{"id":19680,"date":"2019-08-29T00:00:35","date_gmt":"2019-08-28T16:00:35","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=19680"},"modified":"2021-08-04T10:31:49","modified_gmt":"2021-08-04T02:31:49","slug":"%e7%a5%9e%e7%b6%93%e7%99%bc%e7%82%8e%e5%8a%a0%e5%8a%87%e5%a4%a7%e8%85%a6%e9%80%80%e5%8c%96-%e6%8a%91%e5%88%b6%e9%97%9c%e9%8d%b5%e8%9b%8b%e7%99%bd%e8%b3%aa%e9%99%8d%e3%80%8c%e8%85%a6%e7%81%ab%e3%80%8d","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/19680\/","title":{"rendered":"\u795e\u7d93\u767c\u708e\u52a0\u5287\u5927\u8166\u9000\u5316  \u6291\u5236\u95dc\u9375\u86cb\u767d\u8cea\u964d\u300c\u8166\u706b\u300d"},"content":{"rendered":"<p>\u5927\u8166\u795e\u7d93\u767c\u708e\u662f\u795e\u7d93\u9000\u5316\u75be\u75c5\uff08\u8b6c\u5982\uff0c\u963f\u8332\u6d77\u9ed8\u75c7\uff08AD\uff09\u3001\u4ea8\u4e01\u9813\u821e\u8e48\u75c7\uff08HD\uff09 <sup>1<\/sup> \uff09\u7684\u91cd\u8981\u81f4\u75c5\u539f\u56e0\uff0c\u5982\u4f55\u6297\u5927\u8166\u795e\u7d93\u767c\u706b\u5462\uff1f\u672c\u9662\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240<a href=\"http:\/www.ibms.sinica.edu.tw\/yijuang-chern\/\">\u9673\u5100\u838a\u7279\u8058\u7814\u7a76\u54e1<\/a>\u53ca\u91a3\u79d1\u5b78\u5718\u968a\uff0c\u8207\u6797\u53e3\u9577\u5e9a\u91ab\u9662\u53ca\u81fa\u5317\u69ae\u6c11\u7e3d\u91ab\u9662\u7684\u91ab\u5b78\u5718\u968a\u6700\u65b0\u7814\u7a76\u767c\u73fe\uff0c\u900f\u904e\u6291\u5236\u5fae\u81a0\u7d30\u80de\uff08microglia\uff09 <sup>2<\/sup> \u4e2d\u7684\u86cb\u767d\u8cea \u201cGalectin-3\u201d\uff0c\u53ef\u4ee5\u6709\u6548\u5730\u964d\u4f4e\u7d30\u80de\u7684\u767c\u708e\u53cd\u61c9\uff0c\u6e1b\u7de9\u795e\u7d93\u9000\u5316\u75be\u75c5\u7684\u75c7\u72c0\uff0c\u5ef6\u9577\u5c0f\u9f20\u58fd\u547d\u3002\u7814\u7a76\u5df2\u65bc\u672c\uff088\uff09\u67082\u65e5\u520a\u767b\u65bc\u570b\u969b\u671f\u520a<strong>\u300a\u81ea\u7136\u901a\u8a0a\u300b(<em>Nature Communications<\/em>)<\/strong>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-19681\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/08\/1-1-1.jpg\" alt=\"\" width=\"836\" height=\"504\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/08\/1-1-1.jpg 836w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/08\/1-1-1-300x181.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/08\/1-1-1-768x463.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/08\/1-1-1-440x264.jpg 440w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/08\/1-1-1-836x504.jpg 1200w\" sizes=\"(max-width: 836px) 100vw, 836px\" \/><\/p>\n<p>\u904e\u5f80\u6587\u737b\u6307\u51fa\uff0c\u8a31\u591a\u795e\u7d93\u9000\u5316\u75be\u75c5\u3001\u4e2d\u98a8\u3001\u5275\u50b7\u578b\u8166\u640d\u50b7\uff08TBI\uff09\u3001\u591a\u767c\u6027\u786c\u5316\u75c7\uff08MS\uff09\u7b49\u8166\u90e8\u75c5\u8b8a\u90fd\u548c\u795e\u7d93\u767c\u708e\u6709\u95dc\uff0c\u9019\u4e9b\u751f\u75c5\u6216\u767c\u751f\u5275\u50b7\u7684\u8166\u4e2d\u6703\u5927\u91cf\u51fa\u73feGalectin-3\uff0c\u4e0d\u904e\u4e26\u4e0d\u6e05\u695a\u6b64\u86cb\u767d\u8cea\u5728\u8166\u4e2d\u7684\u529f\u80fd\u548c\u75c5\u7406\u6a5f\u5236\u3002<\/p>\n<p>\u6b64\u6b21\u7814\u7a76\u5718\u968a\u4ee5HD\u505a\u70ba\u5be6\u9a57\u6a21\u578b\u6642\u767c\u73fe\uff0cHD\u5c0f\u9f20\u7684\u5fae\u81a0\u7d30\u80de\u6703\u51fa\u73fe\u5927\u91cfGalectin-3\u53ca\u7834\u640d\u7684\u6eb6\u9176\u9ad4\uff08lysosomes\uff09 <sup>3<\/sup> \uff0c\u4e26\u89c0\u5bdf\u5230\u767c\u708e\u7684\u5fae\u81a0\u7d30\u80de\u5167\uff0cGalectin-3\u6703\u7d50\u5408\u5728\u7834\u640d\u7684\u6eb6\u9176\u9ad4\u5167\u819c\uff0c\u5e72\u64fe\u7d30\u80de\u6e05\u9664\u7834\u640d\u7684\u6eb6\u9176\u9ad4\uff0c\u52a0\u5287\u795e\u7d93\u767c\u708e\u53cd\u61c9\u3002\u900f\u904e\u85e5\u7269\u6216\u57fa\u56e0\u65b9\u6cd5\u6291\u5236Galectin-3\uff0c\u80fd\u6709\u6548\u5730\u6539\u5584\u7d30\u80de\u6e05\u9664\u6eb6\u9176\u9ad4\u7684\u80fd\u529b\uff0c\u964d\u4f4e\u5fae\u81a0\u7d30\u80de\u7684\u767c\u708e\u53cd\u61c9\uff0c\u9032\u800c\u6e1b\u7de9\u795e\u7d93\u9000\u5316\u75be\u75c5\u7684\u75c5\u7a0b\uff0c\u4e26\u6539\u5584HD\u5c0f\u9f20\u7684\u75c7\u72c0\u53ca\u58fd\u547d\u3002<\/p>\n<p>\u9673\u5100\u838a\u7279\u8058\u7814\u7a76\u54e1\u8868\u793a\uff0c\u300c\u6b64\u7814\u7a76\u8b49\u5be6\u4e86Galectin-3\u5728\u795e\u7d93\u767c\u708e\u53cd\u61c9\u7684\u904b\u4f5c\u6a5f\u5236\u300d\u3002\u6b64\u6b21\u767c\u73fe\u4e0d\u50c5\u53ef\u61c9\u7528\u65bc\u5176\u4ed6\u795e\u7d93\u9000\u5316\u75be\u75c5\uff0c\u5982\u963f\u8332\u6d77\u9ed8\u75c7\uff0c\u4e5f\u662f\u672a\u4f86\u88fd\u85e5\u80fd\u52a0\u4ee5\u61c9\u7528\u7684\u65b0\u7b56\u7565\u3002<\/p>\n<p>\u6b64\u7814\u7a76\u7b2c\u4e00\u4f5c\u8005\u70ba\u672c\u9662\u570b\u969b\u7814\u7a76\u751f\u5b78\u7a0b\uff08TIGP\uff09\u5206\u5b50\u91ab\u5b78\u5b78\u7a0b\u535a\u58eb\u751f\u856d\u5efa\u9756\u3002\u7814\u7a76\u5171\u540c\u4f5c\u8005\u70ba\u7814\u7a76\u52a9\u7406\u9673\u60e0\u7f8e\u3001\u535a\u58eb\u751f\u9673\u7389\u73cd\u3001\u535a\u58eb\u5f8c\u7814\u7a76\u9673\u7165\u6e90\u3001\u9673\u5b8f\u9716\u3001\u5f35\u656c\u90a6\u3002\u6797\u53e3\u9577\u5e9a\u91ab\u9662\u5433\u9038\u5982\u91ab\u5e2b\u3001\u9673\u74ca\u7f8e\u91ab\u5e2b\uff0c\u81fa\u5317\u69ae\u7e3d\u91ab\u9662\u5b8b\u79c9\u6587\u91ab\u5e2b\u3002\u4ee5\u53ca\u672c\u9662\u6797\u4fca\u5b8f\u7814\u7a76\u54e1\u3001\u672c\u9662\u5289\u6276\u6771\u9662\u58eb\u3001\u9673\u5100\u838a\u7279\u8058\u7814\u7a76\u54e1\u3002\u7814\u7a76\u7d93\u8cbb\u6e90\u81ea\u4e2d\u7814\u9662\u53ca\u79d1\u6280\u90e8\u3002<\/p>\n<p>\u8ad6\u6587\u5168\u6587\u3008Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington\u2019s disease\u3009\uff1b<br \/>\n\u7db2\u5740\uff1a<a href=\"https:\/www.nature.com\/articles\/s41467-019-11441-0\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/www.nature.com\/articles\/s41467-019-11441-0<\/a><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right;\">\uff08\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\uff09<\/p>\n<hr \/>\n<p><sup>1<\/sup> 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[&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":19681,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/19680"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=19680"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/19680\/revisions"}],"predecessor-version":[{"id":19682,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/19680\/revisions\/19682"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/19681"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=19680"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=19680"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=19680"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}