{"id":23035,"date":"2020-09-24T00:03:04","date_gmt":"2020-09-23T16:03:04","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=23035"},"modified":"2021-08-26T08:53:54","modified_gmt":"2021-08-26T00:53:54","slug":"%e3%80%90%e5%b0%88%e6%ac%84%e3%80%91%e6%96%b0%e5%86%a0%e8%82%ba%e7%82%8e%ef%bc%88covid-19%ef%bc%89%e5%85%a8%e7%90%83%e5%a4%a7%e6%b5%81%e8%a1%8c%e5%b8%b6%e7%b5%a6%e6%88%91%e5%80%91%e7%9a%84%e6%8c%91","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/23035\/","title":{"rendered":"\u3010\u5c08\u6b04\u3011\u65b0\u51a0\u80ba\u708e\uff08COVID-19\uff09\u5168\u7403\u5927\u6d41\u884c\u5e36\u7d66\u6211\u5011\u7684\u6311\u6230"},"content":{"rendered":"

\u4e16\u754c\u885b\u751f\u7d44\u7e54\uff08WHO\uff09\u65bc2020\u5e743\u670811\u65e5\u5ba3\u5e032019\u5e74\u672b\u5728\u4e2d\u570b\u6b66\u6f22\u767c\u73fe\u7684\u65b0\u51a0\u75c5\u6bd2\uff08SARS-CoV-2\uff09 \u5f15\u8d77\u7684\u65b0\u51a0\u80ba\u708e\uff08COVID-19\uff09\u5df2\u9032\u5165\u5168\u7403\u5927\u6d41\u884c\u3002\u5728\u65b0\u578b\u50b3\u67d3\u75c5\u9632\u6cbb\u74b0\u7bc0\u4e2d\u6975\u70ba\u91cd\u8981\u4e14\u6025\u8feb\u7684\u662f\u611f\u67d3\u8005\u7684\u666e\u904d\u53ca\u5feb\u901f\u6aa2\u6e2c\u3002<\/p>\n

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\"\"

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\"\"

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 <\/p>\n

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 <\/p>\n

\u53c3\u8003\u6587\u737b<\/strong><\/p>\n

1 Kuo, W. Y. et al. Antibody-drug conjugates with HER2-targeting antibodies from synthetic antibody libraries are highly potent against HER2-positive human gastric tumor in xenograft models. MAbs 11, 153-165,\uff082019\uff09.
\n2 Jian, J. W. et al. Effective binding to protein antigens by antibodies from antibody libraries designed with enhanced protein recognition propensities. MAbs 11, 373-387,\uff082019\uff09.
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\n4 Jian, J. W. et al. Predicting Ligand Binding Sites on Protein Surfaces by 3-Dimensional Probability Density Distributions of Interacting Atoms. PLoS One 11, e0160315,\uff082016\uff09.
\n5 Hou, S. C. et al. High throughput cytotoxicity screening of anti-HER2 immunotoxins conjugated with antibody fragments from phage-displayed synthetic antibody libraries. Scientific reports 6, 31878,\uff082016\uff09.
\n6 Tung, C. P. et al. Discovering neutralizing antibodies targeting the stem epitope of H1N1 influenza hemagglutinin with synthetic phage-displayed antibody libraries. Scientific reports 5, 15053,\uff082015\uff09.
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\n8 Peng, H. P., Lee, K. H., Jian, J. W. & Yang, A. S. Origins of specificity and affinity in antibody-protein interactions. Proc Natl Acad Sci U S A 111, E2656-2665,\uff082014\uff09.
\n9 Hsu, H. J. et al. Antibody variable domain interface and framework sequence requirements for stability and function by high-throughput experiments. Structure 22, 22-34,\uff082014\uff09.
\n10 Chang, H. J. et al. Loop-sequence features and stability determinants in antibody variable domains by high-throughput experiments. Structure 22, 9-21,\uff082014\uff09.
\n11 Yu, C. M. et al. Rationalization and design of the complementarity determining region sequences in an antibody-antigen recognition interface. PLoS One 7, e33340,\uff082012\uff09.
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\n14 Lee, Y. C. et al. Effects of signal sequence on phage-displayed disulfide-stabilized single chain antibody variable fragment\uff08sc-dsFv\uff09 libraries. Biochem Biophys Res Commun 411, 348-353,\uff082011\uff09.
\n15 Huang, Y. J. et al. Engineering anti-vascular endothelial growth factor single chain disulfide-stabilized antibody variable fragments\uff08sc-dsFv\uff09 with phage-displayed sc-dsFv libraries. J Biol Chem 285, 7880-7891,\uff082010\uff09.
\n16 Chen, I. C. et al. Signal sequence as a determinant in expressing disulfide-stabilized single chain antibody variable fragments\uff08sc-dsFv\uff09 against human VEGF. Mol Biosyst 6, 1307-1315\uff082010\uff09.
\n17 Chang, H. J. et al. Molecular evolution of cystine-stabilized miniproteins as stable proteinaceous binders. Structure 17, 620-631\uff082009\uff09.
\n18 Hsu, H. J. et al. Factor Xa active site substrate specificity with substrate phage display and computational molecular modeling. J Biol Chem 283, 12343-12353\uff082008\uff09.
\n19 Chen, C. T. et al. Protease substrate site predictors derived from machine learning on multilevel substrate phage display data. Bioinformatics 24, 2691-2697\uff082008\uff09.
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\n21 Hsu, H. J. et al. Assessing computational amino acid beta-turn propensities with a phage-displayed combinatorial library and directed evolution. Structure 14, 1499-1510\uff082006\uff09.<\/p>\n","protected":false},"excerpt":{"rendered":"

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