{"id":2308,"date":"2018-06-07T08:00:23","date_gmt":"2018-06-07T00:00:23","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=2308"},"modified":"2020-12-31T15:02:43","modified_gmt":"2020-12-31T07:02:43","slug":"%e7%a0%b4%e8%a7%a3%e9%81%ba%e5%82%b3%e7%96%be%e7%97%85%e3%80%81%e8%a9%95%e4%bc%b0%e5%a4%a7%e7%9c%be%e7%94%a8%e8%97%a5%e9%a2%a8%e9%9a%aa%e2%94%80%e2%94%80%e5%85%a8%e5%9f%ba%e5%9b%a0%e7%b5%84%e5%88%86","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/2308\/","title":{"rendered":"\u7834\u89e3\u907a\u50b3\u75be\u75c5\u3001\u8a55\u4f30\u5927\u773e\u7528\u85e5\u98a8\u96aa\u2500\u2500\u5168\u57fa\u56e0\u7d44\u5206\u6790"},"content":{"rendered":"<div class=\"aio-icon-header\">\n<h1 class=\"aio-icon-title ult-responsive\" data-ultimate-target=\"#Info-box-wrap-7138 .aio-icon-title\" data-responsive-json-new=\"{&quot;font-size&quot;:&quot;&quot;,&quot;line-height&quot;:&quot;&quot;}\">\u300c\u5168\u57fa\u56e0\u7d44\u5206\u6790\u300d\u6709\u4ec0\u9ebc\u7528<\/h1>\n<\/div>\n<div class=\"aio-icon-description ult-responsive\" data-ultimate-target=\"#Info-box-wrap-7138 .aio-icon-description\" data-responsive-json-new=\"{&quot;font-size&quot;:&quot;&quot;,&quot;line-height&quot;:&quot;&quot;}\">\n<p>\u6bcf\u500b\u4eba\u7684\u8eab\u9ad4\u72c0\u6cc1\u6703\u56e0\u70ba\u5c45\u4f4f\u74b0\u5883\u3001\u751f\u6d3b\u7fd2\u6163\u800c\u6709\u76f8\u7576\u5927\u7684\u5dee\u7570\u3002\u4f46\u5c0d\u65bc\u540c\u4e00\u5bb6\u65cf\u88e1\u7684\u6210\u54e1\u4f86\u8aaa\uff0c\u76f8\u4f3c\u7684\u57fa\u56e0\u5b58\u5728\u89aa\u621a\u624b\u8db3\u4e4b\u9593\uff0c\u5f7c\u6b64\u672a\u4f86\u5065\u5eb7\u8207\u5426\uff0c\u53ef\u4ee5\u5f9e\u5bb6\u65cf\u75c5\u53f2\u4e2d\u770b\u51fa\u4e00\u4e9b\u7aef\u502a\u3002\u4e0d\u904e\uff0c\u6216\u8a31\u5728\u4e0d\u4e45\u7684\u5c07\u4f86\uff0c\u5c31\u53ef\u4ee5\u900f\u904e\u500b\u4eba\u7684\u57fa\u56e0\u8cc7\u8a0a\uff0c\u76f4\u63a5\u8a55\u4f30\u60a3\u75c5\u98a8\u96aa\uff0c\u9084\u80fd\u7be9\u9078\u9069\u5408\u81ea\u5df1\u7684\u7528\u85e5\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2309\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/06\/dr-kwok-pui-yan-01.jpg\" alt=\"\" width=\"4498\" height=\"3306\" \/>\u4e2d\u7814\u9662\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240(\u7c21\u7a31\u751f\u91ab\u6240)\u6240\u9577\u90ed\u6c9b\u6069\u8207\u7814\u7a76\u5718\u968a\uff0c\u6b63\u52aa\u529b\u63a8\u884c\u5169\u500b\u57fa\u56e0\u5206\u6790\u8a08\u756b\uff1a\u4e00\u500b\u91dd\u5c0d\u7f55\u898b\u907a\u50b3\u75be\u75c5\uff1b\u53e6\u4e00\u500b\u5247\u529b\u6c42\u8b93\u5927\u773e\u554f\u8a3a\u3001\u7528\u85e5\u66f4\u52a0\u7cbe\u78ba\u3002<\/p>\n<\/div>\n<div data-ultimate-target=\"#Info-box-wrap-7138 .aio-icon-description\" data-responsive-json-new=\"{&quot;font-size&quot;:&quot;&quot;,&quot;line-height&quot;:&quot;&quot;}\">\n<h2 class=\"contains_subtitle_icon\"><strong><b>\u8acb\u554f\u5bb6\u65cf\u75c5\u53f2\uff1f<\/b><\/strong><\/h2>\n<p>\u8eab\u9ad4\u4e0d\u8212\u670d\u53bb\u770b\u91ab\u751f\u6642\uff0c\u6703\u586b\u4e00\u5f35\u75c5\u6b77\u8868\uff0c\u5176\u4e2d\u4e00\u9805\u5e38\u898b\u7684\u554f\u984c\u662f\uff1a\u5bb6\u65cf\u6709\u54ea\u4e9b\u75c5\u53f2\u3002<\/p>\n<blockquote>\n<h4><strong>\u75be\u75c5\u7684\u6210\u56e0\uff0c\u6709\u4e9b\u662f\u56e0\u70ba\u5148\u5929\u57fa\u56e0\u8b8a\u7570\uff0c\u6709\u4e9b\u662f\u5f8c\u5929\u74b0\u5883\u3001\u98f2\u98df\u3001\u50b3\u67d3\u75c5\u9020\u6210\u3002<\/strong><\/h4>\n<\/blockquote>\n<p>\u8a62\u554f\u5bb6\u65cf\u75c5\u53f2\u7684\u76ee\u7684\u5728\u65bc\uff0c\u76f8\u4f3c\u7684\u57fa\u56e0\u81ea\u7956\u7236\u6bcd\u3001\u96d9\u89aa\uff0c\u518d\u50b3\u5230\u5b50\u4ee3\uff0c\u60f3\u77e5\u9053\u7f55\u898b\u907a\u50b3\u75be\u75c5\u3001\u751a\u6216\u764c\u75c7\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u7cd6\u5c3f\u75c5\u7b49\u767c\u751f\u7684\u6a5f\u6703\uff0c\u904e\u5f80\u662f\u900f\u904e\u8a62\u554f\u300c\u5bb6\u65cf\u75c5\u53f2\u300d\u4f86\u77ad\u89e3\u3002\u4f46\u672a\u4f86\u5c07\u6709\u66f4\u7cbe\u78ba\u7684\u65b9\u5f0f\u9810\u4f30\u60a3\u75c5\u98a8\u96aa\u2014\u2014\u76f4\u63a5\u67e5\u770b\u57fa\u56e0\u8cc7\u8a0a\u3002<\/p>\n<h2 class=\"contains_subtitle_icon\"><strong><b>\u7f55\u898b\u907a\u50b3\u75be\u75c5\uff1a\u5206\u6790\u55ae\u4e00\u57fa\u56e0\u8b8a\u7570<\/b><\/strong><\/h2>\n<blockquote>\n<h4><strong>\u91dd\u5c0d\u55ae\u4e00\u57fa\u56e0\u7570\u5e38\u9020\u6210\u7684\u7f55\u898b\u907a\u50b3\u75be\u75c5\uff0c\u90ed\u6c9b\u6069\u5718\u968a\u4f7f\u7528\u300c\u5168\u57fa\u56e0\u7d44\u907a\u50b3\u5206\u6790\u300d(full genome analysis) \u4f86\u5206\u6790\u75c5\u56e0\u3002<\/strong><\/h4>\n<\/blockquote>\n<p>\u9019\u985e\u7f55\u898b\u907a\u50b3\u75be\u75c5\uff0c\u5305\u542b\u5148\u5929\u6027\u7570\u5e38 (congenital anomalies) \u3001\u795e\u7d93\u9000\u5316\u6027\u75be\u200b\u200b\u75c5 (neurodegenerative disease) \u7b49\u7b49\u3002\u5168\u57fa\u56e0\u7d44\u907a\u50b3\u5206\u6790\u5206\u6210\u5169\u500b\u90e8\u5206\uff0c\u53ea\u8981\u5f9e\u8840\u6db2\u3001\u53e3\u6c34\u53d6\u5f97\u53ef\u4f9b\u5206\u6790\u7684 DNA\uff0c\u5c31\u53ef\u4ee5\u9032\u884c\u5168\u57fa\u56e0\u9ad4\u5b9a\u5e8f (whole genome sequencing)\uff0c\u4e86\u89e3\u8a72 DNA \u7247\u6bb5\u7684\u9e7c\u57fa\u5982\u4f55\u6392\u5217\uff1b\u4ee5\u53ca\u7e6a\u88fd\u5168\u57fa\u56e0\u9ad4\u5716\u8b5c (whole genome mapping)\uff0c\u4e86\u89e3\u8a72 DNA \u7247\u6bb5\u5728\u67d3\u8272\u9ad4\u4e0a\u7684\u4f4d\u7f6e\u3002<\/p>\n<\/div>\n<p>\u9996\u5148\uff0c\u300c\u5168\u57fa\u56e0\u9ad4\u5b9a\u5e8f\u300d\uff0c\u662f\u5c07\u5df2\u767c\u75c5\u60a3\u8005\u7684 23 \u5c0d\u67d3\u8272\u9ad4\u4e2d\uff0c\u6bcf\u4e00\u500b\u57fa\u56e0\u5168\u90e8\u90fd\u5b9a\u5e8f\u3002\u5b9a\u5e8f\u5b8c\u6210\u5f8c\uff0c\u53c3\u8003\u5df2\u77e5\u7684\u751f\u7269\u5b78\u3001\u57fa\u56e0\u7d44\u5b78\u3001\u91ab\u5b78\u7b49\u77e5\u8b58\uff0c\u78ba\u8a8d\u5f71\u97ff\u767c\u75c5\u7684\u57fa\u56e0\uff1b\u6216\u662f\u85c9\u7531\u6bd4\u5c0d\u5065\u5eb7\u96d9\u89aa\u7684\u57fa\u56e0\uff0c\u5f9e\u53ef\u80fd\u7684\u5e8f\u5217\u4e2d\u641c\u5c0b\u57fa\u56e0\u8b8a\u7570\u8655\uff0c\u518d\u627e\u51fa\u7f55\u898b\u907a\u50b3\u75be\u75c5\u7684\u767c\u75c5\u6a5f\u5236\u3002<\/p>\n<p>\u63a5\u8457\uff0c\u518d\u5229\u7528\u300c\u5168\u57fa\u56e0\u9ad4\u5716\u8b5c\u7e6a\u88fd\u300d\uff0c\u4f86\u7d44\u88dd\u9577\u7247\u6bb5\u7684 DNA\uff0c\u4ee5\u63d0\u9ad8\u57fa\u56e0\u6392\u5217\u7684\u6b63\u78ba\u6027\u3001\u4ee5\u53ca\u5075\u6e2c\u7d50\u69cb\u6027\u8b8a\u7570\u7684\u9748\u654f\u5ea6\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2310\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/06\/dr-Kwok-pui-yan-03-e1525353745381-2.jpg\" alt=\"\" width=\"844\" height=\"464\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/06\/dr-Kwok-pui-yan-03-e1525353745381-2.jpg 844w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/06\/dr-Kwok-pui-yan-03-e1525353745381-2-300x165.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/06\/dr-Kwok-pui-yan-03-e1525353745381-2-768x422.jpg 768w\" sizes=\"(max-width: 844px) 100vw, 844px\" \/><\/p>\n<p>\u5982\u4e0a\u5716\u6240\u793a\uff0c\u90ed\u6c9b\u6069\u5718\u968a\u5efa\u7acb\u57fa\u56e0\u5716\u8b5c (gene map) \u7684\u65b9\u6cd5\uff0c\u662f\u5148\u5c07 DNA \u5206\u6210\u8f03\u5927\u7684\u7247\u6bb5\uff0c\u5229\u7528\u7279\u5b9a\u7684\u9175\u7d20\u4f86\u6a19\u8a18 DNA \u4e0a\u7684\u7279\u5b9a\u5e8f\u5217\uff0c\u4e26\u9ecf\u4e0a\u87a2\u5149\u7576\u4f5c\u6a19\u7c64 (label)\u3002\u900f\u904e\u6a5f\u5668\u6e2c\u91cf\u5404\u500b\u87a2\u5149\u6a19\u7c64\u4e4b\u9593\u7684\u8ddd\u96e2\u5f8c\uff0c\u518d\u5f9e\u5f71\u50cf\u7d44\u5408\u6210\u9577 DNA \u7247\u6bb5\uff0c\u4e26\u5b9a\u4f4d\u51fa\u8a72 DNA \u7247\u6bb5\u5728\u67d3\u8272\u9ad4\u7684\u4f4d\u7f6e\u3002<\/p>\n<blockquote>\n<h4><strong>\u5168\u57fa\u56e0\u9ad4\u5716\u8b5c\u7e6a\u88fd\uff0c\u5f4c\u88dc\u4e86\u5168\u57fa\u56e0\u9ad4\u5b9a\u5e8f\u8b80\u53d6\u9577\u5ea6\u9650\u5236\u7684\u7f3a\u61be\uff1b\u800c\u5168\u57fa\u56e0\u9ad4\u5b9a\u5e8f\uff0c\u5247\u63d0\u4f9b\u4e86\u6e96\u78ba\u7684 DNA \u5e8f\u5217\u3002<\/strong><\/h4>\n<\/blockquote>\n<p>\u85c9\u7531\u9019\u5169\u500b\u65b9\u5f0f\uff0c\u5718\u968a\u5f97\u4ee5\u9032\u884c\u5168\u57fa\u56e0\u7d44\u907a\u50b3\u5206\u6790 (full genome analysis) \uff0c\u9032\u800c\u63a2\u8a0e\u7f55\u898b\u907a\u50b3\u75be\u75c5\u7684\u81f4\u75c5\u56e0\u5b50\u3002<\/p>\n<p>\u300cDNA \u88e1\u5145\u6eff\u91cd\u8907\u7684\u5e8f\u5217\uff0c\u8b93\u91cd\u5efa\u5de5\u7a0b\u589e\u6dfb\u96e3\u5ea6\u3002\u4f46\u5982\u679c\u627e\u5230\u7279\u6b8a\u7684\u5e8f\u5217\uff0c\u5c0d\u5b9a\u5e8f\u6703\u5f88\u6709\u5e6b\u52a9\u3002\u300d\u90ed\u6c9b\u6069\u63d0\u5230\u3002\u76f8\u8f03\u65bc\u5c0f\u7247\u6bb5 DNA\uff0c\u5718\u968a\u6240\u4f7f\u7528\u7684\u8f03\u5927 DNA \u7247\u6bb5\u6709\u66f4\u591a\u5e8f\u5217\u7dda\u7d22\uff0c\u53ef\u4ee5\u8fa8\u8a8d\u3001\u62fc\u6e4a\u51fa\u57fa\u56e0\u539f\u672c\u6392\u5217\u7684\u9806\u5e8f\u3002\u5c07\u8fa8\u8a8d\u5927\u7247\u6bb5 DNA \u5f97\u5230\u7684\u57fa\u56e0\u5716\u8b5c\u62fc\u5728\u4e00\u8d77\uff0c\u5c31\u80fd\u91cd\u7d44\u6574\u689d\u67d3\u8272\u9ad4\u3002<\/p>\n<h2 class=\"contains_subtitle_icon\"><strong><b>\u5927\u773e\u5e38\u898b\u75be\u75c5\uff1a\u5206\u6790\u591a\u57fa\u56e0\u95dc\u806f<\/b><\/strong><\/h2>\n<p>\u5c0d\u65bc\u300c\u55ae\u4e00\u300d\u57fa\u56e0\u7570\u5e38\u9020\u6210\u7684\u7f55\u898b\u907a\u50b3\u75be\u75c5\uff0c\u80fd\u85c9\u7531\u5168\u57fa\u56e0\u7d44\u5b9a\u5e8f (whole Genome Sequencing) \u548c\u5168\u57fa\u56e0\u7d44\u5716\u8b5c\u7e6a\u88fd (whole genome mapping) \uff0c\u627e\u5230\u53ef\u80fd\u81f4\u75c5\u7684\u907a\u50b3\u56e0\u5b50\uff0c\u518d\u9032\u4e00\u6b65\u7814\u7a76\u767c\u75c5\u539f\u56e0\u8207\u6a5f\u5236\u3002<\/p>\n<p>\u4f46\u9762\u5c0d\u300c\u591a\u57fa\u56e0\u300d\u4ea4\u4e92\u5f71\u97ff\u7684\u75be\u75c5\uff0c\u4f8b\u5982\u7cd6\u5c3f\u75c5\u3001\u764c\u75c7\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u7cbe\u795e\u75be\u75c5\u7b49\u7b49\uff0c\u4e0a\u8ff0\u7684\u5168\u57fa\u56e0\u7d44\u907a\u50b3\u5206\u6790 (full genome analysis) \u5c31\u7121\u6cd5\u6e2c\u51fa\u5404\u500b\u55ae\u4e00\u57fa\u56e0\u5c0d\u75be\u75c5\u7684\u5f71\u97ff\u7a0b\u5ea6\u3002\u56e0\u70ba\uff0c\u4ee5\u5fc3\u8840\u7ba1\u75be\u75c5\u4f86\u8aaa\uff0c\u5c11\u90e8\u5206\u70ba\u55ae\u57fa\u56e0\u907a\u50b3\u75be\u75c5\uff0c\u800c\u5927\u90e8\u5206\u70ba\u591a\u57fa\u56e0\u52a0\u4e0a\u74b0\u5883\u98f2\u98df\u7b49\u56e0\u5b50\u4ea4\u4e92\u5f71\u97ff\u6240\u81f4\uff0c\u75c5\u56e0\u76f8\u7576\u8907\u96dc\u3002<\/p>\n<blockquote>\n<h4><strong>\u91dd\u5c0d\u591a\u57fa\u56e0\u5f71\u97ff\u7684\u5e38\u898b\u75be\u75c5\uff0c\u90ed\u6c9b\u6069\u7814\u7a76\u5718\u968a\u5229\u7528\u53e6\u4e00\u7a2e\u65b9\u6cd5\uff1a\u5168\u57fa\u56e0\u7d44\u95dc\u806f\u5206\u6790 (genome-wide association study\uff0c\u7c21\u7a31 GWAS )\u3002<\/strong><\/h4>\n<\/blockquote>\n<p>\u5168\u57fa\u56e0\u7d44\u95dc\u806f\u5206\u6790 (GWAS) \u642d\u914d\u91ab\u7642\u8cc7\u6599\u7684\u5927\u6578\u64da\u5206\u6790\uff0c\u671f\u671b\u80fd\u627e\u5230\u8207\u75be\u75c5\u9810\u9632\u3001\u9032\u7a0b\u3001\u53ca\u6cbb\u7642\u76f8\u95dc\u7684<a href=\"https:\/zh.wikipedia.org\/wiki\/%E7%94%9F%E7%89%A9%E6%A8%99%E8%A8%98_(%E9%86%AB%E5%AD%B8)\" target=\"_blank\" rel=\"noopener noreferrer\">\u751f\u7269\u6a19\u8a18<\/a>\u00a0(biomarker)\uff0c\u4e5f\u5c31\u662f\u9ad4\u5167\u53ef\u4ee5\u53cd\u61c9\u67d0\u7a2e\u75be\u75c5\u72c0\u614b\u7684\u6307\u6a19\u3002\u76ee\u524d\uff0c\u90ed\u6c9b\u6069\u5718\u968a\u6b63\u7a4d\u6975\u5730\u8207\u81fa\u7063\u5404\u5927\u91ab\u9662\u5408\u4f5c\uff0c\u904b\u7528\u6b64\u65b9\u6cd5\uff0c\u63a8\u884c\u548c\u5927\u773e\u5065\u5eb7\u606f\u606f\u76f8\u95dc\u7684\u300c\u81fa\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\u3002<\/p>\n<p>\u5728\u81fa\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u4e2d\uff0c\u90ed\u6c9b\u6069\u5718\u968a\u900f\u904e\u6587\u737b\u6536\u96c6\u8207\u75be\u75c5\u76f8\u95dc\u7684\u300c\u5df2\u77e5\u300d\u57fa\u56e0\u8b8a\u7570\u9ede\uff0c\u4e26\u8a2d\u8a08\u9069\u5408\u6aa2\u6e2c\u8a72\u57fa\u56e0\u4f4d\u9ede\u7684\u6676\u7247\uff0c\u4e4b\u5f8c\u75c5\u4eba\u7684\u6aa2\u9ad4\u5c31\u6703\u5229\u7528\u9019\u5f35\u6676\u7247\u9032\u884c\u5168\u57fa\u56e0\u7d44\u95dc\u806f\u5206\u6790 (GWAS)\uff0c\u78ba\u8a8d\u75c5\u4eba\u7684\u57fa\u56e0\u662f\u5426\u5728\u8a72\u8655\u6709\u8b8a\u7570\u60c5\u6cc1\u3002<\/p>\n<p>\u53e6\u4e00\u65b9\u9762\uff0c\u7531\u65bc\u591a\u6578\u75be\u75c5\u7684\u57fa\u56e0\u8b8a\u7570\u9ede\u5c1a\u300c\u672a\u77e5\u300d\uff0c\u5718\u968a\u53ef\u85c9\u7531\u5168\u57fa\u56e0\u7d44\u95dc\u806f\u5206\u6790 (GWAS) \u63a2\u7a76\u5927\u91cf\u7684\u75c5\u60a3\u57fa\u56e0\u6a23\u672c\uff0c\u5f9e\u5927\u6578\u64da\u627e\u51fa\u8207\u8a72\u75be\u75c5\u76f8\u95dc\u7684\u81f4\u75c5\u57fa\u56e0\uff1b\u63db\u53e5\u8a71\u8aaa\uff0c\u7576\u67d0\u7a2e\u75be\u75c5\u7684\u5927\u591a\u6578\u75c5\u60a3\uff0c\u5e7e\u4e4e\u90fd\u5728\u67d0\u8655\u57fa\u56e0\u51fa\u73fe\u554f\u984c\uff0c\u5c31\u80fd\u63a8\u6e2c\u5176\u70ba\u95dc\u9375\u7684\u57fa\u56e0\u8b8a\u7570\u4f4d\u9ede\u3002<\/p>\n<p>\u82e5\u60f3\u4e86\u89e3\u500b\u4eba\u7f79\u60a3\u7cd6\u5c3f\u75c5\u3001\u764c\u75c7\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u7b49\u7b49\u9019\u985e\u5e38\u898b\u75be\u75c5\u7684\u98a8\u96aa\uff0c\u5927\u773e\u53ef\u5148\u9032\u884c\u57fa\u56e0\u6aa2\u6e2c\uff0c\u5efa\u7acb\u81ea\u5df1\u7684\u57fa\u56e0\u907a\u50b3\u8f2a\u5ed3 (gene profile)\uff0c\u4e26\u900f\u904e\u4e0a\u8ff0\u7684\u5168\u57fa\u56e0\u7d44\u95dc\u806f\u5206\u6790 (GWAS) \u89c0\u5bdf\u57fa\u56e0\u8b8a\u7570\u9ede\u6216\u8868\u73fe\u91cf\uff0c\u518d\u8207\u81ea\u5df1\u7684\u81e8\u5e8a\u75c5\u6b77\u6bd4\u5c0d\u5206\u6790\uff0c\u5c31\u53ef\u5f9e\u57fa\u56e0\u8a55\u4f30\u60a3\u75c5\u98a8\u96aa\uff0c\u6bd4\u53c3\u8003\u5bb6\u65cf\u75c5\u53f2\u66f4\u70ba\u6e96\u78ba\u3002<\/p>\n<h2 class=\"contains_subtitle_icon\"><strong><b>\u964d\u4f4e\u85e5\u5bb3\u98a8\u96aa\uff1a\u9ad4\u5916\u57fa\u56e0\u6aa2\u6e2c<\/b><\/strong><\/h2>\n<p>\u53e6\u5916\uff0c\u7531\u65bc\u4e0d\u540c\u7684\u57fa\u56e0\u578b\u6703\u5f71\u97ff\u4eba\u9ad4\u5c0d\u85e5\u7269\u7684\u53cd\u61c9\uff0c\u7d93\u7531\u9ad4\u5916\u7684\u57fa\u56e0\u6aa2\u6e2c (gene test)\uff0c\u4e5f\u80fd\u4e8b\u5148\u5f97\u77e5\u75c5\u60a3\u5c0d\u85e5\u7269\u7684\u53cd\u61c9\uff0c\u5354\u52a9\u91ab\u751f\u9078\u7528\u6700\u9069\u5408\u7684\u85e5\u7269\u3002<\/p>\n<blockquote>\n<h4><strong>\u57fa\u56e0\u6aa2\u6e2c\u9664\u4e86\u8b93\u91ab\u7642\u6c7a\u7b56\u66f4\u7cbe\u6e96\uff0c\u7528\u85e5\u4e5f\u80fd\u66f4\u7b26\u5408\u500b\u4eba\u9700\u6c42\u3002<\/strong><\/h4>\n<\/blockquote>\n<p>\u76ee\u524d\u5e02\u9762\u6d41\u901a\u7684\u85e5\u7269\uff0c\u591a\u6578\u662f\u7531\u6b50\u7f8e\u570b\u5bb6\u91dd\u5c0d\u897f\u65b9\u4eba\u958b\u767c\uff0c\u7528\u5728\u4e9e\u6d32\u4eba\u8eab\u4e0a\u53ef\u80fd\u6c92\u6709\u6548\u679c\u3001\u751a\u81f3\u6709\u5bb3\u3002\u4f8b\u5982\uff0c\u6cbb\u7642\u5fc3\u8840\u7ba1\u75be\u75c5\u5e38\u7528\u7684\u6297\u51dd\u8840\u5291 Warfarin (\u97f3\u8b6f\u83ef\u6cd5\u6797)\u3002<\/p>\n<p>Warfarin \u662f\u5f9e\u8001\u9f20\u85e5\u7814\u767c\u800c\u4f86\uff0c\u5177\u6709\u76f8\u7576\u7a0b\u5ea6\u7684\u6bd2\u6027\uff0c\u904b\u7528\u65bc\u4eba\u9ad4\u91ab\u7642\u53ef\u4ee5\u9810\u9632\u4e2d\u98a8\u3001\u5fc3\u81df\u75c5\u3002\u4f46\u56e0\u70ba\u4e9e\u6d32\u4eba\u7f3a\u4e4f\u4ee3\u8b1d\u6b64\u85e5\u7269\u7684\u57fa\u56e0\uff0c\u5f88\u5bb9\u6613\u7522\u751f\u526f\u4f5c\u7528\uff0c\u7528\u85e5\u904e\u91cf\u6703\u51fa\u8840\u6b7b\u4ea1\u30022006 \u5e74\uff0c\u4e2d\u7814\u9662<a href=\"http:\/www.ibms.sinica.edu.tw\/yuan-tsong-chen\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u9673\u57a3\u5d07\u9662\u58eb<\/a>\u5df2\u7d93\u627e\u5230 Warfarin \u7684<a href=\"http:\/news.ltn.com.tw\/news\/life\/paper\/57887\" target=\"_blank\" rel=\"noopener noreferrer\">\u57fa\u56e0\u6a19\u7684<\/a>\uff0c\u4e26\u8207\u91ab\u9662\u5408\u4f5c\u9032\u884c\u7528\u85e5\u524d\u7684\u57fa\u56e0\u7be9\u6aa2\u3002<\/p>\n<p>\u81f3\u65bc\u5e38\u7528\u65bc\u6cbb\u7642\u7672\u7647\u8207\u4e09\u53c9\u795e\u7d93\u75db\u7684\u85e5\u7269\u00a0<a href=\"http:\/www.tdrf.org.tw\/ch\/02_affair\/aff_01_main.asp?bull_id=4192\" target=\"_blank\" rel=\"noopener noreferrer\">Carbamazepine<\/a>\u00a0(\u5361\u5df4\u6c2e\u5e73)\uff0c\u8aa4\u7528\u6703\u5f15\u8d77\u53f2\u8482\u6587\u751f\u6c0f\u5f37\u751f\u75c7\u5019\u7fa4 (SJS)\uff0c \u8207\u6bd2\u6027\u8868\u76ae\u6eb6\u89e3\u75c7 (TEN) \u7b49\u76ae\u819a\u75c5\u5fb5\u3002\u5728\u7528\u85e5\u524d\u5148\u9032\u884c\u57fa\u56e0\u6aa2\u6e2c\uff0c\u53ef\u4ee5\u907f\u514d\u75c5\u4eba\u70ba\u526f\u4f5c\u7528\u6240\u56f0\u64fe\u3002<\/p>\n<p>\u76ee\u524d\u5728\u81fa\u7063\u90e8\u5206\u5927\u91ab\u9662\u9032\u884c\u55ae\u4e00\u4f4d\u7f6e\u7684\u57fa\u56e0\u6aa2\u6e2c\uff0c\u6240\u8cbb\u4e0d\u8cb2\u3002\u5f8c\u7e8c\u90ed\u6c9b\u6069\u7814\u7a76\u5718\u968a\u82e5\u8207\u5065\u4fdd\u5408\u4f5c\uff0c\u53ef\u4ee5\u8b93\u5927\u773e\u7528\u8f03\u4f4e\u7684\u8cbb\u7528\u4e86\u89e3\u81ea\u5df1\u7684\u57fa\u56e0\u7d44\u8cc7\u8a0a\u3002<\/p>\n<p>\u4f46\u70ba\u4e86\u9054\u6210\u7cbe\u6e96\u91ab\u7642\uff0c\u9664\u4e86\u6aa2\u6e2c\u500b\u4eba\u57fa\u56e0\u8cc7\u8a0a\uff0c\u9084\u9700\u8981\u8490\u96c6\u81e8\u5e8a\u75c5\u6b77\u8cc7\u6599\u3001\u65e5\u5e38\u904b\u52d5\u8207\u98f2\u98df\u7fd2\u6163\u7b49\u7b49\u3002\u8cc7\u8a0a\u8d8a\u8a73\u7d30\uff0c\u5c0d\u75be\u75c5\u9810\u6e2c\u3001\u6cbb\u7642\u8d8a\u6709\u5e6b\u52a9\uff0c\u4f46\u524d\u63d0\u662f\u8981\u7372\u5f97\u500b\u4eba\u7684\u540c\u610f\u3002\u90ed\u6c9b\u6069\u60f3\u50cf\uff0c\u6216\u8a31\u6709\u4e00\u5929\uff0c\u4eba\u4eba\u8eab\u4e0a\u90fd\u6709\u7a7f\u6234\u5f0f\u88dd\u7f6e\u7684\u8ffd\u8e64\u5668\uff0c\u5c31\u53ef\u4ee5\u7cbe\u78ba\u8490\u96c6\u5404\u7a2e\u8a0a\u606f\u3002<\/p>\n<p>\u300c\u4f46\u500b\u4eba\u610f\u9858\u5982\u4f55\uff0c\u9019\u5c31\u4e0d\u77e5\u9053\u4e86\u3002\u300d\u90ed\u6c9b\u6069\u8aaa\u3002<\/p>\n<h2 class=\"contains_subtitle_icon\"><strong><b>\u9700\u8981\u6642\u9593\u8b49\u660e\u6210\u6548<\/b><\/strong><\/h2>\n<p>2018 \u5e74\u521d\uff0c\u91dd\u5c0d\u7f55\u898b\u907a\u50b3\u75be\u75c5\u7684\u5168\u57fa\u56e0\u7d44\u907a\u50b3\u5206\u6790 (full genome analysis) \u8a08\u756b\u624d\u525b\u958b\u59cb\uff0c\u81f3\u5c11\u9700\u8981\u4e00\u5e74\u7684\u6642\u9593\u4f86\u57f7\u884c\uff1b\u81f3\u65bc\u76ee\u6a19\u662f\u904b\u7528\u5168\u57fa\u56e0\u7d44\u95dc\u806f\u5206\u6790 (genome-wide association study) \u63d0\u5347\u5927\u773e\u5065\u5eb7\u7684\u300c\u81fa\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\uff0c\u90ed\u6c9b\u6069\u5247\u671f\u671b\u5728\u9019\u500b\u8a08\u756b\u63a8\u884c\u4e00\u5e74\u534a\u7684\u6642\u5019\uff0c\u8a55\u4f30\u8207\u5065\u4fdd\u7cfb\u7d71\u5408\u4f5c\u7684\u53ef\u884c\u6027\uff0c\u4ee5\u53ca\u662f\u5426\u80fd\u771f\u7684\u627e\u5230\u76ee\u524d\u672a\u77e5\u7684\u81f4\u75c5\u57fa\u56e0\u3002<\/p>\n<blockquote>\n<h4><strong>\u8207\u75be\u75c5\u7be9\u6aa2\u7684\u300c\u76ee\u7684\u6027\u300d\u6aa2\u9a57\u4e0d\u540c\uff0c\u81fa\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u504f\u5411\u300c\u9810\u9632\u6027\u300d\u6aa2\u6e2c\u3002<\/strong><\/h4>\n<\/blockquote>\n<p>\u8a08\u756b\u63a8\u5ee3\u7684\u540c\u6642\uff0c\u9700\u8981\u66f4\u5927\u91cf\u7684\u6a23\u672c\u5354\u52a9\u7814\u7a76\u3002\u4f46\u57fa\u56e0\u7d44\u5206\u6790\u901a\u5e38\u6703\u662f\u5728\u4eba\u5011\u5065\u5eb7\u7684\u6642\u5019\u9032\u884c\uff0c\u4e0d\u540c\u65bc\u4ee5\u5f80\u5927\u773e\u6240\u719f\u6089\u7684\u76ee\u7684\u6027\u75be\u75c5\u7be9\u6aa2\uff0c\u63a8\u5ee3\u7684\u904e\u7a0b\u52e2\u5fc5\u6703\u53d7\u5230\u8cea\u7591\u3002\u9762\u81e8\u9019\u500b\u6311\u6230\uff0c\u90ed\u6c9b\u6069\u8868\u793a\u7814\u7a76\u5718\u968a\u5fc5\u9808\u52a0\u5f37\u793a\u7bc4\u57fa\u56e0\u6aa2\u6e2c\u7684\u5be6\u969b\u76ca\u8655\uff0c\u800c\u975e\u4ee5\u7d14\u7cb9\u63d0\u4f9b\u6578\u64da\u8b93\u79d1\u5b78\u5bb6\u7814\u7a76\u70ba\u7406\u7531\u4f86\u8aaa\u670d\u6c11\u773e\u3002<\/p>\n<h2 class=\"contains_subtitle_icon\"><strong><b>\u53ef\u9810\u5148\u5206\u6790\u65b0\u751f\u5152\u7684\u57fa\u56e0\u55ce\uff1f<\/b><\/strong><\/h2>\n<p>\u5206\u6790\u96d9\u89aa\u7684\u57fa\u56e0\u7d44\u8cc7\u8a0a\uff0c\u7684\u78ba\u53ef\u4ee5\u9810\u6e2c\u65b0\u751f\u5152\u53ef\u80fd\u9762\u81e8\u7684\u907a\u50b3\u75be\u75c5\uff0c\u4f46\u5be6\u969b\u72c0\u6cc1\u4f9d\u7136\u8981\u7b49\u80da\u80ce\u6210\u5f62\u5f8c\u624d\u80fd\u78ba\u8a8d\u3002\u82e5\u662f\u5f9e\u80da\u80ce\u4e2d\u53d6\u51fa\u7d30\u80de\uff0c\u4e26\u5c07\u7d30\u80de\u6838\u4e2d\u7684\u57fa\u56e0\u7d44\u5b8c\u5168\u5b9a\u5e8f\uff0c\u907f\u958b\u75be\u75c5\u8207\u7f3a\u9677\uff0c\u53ea\u7559\u4e0b\u512a\u826f\u7684\u57fa\u56e0\u7d44\u5408\u5c31\u4e0d\u518d\u53ea\u662f\u5922\u60f3\u3002<\/p>\n<p>\u8981\u5b8c\u6574\u5206\u6790\u57fa\u56e0\u7d44\uff0c\u9700\u8981\u7d04\u4e00\u767e\u842c\u500b\u7d30\u80de\u3002\u4f46\u5728\u80da\u80ce\u6642\u671f\uff0c\u9802\u591a\u53ea\u80fd\u53d6\u5f97\u5e7e\u500b\u7d30\u80de\uff0c\u9060\u4e0d\u53ca\u57fa\u56e0\u5b9a\u5e8f\u6240\u9700\u7684\u91cf\u3002\u4f46\u5373\u4f7f\u6280\u8853\u4e0a\u53ef\u884c\uff0c\u5728\u502b\u7406\u5c64\u9762\uff0c\u90ed\u6c9b\u6069\u9084\u662f\u89ba\u5f97\u6975\u4e0d\u59a5\u7576\u3002\u300c\u6211\u5011\u4e0d\u77e5\u9053\u751a\u9ebc\u6a23\u7684\u5bf6\u5bf6\u662f\u6700\u597d\u7684\u3002\u300d\u90ed\u6c9b\u6069\u8a8d\u70ba\uff0c\u8070\u660e\u7684\u3001\u5065\u5eb7\u7684\u3001\u5916\u8c8c\u51fa\u8272\u7684\uff0c\u5c0d\u6bcf\u4f4d\u7236\u6bcd\u800c\u8a00\u300c\u6700\u597d\u7684\u5bf6\u5bf6\u300d\u90fd\u4e0d\u4e00\u6a23\u3002<\/p>\n<p>\u6cc1\u4e14\uff0c\u4e0d\u7b26\u5408\u9019\u4e9b\u7279\u5fb5\u7684\u65b0\u751f\u5152\uff0c\u4e26\u4e0d\u4ee3\u8868\u6c92\u6709\u6d3b\u4e0b\u4f86\u7684\u6b0a\u529b\u3002\u56e0\u6b64\u90ed\u6c9b\u6069\u5f37\u8abf\uff0c\u7528\u5168\u57fa\u56e0\u7d44\u5206\u6790\u4f86\u7be9\u9078\u5c0f\u5b69\uff0c\u7d55\u5c0d\u4e0d\u662f\u500b\u597d\u4e3b\u610f\u3002<\/p>\n<h2 class=\"contains_subtitle_icon\"><strong><b>\u81fa\u7063\u5f97\u5929\u7368\u539a\u7684\u512a\u52e2<\/b><\/strong><\/h2>\n<p>\u6642\u4efb\u751f\u91ab\u6240\u6240\u9577\u7684<a href=\"https:\/www.sinica.edu.tw\/ch\/articles\/17\" target=\"_blank\" rel=\"noopener 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