{"id":19795,"date":"2019-09-12T00:00:52","date_gmt":"2019-09-11T16:00:52","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=19795"},"modified":"2020-12-25T13:41:09","modified_gmt":"2020-12-25T05:41:09","slug":"%e6%8f%ad%e9%96%8b%e6%93%8d%e6%8e%a7%e7%b4%b0%e8%83%9e%e7%94%9f%e6%ad%bb%e5%91%bd%e9%81%8b%e7%9a%84%e9%97%9c%e9%8d%b5%e8%97%89%e4%bb%a5%e9%96%8b%e7%99%bc%e7%99%8c%e7%97%87%e6%96%b0%e7%99%82%e6%b3%95","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/19795\/","title":{"rendered":"\u63ed\u958b\u64cd\u63a7\u7d30\u80de\u751f\u6b7b\u547d\u904b\u7684\u95dc\u9375\u85c9\u4ee5\u958b\u767c\u764c\u75c7\u65b0\u7642\u6cd5"},"content":{"rendered":"<p>\u764c\u75c7\u5df2\u87ec\u806f\u570b\u4eba\u5341\u5927\u6b7b\u56e0\u7684\u9996\u4f4d\uff0c\u5982\u4f55\u6709\u6548\u6bba\u6b7b\u764c\u7d30\u80de\u4e00\u76f4\u662f\u764c\u75c7\u6cbb\u7642\u7684\u91cd\u8981\u8ab2\u984c\u3002\u672c\u9662\u751f\u7269\u5316\u5b78\u7814\u7a76\u6240\u7279\u8058\u7814\u7a76\u54e1<a href=\"https:\/www.ibc.sinica.edu.tw\/zh\/%E4%BA%BA%E5%93%A1\/%E7%A0%94%E7%A9%B6%E4%BA%BA%E5%93%A1\/%E5%B0%88%E4%BB%BB%E7%A0%94%E7%A9%B6%E4%BA%BA%E5%93%A1\/%E9%99%B3%E7%91%9E%E8%8F%AF\/\"><strong>\u9673\u745e\u83ef<\/strong><\/a>\u7814\u7a76\u5718\u968a\uff0c\u5354\u540c\u4e2d\u570b\u91ab\u85e5\u5927\u5b78\u6821\u9577\u6d2a\u660e\u5947\u9662\u58eb\u6700\u65b0\u7814\u7a76\u767c\u73fe\u4e86\u4e00\u5957\u638c\u63a7\u7d30\u80de\u751f\u6b7b\u547d\u904b\u7684\u6a5f\u5236\uff0c\u4e26\u5229\u7528\u6b64\u6a5f\u5236\u958b\u767c\u51fa\u65b0\u7a4e\u764c\u75c7\u6cbb\u7642\u7b56\u7565\uff0c\u7814\u7a76\u5df2\u65bc\u4eca\uff08108\uff09\u5e748\u67086\u65e5\u520a\u767b\u65bc\u570b\u969b\u671f\u520a<strong><em>Journal of Cell Biology<\/em><\/strong>\u3002<\/p>\n<p>\u7814\u7a76\u5718\u968a\u767c\u73fe\u7d30\u80de\u5167\u4e00\u7a2e\u540d\u70baBIK\u7684\u86cb\u767d\uff08\u53c8\u7a31\u6bba\u624b\u86cb\u767d\uff09\u53ef\u4ee5\u5728\u7d30\u80de\u627f\u53d7\u4e0d\u540c\u58d3\u529b\u6642\u626e\u6f14\u8457\u64cd\u63a7\u7d30\u80de\u751f\u6b7b\u547d\u904b\u7684\u89d2\u8272\u3002\u5728DNA\u640d\u50b7\u6642BIK\u7684\u6cdb\u7d20\u63a5\u5408\u9176ASB11\u8868\u73fe\u91cf\u6e1b\u5c11\uff0c\u9032\u800c\u5c0e\u81f4BIK\u6cdb\u7d20\u5316\u4fee\u98fe\u6e1b\u5c11\u800c\u86cb\u767d\u8cea\u7a69\u5b9a\u5ea6\u589e\u9ad8\uff0c\u85c9\u4ee5\u4fc3\u9032\u7d30\u80de\u51cb\u4ea1\u3002\u53cd\u4e4b\uff0c\u5728\u5167\u8cea\u7db2\u58d3\u529b\u5b58\u5728\u4e0bASB11\u8868\u73fe\u63d0\u5347\uff0c\u9032\u800c\u589e\u52a0BIK\u6cdb\u7d20\u5316\u4fee\u98fe\u53ca\u5176\u964d\u89e3\uff0c\u5982\u6b64\u53ef\u4f7f\u7d30\u80de\u5728\u58d3\u529b\u4e0b\u5b58\u6d3b\u3002<\/p>\n<p>\u6d2a\u660e\u5947\u9662\u58eb\u5728\u591a\u5e74\u524d\u5373\u958b\u767c\u51fa\u4ee5\u6d3b\u5316\u614bBIK\u4f5c\u70ba\u764c\u75c7\u57fa\u56e0\u6cbb\u7642\u7684\u65b9\u6cd5\uff0c\u4e26\u5728\u591a\u7a2e\u764c\u75c7\uff0c\u4f8b\u5982\u4e73\u764c\u3001\u80ba\u764c\u3001\u809d\u764c\u3001\u80f0\u81df\u764c\u3001\u524d\u5217\u817a\u764c\u7684\u81e8\u5e8a\u524d\u8a66\u9a57\u5f97\u5230\u4e0d\u932f\u7684\u7642\u6548\uff0c\u6b64\u6b21\u9673\u745e\u83ef\u5718\u968a\u8207\u6d2a\u9662\u58eb\u5408\u4f5c\uff0c\u5229\u7528IRE1\u03b1\u6291\u5236\u5291\u963b\u65b7BIK\u6cdb\u7d20\u5316\u964d\u89e3\u9014\u5f91\uff0c\u7814\u7a76\u986f\u793a\u8a72\u6291\u5236\u5291\u8207\u6d3b\u5316\u614bBIK\u5408\u4f75\u4f7f\u7528\uff0c\u53ef\u4ee5\u5728\u7d30\u80de\u53ca\u52d5\u7269\u6a21\u578b\u5927\u5e45\u589e\u52a0\u6bd2\u6bba\u764c\u7d30\u80de\u7684\u4f5c\u7528\uff0c\u5c0d\u764c\u75c7\u6cbb\u7642\u958b\u555f\u4e86\u65b0\u5951\u6a5f\u3002<\/p>\n<p>\u6b64\u7814\u7a76\u7b2c\u4e00\u4f5c\u8005\u70ba\u672c\u9662\u751f\u5316\u6240\u9673\u98db\u6f90\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\uff0c\u901a\u8a0a\u4f5c\u8005\u70ba\u9673\u745e\u83ef\u7279\u8058\u7814\u7a76\u54e1\uff0c\u5171\u540c\u4f5c\u8005\u70ba\u53f0\u5927\u751f\u5316\u79d1\u5b78\u7814\u7a76\u6240\u78a9\u58eb\u751f\u9ec3\u654f\u745c\u3001\u4f55\u5176\u5bf0\u3001\u751f\u5316\u6240\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\u6797\u88d5\u654f\u3001\u7814\u7a76\u6280\u5e2b\u6797\u6dd1\u59a4\u535a\u58eb\u3001\u53f0\u5317\u91ab\u5b78\u5927\u5b78\u9673\u5ffb\u6021\u52a9\u7406\u6559\u6388\u3001\u4ee5\u53ca\u4e2d\u570b\u91ab\u85e5\u5927\u5b78\u6d2a\u660e\u5947\u9662\u58eb\uff0c\u7814\u7a76\u7d93\u8cbb\u6e90\u81ea\u672c\u9662\u6df1\u8015\u8a08\u756b\u3002<\/p>\n<p>\u8ad6\u6587\u540d\u7a31: BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.<br \/>\n\u8ad6\u6587\u9023\u7d50: <a href=\"http:\/jcb.rupress.org\/content\/early\/2019\/08\/05\/jcb.201901156.long\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/jcb.rupress.org\/content\/early\/2019\/08\/05\/jcb.201901156.long<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-19796 aligncenter\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/09\/3-2-1024x647.jpg\" alt=\"\" width=\"800\" height=\"505\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/09\/3-2-1024x647.jpg 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/09\/3-2-300x189.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/09\/3-2-768x485.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/09\/3-2-1080x682.jpg 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/09\/3-2.jpg 1767w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right;\">\uff08\u751f\u7269\u5316\u5b78\u7814\u7a76\u6240\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u764c\u75c7\u5df2\u87ec\u806f\u570b\u4eba\u5341\u5927\u6b7b\u56e0\u7684\u9996\u4f4d\uff0c\u5982\u4f55\u6709\u6548\u6bba\u6b7b\u764c\u7d30\u80de\u4e00\u76f4\u662f\u764c\u75c7\u6cbb\u7642\u7684\u91cd\u8981\u8ab2\u984c\u3002\u672c\u9662\u751f\u7269\u5316\u5b78\u7814\u7a76\u6240\u7279\u8058\u7814\u7a76\u54e1\u9673\u745e\u83ef\u7814 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":19796,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[988,984],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/19795"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=19795"}],"version-history":[{"count":2,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/19795\/revisions"}],"predecessor-version":[{"id":19853,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/19795\/revisions\/19853"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/19796"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=19795"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=19795"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=19795"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}