{"id":23086,"date":"2020-10-08T00:03:55","date_gmt":"2020-10-07T16:03:55","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=23086"},"modified":"2021-07-21T13:01:33","modified_gmt":"2021-07-21T05:01:33","slug":"%e5%bf%83%e7%90%86%e5%a3%93%e5%8a%9b%e6%9c%83%e9%80%a0%e6%88%90%e7%94%9f%e7%90%86%e7%96%bc%e7%97%9b-%e4%bb%a5%e8%bd%89%e8%ad%af%e9%86%ab%e5%ad%b8%e6%8e%a2%e7%a9%b6%e7%ba%96%e7%b6%ad%e8%82%8c","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/23086\/","title":{"rendered":"\u5fc3\u7406\u58d3\u529b\u6703\u9020\u6210\u751f\u7406\u75bc\u75db\u2013 \u4ee5\u8f49\u8b6f\u91ab\u5b78\u63a2\u7a76\u7e96\u7dad\u808c\u75db\u75c7\u75c5\u7406\u6a5f\u8f49"},"content":{"rendered":"

\u53ef\u66fe\u60f3\u904e\uff0c\u53cd\u8986\u5fc3\u7406\u58d3\u529b\u9664\u4e86\u9020\u6210\u7126\u616e\u3001\u6182\u9b31\u7b49\u5fc3\u7406\u554f\u984c\u5916\uff0c\u7adf\u7136\u4e5f\u6703\u9020\u6210\u751f\u7406\u4e0a\u6162\u6027\u5168\u8eab\u75bc\u75db?\u672c\u9662\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u9673\u5fd7\u6210\u7814\u7a76\u54e1\uff0c\u8207\u8f49\u8b6f\u91ab\u5b78\u5b78\u7a0b\u535a\u58eb\u751f\u3001\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u9644\u8a2d\u91ab\u9662\u6d2a\u5fd7\u61b2\u4e3b\u6cbb\u91ab\u5e2b\u5171\u7d44\u7814\u7a76\u5718\u968a\uff0c\u627e\u51fa\u7e96\u7dad\u808c\u75db\u75c7\u53ef\u80fd\u7684\u81f4\u75c5\u6a5f\u8f49\u53ca\u95dc\u9375\u6291\u5236\u5291\uff0c\u672a\u4f86\u53ef\u671b\u65bc\u7e96\u7dad\u808c\u75db\u75c7\u7684\u81e8\u5e8a\u6cbb\u7642\u3002\u7814\u7a76\u8ad6\u6587\u5df2\u65bc\u4eca\uff08109\uff09\u5e749\u6708\u767c\u8868\u5728\u570b\u969b\u98a8\u6fd5\u514d\u75ab\u79d1\u6b0a\u5a01\u91ab\u5b78\u671f\u520a Annals of the Rheumatic Diseases<\/em>\u3002<\/p>\n

\"\"<\/p>\n

\u7e96\u7dad\u808c\u75db\u75c7 (fibromyalgia) \u662f\u4e00\u7a2e\u5f88\u5e38\u898b\u537b\u53c8\u795e\u79d8\u7684\u75bc\u75db\u75c5\u3002\u5728\u6210\u5e74\u4eba\u4e2d\uff0c\u7d04\u67092~6%\u7684\u4eba\u7f79\u60a3\u6b64\u75c5\uff0c\u662f\u795e\u7d93\u79d1\u53ca\u75bc\u75db\u79d1\u9580\u8a3a\u5e38\u898b\u7684\u75bc\u75db\u75be\u60a3\u4e4b\u4e00\u3002\u5176\u7279\u5fb5\u662f\u6162\u6027\u5ee3\u6cdb\u6027\u808c\u8089\u75bc\u75db\uff0c\u4e26\u4f34\u96a8\u75b2\u52de\u3001\u5931\u7720\u3001\u7126\u616e\u548c\u6182\u9b31\u3002\u9019\u4e9b\u60c5\u5f62\u6703\u56b4\u91cd\u5f71\u97ff\u75c5\u4eba\u7684\u751f\u6d3b\u54c1\u8cea\uff0c\u751a\u81f3\u5c0e\u81f4\u5931\u80fd\u3002\u904e\u53bb\u7684\u81e8\u5e8a\u7814\u7a76\u767c\u73fe\uff0c\u65e5\u5e38\u751f\u6d3b\u7cbe\u795e\u58d3\u529b\u88ab\u8a8d\u70ba\u6703\u8a98\u767c\u6216\u52a0\u91cd\u7e96\u7dad\u808c\u75db\u75c7\u75c7\u72c0\u3002\u7136\u800c\uff0c\u58d3\u529b\u66dd\u9732\u8207\u75be\u75c5\u767c\u751f\u9593\u7684\u56e0\u679c\u95dc\u4fc2\u5728\u81e8\u5e8a\u7814\u7a76\u4e0a\u4ecd\u7136\u96e3\u4ee5\u8a8d\u5b9a\uff0c\u4e14\u91ab\u5b78\u4e0a\u5c0d\u65bc\u8a72\u75c5\u7684\u75c5\u751f\u7406\u6a5f\u8f49\u4e5f\u4ecd\u7136\u4e0d\u6e05\u695a\u3002\u7531\u65bc\u7e96\u7dad\u808c\u75db\u75c7\u548c\u4e00\u822c\u7684\u808c\u8089\u767c\u708e\u6027\u75bc\u75db\u75be\u75c5\u4e0d\u540c\uff0c\u62bd\u8840\u6aa2\u67e5\u901a\u5e38\u5448\u73fe\u6b63\u5e38\u7684\u7d50\u679c\uff0c\u6545\u75c5\u4eba\u5e38\u5e38\u65bc\u5404\u79d1\u9580\u8a3a\u8a73\u7d30\u6aa2\u67e5\u5f8c\u537b\u6c92\u6709\u767c\u73fe\u660e\u78ba\u75c5\u56e0\u3002\u76ee\u524d\u7e96\u7dad\u808c\u75db\u75c7\u7684\u8a3a\u65b7\u7f3a\u4e4f\u81e8\u5e8a\u53ef\u7528\u7684\u751f\u7269\u6a19\u8a18\uff0c\u4e3b\u8981\u4ef0\u8cf4\u81e8\u5e8a\u75c7\u72c0\u53ca\u6392\u9664\u5176\u5b83\u75be\u75c5\u3002\u73fe\u968e\u6bb5\u5c0d\u65bc\u75be\u75c5\u7684\u6cbb\u7642\uff0c\u8655\u7406\u4e0a\u4ecd\u4ee5\u7de9\u89e3\u75c7\u72c0\u70ba\u4e3b\u3002<\/p>\n

\u79d1\u6280\u90e8\u9577\u671f\u6df1\u8015\u57fa\u790e\u7814\u7a76\uff0c\u4e26\u914d\u5408\u300c 5+2 \u7522\u696d\u5275\u65b0\u8a08\u756b\u300d\u653f\u7b56\u53ca\u8cc7\u6e90\u6574\u5408\u76ee\u6a19\uff0c\u63a8\u52d5\u300c\u4ee5\u75be\u75c5\u70ba\u5c0e\u5411\u4e4b\u8166\u8207\u5fc3\u667a\u79d1\u5b78\u5c08\u6848\u7814\u7a76\u8a08\u756b(106-108)\u300d\u53ca\u300c\u53f0\u7063\u8166\u79d1\u6280\u767c\u5c55\u53ca\u570b\u969b\u8e8d\u5347\u8a08\u756b(108-109)\u300d\uff0c\u81ea106\u5e74\u5ea6\u8d77\u5df2\u88dc\u52a9\u6578\u500b\u512a\u79c0\u5718\u968a\u9032\u884c\u5275\u65b0\u3001\u6df1\u5165\u53ca\u5177\u9577\u9060\u898f\u5283\u4e4b\u8166\u8207\u5fc3\u667a\u79d1\u5b78\u9818\u57df\u7814\u7a76\uff0c\u4fc3\u9032\u57fa\u790e\u79d1\u7814\u7522\u51fa\u61c9\u7528\u65bc\u4eba\u985e\u798f\u7949\u4e4b\u6548\u76ca\u3002\u5728\u524d\u8ff0\u8a08\u756b\u652f\u6301\u4e0b\uff0c\u9673\u5fd7\u6210\u7814\u7a76\u54e1\u8207\u6d2a\u5fd7\u61b2\u91ab\u5e2b\u5171\u7d44\u8de8\u9818\u57df\u8f49\u8b6f\u7814\u7a76\u5718\u968a\uff0c\u7d93\u7531\u5efa\u7acb\u52d5\u7269\u7684\u58d3\u529b\u6a21\u578b\uff0c\u627e\u51fa\u7e96\u7dad\u808c\u75db\u75c7\u53ef\u80fd\u7684\u81f4\u75c5\u6a5f\u8f49\u3002\u4ee5\u566a\u97f3\u523a\u6fc0\u4f5c\u70ba\u5fc3\u7406\u58d3\u529b\u6e90\uff0c\u7814\u7a76\u767c\u73fe\uff0c\u5c0f\u9f20\u5728\u7d93\u7531\u53cd\u8986\u53ca\u9593\u6b47\u6027\u5fc3\u7406\u58d3\u529b\u523a\u6fc0\u5f8c\uff0c\u6703\u767c\u751f\u9577\u671f\u7684\u975e\u767c\u708e\u6027\u75bc\u75db\u8868\u73fe\uff0c\u4e26\u4f34\u96a8\u75b2\u52de\u53ca\u7126\u616e\u7b49\u884c\u70ba\u8b8a\u5316\uff0c\u5c31\u5982\u540c\u81e8\u5e8a\u4e0a\u7e96\u7dad\u808c\u75db\u75c7\u7684\u75c5\u60c5\u8868\u73fe\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4e5f\u767c\u73fe\u53cd\u8986\u58d3\u529b\u66dd\u9732\u6703\u5f15\u767c\u751f\u7269\u9ad4\u5167\u7522\u751f\u904e\u91cf\u7684\u6c27\u5316\u58d3\u529b\uff0c\u800c\u9020\u6210\u9ad4\u5167\u8102\u8cea\u7684\u6c27\u5316\u6027\u50b7\u5bb3\uff0c\u9032\u800c\u5c0e\u81f4\u7e8c\u767c\u6027\u7684\u6eb6\u8840\u5375\u78f7\u810216:0 (LPC16:0)\u6fc3\u5ea6\u4e0a\u5347\u3002\u5176\u4e2d\uff0c\u904e\u91cf\u7684\u6c27\u5316\u8102\u8ceaLPC16:0\u6703\u6d3b\u5316\u808c\u8089\u7d44\u7e96\u4e0a\u5e38\u898b\u7684\u7b2c\u4e09\u578b\u9178\u611f\u77e5\u96e2\u5b50\u901a\u9053(ASIC3)\uff0c\u56e0\u800c\u5c0e\u81f4\u75bc\u75db\u8a0a\u865f\u7684\u6d3b\u5316\uff0c\u800c\u9020\u6210\u6162\u6027\u75bc\u75db\u904e\u654f\u611f\u8868\u73fe\u3002<\/p>\n

\u6c27\u5316\u8102\u8ceaLPC16:0\u9664\u4e86\u8868\u73fe\u5728\u52d5\u7269\u6a21\u578b\u4e0a\uff0c\u81e8\u5e8a\u4e0a\u4e5f\u53ef\u89c0\u5bdf\u5230\u76f8\u5c0d\u61c9\u7684\u8868\u73fe\u3002\u85c9\u7531\u8cea\u8b5c\u5100\u7684\u5206\u6790\u7e96\u7dad\u808c\u75db\u75c7\u75c5\u4eba\u7684\u8840\u6db2\u6aa2\u9ad4\uff0c\u5728\u75c5\u6cc1\u56b4\u91cd\u540c\u6642\u627f\u53d7\u9ad8\u6c27\u5316\u58d3\u529b\u7684\u75c5\u4eba\u8eab\u4e0a\u4e5f\u53ef\u89c0\u5bdf\u5230\u904e\u91cf\u7684\u8102\u8ceaLPC16:0\u8868\u73fe\u3002\u9664\u4e0a\u8ff0\u6a5f\u8f49\u5916\uff0c\u8a72\u7814\u7a76\u4e5f\u767c\u73fe\uff0c\u85c9\u7531\u6291\u5236\u6c27\u5316\u8102\u8ceaLPC16:0\u7684\u751f\u6210\uff0c\u85e5\u7269\u8840\u5c0f\u677f\u6d3b\u5316\u56e0\u5b50\u4e59\u91af\u6c34\u89e3\u9175\u7d20\u6291\u5236\u5291(platelet-activating factor-acetylhydrolase inhibitor; darapladib)\u5728\u52d5\u7269\u5be6\u9a57\u4e0a\u53ef\u6709\u6548\u6e1b\u8f15\u58d3\u529b\u6240\u9020\u6210\u7684\u75bc\u75db\u53cd\u61c9\u3002\u8a72\u767c\u73fe\u76ee\u524d\u6b63\u5728\u7533\u8acb\u570b\u969b\u5c08\u5229\uff0c\u672a\u4f86\u53ef\u671b\u7528\u65bc\u7e96\u7dad\u808c\u75db\u75c7\u7684\u81e8\u5e8a\u6cbb\u7642\u3002\u6b64\u5916\uff0c\u85c9\u7531\u7814\u7a76\u9019\u7a2e\u58d3\u529b\u6240\u5f15\u767c\u75bc\u75db\u7684\u6a5f\u8f49\uff0c\u53ef\u4ee5\u5e6b\u52a9\u91d0\u6e05\u7e96\u7dad\u808c\u75db\u75c7\u53ef\u80fd\u7684\u81f4\u75c5\u539f\u56e0\uff0c\u4ee5\u5e6b\u52a9\u767c\u5c55\u66f4\u597d\u7684\u8a3a\u65b7\u548c\u6cbb\u7642\u65b9\u5f0f\u3002\u672a\u4f86\u5718\u968a\u4e5f\u5c07\u81f4\u529b\u65bc\u6c27\u5316\u8102\u8ceaLPC16:0\u548c\u7e96\u7dad\u808c\u75db\u75c7\u81e8\u5e8a\u95dc\u806f\u6027\u5206\u6790\u3002<\/p>\n

\u6b64\u57fa\u790e\u79d1\u5b78\u8207\u81e8\u5e8a\u91ab\u5b78\u7684\u8de8\u9818\u57df\u5718\u968a\u7814\u7a76\u7d50\u679c\u4e0d\u50c5\u63d0\u4f9b\u4e86\u5fc3\u7406\u58d3\u529b\u53ef\u8a98\u767c\u6162\u6027\u751f\u7406\u75bc\u75db\u7684\u76f4\u63a5\u5be6\u9a57\u6027\u8b49\u64da\uff0c\u70ba\u904e\u53bb\u9577\u671f\u7684\u81e8\u5e8a\u89c0\u5bdf\u6027\u7814\u7a76\u7d50\u679c\u63d0\u4f9b\u4e86\u75c5\u751f\u7406\u6a5f\u8f49\u7684\u5408\u7406\u89e3\u91cb\uff0c\u4e5f\u70ba\u672a\u4f86\u7e96\u7dad\u808c\u75db\u75c7\u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u826f\u597d\u7684\u8f49\u8b6f\u7814\u7a76\u5e73\u53f0\u3002\u9673\u5fd7\u6210\u548c\u6d2a\u5fd7\u61b2\u5718\u968a\u4e5f\u5f37\u8abf\uff0c\u6b64\u7814\u7a76\u6210\u679c\u5c6c\u65bc\u79d1\u6280\u90e8\u795e\u7d93\u79d1\u5b78\u5c08\u6848\u8a08\u756b\u3002\u9664\u5718\u968a\u52aa\u529b\u5916\uff0c\u52a0\u4e0a\u9ad8\u91ab\u8102\u8cea\u79d1\u5b78\u66a8\u8001\u5316\u7814\u7a76\u4e2d\u5fc3\u9673\u73e0\u749c\u6559\u6388\u53ca\u8521\u660e\u61b2\u535a\u58eb\u7684\u8102\u8cea\u5b9a\u91cf\u5206\u6790\uff0c\u81fa\u5927\u6838\u5fc3\u5be6\u9a57\u5ba4\u5354\u52a9\u7684\u8102\u8cea\u8cea\u8b5c\u5206\u6790\uff0c\u548c\u4e2d\u7814\u9662\u751f\u91ab\u6240\u8207\u81fa\u7063\u5c0f\u9f20\u8a3a\u6240\u7684\u652f\u6301\u624d\u80fd\u5b8c\u6210\u3002\u8ad6\u6587\u7b2c\u4e00\u4f5c\u8005\u6d2a\u5fd7\u61b2\u91ab\u5e2b\u70ba\u672c\u9662\u8f49\u8b6f\u91ab\u5b78\u5b78\u7a0b\u535a\u58eb\u73ed\u5b78\u751f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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