{"id":22819,"date":"2020-08-27T00:04:50","date_gmt":"2020-08-26T16:04:50","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=22819"},"modified":"2020-12-22T17:22:15","modified_gmt":"2020-12-22T09:22:15","slug":"%e5%9f%ba%e5%9b%a0%e4%b8%96%e7%95%8c%e8%a3%a1%e4%b9%9f%e6%9c%89%e6%ad%bb%e4%ba%a1%e6%87%b8%e6%a1%88%ef%bc%81%e7%a0%b4%e8%a7%a3%e6%a0%b8%e7%b3%96%e6%a0%b8%e9%85%b8%e7%9a%84%e9%99%8d%e8%a7%a3%e4%b9%8b","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/22819\/","title":{"rendered":"\u57fa\u56e0\u4e16\u754c\u88e1\u4e5f\u6709\u6b7b\u4ea1\u61f8\u6848\uff01\u7834\u89e3\u6838\u7cd6\u6838\u9178\u7684\u964d\u89e3\u4e4b\u8b0e"},"content":{"rendered":"<p>\u7d30\u80de\u88e1\u7684RNA(\u8a3b\u4e00)(\u6838\u7cd6\u6838\u9178)\u58fd\u547d\u77ed\u66ab\uff0c\u542b\u6709\u6b63\u78ba\u57fa\u56e0\u5bc6\u78bc\u7684RNA\u59cb\u80fd\u5b58\u6d3b\u4e26\u7528\u65bc\u88fd\u9020\u86cb\u767d\u8cea\uff0c\u53cd\u4e4b\uff0c\u5e36\u6709\u932f\u8aa4\u8a0a\u606f\u7684RNA\u5247\u6703\u88ab\u7d30\u80de\u9175\u7d20\u964d\u89e3\u6b7b\u4ea1\u3002RNA\u964d\u89e3\u6a5f\u5236(degradation)\u4e0d\u50c5\u53ef\u8abf\u63a7\u52d5\u690d\u7269\u7684\u57fa\u56e0\u8868\u73fe\u91cf\uff0c\u4e5f\u6538\u95dc\u65bc\u690d\u7269\u5982\u4f55\u5c0d\u6297\u75c5\u539f\u83cc\u5165\u4fb5\uff0c\u85c9\u6b64\u6bba\u6b7b\u75c5\u6bd2RNA\u3002\u4f46\u6b64\u6a5f\u5236\u4f55\u6642\u767c\u751f\uff1f\u5f15\u767c\u964d\u89e3\u7684\u56e0\u5b50\u70ba\u4f55\uff1f\u904e\u53bb\u5c1a\u672a\u88ab\u5b8c\u5168\u7406\u89e3\u3002<\/p>\n<p>\u672c\u9662\u8fb2\u696d\u751f\u7269\u79d1\u6280\u7814\u7a76\u4e2d\u5fc3\u9673\u8377\u660e\u526f\u7814\u7a76\u54e1\u9996\u6b21\u7834\u89e3RNA\u7684\u300c\u6b7b\u4ea1\u6642\u9593\u300d\uff0c\u5176\u5718\u968a\u4e5f\u662f\u5168\u7403\u7b2c\u4e00\u4f4d\u5229\u7528\u4e0a\u5104\u689d\u7684RNA\u964d\u89e3\u7247\u6bb5\u5b9a\u5e8f\u8cc7\u6599\uff0c\u8b49\u660e\u8a31\u591a\u300c\u6709\u554f\u984c\u300d\u7684RNA\u6703\u5728\u9996\u6b21\u8f49\u8b6f(\u8a3b\u4e8c)(translation)\u904e\u7a0b\u4e2d\u88ab\u7d30\u80de\u5075\u6e2c\u7570\u5e38\u4e26\u5c07\u5176\u964d\u89e3\u3002\u7814\u7a76\u6210\u679c\u5df2\u65bc\u4eca(2020)\u5e744\u6708\u767c\u8868\u5728\u300a\u690d\u7269\u7d30\u80de\u300b(<em>The 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\u7d30\u80de\u555f\u52d5\u964d\u89e3\u7a0b\u5e8f<\/strong><\/p>\n<p>\u9673\u8377\u660e\u5718\u968a\u5f9eRNA\u964d\u89e3\u7247\u6bb5\u88e1\uff0c\u627e\u5230\u5916\u986f\u5b50\u9023\u63a5\u8907\u5408\u9ad4(\u8a3b\u4e09)\u5b58\u5728\u7684\u8b49\u64da\uff0c\u6b64\u767c\u73fe\u63ed\u9732\u51fa\u5169\u500b\u91cd\u8981\u610f\u7fa9\uff1a\u9996\u5148\uff0c\u7531\u65bc\u7d30\u80de\u6703\u89e3\u78bcRNA\u7684\u6838\u9178\u8a9e\u8a00\uff0c\u7d93\u904e\u4e00\u6b21\u6b21\u7684\u8f49\u8b6f\u4f5c\u7528\u4f86\u88fd\u9020\u86cb\u767d\u8cea\u3002\u5728\u7d30\u80de\u57f7\u884c\u9996\u6b21\u8f49\u8b6f\u524d\uff0c\u5916\u986f\u5b50\u9023\u63a5\u8907\u5408\u9ad4\u4ecd\u9644\u8457\u5728RNA\u4e0a\uff0c\u5728\u6b63\u5e38\u60c5\u6cc1\u4e0b\uff0c\u7576RNA\u7d93\u904e\u7b2c\u4e00\u6b21\u8f49\u8b6f\u5f8c\uff0c\u6b64\u8907\u5408\u9ad4\u5373\u88ab\u79fb\u9664\uff1b\u76f8\u53cd\u5730\uff0c\u82e5\u7d30\u80de\u6aa2\u67e5\u767c\u73feRNA\u5305\u542b\u932f\u8aa4\u5e8f\u5217\uff0c\u5b9b\u5982\u51fa\u73fe\u8b66\u793a\u97f3\uff0c\u8f49\u8b6f\u6a5f\u5668\u88ab\u6309\u4e0b\u300c\u66ab\u505c\u9375\u300d\uff0c\u4e26\u4fc3\u4f7f\u7d30\u80de\u9175\u7d20\u5c07\u6b64\u7247\u6bb5\u964d\u89e3\u3002\u56e0\u6b64\uff0c\u7576RNA\u6b7b\u4ea1\u7247\u6bb5\u542b\u6709\u5916\u986f\u5b50\u9023\u63a5\u8907\u5408\u9ad4\uff0c\u8868\u793a\u5176\u6b7b\u4ea1\u6642\u9593\u767c\u751f\u5728\u7b2c\u4e00\u6b21\u8f49\u8b6f\u5b8c\u6210\u524d\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u7531\u65bc\u52d5\u690d\u7269\u7684\u7d30\u80de\u5167\u90fd\u6709RNA\uff0c\u7814\u7a76\u5718\u968a\u4e5f\u9032\u4e00\u6b65\u5f9e\u963f\u62c9\u4f2f\u82a5\u3001\u6c34\u7a3b\u3001\u7dda\u87f2\uff0c\u6216\u662f\u4eba\u985e\u7d30\u80de\u7684RNA\u964d\u89e3\u7247\u6bb5\u4e2d\uff0c\u90fd\u89c0\u5bdf\u5230\u5916\u986f\u5b50\u9023\u63a5\u8907\u5408\u9ad4\u7684\u8db3\u8de1\u3002\u9019\u4e9b\u907a\u7559\u7684\u76f8\u540c\u8b49\u64da\u4e5f\u8b93\u88ab\u964d\u89e3\u7684RNA\u300c\u6b7b\u6709\u5c0d\u8b49\u300d\uff0c\u8b49\u660e\u6b64\u964d\u89e3\u6a5f\u5236\u767c\u751f\u5728\u5927\u91cf\u8f49\u8b6f\u524d\u3002<\/p>\n<p>\u70ba\u4ec0\u9ebc\u5916\u986f\u5b50\u9023\u63a5\u8907\u5408\u9ad4\u4e0d\u6703\u96a8\u8457RNA\u964d\u89e3\u800c\u6d88\u5931\uff1f\u9673\u8377\u660e\u8868\u793a\uff0c\u7531\u65bc\u5916\u986f\u5b50\u9023\u63a5\u8907\u5408\u9ad4\u7684\u6027\u8cea\u6703\u963b\u64cb\u7d30\u80de\u57f7\u884c\u964d\u89e3\uff0c\u7d30\u80de\u9175\u7d20\u7121\u6cd5\u5c07\u5176\u79fb\u9664\uff0c\u525b\u597d\u53ef\u4ee5\u505a\u70ba\u7834\u89e3RNA\u6b7b\u4ea1\u6642\u9593\u7684\u6709\u529b\u8b49\u64da\uff0c\u63a8\u6e2c\u964d\u89e3\u767c\u751f\u6642RNA\u7684\u72c0\u614b\u3002<\/p>\n<div id=\"attachment_21652\" style=\"width: 1034px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21652\" class=\"aligncenter size-large wp-image-22822\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/08\/1-2-2-1024x542.jpg\" alt=\"\" width=\"1024\" height=\"542\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/08\/1-2-2-1024x542.jpg 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/08\/1-2-2-300x159.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/08\/1-2-2-768x407.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/08\/1-2-2-1080x572.jpg 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/08\/1-2-2.jpg 1269w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">\u5728\u6b63\u5e38\u60c5\u6cc1\u4e0b\uff0c\u6838\u7cd6\u9ad4\u5c07mRNA\u8f49\u8b6f\u6210\u86cb\u767d\u8cea\uff1b\u7576RNA\u5e8f\u5217\u4e0d\u6b63\u78ba\u6642(\u5982\u5716\u53f3)\uff0c\u6574\u500b\u8f49\u8b6f\u6a5f\u5668\u6703\u66ab\u505c\uff0c\u7d30\u80de\u9175\u7d20\u5f9eRNA\u982d\u7aef\u958b\u59cb\uff0c\u9010\u6b65\u5c07\u6b64\u7247\u6bb5\u964d\u89e3\u3002\u5916\u986f\u5b50\u9023\u63a5\u8907\u5408\u9ad4\u56e0\u5176\u6027\u8cea\u6703\u963b\u64cb\u964d\u89e3\uff0c\u4e0d\u6703\u88ab\u79fb\u9664\uff0cRNA\u6b7b\u4ea1\u7247\u6bb5\u6545\u542b\u6709\u6b64\u8907\u5408\u9ad4\u7684\u8db3\u8de1\u3002<\/p><\/div>\n<p>&nbsp;<\/p>\n<p><strong>\u5c0d\u5167\u8abf\u63a7\u57fa\u56e0\u8868\u73fe\u91cf \u5c0d\u5916\u6bba\u6b7b\u75c5\u6bd2RNA<\/strong><\/p>\n<p>\u9673\u8377\u660e\u6307\u51fa\uff0c\u690d\u7269\u7d30\u80de\u5167\u57f7\u884cRNA\u964d\u89e3\u6a5f\u5236\uff0c\u5c0d\u5167\u53ef\u8abf\u63a7\u57fa\u56e0\u8868\u73fe\u91cf\uff0c\u5c0d\u5916\u4e5f\u80fd\u963b\u64cb\u75c5\u539f\u83cc\u5165\u4fb5\uff0c\u6bba\u6b7b\u75c5\u6bd2\u7684RNA\uff0c\u4f7f\u5176\u7121\u6cd5\u8907\u88fd\u3001\u7522\u751f\u86cb\u767d\u8cea\u3002\u53e6\u5916\uff0c\u7576\u690d\u7269\u9047\u5230\u75c5\u539f\u83cc\u6216\u5bb3\u87f2\u653b\u64ca\u6642\uff0c\u6703\u555f\u52d5\u9632\u79a6\u53cd\u61c9\uff0c\u4f46\u82e5\u904e\u91cf\u8868\u9054\u9632\u79a6\u76f8\u95dc\u57fa\u56e0\uff0c\u53ef\u80fd\u9020\u6210\u690d\u7269\u751f\u9577\u9072\u6eef\u3001\u7d30\u80de\u51cb\u4ea1\uff0c\u5c31\u50cf\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\u592a\u5f37\u6216\u592a\u5f31\uff0c\u90fd\u6703\u5c0d\u8eab\u9ad4\u9020\u6210\u50b7\u5bb3\u3002\u56e0\u6b64\uff0c\u7814\u7a76RNA\u964d\u89e3\uff0c\u5c07\u6709\u52a9\u65bc\u589e\u9032\u5c0d\u8fb2\u4f5c\u7269\u9632\u79a6\u6a5f\u5236\u7684\u4e86\u89e3\uff0c\u4ee5\u53ca\u958b\u767c\u8abf\u63a7\u57fa\u56e0\u8868\u9054\u7684\u65b9\u6cd5\uff0c\u70ba\u8fb2\u696d\u751f\u7269\u79d1\u6280\u7684\u767c\u5c55\u63d0\u4f9b\u65b0\u7684\u5de5\u5177\u53ca\u65b9\u5411\u3002<\/p>\n<p>\u5f9e\u5c0f\u611b\u770b\u63a8\u7406\u5c0f\u8aaa\u7684\u9673\u8377\u660e\u8aaa\uff0c\u89e3\u5bc6RNA\u964d\u89e3\u6a5f\u5236\uff0c\u7336\u5982\u5728\u9032\u884c\u57fa\u56e0\u4e16\u754c\u7684\u72af\u7f6a\u73fe\u5834\u8abf\u67e5\uff0c\u73fe\u5834\u7559\u4e0b\u7684\u7269\u8b49\uff0c\u90fd\u53ea\u662f\u4e00\u689d\u689d\u7684RNA\u5e8f\u5217\u3002\u5979\u8207\u5be6\u9a57\u5ba4\u540c\u4ec1\u7576\u8d77\u300c\u9375\u76e4\u67ef\u5357\u300d\uff0c\u5f9e\u4e0a\u5104\u689d\u7684RNA\u964d\u89e3\u7247\u6bb5\u4e2d\uff0c\u8490\u96c6\u7269\u8b49\u3001\u627e\u51fa\u6b7b\u56e0\u53ca\u51f6\u624b\uff0c\u53ca\u63a8\u8ad6\u6b7b\u4ea1\u6642\u9593\u3002\u76ee\u524d\u570b\u5167\u5916\u76f8\u95dc\u7684\u7814\u7a76\u9084\u4e0d\u591a\uff0c\u5979\u7684\u5718\u968a\u672a\u4f86\u5c07\u9032\u4e00\u6b65\u91d0\u6e05\u6b64\u8abf\u63a7\u80cc\u5f8c\u7684\u6a5f\u5236\uff0c\u53ca\u5176\u5728\u690d\u7269\u9632\u79a6\u8207\u751f\u9577\u5e73\u8861\u4e0a\u7684\u89d2\u8272\u3002<\/p>\n<p>\u672c\u8ad6\u6587\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u70ba\u672c\u9662\u8fb2\u751f\u4e2d\u5fc3\u7814\u7a76\u52a9\u7406\u674e\u6eab\u742a\u3001\u4faf\u535a\u7ff0\u3001\u4faf\u653f\u5b87\uff0c\u8ad6\u6587\u5168\u6587\uff1a\u3008Widespread Exon Junction Complex Footprints in the RNA Degradome Mark mRNA Degradation before Steady State Translation\u3009\uff0c\u7db2\u5740\uff1a <a href=\"http:\/www.plantcell.org\/content\/32\/4\/904\">http:\/www.plantcell.org\/content\/32\/4\/904<\/a><\/p>\n<hr \/>\n<p>(\u8a3b\u4e00)RNA\u662fDNA\u89e3\u78bc\u7522\u751f\u86cb\u767d\u8cea\u7684\u4e2d\u9593\u7269\u8cea\uff0c\u8f49\u9304\u51fa\u7684RNA\u9700\u8981\u7d93\u904e\u7de8\u8f2f\uff0c\u624d\u80fd\u51fa\u73fe\u6709\u610f\u7fa9\u7684RNA\u8a0a\u865f\uff0c\u518d\u7cbe\u6e96\u5730\u88fd\u9020\u6240\u5c0d\u61c9\u7684\u86cb\u767d\u8cea\u3002<br \/>\n(\u8a3b\u4e8c)\u8f49\u8b6f\u662f\u6839\u64daRNA\u7684\u6838\u82f7\u9178\u5e8f\u5217\uff0c\u6c7a\u5b9a\u80fa\u57fa\u9178\u5e8f\u5217\uff0c\u7522\u751f\u7279\u5b9a\u86cb\u767d\u8cea\u7684\u904e\u7a0b\u3002<br \/>\n(\u8a3b\u4e09)\u7d93\u904eRNA\u526a\u63a5\uff0c\u5167\u542b\u5b50\u662f\u88ab\u79fb\u9664\u7684\u57fa\u56e0\u7247\u6bb5\uff0c\u800c\u5916\u986f\u5b50\u5247\u662f\u88ab\u4fdd\u5b58\u4e0b\u4f86\u7684\u90e8\u5206\uff0c\u4e00\u500b\u57fa\u56e0\u53ef\u70ba\u591a\u500b\u5916\u986f\u5b50\u6240\u7d44\u6210 \u3002\u5728\u526a\u63a5\u904e\u7a0b\u4e2d\uff0c\u5916\u986f\u5b50\u9023\u63a5\u8907\u5408\u9ad4\u6703\u88ab\u7f6e\u653e\u5728\u5916\u986f\u5b50\u7684\u4ea4\u63a5\u8655\u3002<\/p>\n<p style=\"text-align: right;\">\uff08\u8fb2\u696d\u751f\u7269\u79d1\u6280\u7814\u7a76\u4e2d\u5fc3\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7d30\u80de\u88e1\u7684RNA(\u8a3b\u4e00)(\u6838\u7cd6\u6838\u9178)\u58fd\u547d\u77ed\u66ab\uff0c\u542b\u6709\u6b63\u78ba\u57fa\u56e0\u5bc6\u78bc\u7684RNA\u59cb\u80fd\u5b58\u6d3b\u4e26\u7528\u65bc\u88fd\u9020\u86cb\u767d\u8cea\uff0c\u53cd\u4e4b\uff0c\u5e36\u6709\u932f\u8aa4\u8a0a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":22892,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/22819"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=22819"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/22819\/revisions"}],"predecessor-version":[{"id":22891,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/22819\/revisions\/22891"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/22892"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=22819"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=22819"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=22819"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}