{"id":21889,"date":"2020-05-21T00:03:03","date_gmt":"2020-05-20T16:03:03","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=21889"},"modified":"2020-05-21T10:52:35","modified_gmt":"2020-05-21T02:52:35","slug":"%e3%80%8c%e8%a2%ab%e5%9c%88%e4%bd%8f%e7%9a%84%e5%bf%83%e9%9d%88%ef%bc%81%e3%80%8d-%e9%a6%96%e5%ba%a6%e5%bb%ba%e6%a7%8b%e8%87%aa%e9%96%89%e7%97%87%e8%85%a6%e7%b5%84%e7%b9%94%e7%9a%84%e7%92%b0%e7%8b%80r","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/21889\/","title":{"rendered":"\u300c\u88ab\u5708\u4f4f\u7684\u5fc3\u9748\uff01\u300d \u9996\u5ea6\u5efa\u69cb\u81ea\u9589\u75c7\u8166\u7d44\u7e54\u7684\u74b0\u72c0RNA\u8207\u57fa\u56e0\u9593\u8abf\u63a7\u7db2\u8def\u5716\u8b5c"},"content":{"rendered":"<p>\u81ea\u9589\u75c7\u8b5c\u7cfb\u969c\u7919 (ASD\uff0c\u5168\u540d\u70ba autism spectrum disorder)\u662f\u4e00\u7a2e\u8166\u90e8\u767c\u80b2\u969c\u7919\u6240\u5c0e\u81f4\u7684\u8907\u96dc\u75be\u75c5\uff0c\u60a3\u8005\u5f80\u5f80\u5728\u793e\u4ea4\u6e9d\u901a\u3001\u4e92\u52d5\u53ca\u8868\u9054\u4e0a\u6709\u969c\u7919\uff0c\u6210\u56e0\u76ee\u524d\u4ecd\u672a\u6709\u5b9a\u8ad6\uff0c\u666e\u904d\u8a8d\u70ba\u8207\u907a\u50b3\u53ca\u57fa\u56e0\u8b8a\u7570\u6709\u95dc\u3002\u672c\u9662\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u7814\u7a76\u54e1\u838a\u6a39\u8ac4\u7814\u7a76\u5718\u968a\uff0c\u9996\u6b21\u7cfb\u7d71\u6027\u5efa\u69cb\u74b0\u72c0RNA\uff08circular RNA\uff09\uff08*\u8a3b\u4e00\uff09\u5728\u81ea\u9589\u75c7\u8166\u90e8\u7684\u57fa\u56e0\u8abf\u63a7\u7db2\u8def\u5716\u8b5c\uff0c\u6709\u52a9\u65bc\u589e\u9032\u5c0d\u81ea\u9589\u75c7\u81f4\u75c5\u5206\u5b50\u6a5f\u5236\u7684\u7406\u89e3\u3002\u8a72\u7bc7\u8ad6\u6587\u5df2\u65bc\u4eca\uff08109\uff09\u5e743\u6708\u520a\u767b\u5728\u300a\u57fa\u56e0\u9ad4\u7814\u7a76\u300b\uff08<em>Genome Research<\/em>\uff09\u3002<\/p>\n<div id=\"attachment_21652\" style=\"width: 610px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" aria-describedby=\"caption-attachment-21652\" class=\"aligncenter size-large wp-image-21890\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/05\/1-1-788x1024.jpg\" alt=\"\" width=\"600\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/05\/1-1-788x1024.jpg 788w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/05\/1-1-231x300.jpg 231w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/05\/1-1-768x998.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/05\/1-1-1182x1536.jpg 1182w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/05\/1-1-1575x2048.jpg 1575w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/05\/1-1-1080x1404.jpg 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/05\/1-1-scaled.jpg 1969w\" sizes=\"(max-width: 788px) 100vw, 788px\" \/><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">\uff08\u6b64\u5c01\u9762\u5716\u7247\u8a2d\u8a08\u9748\u611f\u4f86\u81ea\u65bc\u7d00\u9304\u7247\u300a\u9059\u9060\u661f\u7403\u7684\u5b69\u5b50\u300b\uff0c\u56e0\u7121\u6cd5\u878d\u5165\u5730\u7403\u8ecc\u9053\uff0c\u4e00\u500b\u4eba\u5b64\u7368\u5730\u5f85\u5728\u81ea\u5df1\u7684\u661f\u7403\u4e0a\u3002\u7e6a\u5716\uff0f\u5f90\u7dad\u99ff\uff09<\/p><\/div>\n<p><em>\uff08*\u8a3b\u4e00\uff09\u74b0\u72c0RNA\u56e0\u5176\u69cb\u578b\u95dc\u4fc2\u4e0d\u6613\u88ab\u6838\u9178\u5916\u5207\u9176\u964d\u89e3\uff0c\u56e0\u6b64\u6bd4\u5176\u4ed6RNA\u66f4\u52a0\u7a69\u5b9a\uff0c\u9069\u5408\u958b\u767c\u70ba\u65b0\u578b\u81e8\u5e8a\u8a3a\u65b7\u7684\u751f\u7269\u6a19\u8a18\u3002\u8fd1\u5e74\u4f86\u96a8\u8457\u6b21\u4e16\u4ee3\u5b9a\u5e8f\u6280\u8853\u5feb\u901f\u767c\u5c55\uff0c\u9678\u7e8c\u767c\u73fe\u5927\u91cf\u7684\u74b0\u72c0RNA\u5b58\u5728\u5404\u7a2e\u751f\u7269\u9ad4\u4e2d\u3002<\/em><\/p>\n<p>\u74b0\u72c0RNA\u662f\u4e00\u7a2e\u55ae\u93c8\u5c01\u9589\u5f0f\u74b0\u578b\u7d50\u69cb\uff0c\u4e14\u7279\u5225\u9ad8\u5ea6\u8868\u73fe\u5728\u795e\u7d93\u7cfb\u7d71\u3002\u838a\u6a39\u8ac4\u7814\u7a76\u5718\u968a\u5229\u7528\u5927\u6578\u64da\u5206\u6790\u627e\u5230\u5728\u81ea\u9589\u75c7\u60a3\u8005\u5927\u8166\u76ae\u8cea\u4e2d\u8868\u73fe\u91cf\u7570\u5e38\u7684\u74b0\u72c0RNA\uff0c\u4e26\u9810\u6e2c\u5176\u8abf\u63a7\u8def\u5f91\uff0c\u7d50\u5408\u5206\u5b50\u751f\u7269\u5be6\u9a57\u5f8c\u8b49\u5be6\uff1a\u74b0\u72c0RNA\u50cf\u6d77\u7dbf\u4e00\u6a23\u5438\u9644\u7279\u5b9a\u7684\u5faeRNA\uff08miRNA\uff09\uff0c\u4f7f\u5176\u5931\u53bb\u6216\u964d\u4f4e\u5c0d\u4e0b\u6e38\u81ea\u9589\u75c7\u98a8\u96aa\u57fa\u56e0\u8abf\u63a7\u7684\u80fd\u529b\u3002\u6709\u95dc\u74b0\u72c0RNA\u3001\u5faeRNA\u3001\u8207\u4e0b\u6e38\u57fa\u56e0\u5728\u81ea\u9589\u75c7\u8166\u90e8\u7684\u8abf\u63a7\u7db2\u8def\u95dc\u4fc2\uff0c\u904e\u53bb\u4e26\u672a\u88ab\u6709\u7cfb\u7d71\u5730\u63a2\u8a0e\u3002<\/p>\n<p>\u838a\u6a39\u8ac4\u6240\u7387\u9818\u7684\u5927\u6578\u64da\u5206\u6790\u8207\u795e\u7d93\u79d1\u5b78\u5be6\u9a57\u5ba4\u5718\u968a\uff0c\u900f\u904e\u5148\u524d\u958b\u767c\u7684\u74b0\u72c0RNA\u5075\u6e2c\u8edf\u9ad4\uff08NCLscan\uff09\uff0c\u8a2d\u8a08\u5927\u6578\u64da\u5206\u6790\u6d41\u7a0b\u3002\u5f9e\u8d85\u904e200\u500b\u6a23\u672c\u7684\u8f49\u9304\u9ad4\u5b9a\u5e8f\uff08RNA-seq\uff09\u8cc7\u6599\uff0c\u627e\u523060\u500b\u5728\u81ea\u9589\u75c7\u60a3\u8005\u5927\u8166\u76ae\u8cea\u4e2d\u8868\u73fe\u7570\u5e38\u7684\u74b0\u72c0RNA\uff1b\u7d93\u7d71\u8a08\u6a21\u578b\u5206\u6790\u986f\u793a\uff0c\u6839\u64da\u6b6460\u500b\u74b0\u72c0RNA\u7684\u8868\u73fe\u60c5\u5f62\uff0c\u80fd\u6709\u6548\u5340\u5225\u81ea\u9589\u75c7\u8207\u975e\u81ea\u9589\u75c7\u6a23\u672c\uff0c\u56e0\u6b64\u53ef\u5224\u5b9a\u9019\u4e9b\u74b0\u72c0RNA\u8207\u81ea\u9589\u75c7\u7684\u767c\u751f\u61c9\u6709\u95dc\u9023 \uff08\u5716\u4e00\uff09\u3002<\/p>\n<div id=\"attachment_21652\" style=\"width: 1010px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" aria-describedby=\"caption-attachment-21652\" class=\"aligncenter size-large wp-image-21897\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/05\/\u7db2\u9801\u7528\u5716-11-1024x469.jpg\" alt=\"\" width=\"1000\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/05\/\u7db2\u9801\u7528\u5716-11-1024x469.jpg 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/05\/\u7db2\u9801\u7528\u5716-11-300x137.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/05\/\u7db2\u9801\u7528\u5716-11-768x352.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/05\/\u7db2\u9801\u7528\u5716-11-1536x704.jpg 1536w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/05\/\u7db2\u9801\u7528\u5716-11-2048x938.jpg 2048w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/05\/\u7db2\u9801\u7528\u5716-11-1080x495.jpg 1080w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">\u5716\u4e00\u3001\u5075\u6e2c\u5728\u81ea\u9589\u75c7\u60a3\u8005\u5927\u8166\u76ae\u8cea\u4e2d\u8868\u73fe\u7570\u5e38\u768460\u500b\u74b0\u72c0RNA\u3002A\u5716\u986f\u793a22\u500b\uff08\u7d05\u9ede\uff09\u8868\u73fe\u91cf\u5728\u81ea\u9589\u75c7\u60a3\u8005\u986f\u8457\u4e0a\u5347\uff0c38\u500b\uff08\u7da0\u9ede\uff09\u8868\u73fe\u91cf\u5728\u81ea\u9589\u75c7\u60a3\u8005\u986f\u8457\u4e0b\u964d\uff0c\u5176\u9918\uff08\u7070\u9ede\uff09\u8868\u793a\u5728\u81ea\u9589\u75c7\u8207\u975e\u81ea\u9589\u75c7\u8005\u9593\u7121\u986f\u8457\u5dee\u7570\u3002\u5728\u6b64\u6bcf\u4e00\u9ede\u8868\u793a\u4e00\u500b\u74b0\u72c0RNA\u3002B\u5716\u986f\u793a\u901960\u500b\u74b0\u72c0RNA\u7684\u8868\u73fe\u91cf\u80fd\u6709\u6548\u5340\u5225\u81ea\u9589\u75c7\uff08\u7d05\u9ede\uff09\u548c\u975e\u81ea\u9589\u75c7\uff08\u7da0\u9ede\uff09\u6a23\u672c\u3002\u5728\u6b64\u6bcf\u4e00\u9ede\u8868\u793a\u4e00\u500b\u8166\u7d44\u7e54\u6a23\u672c\u3002<\/p><\/div>\n<p>&nbsp;<\/p>\n<p><strong>\u74b0\u72c0RNA\u8abf\u63a7\u7db2\u8def \u548c\u81ea\u9589\u75c7\u98a8\u96aa\u57fa\u56e0\u9ad8\u5ea6\u76f8\u95dc<\/strong><\/p>\n<p>\u70ba\u6b64\uff0c\u5718\u968a\u9032\u4e00\u6b65\u9810\u6e2c\u9019\u4e9b\u74b0\u72c0RNA\u7684\u4e0b\u6e38\u8abf\u63a7\u8def\u5f91\uff0c\u5efa\u69cb\u51fa8,170\u500b\u74b0\u72c0RNA\u3001\u5faeRNA\u3001\u4fe1\u4f7fRNA\uff08mRNA\uff09\uff08*\u8a3b\u4e8c\uff09\u9593\u7684\u4ea4\u4e92\u8abf\u63a7\u7db2\u8def\uff08\u5716\u4e8c\uff09\uff0c\u63a5\u8457\u518d\u900f\u904e\u57fa\u56e0\u5bcc\u96c6\u5206\u6790\uff08*\u8a3b\u4e09\uff09\uff0c\u767c\u73fe\u9019\u4e9b\u7db2\u8def\u6240\u8abf\u63a7\u7684\u4e0b\u6e38\u76ee\u6a19\u57fa\u56e0\uff0c\u986f\u8457\u96c6\u4e2d\u5728\u5df2\u77e5\u7684\u81ea\u9589\u75c7\u98a8\u96aa\u57fa\u56e0\u3002<\/p>\n<p><em>\uff08*\u8a3b\u4e8c\uff09miRNA\u6703\u6291\u5236mRNA\u7684\u57fa\u56e0\u8868\u9054\uff0c\u7576miRNA\u7d50\u5408\u81f3\u76ee\u6a19\u57fa\u56e0mRNA\u5e8f\u5217\u4e0a\uff0c\u4f7fmRNA\u7121\u6cd5\u9032\u884c\u8f49\u8b6f\u4f5c\u7528\u800c\u7522\u751f\u86cb\u767d\u8cea\u3002\u7576\u74b0\u72c0RNA\u5438\u9644miRNA\uff0c\u5c07\u4f7fmiRNA\u5931\u53bb\u6216\u964d\u4f4e\u5176\u8abf\u63a7\u4e0b\u6e38\u57fa\u56e0\u8868\u9054\u7684\u80fd\u529b\u3002<\/em><br 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class=\"wp-caption-text\">\u5716\u4e8c\u3001\u74b0\u72c0RNA\u8abf\u63a7\u7db2\u8def\u3002A\u5716\u70ba\u74b0\u72c0RNA\u3001\u5faeRNA\u3001\u4fe1\u4f7fRNA\u9593\u4ea4\u4e92\u8abf\u63a7\u7db2\u8def\u793a\u610f\u5716\u3002B\u5716\u70ba\u6240\u9810\u6e2c\u7684\u5176\u4e2d\u90e8\u5206\u7684\u8abf\u63a7\u7db2\u8def\uff0c\u7d05\u8272\u5b57\u9ad4\u986f\u793a\u6b64\u7db2\u8def\u4e2d\u768412\u500b\u5df2\u77e5\u7684\u81ea\u9589\u75c7\u98a8\u96aa\u57fa\u56e0\u3002<\/p><\/div>\n<p>&nbsp;<\/p>\n<p>\u838a\u6a39\u8ac4\u8aaa\u660e\uff0c\u9019\u500b\u7814\u7a76\u9664\u8a2d\u8a08\u5927\u6578\u64da\u5206\u6790\u6d41\u7a0b\u4f86\u5efa\u69cb\u74b0\u72c0RNA\u7684\u8abf\u63a7\u7db2\u8def\u95dc\u4fc2\uff0c\u4e5f\u7d50\u5408\u5206\u751f\u5be6\u9a57\u9a57\u8b49\u3002\u5718\u968a\u6311\u9078\u4e00\u500b\u5728\u81ea\u9589\u75c7\u60a3\u8005\u8166\u90e8\u8868\u73fe\u91cf\u660e\u986f\u4e0a\u5347\u7684\u74b0\u72c0RNA\uff08\u547d\u540d\u70bacircARID1A\uff09\uff0c\u65bc\u4eba\u985e\u795e\u7d93\u7d30\u80de\u5be6\u9a57\u9a57\u8b49\u5f8c\u767c\u73fe\uff0c 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class=\"wp-caption-text\">\u5716\u56db\u3001\u672c\u7814\u7a76\u6240\u9700\u7684\u77e5\u8b58\u80cc\u666f\u96f7\u9054\u5716\u3002\u76ee\u524d\u8a72\u7814\u7a76\u5718\u968a\u4e2d\u6709\u4e00\u534a\u662f\u300c\u7d14\u7406\u5de5\u300d\u80cc\u666f\uff0c\u53e6\u4e00\u534a\u662f\u300c\u7d14\u5206\u5b50\u751f\u7269\u300d\u80cc\u666f\uff0c\u4e00\u500b\u7406\u60f3\u7684\u751f\u7269\u8cc7\u8a0a\u5718\u968a\u6975\u9700\u8981\u4e0a\u8ff0\u5169\u7a2e\u80cc\u666f\u7684\u540c\u4ec1\u7dca\u5bc6\u5408\u4f5c\u3002\u6b61\u8fce\u5177\u5099\u4e0a\u8ff0\u4efb\u4e00\u80cc\u666f\u7684\u540c\u5b78\u52a0\u5165\u5d84\u65b0\u7684\u91ab\u7642\u5927\u6578\u64da\u5206\u6790\u4e16\u754c\u3002\u8a73\u60c5\u8acb\u4e0a\u838a\u6a39\u8ac4\u8001\u5e2b\u5be6\u9a57\u5ba4\u7db2\u7ad9\u67e5\u8a62\uff1a<a href=\"http:\/idv.sinica.edu.tw\/trees\/\">http:\/idv.sinica.edu.tw\/trees\/<\/a><\/p><\/div>\n<p>&nbsp;<\/p>\n<p>\u672c\u8ad6\u6587\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u5305\u62ec\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u9673\u5f65\u5982\u3001\u9673\u5609\u7469\u3001\u9ea5\u5fb7\u502b\u535a\u58eb\uff0c\u901a\u8a0a\u4f5c\u8005\u70ba\u838a\u6a39\u8ac4\u7814\u7a76\u54e1\u3002<\/p>\n<p>\u5168\u6587\u8a73\u898b\uff1a<a href=\"https:\/genome.cshlp.org\/content\/30\/3\/375.full.pdf+html\">https:\/genome.cshlp.org\/content\/30\/3\/375.full.pdf+html<\/a><\/p>\n<p style=\"text-align: right;\">\uff08\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u81ea\u9589\u75c7\u8b5c\u7cfb\u969c\u7919 (ASD\uff0c\u5168\u540d\u70ba autism spectrum disorder)\u662f\u4e00\u7a2e\u8166\u90e8\u767c\u80b2\u969c\u7919\u6240\u5c0e\u81f4\u7684 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