{"id":21637,"date":"2020-04-09T00:00:33","date_gmt":"2020-04-08T16:00:33","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=21637"},"modified":"2021-09-30T11:53:13","modified_gmt":"2021-09-30T03:53:13","slug":"%e3%80%90%e4%b8%ad%e7%a0%94%e6%8a%97%e7%96%ab1%e3%80%91%e5%9b%9b%e5%a4%a7%e7%96%ab%e8%8b%97%e5%b9%b3%e5%8f%b0%e5%88%86%e9%a0%ad%e5%90%88%e6%93%8a%ef%bc%8c%e5%b7%b2%e8%a3%bd%e5%82%99%e5%80%99%e9%81%b8","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/21637\/","title":{"rendered":"\u3010\u4e2d\u7814\u6297\u75ab1\u3011\u56db\u5927\u75ab\u82d7\u5e73\u53f0\u5206\u982d\u5408\u64ca\uff0c\u5df2\u88fd\u5099\u5019\u9078\u75ab\u82d7\uff0c\u5373\u5c07\u9032\u5165\u52d5\u7269\u5be6\u9a57"},"content":{"rendered":"

\u4e2d\u7814\u9662\u65b0\u51a0\u80ba\u708e\u75ab\u82d7\u7814\u767c\u73fe\u6cc1<\/h1>\n

(\u6700\u5f8c\u66f4\u65b0\uff1a2020 \/ 03 \/ 25) \u65b0\u578b\u51a0\u72c0\u75c5\u6bd2 (COVID-19) \u5168\u7403\u5ef6\u71d2\uff0c\u5728\u75ab\u60c5\u7206\u767c\u7576\u4e0b\uff0c\u6700\u6025\u5207\u7684\u662f\u627e\u5230\u6aa2\u9a57\u8a66\u5291\u548c\u6709\u6548\u85e5\u7269\uff0c\u4f46\u9577\u671f\u4f86\u8aaa\uff0c\u75ab\u82d7\u624d\u662f\u5b8c\u52dd\u65b0\u8208\u50b3\u67d3\u75c5\u7684\u89e3\u65b9\u3002\u5c24\u5176\u65b0\u51a0\u80ba\u708e (COVID-19) \u53ef\u80fd\u6d41\u611f\u5316\uff0c\u75ab\u82d7\u5728\u672a\u4f86\u9632\u75ab\u5de5\u4f5c\u4e0a\u6108\u5f62\u91cd\u8981\u3002\u4e2d\u7814\u9662\u5167\u6578\u9593\u5be6\u9a57\u5ba4\u6b63\u5206\u982d\u4e26\u9032\uff0c\u8207\u8a6d\u8a50\u591a\u8b8a\u7684\u75c5\u6bd2\u6436\u6642\u9593\u3002\u4f46\uff0c\u5230\u5e95\u9084\u8981\u591a\u4e45\u624d\u6709\u75ab\u82d7\u53ef\u7528\u5462\uff1f\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u80e1\u54f2\u9298\u9577\u8058\u526f\u7814\u7a76\u54e1\u8aaa\u660e\uff1a\u4e2d\u7814\u9662\u5167\u5df2\u6709\u5019\u9078\u75ab\u82d7\uff0c4 \u6708\u5c07\u9032\u5165\u52d5\u7269\u5be6\u9a57\uff0c\u4f46\u75ab\u82d7\u7814\u767c\u4e0d\u53ef\u8e81\u9032\uff0c\u4ee5\u514d\u5f15\u767c\u56b4\u91cd\u5f8c\u679c\u3002\u8ddf\u8457\u7814\u4e4b\u6709\u7269<\/a>\u4e00\u8d77\u4f86\u4e86\u89e3\uff01<\/p>\n

\u65b0\u51a0\u80ba\u708e\u53ef\u80fd\u6d41\u611f\u5316<\/b><\/strong><\/h2>\n

\u65b0\u51a0\u80ba\u708e\u548c\u00a0SARS<\/a>\u00a0\u90fd\u662f\u6e90\u81ea\u51a0\u72c0\u75c5\u6bd2\uff0c\u4f46\u4e0d\u50cf SARS \u7684\u9ad8\u81f4\u6b7b\u7387\u3001\u4f4e\u50b3\u67d3\u7387\u3002<\/p>\n

\n

\u65b0\u51a0\u75c5\u6bd2\u7684\u300c\u751f\u5b58\u7b56\u7565\u300d\u70ba\u4f4e\u81f4\u6b7b\u7387\u3001\u9ad8\u50b3\u67d3\u7387\uff0c\u53ef\u80fd\u8f49\u8b8a\u6210\u5982\u6d41\u611f\u822c\u6301\u7e8c\u5b58\u5728\u3001\u5468\u671f\u5faa\u74b0\u7684\u50b3\u67d3\u75c5\uff0c\u672a\u4f86\u9632\u75ab\u975e\u75ab\u82d7\u4e0d\u53ef\u3002<\/strong><\/h4>\n<\/blockquote>\n

\u65b0\u51a0\u75c5\u6bd2\u70ba\u4ec0\u9ebc\u9019\u9ebc\u5bb9\u6613\u50b3\u67d3\uff1f\u5b83\u7684\u5916\u89c0\u8207SARS\u3001MERS<\/a>\u00a0\u7b49\u51a0\u72c0\u75c5\u6bd2<\/a>\u985e\u4f3c\uff0c\u5916\u5957\u819c\u4e0a\u5177\u6709\u300c\u7687\u51a0\u300d\u72c0\u7a81\u8d77\u7684\u68d8\u86cb\u767d ( spike protein )\uff0c\u4e5f\u662f\u653b\u5165\u5bbf\u4e3b\u7d30\u80de\u7684\u4e3b\u8981\u6b66\u5668\u3002\u4f46\u65b0\u51a0\u75c5\u6bd2\u66f4\u72e1\u733e\uff0c\u5b83\u7684\u68d8\u86cb\u767d\u8207\u4eba\u9ad4\u7d30\u80de\u7684\u89aa\u548c\u529b\uff0c\u6bd4 SARS \u75c5\u6bd2\u9ad8\u51fa 10 ~ 30 \u500d\uff0c\u63db\u53e5\u8a71\u8aaa\uff0c\u4e0d\u9700\u8981\u5927\u91cf\u75c5\u6bd2\u5373\u8db3\u4ee5\u5165\u4fb5\u4eba\u9ad4\uff0c\u96ea\u4e0a\u52a0\u971c\u7684\u662f\uff0c\u7576\u4eba\u9ad4\u906d\u5230\u611f\u67d3\uff0c\u53ef\u80fd\u9577\u6642\u9593\u6c92\u75c7\u72c0\uff0c\u4f46\u5e36\u6709\u50b3\u67d3\u529b\uff0c\u5927\u5927\u589e\u52a0\u9632\u75ab\u7684\u96e3\u5ea6\u3002<\/p>\n

\u56e0\u6b64\uff0c\u65b0\u51a0\u75c5\u6bd2\u96d6\u7136\u81f4\u6b7b\u7387\u4e0d\u9ad8\uff0c\u4f46\u56e0\u8457\u8d85\u5f37\u50b3\u67d3\u529b\uff0c\u4ee4\u4eba\u64d4\u5fc3\u5b83\u6703\u5982 1918 \u5e74\u897f\u73ed\u7259\u6d41\u611f<\/a>\u822c\u5728\u5168\u7403\u9020\u6210\u5927\u6d41\u884c\uff0c\u5e7e\u5104\u4eba\u88ab\u611f\u67d3\u3001\u5e7e\u5343\u842c\u4eba\u6b7b\u4ea1\uff0c\u5168\u9762\u7671\u7613\u5404\u570b\u91ab\u7642\u9ad4\u7cfb\u3002\u679c\u771f\u5982\u6b64\uff0c\u672a\u4f86\u552f\u6709\u7814\u767c\u51fa\u6709\u6548\u75ab\u82d7\uff0c\u800c\u4e14\u591a\u6578\u4eba\u90fd\u80fd\u65bd\u6253\u5f97\u5230\u4fdd\u8b77\uff0c\u624d\u7b97\u5fb9\u5e95\u63a7\u5236\u75ab\u60c5\u3002<\/p>\n

\"\u65b0\u51a0\u75c5\u6bd2\u5728\u96fb\u5b50\u986f\u5fae\u93e1\u4e0b\u7684\u5f71\u50cf\uff0c\u8868\u9762\u7a81\u8d77\u7684\u68d8\u86cb\u767d\uff0c\u662f\u5b83\u5011\u9032\u653b\u7d30\u80de\u7684\u91cd\u8981\u6b66\u5668\u3002\u5716\u7247\u4f86\u6e90\u2502iStock\"

\u65b0\u51a0\u75c5\u6bd2\u5728\u96fb\u5b50\u986f\u5fae\u93e1\u4e0b\u7684\u5f71\u50cf\uff0c\u8868\u9762\u7a81\u8d77\u7684\u68d8\u86cb\u767d\uff0c\u662f\u5b83\u5011\u9032\u653b\u7d30\u80de\u7684\u91cd\u8981\u6b66\u5668\u3002 \u5716\u7247\u4f86\u6e90\u2502iStock<\/p><\/div>\n

 <\/p>\n

\u4e2d\u7814\u9662\u75ab\u82d7\u5718\u968a\uff0c\u5206\u982d\u5408\u64ca\uff01<\/b><\/strong><\/h2>\n

\u4e2d\u7814\u9662\u6578\u9593\u5be6\u9a57\u5ba4\u6b63\u4ee5\u81ea\u8eab\u7d93\u9a57\u548c\u5c08\u9577\u51fa\u767c\uff0c\u5206\u982d\u7814\u767c\u4e0d\u540c\u7a2e\u985e\u7684\u75ab\u82d7\uff0c\u4ee5\u671f\u53ca\u6642\u627e\u5230\u6700\u597d\u7684\u89e3\u65b9\u3002<\/p>\n

\u7814\u7a76\u8005\u5e38\u4ee5\u75c5\u6bd2\u6700\u5916\u5c64\u7684\u7269\u8cea\u7576\u4f5c\u6297\u539f\uff0c\u4ee5\u523a\u6fc0\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\uff0c\u7522\u751f\u76f8\u5c0d\u61c9\u7684\u6297\u9ad4\uff0c\u8b93\u514d\u75ab\u7cfb\u7d71\u300c\u8a18\u4f4f\u300d\u75c5\u6bd2\uff0c\u672a\u4f86\u5373\u53ef\u8fa8\u8b58\u3001\u4e2d\u548c\u8207\u6d88\u6ec5\u75c5\u6bd2\uff0c\u4f8b\u5982\uff1a\u51a0\u72c0\u75c5\u6bd2\u8868\u9762\u80fd\u4fb5\u5165\u7d30\u80de\u7684\u68d8\u86cb\u767d\uff0c\u5373\u662f\u88fd\u4f5c\u75ab\u82d7\u7684\u91cd\u9ede\u4e4b\u4e00\u3002\u4e2d\u7814\u9662\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240\u7684\u8d99\u88d5\u5c55<\/a>\u7814\u7a76\u54e1\u81f4\u529b\u65bc\u300c\u6b21\u55ae\u5143\u75ab\u82d7\u300d\uff0c\u5373\u4f7f\u7528\u51a0\u72c0\u75c5\u6bd2\u5916\u570d\u68d8\u86cb\u767d\u4f5c\u70ba\u6297\u539f\uff0c\u56e0\u70ba\u53ea\u5229\u7528\u4e86\u65b0\u51a0\u75c5\u6bd2\u7684\u90e8\u5206\u7d50\u69cb\u3001\u4e0d\u9700\u7528\u5230\u6574\u9846\u75c5\u6bd2\uff0c\u6bd4\u8d77\u6d3b\u6bd2\u6216\u6e1b\u6bd2\u75ab\u82d7\u4f86\u8aaa\uff0c\u76f8\u5c0d\u5b89\u5168\u7684\u591a\u3002<\/p>\n

\u8fb2\u696d\u751f\u7269\u79d1\u6280\u7814\u7a76\u4e2d\u5fc3\u856d\u57f9\u6587<\/a>\u7814\u7a76\u54e1\u5247\u8457\u624b\u300c\u985e\u75c5\u6bd2\u9846\u7c92\u75ab\u82d7 (virus-like particle\uff0cVLP)\u300d\uff0c\u5148\u5c07\u75c5\u6bd2\u90e8\u5206\u57fa\u56e0\u8f49\u6b96\u5230\u7279\u5b9a\u7d30\u80de\u4e2d\uff0c\u8b93\u7d30\u80de\u751f\u7522\u985e\u4f3c\u75c5\u6bd2\u9846\u7c92\u7684\u4e00\u7a2e\u300c\u7a7a\u6bbc\u300d\u86cb\u767d\u8cea\u2014-\u5982\u57fa\u8cea\u86cb\u767d\uff08matrix protein\uff0c\u70ba\u75c5\u6bd2\u5916\u5957\u819c\u5167\u7684\u4e00\u5c64\u69cb\u9020\uff09\uff0c\u88dd\u4e0a\u75c5\u6bd2\u8868\u9762\u7684\u68d8\u86cb\u767d\u6297\u539f\uff0c\u88fd\u9020\u4e00\u9846\u9846\u5b9b\u5982\u75c5\u6bd2\u300c\u7acb\u9ad4\u96d5\u50cf\u300d\u7684\u7a7a\u6bbc\u7c92\u5b50\uff0c\u4f46\u5167\u90e8\u4e0d\u5177\u907a\u50b3\u7269\u8cea\u7684\u300c\u5047\u75c5\u6bd2\u300d\u3002<\/p>\n

\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240\u7684\u5f35\u96ef<\/a>\u7814\u7a76\u54e1\u5247\u53e6\u95e2\u8e4a\u5f91\uff0c\u7814\u767c\u300c\u6e1b\u6bd2\u725b\u75d8\u75c5\u6bd2\u75ab\u82d7\u300d\u3002\u6982\u5ff5\u662f\uff1a\u4ee5\u57fa\u56e0\u91cd\u7d44\u6280\u8853\u88fd\u9020\u7a81\u8b8a\u7684\u725b\u75d8\u75c5\u6bd2\uff0c\u6e1b\u5f31\u5176\u6bd2\u6027\u3001\u50b3\u67d3\u529b\uff0c\u518d\u8b93\u725b\u75d8\u75c5\u6bd2\u53bb\u8868\u73fe\u68d8\u86cb\u767d\uff0c\u507d\u88dd\u6210\u65b0\u51a0\u75c5\u6bd2\u3002<\/p>\n

\u4e2d\u7814\u9662\u751f\u91ab\u6240\u7684\u80e1\u54f2\u9298<\/a>\u9577\u8058\u526f\u7814\u7a76\u54e1\u5247\u7814\u767c\u53ef\u6a21\u4eff\u51a0\u72c0\u75c5\u6bd2\u7684\u300c\u5948\u7c73\u75ab\u82d7\u300d\uff0c\u4ee5\u751f\u7269\u6027\u539f\u6599\u88fd\u4f5c\u4e2d\u7a7a\u5948\u7c73\u7c92\u5b50\uff0c\u5916\u9762\u9ecf\u4e0a\u65b0\u51a0\u75c5\u6bd2\u7684\u68d8\u86cb\u767d (\u6b21\u55ae\u5143\u6297\u539f)\uff0c\u5167\u90e8\u88dd\u5165\u53ef\u523a\u6fc0\u514d\u75ab\u7cfb\u7d71\u53cd\u61c9\u7684\u4f50\u5291\uff0c\u8abf\u6574\u514d\u75ab\u7cfb\u7d71\u5c0d\u65bc\u6b21\u55ae\u4f4d\u6297\u539f\u7684\u53cd\u61c9\uff0c\u6e1b\u5c11\u904e\u654f\u3002\u76ee\u524d\u5df2\u7d93\u627e\u5230\u5019\u9078\u75ab\u82d7\uff0c\u6253\u5728\u8001\u9f20\u8eab\u4e0a\u53ef\u7522\u751f\u6297\u9ad4\uff0c\u5373\u5c07\u9032\u5165\u4e0b\u4e00\u6b65\u52d5\u7269\u5be6\u9a57\u968e\u6bb5\u3002(\u95dc\u65bc\u51a0\u72c0\u75c5\u6bd2\u5948\u7c73\u75ab\u82d7\u8acb\u898b\uff1a\u65b0\u51a0\u80ba\u708e\u75ab\u82d7\u7814\u767c\u5927\u76f4\u64ca\uff01\u5047\u626e\u51a0\u72c0\u75c5\u6bd2\u7684\u5948\u7c73\u75ab\u82d7\u2013\u5c08\u8a2a\u80e1\u54f2\u9298<\/a>)<\/p>\n

\"\u8cc7\u6599\u4f86\u6e90\u2502\u80e1\u54f2\u9298\u5716\u8aaa\u8a2d\u8a08\u2502\u9ec3\u66c9\u541b\u3001\u6797\u6d35\u5b89\"

\u8cc7\u6599\u4f86\u6e90\u2502\u80e1\u54f2\u9298 \u5716\u8aaa\u8a2d\u8a08\u2502\u9ec3\u66c9\u541b\u3001\u6797\u6d35\u5b89<\/p><\/div>\n

 <\/p>\n

\u88fd\u5099\u51fa\u5019\u9078\u75ab\u82d7\uff0c\u63a5\u4e0b\u4f86\u7684\u95dc\u9375\u662f\u7d30\u80de\u53ca\u52d5\u7269\u8a66\u9a57\u7684\u5efa\u7acb\u3002\u65b0\u51a0\u75c5\u6bd2\u53ef\u4ee5\u611f\u67d3\u4eba\u9ad4\uff0c\u537b\u4e0d\u5bb9\u6613\u611f\u67d3\u4e00\u822c\u5be6\u9a57\u52d5\u7269\uff0c\u6240\u4ee5\u5fc5\u9808\u5099\u88fd\u53ef\u6a21\u64ec\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u7684\u52d5\u7269\u6a21\u5f0f\u3002\u76ee\u524d\uff0c\u751f\u91ab\u6240\u9676\u79d8\u83ef<\/a>\u7814\u7a76\u54e1\u6b63\u7dca\u947c\u5bc6\u9f13\u4fee\u6539\u5be6\u9a57\u5c0f\u9f20\u7684\u57fa\u56e0\uff0c\u751f\u7522\u53ef\u88ab\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u7684\u57fa\u6539\u8001\u9f20\uff0c\u63d0\u4f9b\u5176\u4ed6\u7814\u7a76\u54e1\u6e2c\u8a66\u5019\u9078\u75ab\u82d7\u7684\u5b89\u5168\u6027\u548c\u4fdd\u8b77\u529b\u3002\u751f\u91ab\u6240\u6797\u5b9c\u73b2<\/a>\u7814\u7a76\u54e1\u4e5f\u7a4d\u6975\u5efa\u7acb\u75c5\u6bd2\u57f9\u990a\u53ca\u6e2c\u8a66\u5e73\u53f0\uff0c\u4ee5\u63d0\u4f9b\u75c5\u6bd2\u4f86\u6e90\u2026\u2026\u75ab\u82d7\u7814\u767c\u7684\u6bcf\u500b\u74b0\u7bc0\uff0c\u9700\u8981\u4e0d\u540c\u7684\u5c08\u696d\u5be6\u9a57\u5ba4\u4e92\u76f8\u652f\u63f4\u3001\u5408\u4f5c\uff0c\u5718\u9ad4\u4f5c\u6230\uff01<\/p>\n

 <\/p>\n

\u6b32\u700f\u89bd\u5b8c\u6574\u7cbe\u91c7\u6587\u7ae0\uff0c\u8acb\u81f3\u7814\u4e4b\u6709\u7269\u5b98\u7db2\uff1a<\/strong><\/h2>\n

https:\/research.sinica.edu.tw\/covid-19-vaccine-academia-sinica\/<\/a><\/em><\/h2>\n

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