u8981\u3001\u4eba\u985e\u9084\u6c92\u767c\u73fe\u7684\u529f\u80fd\uff1f\u526a\u6389\u9019\u500b\u57fa\u56e0\u6703\u4e0d\u6703\u9020\u6210\u56b4\u91cd\u7684\u526f\u4f5c\u7528\uff1f\u76ee\u524d\u7684\u79d1\u5b78\u4ecd\u7121\u6cd5\u9810\u6599\u3002<\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" src=\"https:\/research.sinica.edu.tw\/img\/team\/58.svg\" alt=\"\u554f\" width=\"45\" height=\"54\" \/>\u770b\u4f86\u57fa\u56e0\u7de8\u8f2f\u5bf6\u5bf6\u73fe\u968e\u6bb5\u9084\u662f\u6bcd\u6e6f\u554a\uff01\u60a8\u76ee\u524d\u5728\u6539\u9020\u4eba\u985e\u7684\u4ec0\u9ebc\u57fa\u56e0\u5462\uff1f<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/research.sinica.edu.tw\/img\/talker\/55.svg\" alt=\"\u7b54\" width=\"45\" height=\"54\" \/>CRISPR \u9580\u6abb\u5f88\u4f4e\uff0c\u8a31\u591a\u4eba\u5f88\u5feb\u8dd1\u5230\u61c9\u7528\u9762\u3002\u4f46\u6211\u6bd4\u8f03\u95dc\u5fc3\u5b89\u5168\u6027\u3001\u526f\u4f5c\u7528\u7b49\u554f\u984c\u3002<\/p>\n<p style=\"text-align: center;\"><strong>\u5728\u7d30\u80de\u88e1\u4e1f\u9032\u4e00\u628a\u526a\u5200\u548c DNA\uff0c\u96e3\u9053\u7d30\u80de\u5b8c\u5168\u6c92\u53cd\u61c9\u55ce\uff1f\u6211\u4e0d\u592a\u76f8\u4fe1\u3002<\/strong><\/p>\n<p>\u6700\u8fd1\u6211\u7684\u5be6\u9a57\u5ba4\u767c\u73fe\uff0c\u7d30\u80de\u5c0d\u5916\u4f86 DNA \u8ddf RNA \u7684\u514d\u75ab\u53cd\u61c9\u5f88\u6fc0\u70c8\uff1a\u7d30\u80de\u6703\u8a8d\u51fa\u9019\u4e9b RNA \u8ddf DNA \u4e0d\u662f\u81ea\u5df1\u7684\uff0c\u7522\u751f\u767c\u708e\u53cd\u61c9\uff0c\u751a\u81f3\u653e\u51fa\u6c42\u6551\u8a0a\u865f\uff1a\u300c\u6709\u5947\u602a\u7684 RNA \u6216 DNA \u51fa\u73fe\uff01\u300d\u5982\u679c\u7d30\u80de\u6703\u5c0d CRISPR \u51fa\u73fe\u767c\u708e\u53cd\u61c9\uff0c\u672a\u4f86\u60f3\u5728\u6d3b\u9ad4\u4e0a\u9032\u884c\u6cbb\u7642\uff0c\u554f\u984c\u5c31\u5f88\u5927\u3002<\/p>\n<p>\u53e6\u4e00\u500b\u91cd\u8981\u7684\u554f\u984c\uff1a\u96d6\u7136\u73fe\u5728\u6709\u4e00\u628a\u7cbe\u6e96\u6709\u6548\u7684\u57fa\u56e0\u526a\u5200\uff0c\u4f46\u4fee\u5fa9\u904e\u7a0b\u662f\u7d30\u80de\u5728\u63a7\u5236\uff0c\u8ddf\u526a\u5200\u4e00\u9ede\u95dc\u4fc2\u90fd\u6c92\u6709\u3002\u7406\u60f3\u72c0\u6cc1\u4e0b\uff0c\u7576 Cas9 \u526a\u958b DNA \u6642\uff0c\u6703\u6709\u6a5f\u6703\u66f4\u6539 DNA\uff0c\u4f46\u7d30\u80de\u9858\u4e0d\u9858\u610f\u5c07\u6b63\u78ba\u7684 DNA \u7247\u6bb5\u63a5\u4e0a\u53bb\uff1f\u7576\u7d30\u80de\u5df2\u51fa\u73fe\u767c\u708e\u53cd\u61c9\uff0c\u5b83\u6703\u600e\u9ebc\u4fee\u5fa9 DNA\uff1f\u76ee\u524d\u4ecd\u6c92\u8fa6\u6cd5\u638c\u63e1\u3002<\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" src=\"https:\/research.sinica.edu.tw\/img\/team\/58.svg\" alt=\"\u554f\" width=\"45\" height=\"54\" \/>\u7d30\u80de\u6703\u600e\u9ebc\u4fee\u5fa9\u81ea\u5df1\u7684 DNA\uff1f<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/research.sinica.edu.tw\/img\/talker\/55.svg\" alt=\"\u7b54\" width=\"45\" height=\"54\" \/>\u6700\u91cd\u8981\u7684 DNA \u4fee\u5fa9\u65b9\u5f0f\u6709\u5169\u7a2e\uff1a<\/p>\n<p>\u4e00\u7a2e\u662f\u975e\u540c\u6e90\u6027\u672b\u7aef\u7d50\u5408 (NHEJ)\uff1a\u76f4\u63a5\u5c07 DNA \u96d9\u80a1\u65b7\u88c2\u7684\u5c3e\u7aef\u62c9\u8fd1\u3001\u9ecf\u4e0a\u3002\u5982\u679c\u7d30\u80de\u9078\u64c7\u9019\u689d\u8def\uff0c\u5c31\u4e0d\u6703\u63a5\u53d7\u5916\u4f86\u7684 DNA \u7247\u6bb5\u3002<\/p>\n<p>\u4e00\u7a2e\u662f\u540c\u6e90\u6027\u91cd\u7d44 (HDR)\uff1a\u6b63\u5e38\u7684 DNA \u6709\u5169\u526f\uff0c\u4eca\u5929\u65b7\u5728\u67d0\u4e00\u526f\u7684\u67d0\u500b\u4f4d\u7f6e\uff0c\u53e6\u4e00\u526f\u901a\u5e38\u4e0d\u6703\u9019\u9ebc\u5de7\u5408\u65b7\u5728\u540c\u4e00\u500b\u4f4d\u7f6e\uff0c\u53ef\u4ee5\u4f5c\u70ba\u4fee\u5fa9\u6a21\u677f\uff0c\u8907\u88fd\u4e00\u6bb5\u6b63\u78ba DNA\uff0c\u63a5\u5728 DNA \u7684\u65b7\u53e3\u8655\u3002<\/p>\n<div id=\"attachment_21652\" style=\"width: 1034px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" aria-describedby=\"caption-attachment-21652\" src=\"https:\/research.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/lin-chia-hung2-2-1.jpg\" alt=\"\" width=\"1024\" \/><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">\u7d30\u80de\u4fee\u5fa9 DNA \u6709\u5169\u689d\u8def\uff0cNHEJ \u662f\u76f4\u63a5\u628a\u65b7\u88c2\u8655\u63a5\u8d77\u4f86\uff0cHDR \u662f\u62ff\u53e6\u4e00\u526f DNA \u505a\u6a21\u677f\u8907\u88fd\u6b63\u78ba\u7684 DNA \u7247\u6bb5\uff0c\u63a5\u5728\u65b7\u88c2\u8655\u3002\u7576\u7d30\u80de\u9078\u64c7\u8d70 HDR\uff0c\u624d\u6709\u53ef\u80fd\u63a5\u53d7\u5916\u754c\u9001\u5165\u7684\u6b63\u78ba\u57fa\u56e0\u3002<br \/>\u5716\u8aaa\u8a2d\u8a08\u2502\u9ec3\u66c9\u541b\u3001\u6797\u6d35\u5b89 \u8cc7\u6599\u4f86\u6e90\u2502\u51cc\u5609\u9d3b\u2502iStock<\/p><\/div>\n<p>\u7576\u7d30\u80de\u9078\u64c7\u8d70 HDR \u9019\u689d\u8def\uff0c\u624d\u6709\u53ef\u80fd\u63a5\u53d7\u63a5\u53d7\u6211\u5011\u9001\u9032\u53bb\u7684 DNA \u7247\u6bb5\uff0c\u5b8c\u6210\u57fa\u56e0\u7de8\u8f2f\u3002\u53ef\u60dc\u7684\u662f\uff0c\u7d30\u80de\u559c\u6b61\u8d70 NHEJ\uff0c\u76f4\u63a5\u628a\u65b7\u6389\u7684 DNA \u5169\u7aef\u63a5\u8d77\u4f86\uff0c\u96d6\u7136\u9019\u689d\u8def\u7834\u58de\u6027\u5f88\u5927\uff0cDNA \u5e8f\u5217\u53ef\u80fd\u591a\u4e00\u4e9b\u3001\u5c11\u4e00\u4e9b\uff0c\u7121\u6cd5\u6307\u63ee\u7d30\u80de\u505a\u51fa\u6b63\u78ba\u7684\u86cb\u767d\u8cea\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2 style=\"text-align: center;\"><strong>\u6b32\u700f\u89bd\u5b8c\u6574\u7cbe\u91c7\u6587\u7ae0\uff0c\u8acb\u81f3\u7814\u4e4b\u6709\u7269\u5b98\u7db2\uff1a<\/strong><\/h2>\n<h2 style=\"text-align: center;\"><a href=\"https:\/research.sinica.edu.tw\/gene-editing-baby-aids-dna-repair\/\"><em>https:\/research.sinica.edu.tw\/gene-editing-baby-aids-dna-repair\/<\/em><\/a><\/h2>\n<h2 style=\"text-align: center;\"><strong>\uff08\u8d95\u5feb\u9ede\u9032\u4f86\u5594\uff01\u9084\u6709\u66f4\u591a\u7cbe\u91c7\u5716\u6587\uff01\uff09<\/strong><\/h2>\n","protected":false},"excerpt":{"rendered":"<p>\u4eba\u9ad4\u57fa\u56e0\u7de8\u8f2f\u7684\u73fe\u6cc1\u8207\u672a\u4f86 2020 \u5e74\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u51fa\u7210\uff0c\u57fa\u56e0\u7de8\u8f2f\u6280\u8853 CRISPR \u767c\u660e\u8005&#8211;\u73cd\u59ae\u4f5b 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