{"id":21651,"date":"2020-04-09T00:00:52","date_gmt":"2020-04-08T16:00:52","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=21651"},"modified":"2021-07-22T13:11:58","modified_gmt":"2021-07-22T05:11:58","slug":"%e6%8a%91%e5%88%b6%e4%ba%a8%e4%b8%81%e9%a0%93%e6%b0%8f%e8%88%9e%e8%b9%88%e7%97%87%e7%9a%84%e6%96%b0%e7%ad%96%e7%95%a5","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/21651\/","title":{"rendered":"\u6291\u5236\u4ea8\u4e01\u9813\u6c0f\u821e\u8e48\u75c7\u7684\u65b0\u7b56\u7565"},"content":{"rendered":"<p><strong>\u8b93\u300c\u58de\u86cb\u767d\u300d\u88ab\u5206\u624b\uff01\u96d9\u6975\u6027\u80dc\u80bd\u5206\u5b50 \u6291\u5236\u4ea8\u4e01\u9813\u6c0f\u821e\u8e48\u75c7\u7684\u65b0\u7b56\u7565<\/strong><\/p>\n<p>\u4ea8\u4e01\u9813\u6c0f\u821e\u8e48\u75c7(Huntington\u2019s Disease)\u662f\u4e00\u7a2e\u795e\u7d93\u9000\u5316\u75be\u75c5\uff0c\u56e0\u70ba\u7a81\u8b8a\u57fa\u56e0\u8b93\u4ea8\u4e01\u9813\u86cb\u767d(mHtt)\u7570\u5e38\u805a\u96c6\uff0c\u9020\u6210\u8166\u90e8\u795e\u7d93\u6301\u7e8c\u6027\u9000\u5316\u3002\u60a3\u8005\u767c\u75c5\u5f8c\u624b\u8173\u4e0d\u807d\u4f7f\u559a\uff0c\u50cf\u5728\u8df3\u821e\u4e00\u6a23\uff0c\u672b\u671f\u6025\u901f\u9000\u5316\uff0c\u5e73\u5747\u5b58\u6d3b\u7d0415\u81f320\u5e74\uff0c\u76ee\u524d\u4ecd\u7121\u6cd5\u5b8c\u5168\u6cbb\u7652\u3002<\/p>\n<p>\u672c\u9662\u5316\u5b78\u7814\u7a76\u6240\u9ec3\u4eba\u5247\u526f\u7814\u7a76\u54e1\u8207\u524d\u751f\u7269\u91ab\u5b78\u7814\u7a76\u6240\u675c\u90a6\u61b2\u52a9\u7814\u7a76\u54e1\u7d44\u6210\u7684\u7814\u7a76\u5718\u968a\uff0c\u8a2d\u8a08\u51fa\u300c\u96d9\u6975\u6027\u80dc\u80bd\u5206\u5b50\u300d\uff0c\u80fd\u5920\u5c07\u4e00\u5718\u5718\u805a\u96c6\u7684\u4ea8\u4e01\u9813\u86cb\u767d\u5206\u6563\u958b\u4f86\uff0c\u5c07\u6b64\u5206\u5b50\u900f\u904e\u9f3b\u8154\u7d66\u85e5\u81f3\u7f79\u75c5\u5c0f\u9f20\u5f8c\uff0c\u5c0f\u9f20\u7684\u904b\u52d5\u8207\u8a8d\u77e5\u529f\u80fd\u5931\u8abf\u660e\u986f\u5f97\u5230\u6539\u5584\u3002\u672c\u7814\u7a76\u5df2\u65bc\u4eca\uff082020\uff09\u5e741\u6708\u520a\u767b\u65bc\u300a\u5148\u9032\u79d1\u5b78\u300b(<em>Advanced Science<\/em>)\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u96d9\u6975\u6027\u80dc\u80bd\u5206\u5b50\u53ef\u8fa8\u8b58\u8b8a\u7570\u7684\u300c\u58de\u86cb\u767d\u300d\u4f7f\u5176\u5206\u6563\u958b\u4f86<\/strong><\/p>\n<p>\u9ec3\u4eba\u5247\u6307\u51fa\uff0c\u7f79\u60a3\u4ea8\u4e01\u9813\u6c0f\u821e\u8e48\u75c7\u7684\u75c5\u4eba\uff0c\u8b8a\u7570\u7684\u4ea8\u4e01\u9813\u86cb\u767d\u5e36\u6709\u904e\u9577\u7684\u805a\u9ea9\u91af\u80fa\u9178\u93c8(polyglutamine)\uff0c\u96a8\u8457\u805a\u9ea9\u91af\u80fa\u9178\u93c8\u7684\u589e\u52a0\uff0c\u4ea8\u4e01\u9813\u86cb\u767d\u5bb9\u6613\u5806\u7a4d\u5728\u8166\u90e8\uff0c\u7834\u58de\u795e\u7d93\u5143\u3002\u7814\u7a76\u5718\u968a\u8a2d\u8a08\u51fa\u96d9\u6975\u6027\u80dc\u80bd\u5206\u5b50\uff0c\u5206\u5b50\u7684\u5176\u4e2d\u4e00\u7aef\u53ef\u4ee5\u8fa8\u8b58\u8b8a\u7570\u7684\u4ea8\u4e01\u9813\u86cb\u767d\u4e26\u9644\u8457\u4e0a\u53bb\uff0c\u5206\u5b50\u7684\u53e6\u4e00\u7aef\u5e36\u6b63\u96fb\uff0c\u53ef\u4ee5\u5229\u7528\u96fb\u8377\u6392\u65a5\u529b\uff0c\u628a\u805a\u96c6\u7684\u8b8a\u7570\u86cb\u767d\u5206\u6563\u958b\u4f86\uff0c\u8b93\u8b8a\u7570\u7684\u4ea8\u4e01\u9813\u58de\u86cb\u767d\u300c\u88ab\u5206\u624b\u300d\uff0c\u6e1b\u5c11\u5c0d\u795e\u7d93\u7d30\u80de\u7684\u6bd2\u6027\u53ca\u640d\u50b7\u3002<\/p>\n<p>\u7814\u7a76\u5718\u968a\u4e5f\u767c\u73fe\uff0c\u5c07\u96d9\u6975\u6027\u80dc\u80bd\u5206\u5b50\u900f\u904e\u9f3b\u8154\u7d66\u85e5\u81f3\u7f79\u75c5\u5c0f\u9f20\uff0c\u53ef\u4ee5\u4f7f\u5c0f\u9f20\u5728\u6efe\u7b52\u8dd1\u6b65\u6a5f\u4e0a\u7dad\u6301\u5e73\u8861\uff0c\u904b\u52d5\u529f\u80fd\u7372\u5f97\u986f\u8457\u6539\u5584\uff0c\u4e26\u4e14\u5728T\u578b\u8ff7\u5bae\u5be6\u9a57\u4e2d\uff0c\u5c55\u73fe\u8f03\u597d\u7684\u8a8d\u77e5\u529f\u80fd\u3002<\/p>\n<div 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class=\"wp-caption-text\">\u96d9\u6975\u6027\u80dc\u80bd\u5206\u5b50\uff0c\u4e00\u7aef\u53ef\u4ee5\u8fa8\u8b58\u8b8a\u7570\u7684\u4ea8\u4e01\u9813\u86cb\u767d\uff0c\u53e6\u4e00\u7aef\u5e36\u6b63\u96fb\uff0c\u80fd\u5229\u7528\u96fb\u8377\u6392\u65a5\u529b\uff0c\u963b\u6b62\u8b8a\u7570\u7684\u4ea8\u4e01\u9813\u86cb\u767d(mHtt)\u5806\u7a4d\uff0c\u6539\u5584\u8b8a\u7570\u86cb\u767d\u6240\u9020\u6210\u7684\u904b\u52d5\u8207\u8a8d\u77e5\u529f\u80fd\u5931\u8abf\u3002<\/p><\/div>\n<p>&nbsp;<\/p>\n<p><strong>\u7387\u5148\u5f9e\u6d3b\u7d30\u80de\u8ffd\u8e64\u8b8a\u7570\u86cb\u767d\u7684\u52d5\u614b\u7d50\u69cb\u8b8a\u5316<\/strong><\/p>\n<p>\u904e\u53bb\u6709\u95dc\u4ea8\u4e01\u9813\u6c0f\u821e\u8e48\u75c7\u7684\u7814\u7a76\uff0c\u4e0d\u6613\u5f9e\u751f\u7269\u9ad4\u5167\u89c0\u5bdf\u8b8a\u7570\u86cb\u767d\u805a\u96c6\u5316\u7684\u904e\u7a0b\uff0c\u9ec3\u4eba\u5247\u8868\u793a\uff0c\u672c\u7814\u7a76\u53e6\u4e00\u7a81\u7834\u662f\u5efa\u7acb\u751f\u7269\u5149\u96fb\u5f71\u50cf\u5e73\u81fa\uff0c\u900f\u904e\u87a2\u5149\u5f71\u50cf\u986f\u5fae\u7cfb\u7d71\uff0c\u89c0\u6e2c\u4ea8\u4e01\u9813\u86cb\u767d\u5728\u6d3b\u7d30\u80de\u4e2d\u805a\u96c6\u8207\u5206\u6563\u7684\u904e\u7a0b\u3002\u7814\u7a76\u5718\u968a\u5728\u5c0f\u9f20\u795e\u7d93\u7d30\u80de\u5be6\u9a57\u4e2d\uff0c\u628a\u8b8a\u7570\u7684\u4ea8\u4e01\u9813\u86cb\u767d\u6a19\u793a\u4e0a\u5169\u7a2e\u4e0d\u540c\u7684\u87a2\u5149\u86cb\u767d\uff0c\u6b64\u6642\uff0c\u82e5\u8b8a\u7570\u7684\u4ea8\u4e01\u9813\u86cb\u767d\u4e92\u76f8\u9760\u8fd1\uff0c\u5c07\u6539\u8b8a\u87a2\u5149\u86cb\u767d\u7684\u653e\u5149\u7279\u6027\uff0c\u85c9\u6b64\u89c0\u5bdf\u8b8a\u7570\u86cb\u767d\u662f\u5426\u805a\u96c6\uff0c\u4ee5\u53ca\u96d9\u6975\u6027\u80dc\u80bd\u5206\u5b50\u7684\u6291\u5236\u6548\u679c\u3002\u76ee\u524d\u5df2\u7372\u5f97\u548c\u6b64\u7814\u7a76\u76f8\u95dc\u7684\u81fa\u7063\u5c08\u5229\uff0c\u5176\u4ed6\u570b\u5bb6\u5c08\u5229\u5247\u6b63\u7533\u8acb\u4e2d\u3002<\/p>\n<p>\u672c\u8ad6\u6587\u7531\u672c\u9662\u4ee5\u53ca\u79d1\u6280\u90e8\u652f\u6301\u3002\u7b2c\u4e00\u4f5c\u8005\u70ba\u672c\u9662\u5316\u5b78\u6240\u4f55\u745e\u7389\u535a\u58eb\u3001\u901a\u8a0a\u4f5c\u8005\u70ba\u9ec3\u4eba\u5247\u526f\u7814\u7a76\u54e1\u3001\u4f55\u745e\u7389\u535a\u58eb\uff0c\u53ca\u524d\u751f\u91ab\u6240\u675c\u90a6\u61b2\u52a9\u7814\u7a76\u54e1\u3002\u7814\u7a76\u5718\u968a\u9084\u5305\u62ec\u570b\u885b\u9662\u751f\u91ab\u5de5\u7a0b\u8207\u5948\u7c73\u91ab\u5b78\u6240\u7684\u9673\u4ec1\u711c\u526f\u7814\u7a76\u54e1\uff0c\u4ee5\u53ca\u672c\u9662\u7d30\u80de\u8207\u500b\u9ad4\u751f\u7269\u5b78\u7814\u7a76\u6240\u7684\u5ed6\u6c38\u8c50\u526f\u7814\u7a76\u54e1\u3002<\/p>\n<p>\u671f\u520a\u8ad6\u6587\u9023\u7d50: <a href=\"https:\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/advs.201901165\">https:\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/advs.201901165<\/a><\/p>\n<div id=\"attachment_21652\" style=\"width: 797px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21652\" class=\"wp-image-21652 size-large\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/04\/1-2-2-1.jpg\" alt=\"\" width=\"787\" height=\"586\" \/><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">\u4e2d\u7814\u9662\u5316\u5b78\u6240\u4f55\u745e\u7389\u535a\u58eb(\u5de6)\u3001\u9ec3\u4eba\u5247\u526f\u7814\u7a76\u54e1(\u53f3)<\/p><\/div>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right;\">\uff08\u5316\u5b78\u7814\u7a76\u6240\u3001\u79d8\u66f8\u8655\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8b93\u300c\u58de\u86cb\u767d\u300d\u88ab\u5206\u624b\uff01\u96d9\u6975\u6027\u80dc\u80bd\u5206\u5b50 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[&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":21654,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/21651"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=21651"}],"version-history":[{"count":0,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/21651\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/21654"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=21651"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=21651"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=21651"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}