{"id":21296,"date":"2020-02-20T00:00:25","date_gmt":"2020-02-19T16:00:25","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=21296"},"modified":"2021-07-22T13:36:38","modified_gmt":"2021-07-22T05:36:38","slug":"%e6%bc%b8%e5%87%8d%e7%97%87%e3%80%81%e7%b5%90%e8%85%b8%e7%82%8e%e7%9a%84%e6%95%91%e6%98%9f%ef%bc%9a%e8%aa%bf%e7%af%80%e7%b4%b0%e8%83%9e%e6%b0%a7%e5%8c%96%e5%a3%93%e5%8a%9b","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/21296\/","title":{"rendered":"\u6f38\u51cd\u75c7\u3001\u7d50\u8178\u708e\u7684\u6551\u661f\uff1a\u8abf\u7bc0\u7d30\u80de\u6c27\u5316\u58d3\u529b"},"content":{"rendered":"

\u795e\u7d93\u9000\u5316\u53ca\u767c\u708e\u53cd\u61c9\u8207\u7d30\u80de\u6297\u6c27\u5316\u80fd\u529b\u90fd\u6709\u95dc\uff01\u4eba\u985e\u7d30\u80de\u82e5\u6297\u6c27\u5316\u529b\u8870\u9000\uff0c\u9020\u6210\u7d30\u80de\u5167\u6c27\u5316\u58d3\u529b\u589e\u52a0\uff0c\u5c0e\u81f4\u7d30\u80de\u8870\u8001\u51cb\u96f6\u4fbf\u53ef\u80fd\u7522\u751f\u6f38\u51cd\u75c7\u548c\u7d50\u8178\u708e\u7b49\u985e\u4f3c\u75c5\u75c7\u3002\u672c\u9662\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u674e\u6587\u83ef\u9662\u58eb\u8207\u4e2d\u570b\u91ab\u85e5\u5927\u5b78\u3001\u81fa\u5927\u91ab\u9662\u5408\u4f5c\u7814\u7a76\u767c\u73fe\uff0c\u751f\u7269\u9ad4\u5167\u7684\u6297\u6c27\u5316\u9175\u7d20GPx7\u548cGPx8\u53ef\u4ee5\u5075\u6e2c\u3001\u8abf\u63a7\u6c27\u5316\u58d3\u529b\uff0c\u4e0d\u50c5\u80fd\u5e73\u8861\u7d30\u80de\u591a\u9918\u7684\u6c27\u5316\u6d3b\u52d5\uff0c\u66f4\u80fd\u5354\u52a9\u85e5\u7269\u6e2c\u8a66\uff0c\u900f\u904e\u76f8\u95dc\u6a5f\u5236\u7684\u6291\u5236\u5291\u6cbb\u7642\u75be\u75c5<\/p>\n

\u7d30\u80de\u4ee3\u8b1d\u6642\u6703\u7522\u751f\u6d3b\u6027\u6c27\u985e\uff08Reactive oxygen species, ROS\uff09\uff0c\u4e5f\u662f\u514d\u75ab\u7d30\u80de\u4f5c\u6230\u6642\u7684\u6b66\u5668\u3002\u4f46\u662f\u96a8\u8457\u5e74\u7d00\u589e\u9577\u548c\u74b0\u5883\u7684\u5f71\u97ff\uff0c\u7d2f\u7a4d\u904e\u591a\u6d3b\u6027\u6c27\u985e\u537b\u6703\u589e\u52a0\u7d30\u80de\u5167\u6c27\u5316\u58d3\u529b\uff0c\u9020\u6210\u7d30\u80de\u8870\u8001\u3002\u7136\u800c\uff0c\u751f\u7269\u9ad4\u4e2d\u7684\u300c\u6297\u6c27\u5316\u7a40\u80f1\u7518\u80bd\uff08GPx\uff09\u300d\u9175\u7d20\u80fd\u62b5\u6297\u6d3b\u6027\u6c27\u985e\uff0c\u8fc5\u901f\u5c07\u9ad4\u5167\u6240\u7522\u751f\u7684\u6d3b\u6027\u6c27\u985e\u900f\u904e\u6c27\u5316\u9084\u539f\u7684\u65b9\u5f0f\u4ee3\u8b1d\u6210\u6bd2\u6027\u8f03\u5c0f\u6216\u7121\u6bd2\u7684\u7269\u8cea\u3002<\/p>\n

\u6b64\u6b21\u8de8\u55ae\u4f4d\u7814\u7a76\u767c\u73fe\uff0c\u6297\u6c27\u5316\u7a40\u80f1\u7518\u80bd7\uff08GPx7\uff09\u548c\u6297\u6c27\u5316\u7a40\u80f1\u7518\u80bd8\uff08GPx8\uff09\u9175\u7d20\u4e3b\u8981\u529f\u80fd\u70ba\u5e73\u8861\u591a\u9918\u7684\u6d3b\u6027\u6c27\u985e\uff0c\u9054\u6210\u9ad4\u5167\u514d\u75ab\u9632\u79a6\u7cfb\u7d71\u8207\u6297\u6c27\u5316\u5169\u5927\u7cfb\u7d71\u7684\u5e73\u8861\uff0c\u7dad\u6301\u5065\u5eb7\u6700\u4f73\u72c0\u614b\u3002GPx7\u548cGPx8\u4e5f\u53ef\u4ee5\u505a\u70ba\u6d3b\u6027\u6c27\u985e\u611f\u6e2c\u5668\uff0c\u8abf\u63a7\u6c27\u5316\u58d3\u529b\u4f86\u907f\u514d\u904b\u52d5\u795e\u7d93\u5143\u548c\u767c\u708e\u6027\u8178\u9053\u75be\u75c5\u7684\u7522\u751f\u3002<\/p>\n

 <\/p>\n

\u5c0e\u81f4\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\u7684\u57fa\u56e0\uff1a<\/strong>GPx7<\/strong><\/p>\n

\u5927\u8166\u548c\u810a\u9ad3\u795e\u7d93\u5143\u5c0d\u65bc\u6d3b\u6027\u6c27\u985e\u7279\u5225\u654f\u611f\uff0c\u674e\u6587\u83ef\u9662\u58eb\u5be6\u9a57\u5ba4\u8b1d\u548f\u9716\u535a\u58eb\u53ca\u967d\u660e\u5927\u5b78\u751f\u5316\u6240\u535a\u58eb\u751f\u8607\u82b3\u5100\u7814\u7a76\u767c\u73fe\uff0c\u5254\u9664GPx7\u57fa\u56e0\u7684\u5c0f\u9f20\u6703\u51fa\u73fe\u904b\u52d5\u795e\u7d93\u5143\u9000\u5316\u7684\u75c7\u72c0\uff0c\u6210\u9577\u523011\u500b\u6708\u5927\u6642\uff08\u76f8\u7576\u65bc\u4eba\u985e\u7684\u4e2d\u5e74\uff09\u884c\u52d5\u529b\u6e1b\u5f31\uff0c\u5176\u4e2d\u7d0410%\u7684\u5c0f\u9f20\u7684\u5f8c\u80a2\u6703\u56b4\u91cd\u7671\u7613\u3002\u76f8\u8f03\u65bc\u4e00\u822c\u5c0f\u9f20\u5e73\u57472-3\u5e74\u7684\u751f\u547d\u9031\u671f\uff0c\u904b\u52d5\u795e\u7d93\u5143\u9000\u5316\u7684\u75c5\u9f20\u6703\u63d0\u65e9\u572815\u500b\u6708\u5f8c\u5c31\u9010\u6f38\u6b7b\u4ea1\u3002<\/p>\n

\u7814\u7a76\u5718\u968a\u9032\u4e00\u6b65\u5c07\u75c5\u9f20\u7684\u810a\u9ad3\u7d44\u7e54\u9032\u884c\u514d\u75ab\u87a2\u5149\u67d3\u8272\u5206\u6790\uff0c\u767c\u73fe\u75c5\u9f20\u7684\u904b\u52d5\u795e\u7d93\u5143\u6578\u91cf\u76f8\u8f03\u65bc\u540c\u9f61\u6b63\u5e38\u5c0f\u9f20\u5927\u5e45\u6e1b\u5c11\u4e86\u7d0420%\uff0c\u904b\u52d5\u795e\u7d93\u5143\u9023\u63a5\u81f3\u808c\u8089\u7684\u7a81\u89f8\u7d50\u69cb\u4e5f\u9010\u6f38\u51cb\u96f6\u3001\u9000\u51fa\u63a5\u5408\u8655\uff0c\u986f\u793a\u904b\u52d5\u795e\u7d93\u5143\u6162\u6162\u5730\u5931\u53bb\u63a7\u5236\u808c\u8089\u7684\u80fd\u529b\u3002\u7d9c\u4e0a\u6240\u8ff0\uff0c\u7f3a\u4e4fGPx7\u5c07\u6703\u5c0e\u81f4\u810a\u9ad3\u4e2d\u7684\u904b\u52d5\u795e\u7d93\u5143\u840e\u7e2e\u51cb\u4ea1\uff0c\u51fa\u73fe\u4e0b\u80a2\u7671\u7613\u7b49\u985e\u4f3c\u6f38\u51cd\u75c7\u7684\u75c5\u5fb5\u3002\u63a5\u7e8c\u8207\u53f0\u5927\u91ab\u9662\u795e\u7d93\u90e8\u8521\u529b\u51f1\u91ab\u5e2b\u4ee5\u53ca\u53f0\u5317\u91ab\u5b78\u5927\u5b78\u9673\u51f1\u7b60\u526f\u6559\u6388\u5408\u4f5c\u7814\u7a76\u4e2d\u4e5f\u767c\u73fe\uff0c\u6f38\u51cd\u75c7\u75c5\u4eba\u7684GPx7\u8868\u73fe\u91cf\u7684\u78ba\u660e\u986f\u4f4e\u65bc\u4e00\u822c\u4eba\u3002<\/p>\n

\u81f3\u65bc\u5982\u4f55\u5c0d\u6297\u6c27\u5316\u58d3\u529b\uff1f\u7814\u7a76\u5718\u968a\u8207\u672c\u9662\u57fa\u56e0\u9ad4\u4e2d\u5fc3\u80e1\u6625\u7f8e\u52a9\u7814\u7a76\u54e1\u5408\u4f5c\u767c\u73fe\uff0cGPx7\u4ea6\u53ef\u505a\u70ba\u6c27\u5316\u58d3\u529b\u7684\u611f\u6e2c\u86cb\u767d\uff0c\u7576\u7d30\u80de\u611f\u53d7\u5230\u904e\u591a\u7684\u6d3b\u6027\u6c27\u985e\u6642\uff0c\u5c31\u6703\u555f\u52d5O-GlcNAcylation[1]<\/a>\u91a3\u5316\u8abf\u7bc0\u6a5f\u5236\u3002<\/p>\n

\n

[1]<\/a> O-GlcNAcylation\uff1a\u5728\u6b63\u5e38\u7684\u7d30\u80de\u4e2d\uff0c\u5169\u500b\u9175\u7d20\u76f8\u8f14\u76f8\u6210\u4fdd\u6301\u91a3\u5316\u52d5\u614b\u5e73\u8861\uff0c\u4f7f\u86cb\u767d\u8cea\u80fd\u5920\u6b63\u5e38\u4f5c\u7528\uff1b\u7136\u800c\u7576\u91a3\u5316\u8abf\u7bc0\u6a5f\u5236\u5931\u8861\u6642\uff0c\u5bb9\u6613\u5c0e\u81f4\u86cb\u767d\u8cea\u7684\u529f\u80fd\u7570\u5e38\u53ca\u5806\u758a\u3002O-GlcNAcylation\u662f\u5c07\u86cb\u767d\u8cea\u52a0\u4e0aO \u9023\u7d50\u4e59\u91af\u8461\u8404\u6c28\u7cd6(O-GlcNAc)\u7684\u91a3\u5316\u4f5c\u7528\uff0c\u9032\u800c\u5f71\u97ff\u86cb\u767d\u8cea\u529f\u80fd\uff0c\u7531\u5169\u7a2e\u9175\u7d20\u5354\u52a9\u5b8c\u6210\u6b63\u5411\u8207\u9006\u5411\u8f49\u63db\u7684\u53cd\u61c9\uff1aO \u9023\u7d50\u4e59\u91af\u8461\u8404\u6c28\u7cd6\u8f49\u79fb\u9176O-GlcNAc transferase (OGT)\u5354\u52a9\u86cb\u767d\u8cea\u7684\u91a3\u5316\uff0c\u800cO \u9023\u7d50\u4e59\u91af\u8461\u8404\u6c28\u7cd6\u82f7\u9176O-GlcNAcase (OGA)\u5247\u662f\u8ca0\u8cac\u79fb\u9664\u86cb\u767d\u8cea\u7684\u91a3\u5316\u3002<\/p>\n

\n

\u7531\u65bc\u75c5\u9f20\u7f3a\u4e4fGPx7\u4fbf\u7121\u6cd5\u6291\u5236OGA\u5c0d\u91a3\u5316\u7684\u9006\u5411\u53cd\u61c9\uff0c\u4f7f\u6b63\u5411\u91a3\u5316\u53cd\u61c9\u7121\u6cd5\u7de9\u89e3\u6c27\u5316\u58d3\u529b\uff0c\u56e0\u58d3\u529b\u800c\u53d7\u50b7\u7684\u904b\u52d5\u795e\u7d93\u5143\u7d30\u80de\u53ea\u80fd\u9010\u6b65\u9081\u5411\u51cb\u4ea1\u3002\u65bc\u662f\u7814\u7a76\u5718\u968a\u6301\u7e8c\u9935\u98df\u5254\u9664GPx7\u7684\u5c0f\u9f20OGA\u6291\u5236\u5291Thiamet-G\uff08TMG\uff093\u500b\u6708\u3002\u7d50\u679c\u767c\u73fe\u5c0f\u9f20\u9ad4\u5167\u7684\u91a3\u5316\u6b63\u5411\u53cd\u61c9\u4e0a\u5347\uff0c\u904b\u52d5\u795e\u7d93\u5143\u6578\u91cf\u975e\u4f46\u6c92\u6709\u6e1b\u9000\uff0c\u9023\u63a5\u81f3\u808c\u8089\u7684\u7a81\u89f8\u7d50\u69cb\u4e5f\u4e0d\u518d\u9000\u5316\uff0c\u904b\u52d5\u80fd\u529b\u660e\u986f\u8b8a\u597d\u3002\u6b64\u6b21\u7814\u7a76\u5efa\u7acb\u5e74\u9f61\u3001\u6c27\u5316\u58d3\u529b\u3001<\/p>\n

\u91a3\u5316\u8abf\u7bc0\u6a5f\u5236\u4e09\u8005\u4e92\u76f8\u727d\u52d5\u7684\u52d5\u7269\u6a21\u578b\uff0c\u5e0c\u671b\u80fd\u6a21\u64ec\u4eba\u9ad4\u5be6\u969b\u904b\u4f5c\u7684\u65b9\u5f0f\uff0c\u627e\u5230\u6f38\u51cd\u75c7\u81f4\u75c5\u6a5f\u5236\u548c\u6cbb\u7642\u7684\u7b56\u7565\u3002<\/p>\n

 <\/p>\n

\u6cbb\u7642\u7d50\u8178\u708e\u7684\u95dc\u9375\uff1a<\/strong>GPx8<\/strong><\/p>\n

GPx8\u5247\u80fd\u6291\u5236\u5de8\u566c\u7d30\u80de\u5167\u6d3b\u6027\u6c27\u985e\u6240\u5f71\u97ff\u7684\u767c\u708e\u53cd\u61c9\uff0c\u907f\u514d\u5c0e\u81f4\u7d50\u8178\u708e\u53ca\u6162\u6027\u767c\u708e\u5c0e\u81f4\u7684\u5927\u8178\u764c\u7b49\u75be\u75c5\u3002<\/p>\n

\u4e2d\u570b\u91ab\u5b78\u5927\u5b78\u5f90\u5a55\u7433\u52a9\u7406\u6559\u6388\u7814\u7a76\u767c\u73fe\uff0c\u5254\u9664GPx8\u57fa\u56e0\u7684\u5c0f\u9f20\u8178\u9053\u83cc\u53e2\u7684\u8c50\u5bcc\u6027\u53ca\u591a\u6a23\u6027\u6703\u56e0\u6b64\u964d\u4f4e\u3002\u5f90\u5a55\u7433\u8868\u793a\uff0c\u4eba\u9ad4\u8178\u9053\u5167\u6709\u5f88\u591a\u7d30\u83cc\uff0c\u82e5\u514d\u75ab\u7cfb\u7d71\u8996\u7d30\u83cc\u70ba\u75c5\u539f\u9ad4\u5165\u4fb5\uff0c\u514d\u75ab\u7cfb\u7d71\u4e2d\u7684\u5de8\u566c\u7d30\u80de\u4fbf\u6703\u7522\u751f\u6d3b\u6027\u6c27\u985e\uff0c\u4e5f\u6703\u540c\u6642\u6d3b\u5316\u86cb\u767d\u8ceacaspase-4\u53ca\u767c\u708e\u9ad4\u3002\u767c\u708e\u9ad4\u9664\u4e86\u8b58\u5225\u5404\u985e\u75c5\u539f\u9ad4\u4ee5\u53ca\u5371\u96aa\u4fe1\u865f\u5916\uff0c\u4e5f\u6703\u7522\u751f\u7d30\u80de\u6fc0\u7d20\uff0c\u7522\u751f\u767c\u708e\u53cd\u61c9\u3002<\/p>\n

\u7814\u7a76\u767c\u73fe\uff0c\u7f3a\u5c11GPx8\u5c31\u7121\u6cd5\u6291\u5236caspase-4\u6d3b\u5316\uff0c\u4f7f\u5f97\u767c\u708e\u53cd\u61c9\u505c\u4e0d\u4e0b\u4f86\uff0c\u8178\u9053\u6301\u7e8c\u7684\u6162\u6027\u767c\u708e\u5373\u70ba\u5c0e\u81f4\u7d50\u8178\u708e\u3001\u514b\u9686\u6c0f\u75c7\u53ca\u5927\u8178\u764c\u7b49\u75be\u75c5\u7684\u4e3b\u56e0\u3002<\/p>\n

\u5f90\u5a55\u7433\u52a9\u7406\u6559\u6388\u8207\u4e2d\u570b\u91ab\u85e5\u5927\u5b78\u9644\u8a2d\u91ab\u9662\u5468\u4ec1\u5049\u91ab\u5e2b\uff0c\u53ca\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u5b78\u8005\u85cd\u5fe0\u4eae\u8b1b\u5ea7\u6559\u6388\u7684\u5408\u4f5c\u7814\u7a76\u4e2d\u4e5f\u767c\u73fe\uff0c\u8a31\u591a\u6f70\u760d\u6027\u7d50\u8178\u708e\u75c5\u60a3\u7684\u6aa2\u9ad4\u7d44\u7e54\u4e2d\uff0cGPx8\u57fa\u56e0\u8868\u73fe\u78ba\u5be6\u504f\u4f4e\uff0c\u986f\u793a\u6b64\u4e00\u57fa\u56e0\u7684\u7f3a\u4e4f\u8207\u7d50\u8178\u708e\u5b58\u5728\u8457\u5bc6\u5207\u95dc\u4fc2\u3002<\/p>\n

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\u6b64\u6b21\u7814\u7a76\u5718\u968a\u5305\u62ec\u672c\u9662\u57fa\u56e0\u9ad4\u4e2d\u5fc3\u80e1\u6625\u7f8e\u52a9\u7814\u7a76\u54e1\u3001\u751f\u91ab\u6240\u65bd\u4fee\u660e\u7814\u7a76\u54e1\u3001\u81fa\u5927\u91ab\u9662\u795e\u7d93\u90e8\u8521\u529b\u51f1\u4e3b\u6cbb\u91ab\u5e2b\u3001\u81fa\u5317\u91ab\u5b78\u5927\u5b78\u9673\u51f1\u7b60\u526f\u6559\u6388\uff0c\u4ee5\u53ca\u4e2d\u570b\u91ab\u5b78\u5927\u5b78\u5f90\u5a55\u7433\u52a9\u7406\u6559\u6388\u3001\u4e2d\u570b\u91ab\u85e5\u5927\u5b78\u9644\u8a2d\u91ab\u9662\u6d88\u5316\u7cfb\u80c3\u8178\u79d1\u5468\u4ec1\u5049\u4e3b\u4efb\u3001\u5167\u79d1\u8b1b\u5ea7\u6559\u6388\u53ca\u98a8\u6fd5\u514d\u75ab\u79d1\u85cd\u5fe0\u4eae\u91ab\u751f\u548c\u5433\u67cf\u6a1f\u4e3b\u6cbb\u91ab\u5e2b\u3002\u76f8\u95dc\u8ad6\u6587\u5df2\u5206\u5225\u520a\u767b\u65bc\u570b\u969b\u671f\u520a\u300a\u7d30\u80de\u5831\u5c0e\u300b\uff08Cell Reports<\/em>\uff09\u53ca\u300aEMBO\u5206\u5b50\u91ab\u5b78\u300b\uff08EMBO Molecular Medicine<\/em>\uff09\u3002<\/p>\n

\u8ad6\u6587\u9023\u7d50\uff1a<\/p>\n

GPx7\uff1a https:\/www.cell.com\/cell-reports\/pdf\/S2211-1247(19)31367-1.pdf<\/a><\/p>\n

GPx8\uff1ahttps:\/www.embopress.org\/doi\/pdf\/10.15252\/emmm.201809386<\/a><\/p>\n

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