{"id":22476,"date":"2020-07-30T00:04:07","date_gmt":"2020-07-29T16:04:07","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=22476"},"modified":"2020-12-23T14:17:52","modified_gmt":"2020-12-23T06:17:52","slug":"%e8%87%ba%e7%81%a3%e5%8d%8a%e6%95%b8%e8%82%ba%e7%99%8c%e6%82%a3%e8%80%85%e6%b2%92%e5%90%b8%e8%8f%b8-%e7%b2%be%e6%ba%96%e9%86%ab%e7%99%82%e7%a0%94%e7%a9%b6%e7%99%bb%e9%a0%82%e5%b0%96%e6%9c%9f%e5%88%8a","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/22476\/","title":{"rendered":"\u81fa\u7063\u534a\u6578\u80ba\u764c\u60a3\u8005\u6c92\u5438\u83f8 \u7cbe\u6e96\u91ab\u7642\u7814\u7a76\u767b\u9802\u5c16\u671f\u520a"},"content":{"rendered":"

\u80ba\u764c\u50b3\u7d71\u88ab\u8a8d\u70ba\u8207\u5438\u83f8\u756b\u4e0a\u7b49\u865f\uff0c\u4e0d\u904e\uff0c\u81fa\u7063\u7684\u4e0d\u5438\u83f8\u80ba\u764c\u60a3\u8005\u537b\u6bd4\u5438\u83f8\u8005\u591a\u3002\u672c\u9662\u5316\u5b78\u7814\u7a76\u6240\u9673\u7389\u5982\u6240\u9577\u3001\u81fa\u5927\u91ab\u5b78\u9662\u5167\u79d1\u6559\u6388\u694a\u6cee\u6c60\uff08\u672c\u9662\u9662\u58eb\uff09\u8207\u8de8\u55ae\u4f4d\u7814\u7a76\u5718\u968a\u4ee5\u86cb\u767d\u57fa\u56e0\u9ad4\u6280\u8853\u5efa\u7acb\u81fa\u7063\u65e9\u671f\u80ba\u764c\u75c5\u4eba\u7684\u591a\u9ad4\u5b78\uff08\u8a3b\u4e00\uff09\u5927\u6578\u64da\uff0c\u627e\u5230\u4e0d\u5438\u83f8\u80ba\u764c\u60a3\u8005\u53ef\u80fd\u7684\u81f4\u75c5\u6a5f\u5236\u3002\u7814\u7a76\u4e3b\u8981\u6709\u4e09\u500b\u767c\u73fe\uff0c\u9996\u5148\u662f\u80ba\u764c\u548c\u4eba\u9ad4\u9ad4\u5167APOBEC\uff08\u8a3b\u4e8c\uff09\u7a81\u8b8a\u7279\u5fb5\u7684\u9ad8\u4f4e\u3001\u5176\u6b21\u8207\u81f4\u764c\u7269\u7684\u66dd\u9732\u6709\u95dc\uff1b\u6700\u5f8c\u66f4\u767c\u73fe\u4e00\u500b\u5f9e\u672a\u88ab\u767c\u73fe\u7684\u65b0\u4e9e\u578b\u80ba\u764c\uff0c\u53ca\u5176\u81f4\u764c\u57fa\u56e0\u7a81\u8b8a\u7684\u5dee\u7570\uff0c\u6709\u52a9\u65e9\u671f\u767c\u73fe\u81e8\u5e8a\u6f5b\u5728\u7684\u9ad8\u98a8\u96aa\u80ba\u764c\u60a3\u8005\u3002<\/p>\n

\u7814\u7a76\u4e3b\u6301\u4eba\u9673\u7389\u5982\u8868\u793a\uff0c\u300c\u9019\u662f\u6771\u4e9e\u7b2c\u4e00\u5957\u7d50\u5408\u6df1\u5ea6\u591a\u9ad4\u5b78\u5927\u6578\u64da\u53ca\u5b8c\u6574\u81e8\u5e8a\u8cc7\u6599\uff0c\u6df1\u5ea6\u89e3\u6790\u4e0d\u5438\u83f8\u80ba\u764c\u6210\u56e0\u7684\u7814\u7a76\u6210\u679c\u300d\uff0c\u4e5f\u662f\u7f8e\u570b\u81e8\u5e8a\u86cb\u767d\u57fa\u56e0\u9ad4\u5b78\u816b\u7624\u5206\u6790\u806f\u76df\uff08CPTAC\uff09\u9996\u6b21\u548c\u570b\u969b\u806f\u76df\u5718\u968a\uff08\u81fa\u7063\uff09\u651c\u624b\u5408\u4f5c\uff0c\u4ee5\u86cb\u767d\u57fa\u56e0\u9ad4\u5b78\u63ed\u958b\u81fa\u7063\u53ca\u7f8e\u570b\u75c5\u4eba\u80ba\u764c\u751f\u7269\u5b78\u7684\u9762\u7d17\u3002\u81fa\u7f8e\u4e8c\u500b\u7368\u7acb\u6210\u679c\u65bc\u4eca\uff082020\uff09\u5e747\u67089\u65e5\u540c\u6b65\u767c\u8868\u5728\u570b\u969b\u9802\u5c16\u671f\u520a\u300a\u7d30\u80de\u300b(Cell<\/em>)\u4e0a\uff0c\u4e26\u5171\u540c\u69ae\u767b\u672c\u671f\u96dc\u8a8c\u5c01\u9762\u3002<\/p>\n

\"\"

\u300a\u7d30\u80de\u300b(Cell<\/em>)\u5c01\u9762<\/p><\/div>\n

 <\/p>\n

\u80ba\u764c\u81f4\u75c5\u7684\u95dc\u9375\uff1aAPOBEC\u7a81\u8b8a\u7279\u5fb5\u3001\u81f4\u764c\u7269\u6548\u61c9<\/strong><\/p>\n

\u80ba\u764c\u662f\u5168\u7403\u764c\u75c7\u6b7b\u4ea1\u7684\u4e3b\u56e0\uff0c\u5373\u4f7f\u85e5\u7269\u6cbb\u7642\u8fd1\u5e74\u6709\u9577\u8db3\u7684\u9032\u5c55\uff0c5\u5e74\u5b58\u6d3b\u7387\u4ecd\u4f4e\u65bc20\uff05\uff0c\u76ee\u524d\u4ecd\u662f\u570b\u4eba\u764c\u75c7\u6b7b\u4ea1\u982d\u865f\u6bba\u624b\u3002\u7814\u7a76\u6307\u51fa\uff0c\u5728\u7f8e\u570b\u4e0d\u5438\u83f8\u8005\u7d04\u4f54\u80ba\u764c\u60a3\u8005\u768420\uff05\uff0c\u800c\u6771\u4e9e\u5730\u5340\uff08\u5305\u62ec\u81fa\u7063\uff09\u7684\u80ba\u817a\u764c\u6709\u7368\u7279\u7684\u7279\u8272\uff0c\u4e0d\u5438\u83f8\u8005\uff08\u5c24\u5176\u662f\u5973\u6027\uff09\u60a3\u75c5\u7684\u6bd4\u7387\u9ad8\u904e\u65bc\u5438\u83f8\u8005\u3002\u5728\u81fa\u7063\u670950\uff05\u4ee5\u4e0a\u7684\u80ba\u764c\u75c5\u60a3\u4e26\u4e0d\u5438\u83f8\uff0c\u8d85\u904e9\u6210\u5f97\u80ba\u764c\u7684\u5973\u6027\u90fd\u4e0d\u62bd\u83f8\uff0c\u800c\u4e14\u8fd1\u5341\u5e74\u6709\u5e74\u8f15\u5316\u7684\u8da8\u52e2\u3002\u70ba\u91d0\u6e05\u6771\u4e9e\u4e0d\u5438\u83f8\u80ba\u764c\u7684\u81f4\u75c5\u6a5f\u5236\uff0c\u6b64\u7814\u7a76\u5206\u6790\u6771\u4e9e\u5730\u5340103\u540d\u80ba\u764c\u75c5\u60a3\uff0c\u63a2\u7a76\u65e9\u671f\u4e0d\u5438\u83f8\u80ba\u764c\u7684\u767c\u75c5\u8207\u9032\u5c55\u3002<\/p>\n

\u764c\u7d30\u80de\u57fa\u56e0\u7a81\u8b8a\u7d50\u679c\u986f\u793a\uff0c\u6771\u897f\u65b9\u75c5\u4eba\u7a81\u8b8a\u7684\u57fa\u56e0\u80cc\u666f\u5927\u70ba\u4e0d\u540c\uff1b\u80ba\u817a\u764c\u764c\u8b8a\u8207APOBEC\u7684\u7a81\u8b8a\u7279\u5fb5\u5f88\u6709\u95dc\u3002\u7f79\u764c\u60a3\u8005\u4e2d\uff0c\u9ad8\u905474\uff05\u5f9e\u672a\u5438\u83f8\u5e74\u8f15\u5973\u6027\uff08\u5c0f\u65bc60\u6b72\uff09\u548c\u6240\u6709\u7121\u80ba\u764c\u300c\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08EGFR\uff09\u300d(\u8a3b\u4e09)\u9a45\u52d5\u7a81\u8b8a\u7684\u5973\u6027\u60a3\u8005APOBEC\u7a81\u8b8a\u7279\u5fb5\u7a0b\u5ea6\u9ad8\uff0c\u986f\u793aAPOBEC\u7684\u7a81\u8b8a\u7279\u5fb5\u53ef\u80fd\u70ba\u5973\u6027\u65e9\u671f\u80ba\u764c\u7684\u9a45\u52d5\u56e0\u7d20\uff1b\u800c\u9ad8APOBEC\u7a81\u8b8a\u7279\u5fb5\u53c8\u8207\u514d\u75ab\u7642\u6cd5\u7642\u6548\u5448\u6b63\u76f8\u95dc\u3002\u56e0\u6b64\uff0cAPOBEC\u7a81\u8b8a\u7279\u5fb5\u53ef\u80fd\u6210\u70ba\u65e9\u671f\u8a3a\u65b7\u548c\u514d\u75ab\u6cbb\u7642\u7684\u6f5b\u5728\u751f\u7269\u6a19\u8a8c\u7269\u3002<\/p>\n

\u6b64\u5916\uff0c\u7814\u7a76\u4e5f\u767c\u73fe\uff0c\u66b4\u9732\u65bc\u81f4\u764c\u7269\u800c\u5f15\u8d77\u7684\u57fa\u56e0\u9ad4\u7de8\u8f2f\u7a81\u8b8a\u7279\u5fb5\uff0c\u4ea6\u53ef\u80fd\u662f\u764c\u75c7\u65e9\u671f\u7684\u4e3b\u8981\u9a45\u52d5\u56e0\u7d20\u3002\u5728\u90e8\u5206\u8f03\u5e74\u9577\u5973\u6027\uff08\u5927\u65bc70\u6b72\uff09\u4e2d\u7a0b\u5ea6\u8f03\u9ad8\uff0c\u5316\u5b78\u81f4\u764c\u7269\u4ee3\u8b1d\u548c\u89e3\u6bd2\u904e\u7a0b\u53ca\u7279\u5b9a\u9014\u5f91\u7684\u6d3b\u5316\u53ef\u80fd\u5f71\u97ff\u816b\u7624\u764c\u5316\u3001\u60e1\u5316\u548c\u514d\u75ab\u8abf\u7bc0\u7570\u5e38\u3002\u63db\u8a00\u4e4b\uff0c\u6e1b\u5c11\u751f\u6d3b\u4e2d\u81f4\u764c\u7269\u7684\u66b4\u9732\u7387\u53ef\u80fd\u662f\u9810\u9632\u80ba\u764c\u7684\u6709\u6548\u7b56\u7565\u3002<\/p>\n

\"\"

\u57162\uff1a\u7814\u7a76\u5718\u968a\u5408\u5f71<\/p><\/div>\n

 <\/p>\n

\u767c\u73fe\u300c\u65b0\u4e9e\u578b\u300d\u80ba\u764c \u6709\u52a9\u65e9\u671f\u767c\u73fe\u6f5b\u5728\u9ad8\u98a8\u96aa\u60a3\u8005<\/strong><\/p>\n

\u904e\u53bb\u7814\u7a76\u5df2\u77e5\uff0c\u81fa\u7063\u80ba\u764c\u60a3\u8005\u4e3b\u8981\u5728EGFR\u57fa\u56e0\u4e0a\u6703\u767c\u751fDel19\u548cL858R\u5169\u7a2e\u7a81\u8b8a\uff0c\u75c5\u60a3\u82e5\u662f\u767c\u751fL858R\u7a81\u8b8a\uff0c\u5b58\u6d3b\u7387\u8f03\u4f4e\uff0c\u4e14\u5bb9\u6613\u7522\u751f\u60e1\u6027\u80f8\u8154\u7a4d\u6db2\u548c\u764c\u7d30\u80de\u8f49\u79fb\uff0c\u4e0d\u904e\u81f3\u4eca\u4ecd\u672a\u767c\u73fe\u660e\u78ba\u7684\u751f\u7269\u6a5f\u8f49\u3002\u6b64\u6b21\u900f\u904e\u86cb\u767d\u9ad4\u5b78\u7279\u5fb5\u53ef\u5c07\u80ba\u817a\u764c\u5206\u70ba\u4e94\u500b\u4e9e\u578b\uff0c\u5176\u4e2d\u6709\u4e00\u500b\u5f9e\u672a\u88ab\u767c\u73fe\u7684\u65b0\u578b\u65e9\u671f\u80ba\u764c\u300c\u985e\u665a\u671f\u300d\u4e9e\u578b\u3002\u6b64\u4e9e\u578b\u53ef\u5340\u5206\u51faDel19\u548cL858R\u7a81\u8b8a\u7684\u816b\u7624\u5728\u65e9\u671f\u764c\u75c7\u4e4b\u60e1\u6027\u7279\u5fb5\u3002\u56e0\u6b64\uff0c\u81e8\u5e8a\u91ab\u5e2b\u6709\u6a5f\u6703\u53ef\u85c9\u60e1\u6027\u7279\u5fb5\u767c\u73fe\u65e9\u671f\u80ba\u764c\u60a3\u8005\uff0c\u9032\u4e00\u6b65\u63d0\u4f9b\u5bc6\u96c6\u7684\u76e3\u6e2c\u548c\u8003\u616e\u53ef\u80fd\u7684\u4f50\u5291\u52a0\u4ee5\u6cbb\u7642\u3002\u6b64\u5916\uff0c\u300c\u985e\u665a\u671f\u300d\u4e9e\u578b\u7684\u65e9\u671f\u816b\u7624\u4e5f\u53ef\u767c\u73fe\u986f\u8457\u589e\u52a0\u7684\u86cb\u767d\uff0c\u5982\u9593\u8cea\u6eb6\u89e3\u7d20MMP11\u7b49\uff0c\u53ef\u80fd\u53ef\u4ee5\u4f5c\u70ba\u6aa2\u6e2c\u7684\u751f\u7269\u6a19\u8a8c\u3002<\/p>\n

 <\/p>\n

\u6771\u4e9e\u7b2c\u4e00\u500b\u89e3\u6790\u4e0d\u62bd\u83f8\u80ba\u817a\u764c\u4e4b\u591a\u9ad4\u5b78\u5927\u6578\u64da<\/strong><\/p>\n

\u5de5\u6b32\u5584\u5176\u4e8b\uff0c\u5fc5\u5148\u5229\u5176\u5668\uff0c\u6709\u8cf4\u65bc\u6df1\u5ea6\u86cb\u767d\u8cea\u57fa\u56e0\u9ad4\u6280\u8853\u548c\u591a\u9ad4\u5b78\u6578\u64da\u6574\u5408\u5206\u6790\uff0c\u53ca\u81fa\u7063\u80ba\u764c\u81e8\u5e8a\u5718\u968a\u63d0\u4f9b\u9ad8\u54c1\u8cea\u6aa2\u9ad4\u53ca\u81e8\u5e8a\u8cc7\u6599\u5206\u6790\uff0c\u6b64\u6b21\u8de8\u9818\u57df\u53ca\u9662\u6821\u7814\u7a76\u65b9\u80fd\u5c31\u6771\u4e9e\u80ba\u764c\u6709\u6b64\u91cd\u5927\u7a81\u7834\u3002\u80ba\u764c\u5718\u968a\u4e3b\u6301\u4eba\u694a\u6cee\u6c60\u6307\u51fa\uff0c\u300c\u86cb\u767d\u57fa\u56e0\u9ad4\u5b78\u767c\u73fe\u4e0d\u5438\u83f8\u80ba\u764c\u60a3\u8005\u5728\u816b\u7624\u767c\u751f\u548c\u764c\u75c7\u9032\u7a0b\u4e0a\u5b58\u5728\u8457\u4eba\u7a2e\u548c\u5730\u57df\u4e0a\u7684\u7368\u7279\u6027\uff0c\u6b64\u7814\u7a76\u70ba\u65e9\u671f\u4e0d\u5438\u83f8\u8005\u80ba\u817a\u764c\u63d0\u4f9b\u4e86\u65b0\u7684\u898b\u89e3\u300d\u3002<\/p>\n

\u9664\u672c\u9662\u4e4b\u5916\uff0c\u7814\u7a76\u5718\u968a\u6210\u54e1\u7531\u81fa\u7063\u5927\u5b78\u3001\u81fa\u5317\u91ab\u5b78\u5927\u5b78\u3001\u81fa\u4e2d\u69ae\u7e3d\u63d0\u4f9b\u75c5\u4eba\u6aa2\u9ad4\u3001\u81e8\u5e8a\u6578\u64da\u53ca\u6aa2\u6e2c\u6280\u8853\u7b49\uff0c\u5171\u540c\u5448\u73fe\u524d\u6240\u672a\u6709\u7684\u6771\u4e9e\u80ba\u817a\u764c\u5b8c\u6574\u9ce5\u77b0\u5716\u666f\uff0c\u5305\u62ec\u91dd\u5c0d\u7537\u5973\u65cf\u7fa4\u3001\u5438\u83f8\u8207\u4e0d\u5438\u83f8\u65cf\u7fa4\uff0c\u63cf\u7e6a\u51fa\u66f4\u6e05\u6670\u7684\u80ba\u817a\u764c\u75be\u75c5\u9032\u7a0b\uff0c\u4e26\u4e14\u767c\u73fe\u65b0\u7684\u764c\u75c7\u6a19\u8a8c\u7269\u8207\u627e\u51fa\u5c0e\u81f4\u81fa\u7063\u80ba\u817a\u764c\u7684\u53ef\u80fd\u75c5\u56e0\u3002<\/p>\n

\"\"<\/p>\n

 <\/p>\n

\u9996\u6b21\u651c\u624b\u5408\u4f5c \u81fa\u7f8e\u300c\u764c\u75c7\u767b\u6708\u8a08\u756b\u300d\u91cd\u5927\u767c\u73fe<\/strong><\/p>\n

\u672c\u9662\u64c1\u6709\u9818\u5148\u4e16\u754c\u7684\u86cb\u767d\u57fa\u56e0\u9ad4\u6280\u8853\u3001\u751f\u7269\u8cc7\u8a0a\u5206\u6790\u5e73\u53f0\u8207\u5927\u6578\u64da\u5206\u6790\u6280\u8853\uff0c\u4e14\u81fa\u7063\u91ab\u7642\u5718\u968a\u5177\u5099\u5b8c\u5584\u7684\u9577\u671f\u8ffd\u8e64\u8cc7\u6599\u3002\u85c9\u6b64\u512a\u52e2\uff0c\u672c\u9662\u8207\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08National Cancer Institute, NCI\uff09\u65bc2016\u5e74\u7c3d\u7f72\u300c\u764c\u75c7\u767b\u6708\u8a08\u756b\uff08Cancer Moonshot\uff09\u300d\u5408\u4f5c\u5099\u5fd8\u9304\uff0c\u53c3\u8207\u570b\u969b\u764c\u75c7\u86cb\u767d\u57fa\u56e0\u9ad4\u5b78\u806f\u76df\uff08International Cancer Proteogenome Consortium, ICPC\uff09\u3002\u540c\u5e7410\u6708\u81fa\u7063\u901a\u904e\u751f\u91ab\u7522\u696d\u63a8\u52d5\u65b9\u6848\uff0c\u79d1\u6280\u6703\u5831\u5c07\u764c\u75c7\u767b\u6708\u8a08\u756b\u7d0d\u5165\u70ba\u300c\u63a8\u52d5\u7279\u8272\u91cd\u9ede\u7522\u696d\u300d\u7b56\u7565\u4e4b\u4e00\uff0c\u63d0\u4f9b\u5229\u7528\u86cb\u767d\u57fa\u56e0\u9ad4\u5927\u6578\u64da\u958b\u767c\u5275\u65b0\u8a3a\u65b7\u53ca\u65b0\u85e5\u7814\u767c\u4e4b\u5951\u6a5f\u3002<\/p>\n

\u6301\u7e8c\u95dc\u6ce8\u80ba\u816b\u7624\u751f\u7269\u5b78\u53ca\u65e9\u671f\u80ba\u817a\u764c\u7684\u7814\u7a76\u9032\u5c55\uff0c\u5c07\u6709\u52a9\u63a8\u52d5\u80ba\u764c\u6aa2\u6e2c\u958b\u767c\u548c\u76f8\u95dc\u7ba1\u7406\u7b56\u7565\u3002\u300c\u764c\u75c7\u767b\u6708\u8a08\u756b\u300d\u81fa\u7063\u5718\u968a\u8a8d\u70ba\uff0c\u81e8\u5e8a\u8cc7\u8a0a\u3001\u591a\u9ad4\u5b78\u6280\u8853\u53ca\u9ad4\u5b78\u5927\u6578\u64da\u70ba\u767c\u5c55\u764c\u75c7\u7cbe\u6e96\u91ab\u5b78\u4e4b\u5fc5\u8981\u57fa\u790e\u5de5\u7a0b\uff0c\u70ba\u6b32\u6df1\u5165\u7814\u7a76\u548c\u767c\u5c55\u80ba\u817a\u764c\u7cbe\u6e96\u91ab\u7642\u7684\u7814\u7a76\u4eba\u54e1\u548c\u81e8\u5e8a\u91ab\u751f\u7684\u6700\u5927\u5f8c\u76fe\u3002\u82e5\u80fd\u9032\u4e00\u6b65\u51dd\u805a\u8de8\u5b78\u7814\u55ae\u4f4d\u3001\u91ab\u5b78\u4e2d\u5fc3\u53ca\u8de8\u90e8\u6703\u53ca\u7522\u5b78\u5408\u4f5c\uff0c\u900f\u904e\u8207\u570b\u969b\u764c\u75c7\u767b\u6708\u8a08\u756b\u5718\u968a\u5206\u4eab\u5404\u570b\u6578\u64da\u8207\u8cc7\u6e90\uff0c\u6301\u7e8c\u7814\u767c\u65b0\u7b56\u7565\uff0c\u6709\u52a9\u672a\u4f86\u767c\u5c55\u81fa\u7063\u7279\u8272\u7684\u7cbe\u6e96\u91ab\u5b78\u3002<\/p>\n

\u8ad6\u6587\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u70ba\u672c\u9662\u5316\u5b78\u6240\u9673\u8abc\u5982\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\u3001\u672c\u9662\u7d71\u8a08\u6240\u5f35\u96c5\u5a97\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\u53ca\u82f1\u570b\u764c\u75c7\u7814\u7a76\u6240Theodoros I. Roumeliotis\uff0c\u672c\u9662\u8cc7\u8a0a\u6240\u9673\u9be8\u592a\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\u53ca\u6642\u4efb\u672c\u9662\u5316\u5b78\u6240\u6797\u5999\u971e\u535a\u58eb\u5f8c\u7814\u7a76\u54e1 (\u73fe\u4efb\u81fa\u7063\u5927\u5b78)\u4ea6\u5217\u70ba\u5171\u540c\u7b2c\u4e8c\u4f5c\u8005\u3002\u7814\u7a76\u5718\u968a\u5305\u62ec\u672c\u9662\u5316\u5b78\u6240\u9673\u7389\u5982\u6240\u9577\u3001\u81fa\u5927\u91ab\u5b78\u9662\u5167\u79d1\u6559\u6388\u694a\u6cee\u6c60\uff08\u672c\u9662\u9662\u58eb\uff09\u3001\u672c\u9662\u7d71\u8a08\u6240\u9673\u74bf\u5b87\u526f\u7814\u7a76\u54e1\u3001\u82f1\u570b\u764c\u75c7\u7814\u7a76\u6240Jyoti S. Choudhary\u3001\u81fa\u7063\u5927\u5b78\u91ab\u5b78\u6aa2\u9a57\u66a8\u751f\u7269\u6280\u8853\u5b78\u7cfb\u8207\u57fa\u56e0\u9ad4\u66a8\u7cbe\u6e96\u91ab\u5b78\u7814\u7a76\u4e2d\u5fc3\u4fde\u677e\u826f\u6559\u6388\u3001\u81fa\u5927\u91ab\u9662\u5916\u79d1\u91ab\u5e2b\u9673\u6649\u8208\u3001\u672c\u9662\u8cc7\u8a0a\u79d1\u5b78\u7814\u7a76\u6240\u5b8b\u5b9a\u61ff\u7814\u7a76\u54e1\u53ca\u81fa\u5317\u91ab\u5b78\u5927\u5b78\u97d3\u5609\u8389\u52a9\u7406\u6559\u6388\u7b49\u3002\u672c\u6b21\u7814\u7a76\u7d93\u8cbb\u4e3b\u8981\u4f86\u81ea\u79d1\u6280\u90e8\u3001\u4e2d\u7814\u9662\u53ca\u81fa\u7063\u5927\u5b78\u652f\u6301\u3002<\/p>\n

\u672c\u671f\u671f\u520a\u5c01\u9762\u9023\u7d50\uff1a https:\/reurl.cc\/Qdvqv5<\/a><\/p>\n

\u8ad6\u6587\u5168\u6587\u9023\u7d50\uff1a\u3008Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression<\/a>\u3009<\/p>\n

\uff08\u5316\u5b78\u7814\u7a76\u6240\uff09<\/p>\n

\n

(\u8a3b\u4e00)\u591a\u9ad4\u5b78(multiomics): \u751f\u7269\u5206\u6790\u65b9\u6cd5\uff0c\u7bc4\u570d\u5305\u62ec\u57fa\u56e0\u9ad4\u3001\u8f49\u9304\u9ad4\u3001\u8868\u89c0\u907a\u50b3\u3001\u86cb\u767d\u8cea\u9ad4\u3001\u78f7\u9178\u5316\u86cb\u767d\u9ad4\u3001\u4ee3\u8b1d\u9ad4\u5b78\u7b49\u3002
\n(\u8a3b\u4e8c)APOBEC: APOBEC\u5bb6\u65cf\u70baRNA\u7de8\u8f2f\u9176\u3002\u529f\u80fd\u662f\u5c0d\u300cRNA\u5408\u6210\uff08\u8f49\u9304\uff09\u300d\u9032\u884c\u7279\u5b9a\u7684\u6539\u8b8a\uff0c\u4e26\u4f7f\u540c\u4e00\u500b\u86cb\u767d\u8cea\u5728\u4e0d\u540c\u5668\u5b98\u4e2d\u6709\u4e0d\u540c\u529f\u80fd\u3002
\n(\u8a3b\u4e09)EGFR(Epidermal Growth Factor Receptor)\uff1a\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u3002\u4e00\u7a2e\u8a0a\u865f\u63a5\u53d7\u5668\uff0c\u63a5\u6536\u5230\u751f\u9577\u56e0\u5b50\u5f8c\u6703\u4fc3\u4f7f\u8868\u76ae\u7d30\u80de\u6210\u9577\u3002\u4e00\u4f46\u640d\u58de\uff0c\u5c31\u7b97\u6c92\u6709\u63a5\u6536\u5230\u751f\u9577\u56e0\u5b50\uff0c\u7d30\u80de\u4ecd\u6703\u6301\u7e8c\u6210\u9577\u3001\u7a81\u8b8a\uff0c\u6700\u5f8c\u9577\u6210\u816b\u7624\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u80ba\u764c\u50b3\u7d71\u88ab\u8a8d\u70ba\u8207\u5438\u83f8\u756b\u4e0a\u7b49\u865f\uff0c\u4e0d\u904e\uff0c\u81fa\u7063\u7684\u4e0d\u5438\u83f8\u80ba\u764c\u60a3\u8005\u537b\u6bd4\u5438\u83f8\u8005\u591a\u3002\u672c\u9662\u5316\u5b78\u7814\u7a76\u6240\u9673\u7389\u5982\u6240\u9577\u3001\u81fa\u5927\u91ab\u5b78\u9662\u5167\u79d1 […]<\/p>\n","protected":false},"author":1,"featured_media":22481,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/22476"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=22476"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/22476\/revisions"}],"predecessor-version":[{"id":22480,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/22476\/revisions\/22480"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/22481"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=22476"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=22476"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=22476"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}