{"id":21575,"date":"2020-03-19T00:00:43","date_gmt":"2020-03-18T16:00:43","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=21575"},"modified":"2021-08-26T09:10:30","modified_gmt":"2021-08-26T01:10:30","slug":"%e3%80%90%e5%b0%88%e6%ac%84%e3%80%91%e5%be%9e%e7%a0%94%e7%a9%b6%e7%a6%bd%e6%b5%81%e6%84%9f%e7%96%ab%e8%8b%97%e5%88%b0%e9%9d%a2%e5%b0%8dsars-2-0%e5%8d%b1%e6%a9%9f","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/21575\/","title":{"rendered":"\u3010\u5c08\u6b04\u3011\u5f9e\u7814\u7a76\u79bd\u6d41\u611f\u75ab\u82d7\u5230\u9762\u5c0dSARS 2.0\u5371\u6a5f"},"content":{"rendered":"

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\"\"<\/p>\n

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\u505a\u75ab\u82d7\u4e5f\u8981\u8ddf\u6642\u9593\u8cfd\u8dd1\uff0c\u5728\u904e\u53bb\u4e09\u5e74\uff0c\u6211\u5011\u78e8\u7df4\u597d\u4e00\u500b\u5168\u65b0\u7684\u57fa\u56e0\u8f49\u6b96\u7d30\u80de\u682a\u7cfb\u7d71\uff0c\u6211\u5011\u5728\u4e00\u500b\u53ef\u4ee5\u61f8\u6d6e\u57f9\u990a\u7684\u4eba\u985e\u7d30\u80de\u682a\u4e2d\uff0c\u9810\u5148\u8f49\u6b96\u4e00\u500b\u80fd\u5927\u91cf\u8868\u73fe\u7da0\u8272\u87a2\u5149\u86cb\u767d\u7684\u57fa\u56e0\uff0c\u4e14\u5728\u5169\u5074\u9810\u57cb\u4e86\u91cd\u7d44\u9176\u53ef\u8fa8\u8a8d\u7684\u4e0d\u5c0d\u7a31DNA\u5e8f\u5217\uff0c\u96a8\u6642\u53ef\u4ee5\u9001\u9032\u91cd\u7d44\u9176\u548c\u9700\u8981\u8868\u73fe\u7684\u4e00\u7d44\u57fa\u56e0\u5361\u5323\uff0c\u5229\u7528\u91cd\u7d44\u9176\u4f86\u526a\u63a5\u4ea4\u63db\u57fa\u56e0\u5361\u5323\uff0c\u53d6\u4ee3\u539f\u5148\u7684\u7da0\u8272\u87a2\u5149\u57fa\u56e0\uff0c\u5feb\u901f\u7522\u751f\u751f\u7522\u65b0\u578bVLP\u75ab\u82d7\u7684\u7a2e\u99ac\uff0c\u9032\u884c\u5927\u91cf\u751f\u7522\u3002\u6211\u5011\u4e0d\u4f46\u7df4\u5175\u4ea4\u63db\u500b\u7d05\u8272\u87a2\u5149\u86cb\u767d\u57fa\u56e0\uff0c\u66f4\u5df2\u7d93\u8a66\u9a57\u904e\u9019\u4e00\u7d30\u80de\u7cfb\u7d71\u80fd\u751f\u7522\u51fa\u79bd\u6d41\u611f\u7684VLP\u75ab\u82d7\uff0c\u7d93\u672c\u9662\u3001\u5bb6\u755c\u885b\u751f\u8a66\u9a57\u6240\u8207\u53f0\u5927\u7684\u5408\u4f5c\u7814\u7a76\u5718\u968a\u9a57\u8b49\uff0c\u9019\u4e00\u500b\u75ab\u82d7\u80fd\u4fdd\u8b77\u96de\u96bb\u88ab\u9ad8\u75c5\u539fH5N2\u79bd\u6d41\u611f\u611f\u67d3\u5f8c\u6703\u767c\u751f\u7684\u91cd\u75c7\u6b7b\u4ea1\u3002\u96d6\u7136\uff0c\u7814\u7a76\u9019\u7bc7\u8ad6\u6587\u5c1a\u672a\u5b8c\u6210\uff0c\u4f46\u662f\u73fe\u5728\u6b66\u6f22\u80ba\u708e\u7684\u75ab\u60c5\u7dca\u6025\uff0c\u865f\u89d2\u518d\u6b21\u97ff\u8d77\uff0c\u6211\u5011\u4e5f\u53ea\u5f97\u62d4\u528d\u518d\u6230\uff0c\u5118\u5feb\u505a\u51faSARS 2.0\u75c5\u6bd2\u7684VLP\uff0c\u548c\u6211\u5011\u7684\u570b\u5bb6\u968a\u4e00\u8d77\u76e1\u4e00\u500b\u79d1\u5b78\u5bb6\u7684\u6240\u80fd\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Hsiao Pei-Wen*, Huang Chang-Jen, Yang Ning-Sun, Lin En-Hau. \u7522\u751f\u985e\u75c5\u6bd2\u5fae\u7c92\u4e4b\u9ad8\u7522\u7387\u8f49\u6b96\u57fa\u56e0\u54fa\u4e73\u52d5\u7269\u8868\u73fe\u7cfb\u7d71; High-yield transgenic mammalian expression system for generating virus-like particles. TIPO TWI340166 (2011\/04\/11-2026\/12\/13)<\/strong>.<\/li>\n
  2. Chia-Ying Wu,\u00a0Yi-Chun Yeh,\u00a0Yu-Chih Yang,\u00a0Ching Chou,\u00a0Ming-Tsan Liu,\u00a0Ho-Sheng Wu,\u00a0Jia-Tsrong Chan,\u00a0and\u00a0Pei-Wen Hsiao*. (2010) Mammalian expression of virus-like particles for advanced mimicry of authentic influenza virus. PLoS ONE, 5(3): e9784.<\/li>\n
  3. Chia-Ying Wu,\u00a0Yi-Chun Yeh,\u00a0Jia-Tsrong Chan, Yu-Chih Yang,\u00a0Ji-Rong Yang,\u00a0Ming-Tsan Liu,\u00a0Ho-Sheng Wu,\u00a0and\u00a0Pei-Wen Hsiao* (2012) A VLP vaccine induces broad-spectrum cross-protective antibody immunity against H5N1 and H1N1 subtypes of influenza A virus. PLoS ONE 7: e42363.<\/li>\n
  4. Ji-Rong Yang,\u00a0Chih-Yuan Chen,\u00a0Chuan-Yi Kuo,\u00a0Chieh-Yu Cheng,\u00a0Min-Shiuh Lee,\u00a0Ming-Chu Cheng,\u00a0Yu-Chih Yang,\u00a0Chia-Ying Wu,\u00a0Ho-Sheng Wu,\u00a0Ming-Tsan Liu*,\u00a0Pei-Wen Hsiao*. (2016) A novel H6N1 virus-like particle vaccine induces long-lasting cross-clade antibody immunity against human and avian H6N1 viruses. Antiviral Research, 126:8-17.<\/li>\n
  5. Ji-Rong Yang, Chieh-Yu Cheng, Chih-Yuan Chen, Chao-Hua Lin, Chuan-Yi Kuo, Hsiang-Yi Huang, Fu-Ting Wu, Yu-Chih Yang, Chia-Ying Wu, Ming-Tsan Liu *, and Pei-Wen Hsiao*. (2017) A virus-like particle vaccination strategy expands its tolerance to H3N2 antigenic drift by enhancing neutralizing antibodies against hemagglutinin stalk. Antiviral Research, 140: 62-75.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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