{"id":19899,"date":"2019-09-26T00:06:46","date_gmt":"2019-09-25T16:06:46","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=19899"},"modified":"2021-08-04T09:54:29","modified_gmt":"2021-08-04T01:54:29","slug":"%e6%b8%9b%e8%82%a5%e6%b2%bb%e7%99%82%e6%96%b0%e7%99%bc%e7%8f%be%ef%bc%9a%e7%87%83%e7%87%92%e8%84%82%e8%82%aa%e7%9a%84%e9%97%9c%e9%8d%b5","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/19899\/","title":{"rendered":"\u6e1b\u80a5\u6cbb\u7642\u65b0\u767c\u73fe\uff1a\u71c3\u71d2\u8102\u80aa\u7684\u95dc\u9375"},"content":{"rendered":"<p>\u80a5\u80d6\u75c7\u8207\u7cd6\u5c3f\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u4e2d\u98a8\u548c\u764c\u75c7\u7b49\u75be\u75c5\u606f\u606f\u76f8\u95dc\uff0c\u5176\u4e2d\uff0c\u98f2\u98df\u8a98\u5c0e\u7684\u80a5\u80d6\uff08Diet-Induced Obesity, DIO\uff09\u66f4\u662f\u5168\u7403\u95dc\u6ce8\u7684\u5065\u5eb7\u3001\u793e\u6703\u548c\u7d93\u6fdf\u554f\u984c\u3002\u672c\u9662\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3<a href=\"http:\/www.genomics.sinica.edu.tw\/index.php\/tw\/juan-li-jung-\">\u962e\u9e97\u84c9\u7814\u7a76\u54e1<\/a>\u7684\u5718\u968a\u6700\u65b0\u767c\u73fe\uff0c\u80a5\u80d6\u75c7\u548c\u4eba\u9ad4\u5167\u7684\u4e00\u7a2e\u57fa\u56e0Naa10p<a href=\"#_ftn1\" name=\"_ftnref1\">[1]<\/a>\u8868\u9054\u904e\u91cf\u6709\u95dc\uff0c\u672a\u4f86\u85c9\u7531\u6291\u5236\u6210\u4eba\u8102\u80aa\u7d44\u7e54\u4e2d\u7684Naa10p\u7684\u9176\u6d3b\u6027\uff0c\u5c07\u53ef\u4ee5\u6291\u5236\u98f2\u98df\u8a98\u5c0e\u6027\u7684\u80a5\u80d6\u3002\u76f8\u95dc\u7814\u7a76\u6210\u679c\u5df2\u520a\u767b\u65bc\u570b\u969b\u77e5\u540d\u671f\u520a\u300a\u5206\u5b50\u7d30\u80de\u300b\uff08<em>Molecular Cell<\/em>\uff09\uff0c\u4e26\u88ab\u300a\u81ea\u7136\u7d50\u69cb\u53ca\u5206\u5b50\u751f\u7269\u300b\uff08<em>Nature Structure and Molecular Biology<\/em>\uff09\u9078\u70ba\u5c08\u6587\u5831\u5c0e\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter  wp-image-19900\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/09\/1-1-1.jpg\" alt=\"\" width=\"919\" height=\"675\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/09\/1-1-1.jpg 5750w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/09\/1-1-1-300x220.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/09\/1-1-1-768x564.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/09\/1-1-1-1024x753.jpg 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/09\/1-1-1-1080x794.jpg 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/09\/1-1-1-574x422.jpg 574w\" sizes=\"(max-width: 919px) 100vw, 919px\" \/><\/p>\n<p>\u300cNaa10p\u662f\u4eba\u9ad4\u767c\u80b2\u6642\u7684\u91cd\u8981\u86cb\u767d\uff0c\u4f46\u662f\u904e\u91cf\u7684Naa10p\u6703\u5c0e\u81f4\u80a5\u80d6\uff0c\u751a\u81f3\u764c\u8b8a\u3002\u300d\u962e\u9e97\u84c9\u7814\u7a76\u54e1\u8aaa\u3002\u904e\u5f80\u7814\u7a76\u5df2\u77e5\uff0cNaa10p\u7a81\u8b8a\u6703\u5c0e\u81f4\u767c\u80b2\u9072\u7de9\uff0c\u56b4\u91cd\u5982\u7f55\u898b\u75be\u75c5\u5967\u683c\u767b\u75c7\u5019(Ogden syndrome)\u75c5\u4eba\u4e00\u6b72\u534a\u524d\u5373\u6b7b\u4ea1\uff0c\u800c\u9019\u985e\u75c5\u4eba\u7684\u7279\u5fb5\u662f\u76ae\u4e0b\u8102\u80aa\u5f88\u5c11\u3002\u962e\u9e97\u84c9\u7814\u7a76\u54e1\u5718\u968a\u56e0\u6b64\u5e0c\u671b\u66f4\u77ad\u89e3Naa10p\u662f\u5426\u8207\u8102\u80aa\u751f\u6210\u548c\u4ee3\u8b1d\u76f8\u95dc\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u76ee\u524d\u4e5f\u5df2\u77e5\u9ad4\u5167\u4e3b\u5c0e\u8017\u80fd\u7522\u71b1\u7684\u7c73\u8272\u8102\u80aa\u7d30\u80de\uff08beige fat\uff09<a href=\"#_ftn2\" name=\"_ftnref2\">[2]<\/a>\u5728\u6e1b\u80a5\u904e\u7a0b\u4e2d\u626e\u6f14\u95dc\u9375\u89d2\u8272\u3002\u56e0\u70ba\u7c73\u8272\u8102\u80aa\u80fd\u589e\u5f37\u80fd\u91cf\u6d88\u8017\uff0c\u4e00\u65e6\u767c\u751f\u7f3a\u9677\uff0c\u6703\u5c0e\u81f4\u5132\u5b58\u8102\u80aa\u7684\u767d\u8272\u8102\u80aa\u7d44\u7e54\u64f4\u5f35\uff0c\u9032\u800c\u5f15\u767cDIO\u3002\u5be6\u9a57\u8b49\u5be6\uff0c\u7f3a\u4e4f\u7c73\u8272\u8102\u80aa\u7684\u5c0f\u9f20\u6703\u7522\u751f\u80a5\u80d6\u75c7\u4ee5\u53ca\u5168\u8eab\u6027\u4ee3\u8b1d\u529f\u80fd\u969c\u7919\u3002\u56e0\u6b64\uff0c\u76ee\u524d\u6cbb\u7642\u80a5\u80d6\u6700\u5177\u5438\u5f15\u529b\u7684\u7642\u6cd5\u4e4b\u4e00\uff0c\u5373\u70ba\u5728\u767d\u8272\u8102\u80aa\u7d44\u7e54\u4e2d\u4fc3\u9032\u7c73\u8272\u8102\u80aa\u7d30\u80de\u589e\u751f\u3002<\/p>\n<p>\u70ba\u4e86\u9032\u4e00\u6b65\u627e\u51faNaa10p\u8207\u8102\u80aa\u4ee3\u8b1d\u7684\u904b\u4f5c\u6a5f\u5236\uff0c\u962e\u9e97\u84c9\u5718\u968a\u5229\u7528\u5168\u8eab\u548c\u8102\u80aa\u5c08\u4e00\u6027\u5254\u9664Naa10p\u7684\u5c0f\u9f20\u9a57\u8b49Naa10p\u662f\u5426\u5f71\u97ff\u7c73\u8272\u8102\u80aa\u7d30\u80de\u5206\u5316\uff0c\u4ee5\u53ca\u6291\u5236\u80fd\u91cf\u6d88\u8017\u8207\u7522\u71b1\u3002\u7d50\u679c\u767c\u73fe\uff0c\u5254\u9664Naa10p\u57fa\u56e0\u7684\u5c0f\u9f20\u4e0d\u50c5\u660e\u986f\u7626\u5c0f\uff0c\u4e5f\u5927\u5927\u4fc3\u9032\u4e86\u7c73\u8272\u8102\u80aa\u7d30\u80de\u7684\u751f\u6210\u53ca\u7522\u71b1\u6548\u61c9\uff0c\u9054\u6210\u9810\u9632\u9ad8\u8102\u80aa\u98f2\u98df\u5f15\u8d77\u7684\u80a5\u80d6\u3002<\/p>\n<p>\u9664\u4e86\u5c0f\u9f20\u5be6\u9a57\uff0c\u962e\u9e97\u84c9\u7814\u7a76\u54e1\u4e5f\u548c\u81fa\u5927\u91ab\u9662\u5167\u79d1\u90e8\u838a\u7acb\u6c11\u91ab\u5e2b\u53ca\u5f35\u4ee5\u627f\u91ab\u5e2b\u5408\u4f5c\uff0c\u6aa2\u9a57\u4eba\u985e\u8102\u80aa\u7d44\u7e54\uff0c\u77ad\u89e3Naa10p\u8207\u4eba\u985e\u80a5\u80d6\u7684\u76f8\u95dc\u6027\u3002\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u4eba\u985eNaa10p\u7684\u57fa\u56e0\u8868\u73fe\u91cf\uff0c\u4e5f\u8207\u80a5\u80d6\u6210\u6b63\u76f8\u95dc\u3002\u7814\u7a76\u5718\u968a\u8868\u793a\uff0c\u672a\u4f86\u82e5\u6291\u5236\u6210\u4eba\u8102\u80aa\u7d44\u7e54\u4e2d\u7684Naa10p\u7684\u9175\u7d20\u6d3b\u6027\uff0c\u5c07\u53ef\u4ee5\u6291\u5236\u98f2\u98df\u8a98\u5c0e\u6027\u7684\u80a5\u80d6\u3002\u6b64\u9805\u7814\u7a76\u6210\u679c\u4e0d\u50c5\u8b49\u5be6\u4e86Naa10p\u5c0e\u81f4\u80a5\u80d6\u7684\u6a5f\u5236\uff0c\u4e5f\u63d0\u51fa\u80a5\u80d6\u8207\u764c\u8b8a\u7684\u95dc\u9023\uff0c\u66f4\u70ba\u6cbb\u7642\u80a5\u80d6\u63d0\u4f9b\u4e00\u500b\u65b0\u7b56\u7565\u3002<\/p>\n<p>\u962e\u9e97\u84c9\u7814\u7a76\u54e1\u9577\u671f\u81f4\u529b\u65bcNaa10p\u76f8\u95dc\u7814\u7a76\uff0c<a href=\"https:\/www.jci.org\/articles\/view\/42275\">2010\u5e74<\/a>\u5373\u767c\u73fe\uff0c\u4eba\u985eNaa10p\u904e\u91cf\u8868\u9054\uff0c\u53ef\u85c9\u7531\u8207DNA\u7532\u57fa\u9176\u7684\u4f5c\u7528\uff0c\u9020\u6210\u6291\u764c\u57fa\u56e0\u555f\u52d5\u5b50\u7532\u57fa\u5316\uff0c\u9032\u800c\u6291\u5236\u6291\u764c\u57fa\u56e0\u7684\u8868\u73fe\uff0c\u5c0e\u81f4\u80ba\u7d30\u80de\u764c\u5316\u3002<a href=\"http:\/www.genomics.sinica.edu.tw\/2015\/index.php\/en\/news\/news-archives\/524-role-of-n-acetyltransferase-10-protein-in-dna-methylation-and-genomic-imprinting\">2017\u5e74\u7684\u7814\u7a76<\/a>\u66f4\u900f\u904eNaa10p\u57fa\u56e0\u5168\u8eab\u5254\u9664\u5c0f\u9f20\u767c\u73fe\uff0cNaa10p\u53ef\u4ee5\u7dad\u6301\u5c0f\u9f20\u80da\u80ce\u53ca\u5e79\u7d30\u80de\u5168\u57fa\u56e0\u9ad4\u7532\u57fa\u5316\uff0c\u4e26\u4e14\u6a19\u8a18\u5370\u8a18\u5c0d\u5076\u57fa\u56e0\uff0c\u7dad\u6301\u57fa\u56e0\u9ad4\u5370\u8a18\u3002<\/p>\n<p>\u6b64\u8ad6\u6587\u4e3b\u8981\u901a\u8a0a\u4f5c\u8005\u70ba\u672c\u9662\u962e\u9e97\u84c9\u7814\u7a76\u54e1\uff0c\u7b2c\u4e00\u4f5c\u8005\u53ca\u5171\u540c\u901a\u8a0a\u4f5c\u8005\u70ba\u672c\u9662\u535a\u58eb\u5f8c\u7814\u7a76\u5b78\u8005\u674e\u632f\u8aa0\u535a\u58eb\u57f7\u884c\u4e3b\u8981\u5be6\u9a57\u3002\u53c3\u8207\u7814\u7a76\u4eba\u54e1\u5305\u62ec\u962e\u9e97\u84c9\u5be6\u9a57\u5ba4\u6210\u54e1\uff1a\u81fa\u5927\u5206\u5b50\u91ab\u5b78\u7814\u7a76\u6240\u78a9\u58eb\u751f\u65bd\u8b70\u921e\u3001\u7814\u7a76\u52a9\u7406\u5eb7\u660e\u502b\u53ca\u672c\u9662\u570b\u969b\u7814\u7a76\u751f\u5b78\u7a0b\u535a\u58eb\u5019\u9078\u4ebaRamanan Devaraj\u3001\u4ee5\u53ca\u81fa\u5927\u91ab\u9662\u838a\u7acb\u6c11\u91ab\u5e2b\u548c\u5f35\u4ee5\u627f\u91ab\u5e2b\u3002\u7814\u7a76\u7d93\u8cbb\u7531\u4e2d\u7814\u9662\u3001\u79d1\u6280\u90e8\u5171\u540c\u652f\u6301\u3002<\/p>\n<p>\u8ad6\u6587\u9023\u7d50\uff1a<a href=\"https:\/www.sciencedirect.com\/science\/article\/pii\/S1097276519305647?via%3Dihub\">https:\/www.sciencedirect.com\/science\/article\/pii\/S1097276519305647?via%3Dihub<\/a><\/p>\n<p>\u300a\u81ea\u7136\u7d50\u69cb\u53ca\u5206\u5b50\u751f\u7269\u300b\u5c08\u6587\u5831\u5c0e: <a href=\"https:\/www.nature.com\/articles\/s41594-019-0310-2\">https:\/www.nature.com\/articles\/s41594-019-0310-2<\/a><\/p>\n<p>\uff08\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\uff09<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"#_ftnref1\" name=\"_ftn1\">[1]<\/a>Naa10p: \u86cb\u767d\u8ceaN\u7aef\u4e59\u91af\u8f49\u5316\u917610 (N-a-acetyltransferase 10 protein, Naa10p)\uff0c\u4e3b\u8981\u65bc\u7d30\u80de\u8cea\u8ca0\u8cac\u65b0\u751f\u86cb\u767d\u8cea\u4e4bN\u7aef\u4e59\u91af\u5316\uff0c\u4e26\u53c3\u8207\u8abf\u63a7\u7d30\u80de\u9031\u671f\u3001\u751f\u9577\u53ca\u51cb\u4ea1\u7b49\u751f\u7406\u529f\u80fd\u3002<\/p>\n<p><a href=\"#_ftnref2\" name=\"_ftn2\">[2]<\/a>\u7c73\u8272\u8102\u80aa\u7d30\u80de\uff08beige adipocytes\uff09\uff1a\u5206\u5e03\u65bc\u76ae\u4e0b\u767d\u8272\u8102\u80aa\u7d44\u7e54\u4e2d\u985e\u4f3c\u68d5\u8272\u8102\u80aa\u7684\u7d30\u80de\uff0c\u4e3b\u8981\u5c07\u8102\u80aa\u8207\u8461\u8404\u7cd6\u8f49\u5316\u6210\u71b1\u80fd\u4f9b\u8eab\u9ad4\u4f7f\u7528\u3002\u76ee\u524d\u7c73\u8272\u8102\u80aa\u7d30\u80de\u5f62\u6210\u7684\u6a5f\u5236\uff0c\u5c1a\u4e0d\u6e05\u695a\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u80a5\u80d6\u75c7\u8207\u7cd6\u5c3f\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u4e2d\u98a8\u548c\u764c\u75c7\u7b49\u75be\u75c5\u606f\u606f\u76f8\u95dc\uff0c\u5176\u4e2d\uff0c\u98f2\u98df\u8a98\u5c0e\u7684\u80a5\u80d6\uff08Diet-Induced Obes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":19900,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/19899"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=19899"}],"version-history":[{"count":2,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/19899\/revisions"}],"predecessor-version":[{"id":19968,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/19899\/revisions\/19968"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/19900"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=19899"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=19899"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=19899"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}