{"id":21494,"date":"2020-03-05T00:05:43","date_gmt":"2020-03-04T16:05:43","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=21494"},"modified":"2020-12-23T15:50:33","modified_gmt":"2020-12-23T07:50:33","slug":"%e8%82%ba%e8%85%ba%e7%99%8c%e7%a0%94%e7%a9%b6%e6%96%b0%e7%aa%81%e7%a0%b4%ef%bc%81%e9%9d%9e%e7%b7%a8%e7%a2%bc%e5%9f%ba%e5%9b%a0%e8%ae%93%e7%99%8c%e7%b4%b0%e8%83%9e%e9%95%b7%e6%9b%b4%e5%bf%ab","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/21494\/","title":{"rendered":"\u80ba\u817a\u764c\u7814\u7a76\u65b0\u7a81\u7834\uff01\u975e\u7de8\u78bc\u57fa\u56e0\u8b93\u764c\u7d30\u80de\u9577\u66f4\u5feb"},"content":{"rendered":"<p>\u80ba\u764c\u662f\u5168\u7403\u53ca\u81fa\u7063\u764c\u75c7\u5341\u5927\u6b7b\u56e0\u4e4b\u9996\uff0c\u80ba\u817a\u764c\u60a3\u8005\u9010\u5e74\u589e\u52a0\u3002\u672c\u9662\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u5468\u7389\u5c71\u7814\u7a76\u54e1\u3001\u65bd\u67d4\u5408\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\u7b49\u4eba\u7d44\u6210\u7684\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u80ba\u817a\u764c\u7d44\u7e54\u88e1\u7684\u975e\u7de8\u78bc\u6838\u7cd6\u6838\u9178\u300cPTTG3P\u300d\u8868\u73fe\u6108\u9ad8\uff0c\u6703\u4f7f\u764c\u7d30\u80de\u52a0\u901f\u6210\u9577\uff0c\u5728\u5c0f\u9f20\u5be6\u9a57\u4e2d\u4e5f\u8b49\u5be6\u6703\u964d\u4f4e\u5b58\u6d3b\u7387\uff1bPTTG3P\u9ad8\u8868\u73fe\u91cf\u7684\u80ba\u817a\u764c\u75c5\u4eba\uff0c\u4e5f\u5c0d\u81e8\u5e8a\u5316\u7642\u85e5\u7269\uff08\u5982\u9806\u9251\u3001\u7d2b\u6749\u9187\uff09\u7522\u751f\u6297\u85e5\u6027\u3002\u5468\u7389\u5c71\u8868\u793a\uff0c\u6b64\u767c\u73fe\u53ef\u4f5c\u70ba\u5316\u7642\u7528\u85e5\u53c3\u8003\uff0c\u6709\u52a9\u65bc\u5ef6\u9577\u75c5\u4eba\u751f\u547d\u3002<\/p>\n<div id=\"attachment_21512\" style=\"width: 807px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21512\" class=\"wp-image-21512\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/03\/1-2-1-1024x609.jpg\" alt=\"\" width=\"797\" height=\"474\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/03\/1-2-1-1024x609.jpg 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/03\/1-2-1-300x178.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/03\/1-2-1-768x457.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/03\/1-2-1-1536x914.jpg 1536w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/03\/1-2-1-1080x642.jpg 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/03\/1-2-1-287x171.jpg 287w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/03\/1-2-1-287x171-287x171.jpg 574w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/03\/1-2-1.jpg 1920w\" sizes=\"(max-width: 797px) 100vw, 797px\" \/><p id=\"caption-attachment-21512\" class=\"wp-caption-text\">\u672c\u9662\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u5468\u7389\u5c71\u7814\u7a76\u54e1\uff08\u5de6\uff09\u3001\u65bd\u67d4\u5408\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\uff08\u53f3\uff09<\/p><\/div>\n<p>\u5728\u4eba\u985e\u7d30\u80de\u7684\u57fa\u56e0\u9ad4\u4e2d\uff0c\u50c51\/3\u7684\u6838\u7cd6\u6838\u9178\uff08mRNAs \uff09\u80fd\u5920\u8f49\u8b6f\u51fa\u86cb\u767d\u8cea\uff0c\u57f7\u884c\u751f\u7269\u529f\u80fd\u3002\u7d55\u5927\u90e8\u5206\u7684\u6838\u7cd6\u6838\u9178\u7121\u6b64\u529f\u80fd\uff0c\u88ab\u7a31\u70ba\u975e\u7de8\u78bc\u6838\u7cd6\u6838\u9178 \uff08noncoding RNAs, ncRNAs\uff09\uff0c\u904e\u53bb\u88ab\u5b9a\u7fa9\u70ba\u5783\u573e\u57fa\u56e0\u3002\u76f4\u5230\u8fd1\u5e7e\u5e74\u4f86\uff0c\u79d1\u5b78\u5bb6\u767c\u73fencRNAs\u5728\u75be\u75c5\u60e1\u5316\u53ca\u751f\u7269\u7d30\u80de\u5b78\u4e2d\u626e\u6f14\u91cd\u8981\u89d2\u8272\uff0c\u6b63\u5982\u540c\u672c\u6b21\u767c\u73fe\u7684PTTG3P\uff0c\u8207\u80ba\u817a\u764c\u60a3\u8005\u7684\u5b58\u6d3b\u7387\u76f8\u95dc\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3>PTTG3P\u52a0\u901f\u764c\u7d30\u80de\u751f\u9577\u4f7f\u75c5\u4eba\u6b7b\u4ea1\u7387\u63d0\u9ad8<\/h3>\n<p>\u7814\u7a76\u5718\u968a\u900f\u904e\u751f\u7269\u8cc7\u8a0a\u8490\u96c6\u80ba\u817a\u764c\u60a3\u8005\u5b58\u6d3b\u8cc7\u6599\u7684\u57fa\u56e0\u8868\u73fe\u9ad4\u6578\u64da\uff0c\u627e\u52306\u500b\u8207\u80ba\u817a\u764c\u5b58\u6d3b\u6642\u9593\u76f8\u95dc\u7684ncRNAs\uff0c\u5206\u6790\u4e26\u9810\u6e2c\u4ed6\u5011\u7684\u751f\u7269\u529f\u80fd\uff0c\u4ee5\u53ca\u5728\u764c\u5316\u9014\u5f91\u626e\u6f14\u7684\u89d2\u8272\u3002\u7b2c\u4e00\u4f5c\u8005\u65bd\u67d4\u5408\u535a\u58eb\u8868\u793a\uff0c\u5f9e\u9019\u4e9bncRNAs\u4e2d\uff0c\u4ed6\u5011\u767c\u73fePTTG3P\u5728\u5176\u4e2d\u6700\u70ba\u986f\u8457\uff0c\u5728\u80ba\u817a\u764c\u7d30\u80de\u5be6\u9a57\u53ca\u5c0f\u9f20\u6a21\u5f0f\u90fd\u52a0\u901f\u764c\u7d30\u80de\u6210\u9577\uff0c\u964d\u4f4e\u5c0f\u9f20\u5b58\u6d3b\u7387\u3002\u76f8\u53cd\u7684\uff0c\u82e5\u5c07\u5c0f\u9f20\u80ba\u90e8\u764c\u7d30\u80de\u7684PTTG3P\u7684\u8868\u73fe\u91cf\u6e1b\u5c11\u4e00\u534a\uff0c\u816b\u7624\u751f\u6210\u901f\u5ea6\u660e\u986f\u6e1b\u7de9\uff0c\u53ef\u986f\u8457\u63d0\u5347\u5c0f\u9f20\u5b58\u6d3b\u7387\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3>\u4e09\u5927\u56e0\u5b50\u5408\u7d44\u300c\u72af\u7f6a\u8005\u806f\u76df\u300d\u652f\u63f4\u80ba\u817a\u764c\u7d30\u80de\u751f\u9577<\/h3>\n<p>\u5468\u7389\u5c71\u6307\u51fa\uff0c\u904e\u53bb\u7814\u7a76\u5df2\u77e5\uff0c\u80ba\u817a\u764c\u7d30\u80de\u589e\u751f\u8207\u4e0b\u6e38\u8abf\u63a7\u7684BUB1B\u57fa\u56e0\u8868\u73fe\u6709\u95dc\uff0c\u4f46\u4e0d\u6e05\u695a\u5176\u904b\u4f5c\u6a5f\u5236\u3002\u672c\u6b21\u767c\u73fe\u7684PTTG3P\u5728\u4e0a\u6e38\u8207\u8f49\u9304\u56e0\u5b50FOXM1\u4ea4\u4e92\u4f5c\u7528\uff0c\u6d3b\u5316BUB1B\u7684\u57fa\u56e0\u8868\u73fe\u3002\u4e5f\u56e0\u70baPTTG3P\u8868\u73fe\u91cf\u6108\u9ad8\uff0c\u9032\u800c\u4fc3\u4f7f\u6b64\u6a5f\u5236\u904b\u4f5c\uff0c\u8b93\u4e09\u8005\u5b8c\u7f8e\u5408\u9ad4\uff0c\u50cf\u662f\u5408\u7d44\u300c\u72af\u7f6a\u8005\u806f\u76df\u300d\uff0c\u6210\u70ba\u652f\u63f4\u80ba\u817a\u764c\u816b\u7624\u751f\u9577\u7684\u5171\u72af\u7d50\u69cb\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3>PTTG3P\u8868\u73fe\u91cf\u9ad8 \u764c\u7d30\u80de\u5c0d\u5316\u7642\u7522\u751f\u6297\u85e5\u6027<\/h3>\n<p>\u7814\u7a76\u5718\u968a\u4e5f\u5f9e\u764c\u75c7\u57fa\u56e0\u9ad4\u5716\u8b5c\uff08The Cancer Genome Atlas, TCGA\uff09\u7684\u8cc7\u6599\u4e2d\u767c\u73fe\uff0c\u80ba\u817a\u764c\u5316\u7642\u75c5\u4eba\u764c\u7d44\u7e54\u88e1\u7684PTTG3P\u8868\u73fe\u6108\u9ad8\uff0c\u5c0d\u81e8\u5e8a\u5316\u7642\u85e5\u7269\uff08\u9806\u9251\u3001\u7d2b\u6749\u9187\uff09\u7522\u751f\u6297\u85e5\u6027\uff0c\u4f7f\u5f97\u6cbb\u7642\u6548\u679c\u6253\u6298\u6263\u3002\u5468\u7389\u5c71\u5efa\u8b70\uff0c\u5316\u7642\u7528\u85e5\u524d\uff0c\u53ef\u5148\u6aa2\u8996\u60a3\u8005\u764c\u7d44\u7e54\u88e1\u7684PTTG3P\u8868\u73fe\u91cf\uff0c\u6709\u52a9\u65bc\u63d0\u9ad8\u7642\u6548\u3002<\/p>\n<p>\u4eba\u985e\u57fa\u56e0\u7d44\u88e1\u7684ncRNAs\u70ba\u6578\u773e\u591a\uff0c\u672c\u7814\u7a76\u85c9\u7531\u8207\u57fa\u56e0\u5171\u821e\uff08co-expression\uff09\u539f\u7406\u53ca\u751f\u7269\u8cc7\u8a0a\u5206\u6790\uff0c\u5efa\u69cb\u57fa\u56e0\u5171\u540c\u8868\u73fe\u7db2\u8def\uff0c\u627e\u5230\u8207\u80ba\u817a\u764c\u5b58\u6d3b\u6642\u9593\u76f8\u95dc\u7684PTTG3P\uff0c\u9032\u800c\u5206\u6790\u3001\u9810\u6e2c\u5728\u764c\u75c7\u4e0a\u7684\u81f4\u75c5\u6a5f\u5236\u548c\u529f\u80fd\u3002\u5468\u7389\u5c71\u6307\u51fa\uff0c\u6b64\u65b9\u6cd5\u5c0d\u65bc\u5982\u4f55\u6709\u6548\u7387\u3001\u6709\u7cfb\u7d71\u5730\u627e\u5230\u8207\u75be\u75c5\u76f8\u95dc\u7684ncRNAs\uff0c\u63d0\u4f9b\u4e00\u5927\u52a9\u529b\u3002<\/p>\n<p>\u672c\u8ad6\u6587\u7b2c\u4e00\u4f5c\u8005\u70ba\u672c\u9662\u751f\u91ab\u6240\u65bd\u67d4\u5408\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\uff0c\u901a\u8a0a\u4f5c\u8005\u70ba\u5468\u7389\u5c71\u7814\u7a76\u54e1\uff0c\u8ad6\u6587\u5df2\u65bc108\u5e7412\u670819\u65e5\u520a\u767b\u5728\u300a\u6838\u9178\u7814\u7a76\u300b\uff08<em>Nucleic Acids Research<\/em>\uff09\u3002<\/p>\n<p>\u8ad6\u6587\u5168\u6587\uff1a<a href=\"https:\/academic.oup.com\/nar\/advance-article\/doi\/10.1093\/nar\/gkz1149\/5680706\">https:\/academic.oup.com\/nar\/advance-article\/doi\/10.1093\/nar\/gkz1149\/5680706<\/a><\/p>\n<p style=\"text-align: right;\">\uff08\u6587\uff0f\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u3001\u79d8\u66f8\u8655\uff1b\u651d\u5f71\uff0f\u8cc7\u8a0a\u8655\uff09<\/p>\n<div id=\"attachment_21498\" style=\"width: 778px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21498\" class=\"wp-image-21498 size-full\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/03\/1-2-2.png\" alt=\"\" width=\"768\" height=\"552\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/03\/1-2-2.png 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/03\/1-2-2-300x216.png 300w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/><p id=\"caption-attachment-21498\" class=\"wp-caption-text\">a. \u672c\u7814\u7a76\u85c9\u7531\u8207\u57fa\u56e0\u5171\u821e\uff08co-expression\uff09\u539f\u7406\u53ca\u751f\u7269\u8cc7\u8a0a\u5206\u6790\uff0c\u5efa\u69cb\u57fa\u56e0\u5171\u540c\u8868\u73fe\u7db2\u8def\uff0c\u767c\u73fe6\u500bncRNAs\u8207\u80ba\u817a\u764c\u5b58\u6d3b\u7387\u76f8\u95dc\uff0c\u4ee5PTTG3P\u8868\u73fe\u6700\u70ba\u986f\u8457\u3002 b.\u80ba\u817a\u764c\u7d44\u7e54\u88e1\u7684PTTG3P\u8868\u73fe\u6108\u9ad8\uff0c\u6703\u52a0\u901f\u7d30\u80de\u5206\u88c2\u53ca\u6297\u85e5\u6027\uff08\u57161\uff09\uff1b\u82e5\u6291\u5236\u5c0f\u9f20\u80ba\u90e8\u764c\u7d30\u80de\u88e1\u7684PTTG3P\u8868\u73fe\u91cf\uff0c\u816b\u7624\uff08\u57162\u85cd\u8272\u90e8\u5206\uff09\u751f\u6210\u901f\u5ea6\u660e\u986f\u6e1b\u7de9\u3002\u57163\u70ba\u816b\u7624\u4e0b\u6e38\u57fa\u56e0\u8abf\u63a7\u6a5f\u5236\uff0c\u672c\u7814\u7a76\u767c\u73fe\u7684PTTG3P\u548c\u8f49\u9304\u56e0\u5b50FOXM1\u4ea4\u4e92\u4f5c\u7528\uff0c\u4e00\u8d77\u6d3b\u5316BUB1B\u7684\u57fa\u56e0\u8868\u73fe\uff0c\u5c0e\u81f4\u764c\u7d30\u80de\u52a0\u901f\u5206\u88c2\uff0c\u4e09\u5927\u56e0\u5b50\u5408\u4f5c\u5f62\u6210\u300c\u72af\u7f6a\u8005\u806f\u76df\u300d\u4ee5\u652f\u63f4\u80ba\u817a\u764c\u4e0d\u6b63\u5e38\u6210\u9577\u3002<\/p><\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u80ba\u764c\u662f\u5168\u7403\u53ca\u81fa\u7063\u764c\u75c7\u5341\u5927\u6b7b\u56e0\u4e4b\u9996\uff0c\u80ba\u817a\u764c\u60a3\u8005\u9010\u5e74\u589e\u52a0\u3002\u672c\u9662\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u5468\u7389\u5c71\u7814\u7a76\u54e1\u3001\u65bd\u67d4\u5408\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\u7b49 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":21512,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/21494"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=21494"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/21494\/revisions"}],"predecessor-version":[{"id":21708,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/21494\/revisions\/21708"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/21512"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=21494"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=21494"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=21494"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}