{"id":21321,"date":"2020-02-20T00:00:39","date_gmt":"2020-02-19T16:00:39","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=21321"},"modified":"2021-07-22T13:33:26","modified_gmt":"2021-07-22T05:33:26","slug":"%e7%8b%b9%e8%b7%af%e7%9b%b8%e9%80%a2%ef%bc%9a%e7%b5%84%e8%9b%8b%e7%99%bd%e4%bf%ae%e9%a3%be%e6%89%ae%e6%bc%94%e3%80%8c%e5%88%86%e5%ad%90%e6%b8%9b%e9%80%9f%e4%b8%98%e3%80%8d%e7%b7%a9%e8%a7%a3dna","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/21321\/","title":{"rendered":"\u72f9\u8def\u76f8\u9022\uff1a\u7d44\u86cb\u767d\u4fee\u98fe\u626e\u6f14\u300c\u5206\u5b50\u6e1b\u901f\u4e18\u300d\u7de9\u89e3DNA\u4e0a\u7684\u4ea4\u901a\u885d\u7a81"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-21308\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/02\/3-2-e1581994128411.jpg\" alt=\"\" width=\"572\" height=\"390\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/02\/3-2-e1581994128411.jpg 572w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2020\/02\/3-2-e1581994128411-300x205.jpg 300w\" sizes=\"(max-width: 572px) 100vw, 572px\" \/><\/p>\n<p>\u672c\u9662\u7d30\u751f\u6240\u9ad8\u627f\u798f\u526f\u7814\u7a76\u54e1\u8207\u570b\u7acb\u81fa\u7063\u5927\u5b78\u98df\u79d1\u6240\u7f85\u7fca\u798e\u5be6\u9a57\u5ba4\uff0c\u767c\u73fe\u9ad8\u5f37\u5ea6\u8f49\u9304\u7684\u57fa\u56e0\u4e0a\u7684\u7d44\u86cb\u767dH3\u7684\u7532\u57fa\u5316\u4fee\u98fe\uff08H3K4me\uff09\u53ef\u4ee5\u6291\u5236\u5728DNA\u8907\u88fd\u58d3\u529b\u4e0b\u56e0RNA\u8f49\u9304-DNA\u8907\u88fd\u885d\u7a81(transcription-replication conflicts)\u6240\u9020\u6210\u7684\u57fa\u56e0\u7a81\u8b8a\u3002<\/p>\n<p>\u6b64\u7814\u7a76\u6210\u679c\u4e0d\u50c5\u70ba\u56f0\u64fe\u5b78\u754c\u591a\u5e74\u7684\u300cH3K4me\u529f\u80fd\u4e4b\u8b0e\u300d\u589e\u6dfb\u4e86\u4e00\u584a\u91cd\u8981\u62fc\u5716\uff0c\u540c\u6642\u89e3\u91cb\u4e86\u81e8\u5e8a\u4e0a\u7684\u4eba\u985e\u7d30\u80de\u5728\u7f3a\u4e4fH3K4me\u764c\u75c5\u8b8a\u7684\u53ef\u80fd\u539f\u56e0\u3002\u6b64\u8ad6\u6587\u5df2\u65bc\u4eca\uff08109\uff09\u5e742\u670810\u65e5\u520a\u767b\u65bc\u570b\u969b\u671f\u520a\u300a\u81ea\u7136\u901a\u8a0a\u300b\uff08<em>Nature Communications<\/em>\uff09\u3002<\/p>\n<p>\u53c3\u8003\u7db2\u9801\uff1a<a href=\"http:\/icob.sinica.edu.tw\/article.php?id=655\">http:\/icob.sinica.edu.tw\/article.php?id=655<\/a><\/p>\n<p style=\"text-align: right;\">\uff08\u7d30\u80de\u8207\u500b\u9ad4\u751f\u7269\u5b78\u7814\u7a76\u6240\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u672c\u9662\u7d30\u751f\u6240\u9ad8\u627f\u798f\u526f\u7814\u7a76\u54e1\u8207\u570b\u7acb\u81fa\u7063\u5927\u5b78\u98df\u79d1\u6240\u7f85\u7fca\u798e\u5be6\u9a57\u5ba4\uff0c\u767c\u73fe\u9ad8\u5f37\u5ea6\u8f49\u9304\u7684\u57fa\u56e0\u4e0a\u7684\u7d44\u86cb\u767dH3\u7684\u7532\u57fa\u5316\u4fee\u98fe\uff08H3 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":21308,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[988,984],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/21321"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=21321"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/21321\/revisions"}],"predecessor-version":[{"id":21344,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/21321\/revisions\/21344"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/21308"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=21321"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=21321"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=21321"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}