{"id":21816,"date":"2020-05-07T00:00:32","date_gmt":"2020-05-06T16:00:32","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=21816"},"modified":"2021-09-30T11:52:30","modified_gmt":"2021-09-30T03:52:30","slug":"%e5%b0%8d%e6%8a%97%e7%97%85%e6%af%92%e5%8f%a6%e9%97%a2%e8%b9%8a%e5%be%91%ef%bc%81%e5%85%8d%e7%96%ab%e9%81%8e%e6%bf%80%e5%82%b7%e6%95%b5%e4%b8%89%e5%8d%83%e3%80%81%e8%87%aa%e6%90%8d%e4%b8%80%e8%90%ac","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/21816\/","title":{"rendered":"\u5c0d\u6297\u75c5\u6bd2\u53e6\u95e2\u8e4a\u5f91\uff01\u514d\u75ab\u904e\u6fc0\u50b7\u6575\u4e09\u5343\u3001\u81ea\u640d\u4e00\u842c\uff0c\u6e1b\u7de9\u767c\u708e\u6216\u53ef\u626d\u8f49\u6230\u60c5"},"content":{"rendered":"<p>\u4eba\u9ad4\u4f9d\u8cf4\u514d\u75ab\u7cfb\u7d71\u5c0d\u6297\u75c5\u6bd2\uff0c\u4f46\u514d\u75ab\u53cd\u61c9\u5982\u679c\u904e\u6fc0\uff0c\u53cd\u800c\u9020\u6210\u5668\u5b98\u640d\u50b7\u6216\u8870\u7aed\uff0c\u76f4\u63a5\u5c0e\u81f4\u60a3\u8005\u6b7b\u4ea1\u3002\u4e2d\u7814\u9662\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u8b1d\u4e16\u826f\u7279\u8058\u7814\u7a76\u54e1\u9577\u671f\u7814\u7a76\u767c\u73fe\uff0c\u767b\u9769\u75c5\u6bd2\u6703\u523a\u6fc0\u8840\u5c0f\u677f\u7522\u751f\u80de\u5916\u56ca\u6ce1\u548c\u5fae\u6ce1\uff0c\u9032\u800c\u653b\u64ca\u767d\u8840\u7403\uff0c\u5c0e\u81f4\u767c\u708e\u75c5\u75c7\u3002\u7814\u7a76\u5718\u968a\u64da\u6b64\u7814\u767c\u6297\u9ad4\uff0c\u6e1b\u7de9\u767c\u708e\u53cd\u61c9\uff0c\u5df2\u6210\u529f\u5c07\u611f\u67d3\u767b\u9769\u75c5\u6bd2\u7684\u5c0f\u9f20\u5b58\u6d3b\u7387\u63d0\u5347\u81f3 90%\uff0c\u4e26\u65bc 2019 \u5e74 6 \u6708\u520a\u767b\u65bc\u300a\u81ea\u7136\u901a\u8a0a\u300b\uff08Nature Communications\uff09\u3002\u9762\u5c0d\u65b0\u51a0\u75c5\u6bd2\u7b49\u65b0\u8208\u50b3\u67d3\u75c5\uff0c\u6b64\u7a2e\u300c\u6e1b\u7de9\u767c\u708e\u300d\u70ba\u4e3b\u7684\u5275\u65b0\u7642\u6cd5\uff0c\u5c07\u6709\u6a5f\u6703\u5927\u5e45\u964d\u4f4e\u60a3\u8005\u6b7b\u4ea1\u7387\u3002<\/p>\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<p>\u70ba\u4e86\u7dad\u8b77\u4eba\u9ad4\u7684\u7a69\u5b9a\u8207\u548c\u5e73\uff0c\u514d\u75ab\u7cfb\u7d71\u4e00\u65e6\u5075\u6e2c\u5230\u5916\u4f86\u5165\u4fb5\u7269\uff0c\u5373\u555f\u52d5<a href=\"https:\/zh.wikipedia.org\/zh\/%E7%82%8E%E7%97%87\" target=\"_blank\" rel=\"noopener noreferrer\">\u767c\u708e\u53cd\u61c9<\/a>\uff0c\u53ec\u559a\u514d\u75ab\u7d30\u80de\u570d\u527f\u5165\u4fb5\u8005\u3002\u4f46\u767c\u708e\u53cd\u61c9\u5982\u679c\u904e\u5ea6\uff0c\u5f80\u5f80\u6703\u5c0d\u81ea\u8eab\u81df\u5668\u9020\u6210\u56b4\u91cd\u50b7\u5bb3\u3002\u4ee5<a href=\"https:\/www.cdc.gov.tw\/Disease\/SubIndex\/WYbKe3aE7LiY5gb-eA8PBw\" target=\"_blank\" rel=\"noopener noreferrer\">\u767b\u9769\u71b1<\/a>\uff08dengue fever\uff09\u70ba\u4f8b\uff0c\u514d\u75ab\u904e\u6fc0\u6703\u9020\u6210\u300c\u51fa\u8840\u6027\u767b\u9769\u71b1\u300d\uff0c\u56b4\u91cd\u5c07\u9020\u6210\u4f11\u514b\uff1b\u6700\u8fd1\u65b0\u51a0\u80ba\u708e\u9020\u6210\u7684<a href=\"https:\/heho.com.tw\/archives\/70108\" target=\"_blank\" rel=\"noopener noreferrer\">\u80ba\u7e96\u7dad\u5316<\/a>\uff0c\u4e5f\u662f\u514d\u75ab\u904e\u6fc0\u7684\u7d50\u679c\u3002<\/p>\n<p>\u82e5\u60f3\u627e\u51fa\u66f4\u6709\u6548\u7684\u6297\u75c5\u6bd2\u6cbb\u7642\u7b56\u7565\uff0c\u5fc5\u9808\u6df1\u5165\u4e86\u89e3\u75c5\u6bd2\u8207\u514d\u75ab\u7cfb\u7d71\u7684\u4e92\u52d5\u6a5f\u5236\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<h2 class=\"contains_subtitle_icon\"><strong><b>\u514d\u75ab\u53cd\u61c9\u5b9b\u5982\u96d9\u9762\u5203<\/b><\/strong><\/h2>\n<p>\u7576\u75c5\u6bd2\u4fb5\u5165\u4eba\u9ad4\uff0c\u9ad4\u5167\u514d\u75ab\u7d30\u80de\u6703\u7acb\u523b\u767c\u52d5\u653b\u64ca\uff0c\u5982\u672c\u6587\u4e3b\u89d2\u2014-<a href=\"https:\/zh.wikipedia.org\/zh\/%E5%B7%A8%E5%99%AC%E7%BB%86%E8%83%9E\" target=\"_blank\" rel=\"noopener noreferrer\">\u5de8\u566c\u7d30\u80de<\/a>\uff08macrophage\uff09\u8207<a href=\"https:\/zh.wikipedia.org\/zh\/%E4%B8%AD%E6%80%A7%E7%B2%92%E7%BB%86%E8%83%9E\" target=\"_blank\" rel=\"noopener noreferrer\">\u55dc\u4e2d\u6027\u767d\u8840\u7403<\/a>\uff08neutrophil\uff09\u5169\u7a2e\u767d\u8840\u7403\u3002<\/p>\n<p>\u55dc\u4e2d\u6027\u767d\u8840\u7403\uff0c\u6703\u541e\u5403\u5165\u4fb5\u8005\uff0c\u5982\u679c\u6575\u4eba\u592a\u591a\uff0c\u751a\u81f3\u6703\u300c\u81ea\u7206\u300d\u91cb\u653e\u51fa\u81ea\u5df1\u7684\u7db2\u72c0\u907a\u50b3\u7269\u8cea\uff08deoxyribonucleic Acid, DNA\uff09\u9ecf\u4f4f\u7d30\u83cc\uff0c\u518d\u7531\u9644\u8457\u5728 DNA \u7684\u9176\u5c07\u5176\u6bba\u6b7b\u3001\u6e05\u9664\uff0c\u9019\u500b\u904e\u7a0b\u7a31\u4f5c\u55dc\u4e2d\u6027\u767d\u8840\u7403\u80de\u5916\u6355\u6349 \uff08neutrophil extracellular traps, NETs\uff09\u3002<\/p>\n<div id=\"attachment_12003\" style=\"width: 610px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-12003\" class=\"wp-image-12003 size-full\" src=\"https:\/research.sinica.edu.tw\/wp-content\/uploads\/2020\/03\/hsieh-shie-liang-01.jpg\" alt=\"\u55dc\u4e2d\u6027\u7403\u7d30\u80de\u819c\u7834\u88c2\uff0c\u5c0d\u75c5\u539f\u9ad4\u5674\u5c04\u5927\u91cf\u7d72\u72c0\u67d3\u8272\u9ad4\uff0c\u9ad8\u9ecf\u6027\u7684\u67d3\u8272\u9ad4\u6703\u56f0\u4f4f\u75c5\u539f\u9ad4\u3002\u540c\u6642\u55dc\u4e2d\u6027\u7403\u9ad4\u5167\u7684\u514d\u75ab\u86cb\u96a8\u4e4b\u91cb\u51fa\uff0c\u6d88\u6ec5\u75c5\u539f\u9ad4\u3002\u6b64\u6642\u55dc\u4e2d\u6027\u7403\u4e5f\u96a8\u4e4b\u6b7b\u4ea1\u3002\u8cc7\u6599\u4f86\u6e90\u2502NETosis : A Microbicidal Mechanism beyond Cell Death\u5716\u8aaa\u91cd\u88fd\u2502\u6797\u4efb\u9060\u3001\u5f35\u8a9e\u8fb0\" width=\"600\" height=\"668\" \/><p id=\"caption-attachment-12003\" class=\"wp-caption-text\">\u55dc\u4e2d\u6027\u7403\u7d30\u80de\u819c\u7834\u88c2\uff0c\u5c0d\u75c5\u539f\u9ad4\u5674\u5c04\u5927\u91cf\u7d72\u72c0\u67d3\u8272\u9ad4\uff0c\u9ad8\u9ecf\u6027\u7684\u67d3\u8272\u9ad4\u6703\u56f0\u4f4f\u75c5\u539f\u9ad4\u3002\u540c\u6642\u55dc\u4e2d\u6027\u7403\u9ad4\u5167\u7684\u514d\u75ab\u86cb\u96a8\u4e4b\u91cb\u51fa\uff0c\u6d88\u6ec5\u75c5\u539f\u9ad4\u3002\u6b64\u6642\u55dc\u4e2d\u6027\u7403\u4e5f\u96a8\u4e4b\u6b7b\u4ea1\u3002 \u8cc7\u6599\u4f86\u6e90\u2502NETosis : A Microbicidal Mechanism beyond Cell Death \u5716\u8aaa\u91cd\u88fd\u2502\u6797\u4efb\u9060\u3001\u5f35\u8a9e\u8fb0<\/p><\/div>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<p>\u5de8\u566c\u7d30\u80de\uff0c\u4e5f\u6703\u541e\u566c\u3001\u5206\u89e3\u5927\u91cf\u7684\u75c5\u539f\u9ad4\u8207\u53d7\u611f\u67d3\u7d30\u80de\u3002\u7576\u75c5\u539f\u9ad4\u8207\u7d30\u80de\u8868\u9762\u7684\u53d7\u9ad4\u7d50\u5408\uff0c\u624d\u80fd\u9032\u5165\u5de8\u566c\u7d30\u80de\uff0c\u7136\u5f8c\u75c5\u539f\u9ad4\u6703\u88ab\u5206\u89e3\u6210\u788e\u7247\u6392\u51fa\u3002\u9019\u4e9b\u788e\u7247\u6703\u88ab\u7576\u4f5c\u6297\u539f\uff0c\u6d3b\u5316\u5176\u4ed6\u7a2e\u985e\u7684\u767d\u8840\u7403\u3002\u53e6\u5916\uff0c\u5de8\u566c\u7d30\u80de\u548c\u53d7\u611f\u67d3\u7684\u7d30\u80de\u9084\u6703\u5206\u6ccc<a href=\"https:\/zh.wikipedia.org\/zh-hans\/%E7%BB%86%E8%83%9E%E5%9B%A0%E5%AD%90\" target=\"_blank\" rel=\"noopener noreferrer\">\u7d30\u80de\u6fc0\u7d20<\/a>\u00a0\uff08cytokine\uff09\u5f15\u8d77\u767c\u708e\u53cd\u61c9\uff0c\u9032\u4e00\u6b65\u5c0d\u6297\u75c5\u6bd2\u3002<\/p>\n<p>&nbsp;<\/p>\n<div id=\"attachment_12004\" style=\"width: 610px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-12004\" class=\"wp-image-12004 size-full\" src=\"https:\/research.sinica.edu.tw\/wp-content\/uploads\/2020\/03\/hsieh-shie-liang-02.jpg\" alt=\"\u5de8\u566c\u7d30\u80de\uff0c\u4e5f\u6703\u541e\u566c\u5927\u91cf\u7684\u75c5\u539f\u9ad4\uff0c\u7d30\u80de\u5167\u6709\u9176\u53ef\u5206\u89e3\u75c5\u539f\u9ad4\uff0c\u518d\u5c07\u5206\u89e3\u5f8c\u7684\u5ee2\u6599\u6392\u51fa\uff0c\u540c\u6642\u91cb\u653e\u7d30\u80de\u6fc0\u7d20\u5f15\u8d77\u767c\u708e\u53cd\u61c9\u3002\u5716\u8aaa\u8a2d\u8a08\u2502\u9ec3\u66c9\u541b\u3001\u6797\u6d35\u5b89\" width=\"600\" height=\"567\" \/><p id=\"caption-attachment-12004\" class=\"wp-caption-text\">\u5de8\u566c\u7d30\u80de\uff0c\u4e5f\u6703\u541e\u566c\u5927\u91cf\u7684\u75c5\u539f\u9ad4\uff0c\u7d30\u80de\u5167\u6709\u9176\u53ef\u5206\u89e3\u75c5\u539f\u9ad4\uff0c\u518d\u5c07\u5206\u89e3\u5f8c\u7684\u5ee2\u6599\u6392\u51fa\uff0c\u540c\u6642\u91cb\u653e\u7d30\u80de\u6fc0\u7d20\u5f15\u8d77\u767c\u708e\u53cd\u61c9\u3002 \u5716\u8aaa\u8a2d\u8a08\u2502\u9ec3\u66c9\u541b\u3001\u6797\u6d35\u5b89<\/p><\/div>\n<p>&nbsp;<\/p>\n<p>\u7d30\u80de\u6fc0\u7d20\u5305\u62ec\u5e72\u64fe\u7d20\uff08interferon\uff09\u3001\u4fc3\u767c\u708e\u6fc0\u7d20\uff08proinflammatory cytokine\uff09\u3001\u8da8\u5316\u6fc0\u7d20\uff08chemokine\uff09\u7b49\u7b49\u3002\u5e72\u64fe\u7d20\uff0c\u7531\u53d7\u50b7\u7684\u7d30\u80de\u7522\u751f\uff0c\u7528\u4ee5\u8b66\u544a\u9130\u8fd1\u5065\u5eb7\u7684\u7d30\u80de\uff0c\u8d95\u7dca\u88fd\u9020\u53ef\u963b\u6b62\u75c5\u6bd2\u8907\u88fd\u7684\u86cb\u767d\u8cea\uff0c\u6291\u5236\u75c5\u6bd2\u6578\u91cf\u3002\u4fc3\u767c\u708e\u6fc0\u7d20\uff0c\u6703\u589e\u52a0\u8840\u7ba1\u901a\u900f\u6027\uff0c\u8b93\u8840\u6db2\u4e2d\u7684\u767d\u8840\u7403\u80fd\u8f15\u6613\u901a\u904e\u8840\u7ba1\u58c1\u8d95\u5f80\u76ee\u7684\u5730\u3002\u8da8\u5316\u6fc0\u7d20\uff0c\u6703\u5438\u5f15\u66f4\u591a\u767d\u8840\u7403\uff0c\u53ec\u4f86\u66f4\u591a\u63f4\u8ecd\u3002<\/p>\n<p>\u554f\u984c\u4f86\u4e86\uff01\u53d7\u611f\u67d3\u7d30\u80de\u6216\u5de8\u566c\u7d30\u80de\u5206\u6ccc\u7d30\u80de\u6fc0\u7d20\uff0c\u6216\u662f\u55dc\u4e2d\u6027\u767d\u8840\u7403\u80de\u5916\u6355\u6349\uff0c\u672c\u4f86\u90fd\u662f\u70ba\u4e86\u64ca\u9000\u75c5\u539f\u9ad4\u3002\u4f46\u4ee4\u4eba\u907a\u61be\u7684\u662f\uff0c\u767c\u708e\u7684\u526f\u4f5c\u7528\u8207\u767d\u8840\u7403\u7121\u5dee\u5225\u653b\u64ca\uff0c\u6709\u6642\u53cd\u800c\u9020\u6210\u5668\u5b98\u53d7\u640d\u6216\u8870\u7aed\uff0c\u751a\u81f3\u5c0e\u81f4\u60a3\u8005\u6b7b\u4ea1\u3002<\/p>\n<p>\u90a3\u9ebc\uff0c\u6709\u6c92\u6709\u4e00\u7a2e\u6cbb\u7642\u65b9\u6cd5\uff0c\u53ef\u4ee5\u6291\u5236\u904e\u5ea6\u767c\u708e\u53cd\u61c9\uff0c\u4f46\u53c8\u4e0d\u5f71\u97ff\u514d\u75ab\u7cfb\u7d71\u6d88\u6ec5\u75c5\u539f\u9ad4\uff1f\u65e9\u5728 2003 \u5e74\uff0c\u8b1d\u4e16\u826f\u5373\u958b\u59cb\u9019\u9805\u5927\u54c9\u554f\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2 class=\"contains_subtitle_icon\"><strong><b>\u5275\u65b0\u69cb\u60f3\uff1a\u6291\u5236\u767c\u708e\u53cd\u61c9\uff0c\u4f46\u4e0d\u5f71\u97ff\u514d\u75ab\u529b<\/b><\/strong><\/h2>\n<p>2003 \u5e74\uff0c<a href=\"https:\/zh.wikipedia.org\/zh-hans\/SARS%E4%BA%8B%E4%BB%B6\" target=\"_blank\" rel=\"noopener noreferrer\">SARS<\/a>\u00a0( Severe Acute Respiratory Syndrome) \u75ab\u60c5\u7206\u767c\uff0c\u5176\u4e2d\u91cd\u75c7\u60a3\u8005\u51fa\u73fe\u80ba\u7a4d\u6c34\u3001\u547c\u5438\u56f0\u96e3\u7b49\u75c7\u72c0\uff0c\u5747\u975e\u8087\u56e0\u65bc\u75c5\u6bd2\u672c\u8eab\uff0c\u800c\u662f\u514d\u75ab\u904e\u5ea6\u53cd\u61c9\u7684\u7d50\u679c\u3002<\/p>\n<p>\u7576\u80ba\u90e8\u7d30\u80de\u53d7\u611f\u67d3\u51fa\u73fe\u767c\u708e\u53cd\u61c9\uff0c\u4fc3\u767c\u708e\u6fc0\u7d20\u8b93\u8840\u7ba1\u901a\u900f\u6027\u589e\u52a0\u3001\u8840\u6f3f\u6ef2\u5165\u7d44\u7e54\u4e2d\uff0c\u5373\u6703\u9020\u6210\u80ba\u7a4d\u6c34\u3002\u518d\u52a0\u4e0a\uff0c\u8702\u64c1\u800c\u4f86\u7684\u767d\u8840\u7403\u7121\u5dee\u5225\u653b\u64ca\u53d7\u611f\u67d3\u6216\u5065\u5eb7\u80ba\u6ce1\uff0c\u751a\u81f3\u5206\u6ccc\u6fc0\u7d20\u547c\u559a\u66f4\u591a\u767d\u8840\u7403\u524d\u4f86\uff0c\u60e1\u6027\u5faa\u74b0\u4e4b\u4e0b\u5f62\u6210\u7d30\u80de\u6fc0\u7d20\u98a8\u66b4\uff08cytokine storm\uff09\uff0c\u8b93\u80ba\u6ce1\u7d30\u80de\u53d7\u5230\u56b4\u91cd\u640d\u5bb3\uff0c\u5c0e\u81f4\u75c5\u4eba\u547c\u5438\u56f0\u96e3\u3001\u96aa\u8c61\u74b0\u751f\u3002<\/p>\n<p>\u7136\u800c\uff0cSARS 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