{"id":19828,"date":"2019-09-12T00:00:00","date_gmt":"2019-09-11T16:00:00","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=19828"},"modified":"2021-08-04T10:28:57","modified_gmt":"2021-08-04T02:28:57","slug":"%e7%99%b1%e7%98%93%e8%80%85%e7%9a%84%e7%a6%8f%e9%9f%b3%ef%bc%81%e4%ba%ba%e5%b7%a5%e5%90%88%e6%88%90%e5%85%ab%e9%86%a3%e9%ab%94%ef%bc%8c%e4%bf%83%e4%bd%bf%e8%84%8a%e9%ab%93%e7%a5%9e%e7%b6%93%e8%bb%b8","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/19828\/","title":{"rendered":"\u7671\u7613\u8005\u7684\u798f\u97f3\uff01\u4eba\u5de5\u5408\u6210\u516b\u91a3\u9ad4\uff0c\u4fc3\u4f7f\u810a\u9ad3\u795e\u7d93\u8ef8\u7a81\u518d\u751f"},"content":{"rendered":"<pre class=\"aio-icon-title ult-responsive\" data-ultimate-target=\"#Info-box-wrap-7138 .aio-icon-title\" data-responsive-json-new=\"{&quot;font-size&quot;:&quot;&quot;,&quot;line-height&quot;:&quot;&quot;}\"><strong>\u5468\u570d\u795e\u7d93\u8ef8\u7a81\u518d\u751f\r\n\r\n<\/strong>\u5728\u540c\u5b78\u5750\u4e0b\u6642\u5c07\u6905\u5b50\u79fb\u958b\u3001\u7ad9\u7acb\u6642\u76f4\u63a5\u5f4e\u8170\u642c\u91cd\u7269\uff0c\u9019\u4e9b\u52d5\u4f5c\u770b\u4f3c\u7121\u95dc\u7dca\u8981\uff0c\u5176\u5be6\u975e\u540c\u5c0f\u53ef\uff0c\u5f88\u5bb9\u6613\u50b7\u5230\u810a\u9ad3\u795e\u7d93\u3002\u66f4\u56b4\u91cd\u7684\u662f\uff0c\u810a\u9ad3\u795e\u7d93\u53d7\u640d\u5f8c\u7121\u6cd5\u4fee\u5fa9\uff0c\u4e00\u65e6\u9020\u6210\u50b7\u5bb3\uff0c\u53ef\u80fd\u534a\u8eab\u4e0d\u9042\u3002\u597d\u6d88\u606f\u662f\uff0c\u4e2d\u7814\u9662\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u6d2a\u4e0a\u7a0b\u8207\u65e5\u672c\u540d\u53e4\u5c4b\u5927\u5b78\u5408\u4f5c\uff0c\u8fd1\u65e5\u767c\u73fe\uff1a\u4eba\u5de5\u5408\u6210\u7684\u300c\u786b\u9178\u4e59\u91af\u809d\u7d20\u300d\u516b\u91a3\u9ad4\uff0c\u80fd\u8b93\u5c0f\u9f20\u53d7\u640d\u7684\u810a\u9ad3\u795e\u7d93\u8ef8\u7a81\u518d\u751f\uff0c\u6216\u8a31\u5728\u672a\u4f86\u67d0\u4e00\u5929\uff0c\u53ef\u4ee5\u6210\u529f\u4fee\u5fa9\u4eba\u985e\u53d7\u640d\u7684\u810a\u9ad3\u795e\u7d93\u3002<\/pre>\n<div class=\"entry-content\">\n<div class=\"smart_content_wrapper\">\n<div class=\"editway201704 vc_row wpb_row vc_row-fluid dt-default\">\n<div class=\"wpb_column vc_column_container vc_col-sm-12\">\n<div class=\"vc_column-inner\">\n<div class=\"wpb_wrapper\">\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<h2 class=\"contains_subtitle_icon\"><strong><b>\u4eba\u985e\u7684\u795e\u7d93\u7cfb\u7d71\u8207\u795e\u7d93\u5143\u7d30\u80de<\/b><\/strong><\/h2>\n<p>\u4eba\u985e\u7684<a href=\"https:\/zh.wikipedia.org\/zh-hant\/%E7%A5%9E%E7%BB%8F%E7%B3%BB%E7%BB%9F\" target=\"_blank\" rel=\"noopener noreferrer\">\u795e\u7d93\u7cfb\u7d71<\/a>\u5206\u6210\u5169\u500b\u90e8\u5206\uff1a\u5305\u542b\u8166\u548c\u810a\u9ad3\u7684\u4e2d\u6a1e\u795e\u7d93\uff0c\u4ee5\u53ca\u904d\u5e03\u5168\u8eab\u7684\u5468\u570d\u795e\u7d93\u3002<\/p>\n<p>&nbsp;<\/p>\n<div id=\"attachment_10158\" style=\"width: 601px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-10158\" class=\"wp-image-10158 \" src=\"http:\/research.sinica.edu.tw\/wp-content\/uploads\/2019\/09\/hung-shang-cheng-01-.jpg\" alt=\"\u5716\u7247\u4f86\u6e90\u2502iStock\u5716\u8aaa\u8a2d\u8a08\u2502\u9ec3\u66c9\u541b\u3001\u6797\u6d35\u5b89\" width=\"591\" height=\"730\" \/><p id=\"caption-attachment-10158\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90\u2502iStock \u5716\u8aaa\u8a2d\u8a08\u2502\u9ec3\u66c9\u541b\u3001\u6797\u6d35\u5b89<\/p><\/div>\n<p>&nbsp;<\/p>\n<p>\u4f46\u4e0d\u7ba1\u54ea\u500b\u90e8\u4f4d\u7684\u795e\u7d93\uff0c\u57fa\u672c\u55ae\u4f4d\u90fd\u662f<a href=\"https:\/zh.wikipedia.org\/wiki\/%E7%A5%9E%E7%B6%93%E5%85%83\" target=\"_blank\" rel=\"noopener noreferrer\">\u795e\u7d93\u5143\u7d30\u80de<\/a>\u3002\u6240\u6709\u7684\u795e\u7d93\u5143\u90fd\u6709\u4e09\u500b\u57fa\u672c\u69cb\u9020\uff1a\u7d30\u80de\u6838\u6240\u5728\u7684\u7d30\u80de\u9ad4 \uff0c\u8ca0\u8cac\u63a5\u6536\u8a0a\u606f\u7684\u6a39\u72c0\u7a81\u8d77\u2500\u6a39\u7a81 \uff0c\u9084\u6709\u5c07\u795e\u7d93\u8a0a\u606f\u5411\u5916\u50b3\u9001\u3001\u4e00\u689d\u7d30\u9577\u7ba1\u72c0\u7a81\u8d77\u2500\u8ef8\u7a81\u3002<\/p>\n<p>\u795e\u7d93\u5143\u7d30\u80de\u50b3\u9001\u8a0a\u606f\u7684\u65b9\u6cd5\u662f\uff1a\u7d30\u80de\u9ad4\u7684\u795e\u7d93\u885d\u52d5\uff0c\u5148\u7531\u8ef8\u7a81\u50b3\u5230\u672b\u7aef\u7684\u7a81\u89f8\uff0c\u518d\u7531\u4e0b\u4e00\u500b\u795e\u7d93\u5143\u7d30\u80de\u7684\u6a39\u7a81\u63a5\u6536\u3001\u8ef8\u7a81\u50b3\u51fa\uff0c\u5c31\u9019\u6a23\u4e00\u500b\u50b3\u4e00\u500b\uff0c\u5b9b\u5982\u63a5\u529b\u8cfd\u822c\u628a\u8a0a\u606f\u50b3\u51fa\u53bb\uff0c\u76f4\u5230\u76ee\u7684\u90e8\u4f4d\u3002<\/p>\n<p>&nbsp;<\/p>\n<div id=\"attachment_10159\" style=\"width: 606px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-10159\" class=\"wp-image-10159\" src=\"http:\/research.sinica.edu.tw\/wp-content\/uploads\/2019\/09\/hung-shang-cheng-02-.jpg\" alt=\"\u7b2c\u4e00\u500b\u795e\u7d93\u5143\u7d30\u80de\u5c07\u795e\u7d93\u885d\u52d5\u50b3\u5230\u8ef8\u7a81\u672b\u7aef\u7684\u7a81\u89f8\uff0c\u7136\u5f8c\u91cb\u653e\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u5230\u4e0b\u4e00\u500b\u795e\u7d93\u5143\u7d30\u80de\u7684\u6a39\u7a81\u7a81\u89f8\uff0c\u85c9\u6b64\u5c07\u795e\u7d93\u885d\u52d5\u50b3\u7d66\u4e0b\u4e00\u500b\u795e\u7d93\u5143......\u5c31\u9019\u6a23\u628a\u8a0a\u606f\u63a5\u529b\u50b3\u5230\u76ee\u7684\u5730\u3002\u795e\u7d93\u5143\u8ef8\u7a81\u9577\u5ea6\u76f8\u5dee\u5f88\u5927\uff0c\u6709\u7684\u50c5\u5206\u5e03\u5728\u7d30\u80de\u5468\u570d\uff1b\u6709\u7684\u5f88\u9577\uff0c\u50cf\u662f\u6210\u4eba\u7684\u5750\u9aa8\u795e\u7d93\uff0c\u9577\u5ea6\u80fd\u8d85\u904e1.5\u516c\u5c3a\u3002\u5716\u7247\u4f86\u6e90\u2502iStock\u5716\u8aaa\u8a2d\u8a08\u2502\u9ec3\u66c9\u541b\u3001\u6797\u6d35\u5b89\" width=\"596\" height=\"1217\" \/><p id=\"caption-attachment-10159\" class=\"wp-caption-text\">\u7b2c\u4e00\u500b\u795e\u7d93\u5143\u7d30\u80de\u5c07\u795e\u7d93\u885d\u52d5\u50b3\u5230\u8ef8\u7a81\u672b\u7aef\u7684\u7a81\u89f8\uff0c\u7136\u5f8c\u91cb\u653e\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u5230\u4e0b\u4e00\u500b\u795e\u7d93\u5143\u7d30\u80de\u7684\u6a39\u7a81\u7a81\u89f8\uff0c\u85c9\u6b64\u5c07\u795e\u7d93\u885d\u52d5\u50b3\u7d66\u4e0b\u4e00\u500b\u795e\u7d93\u5143\u2026\u2026\u5c31\u9019\u6a23\u628a\u8a0a\u606f\u63a5\u529b\u50b3\u5230\u76ee\u7684\u5730\u3002\u795e\u7d93\u5143\u8ef8\u7a81\u9577\u5ea6\u76f8\u5dee\u5f88\u5927\uff0c\u6709\u7684\u50c5\u5206\u5e03\u5728\u7d30\u80de\u5468\u570d\uff1b\u6709\u7684\u5f88\u9577\uff0c\u50cf\u662f\u6210\u4eba\u7684\u5750\u9aa8\u795e\u7d93\uff0c\u9577\u5ea6\u80fd\u8d85\u904e1.5\u516c\u5c3a\u3002 \u5716\u7247\u4f86\u6e90\u2502iStock \u5716\u8aaa\u8a2d\u8a08\u2502\u9ec3\u66c9\u541b\u3001\u6797\u6d35\u5b89<\/p><\/div>\n<p>&nbsp;<\/p>\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<p>&nbsp;<\/p>\n<p>\u53cd\u904e\u4f86\u8aaa\uff0c\u5982\u679c\u8ef8\u7a81\u53d7\u640d\u3001\u65b7\u88c2\uff0c\u7121\u6cd5\u518d\u751f\uff0c\u5c31\u6703\u963b\u65b7\u795e\u7d93\u8a0a\u606f\u50b3\u905e\uff0c\u56b4\u91cd\u5c07\u5c0e\u81f4\u7671\u7613\u3002\u6d2a\u4e0a\u7a0b\u3001\u9580\u677e\u5065\u6cbb\u8de8\u570b\u5718\u968a\u7684\u7814\u7a76\u6545\u4e8b\uff0c\u5c31\u5f9e\u9019\u88e1\u958b\u59cb\u2026\u2026<\/p>\n<\/div>\n<\/div>\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<h2 class=\"contains_subtitle_icon\"><strong><b>\u8ef8\u7a81\u518d\u751f\u7684\u95dc\u9375\uff1a\u86cb\u767d\u8cea Cortactin<\/b><\/strong><\/h2>\n<p>\u7531\u6d2a\u4e0a\u7a0b\u3001\u9580\u677e\u5065\u6cbb\u7d44\u6210\u7684\u8de8\u570b\u7814\u7a76\u5718\u968a\u767c\u5e03\u3001\u520a\u767b\u65bc\u570b\u969b\u671f\u520a\u300a\u81ea\u7136\uff0d\u5316\u5b78\u751f\u7269\u5b78\u300b\uff08Nature Chemical Biology\uff09\u7684\u7814\u7a76\u8ad6\u6587\u4e2d\uff0c\u65e5\u672c\u5718\u968a\u5f9e\u5c0f\u9f20\u8eab\u4e0a\u53d6\u5f97\u7684<a href=\"https:\/zh.wikipedia.org\/zh-tw\/%E8%83%8C%E6%A0%B9%E7%A5%9E%E7%B6%93%E7%AF%80\" target=\"_blank\" rel=\"noopener noreferrer\">\u80cc\u6839\u795e\u7d93\u7bc0<\/a>\u4f5c\u70ba\u7814\u7a76\u6750\u6599\uff0c\u80cc\u6839\u795e\u7d93\u7bc0\u5c6c\u65bc\u4e0a\u8ff0\u7684\u5468\u570d\u795e\u7d93\u3002<\/p>\n<p>\u7d50\u679c\u767c\u73fe\uff1a \u7576\u795e\u7d93\u5143\u7684\u8ef8\u7a81\u53d7\u640d\u6216\u65b7\u88c2\u6642\uff0c\u8ef8\u7a81\u672b\u7aef\u6703\u5f62\u6210\u7403\u72c0\u51f8\u8d77\u7269\uff0c\u4ee5\u907f\u514d\u795e\u7d93\u5143\u7d30\u80de\u8cea\u6301\u7e8c\u6d41\u5931\uff0c\u4f46\u5728\u6b64\u540c\u6642\uff0c\u4e5f\u963b\u7919\u4e86\u8ef8\u7a81\u751f\u9577\uff0c\u5c0e\u81f4\u8ef8\u7a81\u53d7\u50b7\u5f8c\u7121\u6cd5\u4fee\u5fa9\u3002<\/p>\n<p>\u6240\u5e78\uff0c\u65e5\u672c\u7814\u7a76\u5718\u968a\u53c8\u767c\u73fe\uff1a\u795e\u7d93\u5143\u8ef8\u7a81\u80fd\u5426\u518d\u751f\uff0c\u95dc\u9375\u5728\u7d30\u80de\u5167\u4e00\u7a2e\u540d\u70ba Cortactin \u7684\u86cb\u767d\u8cea\u3002\u7576 Cortactin \u88ab\u78f7\u9178\u6839\u5316\uff0c\u5c31\u6703\u4fc3\u4f7f\u7d30\u80de\u9032\u884c\u81ea\u566c\u4f5c\u7528\uff0c\u8b93\u8ef8\u7a81\u672b\u7aef\u7684\u7403\u72c0\u51f8\u8d77\u7269\u5206\u89e3\u3002\u5982\u6b64\u4e00\u4f86\uff0c\u65b7\u88c2\u7684\u8ef8\u7a81\u5c31\u53ef\u4ee5\u91cd\u65b0\u751f\u9577\u3001\u7522\u751f\u9023\u7d50\u3002<\/p>\n<p>&nbsp;<\/p>\n<div id=\"attachment_10160\" style=\"width: 719px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-10160\" class=\"wp-image-10160\" src=\"http:\/research.sinica.edu.tw\/wp-content\/uploads\/2019\/09\/hung-shang-cheng-03-.jpg\" alt=\"\u7576 Cortactin \u88ab\u78f7\u9178\u6839\u5316\uff0c\u5c31\u6703\u4fc3\u4f7f\u8ef8\u7a81\u672b\u7aef\u7684\u7403\u72c0\u51f8\u8d77\u7269\u5206\u89e3\uff0c\u8b93\u65b7\u88c2\u7684\u8ef8\u7a81\u53ef\u4ee5\u91cd\u65b0\u751f\u9577\u3002\u8cc7\u6599\u4f86\u6e90\u2502\u6d2a\u4e0a\u7a0b\u5716\u8aaa\u91cd\u88fd\uff5c\u9ec3\u66c9\u541b\u3001\u6797\u6d35\u5b89\" width=\"709\" height=\"576\" \/><p id=\"caption-attachment-10160\" class=\"wp-caption-text\">\u7576 Cortactin \u88ab\u78f7\u9178\u6839\u5316\uff0c\u5c31\u6703\u4fc3\u4f7f\u8ef8\u7a81\u672b\u7aef\u7684\u7403\u72c0\u51f8\u8d77\u7269\u5206\u89e3\uff0c\u8b93\u65b7\u88c2\u7684\u8ef8\u7a81\u53ef\u4ee5\u91cd\u65b0\u751f\u9577\u3002 \u8cc7\u6599\u4f86\u6e90\u2502\u6d2a\u4e0a\u7a0b \u5716\u8aaa\u91cd\u88fd\uff5c\u9ec3\u66c9\u541b\u3001\u6797\u6d35\u5b89<\/p><\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p>\u53ef\u60dc\u7684\u662f\uff0c\u5728\u795e\u7d93\u5143\u8ef8\u7a81\u53d7\u640d\u7684\u60c5\u6cc1\u4e0b\uff0cCortactin \u662f\u6c92\u6709\u88ab\u78f7\u9178\u6839\u5316\u3001\u6c92\u6709\u6d3b\u6027\u7684\u72c0\u614b\u3002<\/p>\n<p>\u6d2a\u4e0a\u7a0b\u6307\u51fa\uff0c\u539f\u56e0\u5728\u65bc\u7d30\u80de\u5167\u9084\u6709\u786b\u9178\u8edf\u9aa8\u7d20\uff08Chondroitin Sulfate\uff0c\u4ee5\u4e0b\u7c21\u7a31 CS\uff09\u548c\u78f7\u9178\u6839\u79fb\u9664\u9176\uff08Protein Tyrosine Phosphatase Receptor \u03c3\uff0c\u4ee5\u4e0b\u7c21\u7a31 PTPR\u03c3\uff09\u3002<\/p>\n<p>CS \u5206\u5b50\u6703\u5728\u53d7\u50b7\u7684\u795e\u7d93\u8ef8\u7a81\u9644\u8fd1\u805a\u96c6\uff0c\u4e26\u548c\u795e\u7d93\u5143\u7d30\u80de\u8868\u9762\u7684 PTPR\u03c3 \u7d50\u5408\uff0c\u4f7f\u5b83\u6d3b\u5316\u3002\u4e00\u65e6 PTPR\u03c3 \u88ab\u6d3b\u5316\uff0c\u6703\u79fb\u9664 Cortactin \u7684\u78f7\u9178\u6839\u3002\u6c92\u6709\u78f7\u9178\u6839\u3001\u6c92\u6709\u6d3b\u6027\u7684 Cortactin \u5c31\u7121\u6cd5\u4fc3\u6210\u7d30\u80de\u9032\u884c\u81ea\u566c\u4f5c\u7528\uff0c\u53d7\u640d\u7684\u8ef8\u7a81\u5c31\u7121\u6cd5\u4fee\u5fa9\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"attachment_10161\" style=\"width: 705px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-10161\" class=\"wp-image-10161\" src=\"http:\/research.sinica.edu.tw\/wp-content\/uploads\/2019\/09\/hung-shang-cheng-04-.jpg\" alt=\"\u7b2c\u4e00\u500b\u65b0\u767c\u73fe\uff1aCS \u5206\u5b50\u7d50\u5408\u53d7\u5668 PTPR\u03c3\uff0c\u6703\u79fb\u9664 Cortactin \u7684\u78f7\u9178\u6839\uff0c\u963b\u7919\u795e\u7d93\u5143\u8ef8\u7a81\u518d\u751f\u3002\u8cc7\u6599\u4f86\u6e90\uff5c\u6d2a\u4e0a\u7a0b\u5716\u8aaa\u91cd\u88fd\uff5c\u9ec3\u66c9\u541b\u3001\u6797\u6d35\u5b89\" width=\"695\" height=\"626\" \/><p id=\"caption-attachment-10161\" class=\"wp-caption-text\">\u7b2c\u4e00\u500b\u65b0\u767c\u73fe\uff1a CS 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center;\"><strong>\u8981\u770b\u66f4\u5b8c\u6574\u7684\u7cbe\u91c7\u6587\u7ae0\uff0c\u8acb\u81f3\u7814\u4e4b\u6709\u7269\u5b98\u7db2\uff1a<\/strong><\/h2>\n<h2 style=\"text-align: center;\"><a href=\"http:\/research.sinica.edu.tw\/hung-shang-cheng-glycans-spinal-nerve\/\"><em>http:\/research.sinica.edu.tw\/hung-shang-cheng-glycans-spinal-nerve\/<\/em><\/a><\/h2>\n<h2 style=\"text-align: center;\"><strong>\uff08\u8d95\u5feb\u9ede\u9032\u4f86\u5594\uff01\u9084\u6709\u66f4\u591a\u7cbe\u91c7\u5716\u6587\uff01\uff09<\/strong><\/h2>\n<div class=\"entry-content\">\n<div class=\"smart_content_wrapper\">\n<div class=\"editway201704 vc_row wpb_row vc_row-fluid dt-default\">\n<div class=\"wpb_column vc_column_container vc_col-sm-12\">\n<div class=\"vc_column-inner\">\n<div class=\"wpb_wrapper\">\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5468\u570d\u795e\u7d93\u8ef8\u7a81\u518d\u751f \u5728\u540c\u5b78\u5750\u4e0b\u6642\u5c07\u6905\u5b50\u79fb\u958b\u3001\u7ad9\u7acb\u6642\u76f4\u63a5\u5f4e\u8170\u642c\u91cd\u7269\uff0c\u9019\u4e9b\u52d5\u4f5c\u770b\u4f3c\u7121\u95dc\u7dca\u8981\uff0c\u5176\u5be6\u975e\u540c\u5c0f\u53ef\uff0c\u5f88\u5bb9\u6613\u50b7\u5230 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