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Score\u4f86\u63a8\u4f30\u662f\u5426\u767c\u751f\u9023\u9396\uff0c\u5927\u81f4\u4f30\u7b97\u57fa\u56e0\u6a19\u8a18\u7684\u76f8\u5c0d\u4f4d\u7f6e\u3002<\/p>\n<p>\u7d93\u904e\u591a\u5e74\u7684\u52aa\u529b\uff0c\u7814\u7a76\u4eba\u54e1\u5229\u7528\u57fa\u56e0\u7684\u76f8\u5c0d\u4f4d\u7f6e\u63cf\u7e6a\u51fa\u57fa\u56e0\u5716\u8b5c\u3002\u4eba\u985e\u57fa\u56e0\u5716\u8b5c\u7684\u7528\u9014\uff0c\u5305\u542b\u627e\u5c0b\u81f4\u75c5\u57fa\u56e0\u7684\u76f8\u95dc\u4f4d\u7f6e\uff0c\u5982\u5b5f\u5fb7\u723e\u5f0f\u7684\u55ae\u4e00\u57fa\u56e0\u75be\u75c5\u3001\u8907\u96dc\u6027\u75be\u75c5\uff1b\u53ef\u505a\u5168\u57fa\u56e0\u9ad4\u6383\u63cf\u3001\u7d30\u90e8\u57fa\u56e0\u5206\u6790\uff0c\u4e14\u63a2\u7a76\u57fa\u56e0\u7684\u529f\u80fd\u7b49\u7b49\u3002<\/p>\n<p>\u4ee5\u4e00\u7a2e\u7f55\u898b\u75be\u75c5\u4ea8\u4e01\u9813\u821e\u8e48\u75c7\u70ba\u4f8b\uff0c\u9019\u662f\u55ae\u4e00\u57fa\u56e0\u7a81\u8b8a\u7684\u986f\u6027\u907a\u50b3\u75be\u75c5\uff0c\u60a3\u8005\u8166\u7d30\u80de\u795e\u7d93\u539f\u6301\u7e8c\u9000\u5316\uff0c\u5c0e\u81f4\u6d3b\u52d5\u5931\u63a7\u3001\u667a\u80fd\u6e1b\u9000\uff0c\u60c5\u7dd2\u4e0a\u4e5f\u6703\u6df1\u53d7\u56f0\u64fe\uff0c\u9818\u609f\u529b\u548c\u8a18\u61b6\u4e5f\u6703\u53d7\u5f71\u97ff\u3002\u7576\u5e74\u627e\u5230\u9019\u500b\u57fa\u56e0\u7a81\u8b8a\u9ede\u5c31\u662f\u5229\u7528\u9023\u9396\u5206\u6790\u53ca\u4eba\u985e\u57fa\u56e0\u5716\u8b5c\u3002<\/p>\n<p>\u6211\u5011\u53ef\u900f\u904e\u5bb6\u5ead\u5371\u96aa\u56e0\u5b50\u6bd4\u7387\uff08L\uff09\u7684\u8a08\u7b97\uff0c\u7406\u89e3\u75be\u75c5\u662f\u5426\u6709\u907a\u50b3\u6027\u3002\u7576\u5bb6\u5ead\u5371\u96aa\u56e0\u5b50\u6108\u9ad8\uff0c\u986f\u793a\u907a\u50b3\u6027\u6108\u9ad8\u3002\u4ea8\u4e01\u9813\u821e\u8e48\u75c7\u7684L\u503c(\u5bb6\u5ead\u95dc\u4fc2\u70ba\u5144\u5f1f\u59d0\u59b9\u6642)\u9ad8\u90545000\uff0c\u610f\u5373\u60a3\u8005\u7684\u5144\u5f1f\u59d0\u59b9\u5f97\u75c5\u7684\u6a5f\u7387\u6bd4\u4e00\u822c\u4eba\u9ad8\u51fa5000\u500d\uff1b\u56ca\u816b\u6027\u7e96\u7dad\u5316L\u503c\u662f500\u3001\u81ea\u9589\u75c7\u70ba75\u3001\u601d\u89ba\u601d\u8abf\u75c7\u70ba8\u81f310\u3001 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SNP\uff09\u662f\u5b58\u5728\u65bc\u4eba\u9ad4\u4e2d\u5f88\u597d\u7684\u57fa\u56e0\u6a19\u8a18\uff0c\u9019\u662fDNA\u5e8f\u5217\u4e2d\u55ae\u4e00\u9e7c\u57fa\u5c0d\u767c\u751f\u8b8a\u7570\uff0c\u610f\u5373DNA\u4e2dA\u3001T\u3001C\u3001G\u4e2d\u7684\u6539\u8b8a\u3002\u5728\u4eba\u985e\u907a\u50b3\u57fa\u56e0\u7684\u5404\u7a2e\u5dee\u7570\uff0c\u5982\u9ad4\u8cea\u3001\u7f79\u75c5\u548c\u85e5\u7269\u53cd\u61c9\u7684\u5dee\u7570\u67099\u6210\u90fd\u53ef\u4ee5\u6b78\u56e0\u65bcSNP\u7684\u8b8a\u7570\u3002\u4eba\u9ad4\u4e2d\u5927\u7d04\u670930\u5104\u500bDNA\u9e7c\u57fa\u5c0d\uff0c\u6bcf\u9694100\u81f3300\u500b\u9e7c\u57fa\u5c31\u6703\u5b58\u5728\u4e00\u500bSNP\u3002\u6839\u64da\u7f8e\u570b\u751f\u7269\u79d1\u6280\u8cc7\u8a0a\u4e2d\u5fc3(NCBI)\u7684\u8cc7\u6599\uff0c\u5df2\u6a19\u8a18\u51fa\u4eba\u9ad4\u7d04\u4e00\u5104\u591a\u500bSNPs\u3002<\/p>\n<p>\u76ee\u524d\u91dd\u5c0dSNP\u5df2\u6709\u7cfb\u7d71\u6027\u7684\u6aa2\u6e2c\uff0c\u4e14\u5efa\u7acbSNP\u8207\u75be\u75c5\u4e4b\u9593\u7684\u76f8\u95dc\u8cc7\u6599\u5eab\uff0c\u4fc3\u6210\u500b\u4eba\u5316\u91ab\u5b78\u53ca\u7cbe\u6e96\u6cbb\u7642\u7684\u767c\u5c55\u3002\u8fd1\u5e74\u4f86\uff0cSNP\u7be9\u6aa2\u5df2\u591a\u65b9\u61c9\u7528\u5728\u907a\u50b3\u75be\u75c5\u3001\u8907\u96dc\u6027\u75be\u75c5\u85e5\u7269\u5b78\u8207\u816b\u7624\u91ab\u5b78\u7684\u7814\u7a76\u3002\u6210\u529f\u7684\u56e0\u7d20\u5305\u542b\u79d1\u5b78\u5bb6\u5c0d\u57fa\u56e0\u9ad4\u4e0a\u6bd4\u8f03\u5e38\u898b\u7684SNP\u53ca\u5176\u6392\u5217\u65b9\u5f0f\u5df2\u6709\u8db3\u5920\u77e5\u8b58\uff0c\u9451\u5b9aSNP\u57fa\u56e0\u578b\u7684\u6280\u8853\u4e5f\u975e\u5e38\u6210\u719f\uff0c\u6b63\u78ba\u7387\u905499%\u4ee5\u4e0a\u4e14\u6210\u529f\u7387\u4e5f\u5f88\u9ad8\uff0c\u53e6\u4e00\u500b\u95dc\u9375\u662f\uff0cSNP\u6aa2\u6e2c\u6676\u7247\u50f9\u683c\u8fd1\u5e74\u4f86\u5927\u5e45\u4e0b\u964d\u3002<\/p>\n<p>\u8fd1\u5e74\u4f86\u75be\u75c5\u8207\u57fa\u56e0\u76f8\u95dc\u6027\u7684\u7814\u7a76\u5927\u53d7\u91cd\u8996\uff1b\u5728\u6c92\u6709\u89aa\u5c6c\u95dc\u4fc2\u7684\u65cf\u7fa4\u88e1\uff0c\u900f\u904e\u6bd4\u8f03\u75c5\u60a3\u8207\u5c0d\u7167\u7d44\uff0c\u89c0\u5bdf\u53ef\u80fd\u7684\u81f4\u75c5\u57fa\u56e0\u51fa\u73fe\u6b21\u6578\uff0c\u8207\u671f\u671b\u51fa\u73fe\u6b21\u6578\u4e4b\u9593\u4f5c\u6bd4\u8f03\uff0c\u7528\u5361\u65b9\u6aa2\u5b9a\u7d71\u8a08\u8a72\u57fa\u56e0\u8207\u767c\u75c5\u662f\u5426\u986f\u8457\u76f8\u95dc\u3002\u56e0\u70baSNP\u6aa2\u6e2c\u6676\u7247\u50f9\u683c\u4fbf\u5b9c\uff0c\u6240\u4ee5\u4ee5\u5168\u57fa\u56e0\u6383\u63cf\u6cd5\u627e\u5c0b\u81f4\u75c5\u57fa\u56e0\u975e\u5e38\u6d41\u884c\uff0c\u6839\u64da\u7f8e\u570b\u570b\u5bb6\u4eba\u985e\u57fa\u56e0\u7814\u7a76\u6240(NHGRI)\uff0c\u52302019\u5e74\u70ba\u6b62\uff0c\u4ee5\u5168\u57fa\u56e0\u9ad4\u5206\u6790\u8207\u75be\u75c5\u76f8\u95dc\u7684\u767b\u9304\u8868\u5c31\u67091800\u7a2e\u75be\u75c5\u53ca\u75c7\u72c0\u3001\u8d85\u904e4000\u7bc7\u4ee5\u4e0a\u7684\u8ad6\u6587\uff0c\u9019\u500b\u5927\u6578\u64da\u8cc7\u6599\u63d0\u4f9b\u7814\u7a76\u5b78\u8005\u4e86\u89e3\u81f4\u75c5\u75be\u75c5\u57fa\u56e0\u5728\u67d3\u8272\u9ad4\u7684\u76f8\u95dc\u4f4d\u7f6e\u53ca\u5176\u53ef\u80fd\u4e4b\u81f4\u75c5\u6a5f\u5236\u3002\u5716\u4e00\u70ba\u4eba\u985e\u5168\u57fa\u56e0\u9ad4\u95dc\u806f\u6027\u5206\u6790\u76ee\u9304\u3002<\/p>\n<div 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class=\"wp-caption-text\">\u5716\u4e00\uff1a\u4eba\u985e\u5168\u57fa\u56e0\u9ad4\u95dc\u806f\u6027\u5206\u6790\u76ee\u9304<\/p><\/div>\n<p>\u5728\u5168\u57fa\u56e0\u7d44\u95dc\u806f\u7814\u7a76\u5f8c\uff0c\u5f8c\u7e8c\u8981\u505a\u7684\u662f\u8f49\u8b6f\u91ab\u5b78\u7684\u61c9\u7528\u3002\u5728\u627e\u5230\u76f8\u95dc\u7684SNP\u5f8c\uff0c\u5c31\u6709\u66f4\u591a\u7684\u57fa\u56e0\u8cc7\u8a0a\uff0c\u77e5\u9053SNP\u7684\u529f\u7528\u3001\u54ea\u4e9b\u86cb\u767d\u8cea\u6703\u53d7\u5f71\u97ff\uff1f\u5c31\u80fd\u6709\u66f4\u591a\u7684\u81e8\u5e8a\u61c9\u7528\uff0c\u5982\u767c\u5c55\u751f\u7269\u6a19\u8a18\uff0c\u85c9\u6b64\u77e5\u9053\u54ea\u4e9b\u4eba\u8eab\u4e0a\u651c\u5e36\u7279\u5b9a\u7684SNP\uff0c\u53ef\u767c\u5c55\u76f8\u95dc\u7684\u6cbb\u7642\u65b9\u6cd5\u548c\u9810\u9632\u6a21\u5f0f\uff0c\u5c0d\u767c\u5c55\u7cbe\u6e96\u91ab\u7642\u3001\u500b\u4eba\u5316\u91ab\u7642\u6709\u975e\u5e38\u5927\u7684\u52a9\u76ca\u3002<\/p>\n<p>\u5c0d\u816b\u7624\u91ab\u5b78\u4f86\u8aaa\uff0c\u6bd4\u5982\u6a19\u9776\u6cbb\u7642\uff0c\u6211\u5011\u5fc5\u9808\u5148\u505a\u57fa\u56e0\u9451\u5b9a\uff0c\u624d\u77e5\u9053\u6709\u6c92\u6709\u7279\u5b9a\u57fa\u56e0\u578b\u3001\u85e5\u7269\u662f\u5426\u6703\u53cd\u61c9\uff1b\u4f46\u662f\uff0c\u56e0\u70ba\u76ee\u524d\u627e\u5230\u7684\u98a8\u96aa\u56e0\u5b50\u6548\u7387\u4e0d\u5f37\uff0c\u4e0d\u592a\u80fd\u4f5c\u70ba\u9810\u6e2c\u5de5\u5177\uff0c\u5982\u6211\u5011\u5c1a\u7121\u6cd5\u5229\u7528SNP\u4f86\u9810\u6e2c\u6703\u4e0d\u6703\u5f97\u5230\u7cd6\u5c3f\u75c5\u3001\u5fc3\u81df\u75c5\u6216\u7cbe\u795e\u75be\u75c5\u3002\u4e0d\u904e\uff0c\u5c0d\u65bc\u85e5\u7269\u4e0d\u826f\u53cd\u61c9\uff0c\u8fd1\u5e74\u4e5f\u6709\u8a31\u591a\u7814\u7a76\u9678\u7e8c\u554f\u4e16\uff0c\u53ef\u900f\u904e\u7279\u5b9a\u57fa\u56e0\u4e86\u89e3\u54ea\u4e9b\u4eba\u53ef\u80fd\u662f\u85e5\u7269\u4e0d\u826f\u53cd\u61c9\u7684\u9ad8\u5371\u96aa\u7fa4\u3002\u5716\u4e8c\u70ba\u6297\u7532\u72c0\u817a\u85e5\u5f15\u8d77\u7121\u9846\u7c92\u6027\u767d\u8840\u7403\u75c7\u526f\u4f5c\u7528\u4e4b\u5168\u57fa\u56e0\u7d44\u95dc\u9023\u5206\u6790\u3002<\/p>\n<p>\u4eba\u9ad4\u7684\u7d44\u6210\u975e\u5e38\u5967\u5999\uff0c\u57fa\u56e0\u7814\u7a76\u4e5f\u6d69\u701a\u7121\u57a0\uff0c\u5f8c\u7e8c\u4ecd\u6709\u8a31\u591a\u6311\u6230\u3002\u5982\u8907\u96dc\u6027\u57fa\u56e0\u8207\u57fa\u56e0\u7684\u4ea4\u4e92\u4f5c\u7528\u3001\u8907\u96dc\u6027\u57fa\u56e0\u8207\u74b0\u5883\u56e0\u7d20\u7684\u4ea4\u4e92\u4f5c\u7528\u90fd\u6709\u5f85\u91d0\u6e05\u3002\u65b0\u4e16\u4ee3\u57fa\u56e0\u5b9a\u5e8f\u7684\u6280\u8853\u65e5\u6f38\u6210\u719f\uff0c\u50f9\u683c\u4e5f\u6108\u4f86\u6108\u4f4e\uff0c\u4f46\u662f\u8cc7\u6599\u91cf\u975e\u5e38\u7684\u9f90\u5927\uff0c\u5132\u5b58\u8207\u5206\u6790\u8cc7\u6599\u8981\u82b1\u8cbb\u5f88\u591a\u529b\u6c23\u3001\u56f0\u96e3\u5ea6\u66f4\u70ba\u63d0\u9ad8\u3002\u4e5f\u8a31\u85c9\u7531\u6a5f\u5668\u5b78\u7fd2\u6216\u6df1\u5ea6\u5b78\u7fd2\u4f86\u8655\u7406\u57fa\u56e0\u5927\u6578\u64da\uff0c\u5c07\u53ef\u4ee5\u67f3\u6697\u82b1\u660e\u628a\u57fa\u56e0\u7814\u7a76\u63d0\u5347\u5230\u53e6\u4e00\u500b\u66f4\u9ad8\u7684\u5c64\u6b21!<\/p>\n<div id=\"attachment_20847\" style=\"width: 476px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-20847\" class=\"wp-image-20847\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/12\/3-1\u6f2b\u6b65\u79d1\u7814-\u3010\u672c\u671f\u5c08\u6b04\u3011-\u5716\u72472.jpg\" alt=\"\" width=\"466\" height=\"433\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/12\/3-1\u6f2b\u6b65\u79d1\u7814-\u3010\u672c\u671f\u5c08\u6b04\u3011-\u5716\u72472.jpg 466w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/12\/3-1\u6f2b\u6b65\u79d1\u7814-\u3010\u672c\u671f\u5c08\u6b04\u3011-\u5716\u72472-300x279.jpg 300w\" sizes=\"(max-width: 466px) 100vw, 466px\" \/><p id=\"caption-attachment-20847\" class=\"wp-caption-text\">\u5716\u4e8c\uff1a\u6297\u7532\u72c0\u817a\u85e5\u5f15\u8d77\u7121\u9846\u7c92\u6027\u767d\u8840\u7403\u75c7\u526f\u4f5c\u7528\u4e4b\u5168\u57fa\u56e0\u7d44\u95dc\u9023\u5206\u6790<\/p><\/div>\n<ul>\n<li><strong>\u6df1\u5165\u95b1\u8b80<\/strong><\/li>\n<\/ul>\n<ol>\n<li>The NHGRI-EBI Catalog of published genome-wide association studies\uff1a<a href=\"https:\/www.ebi.ac.uk\/gwas\/\">https:\/www.ebi.ac.uk\/gwas\/<\/a><\/li>\n<li>Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study. (2015), Nature Communications, 6:7633.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u75be\u75c5\u7684\u767c\u751f\uff0c\u9664\u4e86\u74b0\u5883\u3001\u751f\u6d3b\u5f62\u614b\u3001\u98f2\u98df\u53ef\u80fd\u662f\u5f71\u97ff\u56e0\u7d20\uff0c\u6bcf\u500b\u4eba\u7368\u4e00\u7121\u4e8c\u7684\u57fa\u56e0\u4e5f\u662f\u95dc\u9375\u7684\u539f\u56e0\u3002\u907a\u50b3\u6027\u75be\u75c5\u4f9d\u6210\u56e0\u53ef\u7d30\u5206\u6210\u55ae\u4e00\u57fa\u56e0\u7f3a\u9677\u3001\u67d3\u8272\u9ad4\u8b8a\u7570\u3001\u591a\u91cd\u57fa\u56e0\u5171\u540c\u5f71\u97ff\u53ca\u7c92\u7dda\u9ad4\u57fa\u56e0\u8b8a\u7570\u7b49\u3002\u5176\u4e2d\uff0c\u55ae\u4e00\u57fa\u56e0\u7f3a\u9677\u800c\u5f15\u8d77\u7684\u907a\u50b3\u75be\u75c5\u53c8\u7a31\u70ba\u5b5f\u5fb7\u723e\u578b\u75c5\u75c7\u3002<\/p>\n","protected":false},"author":1,"featured_media":20846,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[990,983],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/20845"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=20845"}],"version-history":[{"count":2,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/20845\/revisions"}],"predecessor-version":[{"id":20997,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/20845\/revisions\/20997"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/20846"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=20845"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=20845"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=20845"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}